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Research Update
Dec. 22, 2017
Scientists’ recent analysis of hundreds of thousands of human genomes has identified new links between certain gene sequence variations and body mass index (BMI), a measure of weight relative to height.
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Research Update
Dec. 19, 2017
An international group of researchers revealed several areas of the human genome that convey risk for developing primary sclerosing cholangitis, a disease that can lead to liver damage.
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Research Update
Nov. 28, 2017
Researchers have identified two different molecules that can limit growth of microbes that cause urinary tract infections (UTIs), adding to approaches being pursued to develop new strategies for clinical treatment of UTIs.
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Research Update
Nov. 22, 2017
A recent study has established a correlation between the level of fibroblast growth factor-23 (FGF-23) in the blood of a person with chronic kidney disease (CKD), measured over time, and the risk of death.
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Research Update
Nov. 22, 2017
Researchers have identified a protein present at high levels in blood from infants with biliary atresia that may enable early and accurate detection of this potentially deadly disease.
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Research Update
Nov. 20, 2017
Scientists have developed a new way to replace lost beta cells in mouse models of type 1 diabetes.
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Research Update
Nov. 15, 2017
Using human samples and animal models, researchers have found that an enzyme produced by certain bacteria could disrupt the gut microbiome, potentially playing a significant role in the development of inflammatory bowel disease.
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News Release
Nov. 13, 2017
Obesity during pregnancy — independent of its health consequences such as diabetes — may account for the higher risk of giving birth to an atypically large infant, according to researchers at the National Institutes of Health. Their study appears in JAMA Pediatrics.
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News Release
Nov. 6, 2017
For the first time, scientists have found a connection between abnormalities in how the brain breaks down glucose and the severity of the signature amyloid plaques and tangles in the brain, as well as the onset of eventual outward symptoms, of Alzheimer’s disease.
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Research Update
Nov. 3, 2017
A clinical trial led by a pharmaceutical company with additional support from an NIDDK-supported Cystic Fibrosis Center has shown that a combination of two medications provides significant clinical benefit in a subgroup of patients with cystic fibrosis (CF).
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Research Update
Nov. 1, 2017
In a clinical trial, researchers found that as people lost weight, their appetite and calorie consumption increased, leading to a leveling off of weight loss.
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News Release
Nov. 1, 2017
More than 30 million people in the United States have diabetes – and each one is the most important member of their diabetes care team. This National Diabetes Month, I urge everyone with diabetes to make your care a joint effort between you, your loved ones and your health care team.
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Research Update
Oct. 26, 2017
Scientists found that feeding mice twice a day, with complete food restriction in between, improved metabolism and prevented age- and obesity-associated metabolic defects compared to allowing them 24-hour access to food.
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Research Update
Oct. 5, 2017
Researchers identified two factors that contribute to the critical balance of food intake and calorie burning in mice.
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Research Update
Oct. 3, 2017
Researchers have found that the sugars fructose and glucose cause different metabolic effects and health outcomes in mice, but only in animals eating a high-fat diet.
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News Release
Oct. 2, 2017
The 2017 Nobel Prize in Physiology or Medicine has been awarded to National Institutes of Health grantees Jeffrey C. Hall, Ph.D., of the University of Maine, Orono; Michael Rosbash, Ph.D., of Brandeis University, Waltham, Massachusetts; and Michael W. Young, Ph.D., of Rockefeller University, New York City, for their discoveries of molecular mechanisms controlling the circadian rhythm.
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Research Update
Sept. 28, 2017
Researchers have used sophisticated technologies to examine individual cells from healthy human pancreata to understand how the cells change with age.
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Research Update
Sept. 21, 2017
A long-term study of gastric bypass surgery has shown lasting weight loss and effective remission and prevention of type 2 diabetes for more than a decade.
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Research Update
Sept. 19, 2017
Results of NIDDK-supported research have improved understanding of factors that can help predict vulnerability to severe hypoglycemia in African American and white individuals with type 2 diabetes.
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News Release
Sept. 13, 2017
Can a high-tech water bottle help reduce the recurrence of kidney stones? What about a financial incentive? Those are questions researchers funded by the National Institutes of Health will seek to answer as they begin recruiting participants for a two-year clinical trial at four sites across the country. Scientists will test whether using a smart water bottle that encourages people to drink more water, and therefore urinate, will reduce the recurrence of urinary stone disease, commonly referred to as kidney stones. The trial is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of NIH.
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News Release
Sept. 12, 2017
More than 60 percent of investigational drugs fail in human clinical trials due to a lack of effectiveness, despite promising pre-clinical studies using cell and animal research models. To help combat this translational science problem, the National Institutes of Health announced 13 two-year awards totaling about $15 million per year, with FY18 funds subject to availability, to develop 3-D microphysiological system platforms that model human disease. The funding is for the first phase of a five-year program. These platforms, called “tissue chips,” support living cells and human tissues to mimic the complex biological functions of human organs and systems and provide a new way to test potential drug efficacy.
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Research Update
Sept. 5, 2017
A new study found that in people who do not have chronic kidney disease (CKD), an intensive blood pressure control regimen increases risk of declining kidney function; this risk is generally outweighed by a reduced risk for cardiovascular events and death.
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Research Update
Sept. 5, 2017
Molecules produced by friendly gut bacteria could extend the time that worms, flies, and mice remain healthy during their lives—with potential implications for human health.
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Research Update
Aug. 30, 2017
Proteins involved in ensuring that other proteins are in their proper shapes may have a role to play in mitigating the effects of cystic fibrosis.
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Research Update
Aug. 26, 2017
New insights into outcomes from drug-induced liver injury include the rate of fatal outcomes, frequency of bile duct damage and loss, and racial/ethnic disparities in disease severity.
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Research Update
Aug. 25, 2017
Seasonal variability in the gut microbiome of a traditional hunter-gatherer population in Tanzania provides new insights into how diet and modernization may affect bacteria in the gut.
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Research Update
Aug. 14, 2017
Researchers have identified a protein in the mouse brain responsible for the metabolic syndrome caused by an antipsychotic medication.
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Research Update
Aug. 14, 2017
A newly identified molecular factor key to the activation of energy-burning brown fat could further possibilities for obesity treatment.
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Research Update
Aug. 3, 2017
Scientists have identified an important role for a gut bacterial species and its metabolites in the maturation of a key immune cell.
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Research Update
Aug. 1, 2017
Recent report highlights a successful multicomponent effort that reduced infection rates by 54 percent compared to prior care.
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Research Update
July 26, 2017
Researchers have discovered cellular mechanisms by which the brain regulates aging in mice
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News Release
July 26, 2017
On August 10, Discovery will premiere First in Human, a three-part documentary on the National Institutes of Health Clinical Center, providing an unprecedented, first-hand look at the successes and setbacks that are a part of developing brand-new medicines that may ultimately benefit millions worldwide. Over a period of a year, film crews embedded within the hospital follow four patients who volunteered to participate in experimental treatments in the hopes they will help them, or others in the future. The series also follows the dedicated doctors and nurses who carry out the research while caring for the patients. Narrated by Jim Parsons (“The Big Bang Theory,” “Hidden Figures,”), First in Human will air August 10, 17 and 24 at 9 p.m. ET/PT.
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Research Update
July 24, 2017
Study results point toward an additional pool of candidate targets for vaccines to prevent urinary tract infections
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Research Update
July 20, 2017
Recent studies demonstrate the importance of factors such as the sex of the animals and even their living temperature in designing experiments.
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News Release
July 18, 2017
More than 100 million U.S. adults are now living with diabetes or prediabetes, according to a new report released today by the Centers for Disease Control and Prevention (CDC). The report finds that as of 2015, 30.3 million Americans – 9.4 percent of the U.S. population –have diabetes. Another 84.1 million have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years.
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News Release
July 10, 2017
Using a larger dataset than for any previous human movement study, National Institutes of Health-funded researchers at Stanford University in Palo Alto, California, have tracked physical activity by population for more than 100 countries. Their research follows on a recent estimate that more than 5 million people die each year from causes associated with inactivity.
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Research Update
July 5, 2017
Researchers have discovered that a type of brain immune cell, called microglia, controls food intake and obesity in mice.
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News Release
June 29, 2017
Investigators at the National Institutes of Health and international colleagues have discovered a genetic cause and potential treatment strategy for a rare immune disorder called CHAPLE disease. Children with the condition can experience severe gastrointestinal distress and deep vein blood clots. No effective treatments are available to ameliorate or prevent these life-threatening symptoms.
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News Release
June 28, 2017
New findings from mouse models reveal that the type of immune response that helps maintain healthy metabolism in fatty tissues, called type 2 immunity, also drives obesity-induced nonalcoholic fatty liver disease (NAFLD). The work, led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, shows that the inflammatory environment in the fatty liver is more complex than previously thought.
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Research Update
June 26, 2017
The protein β-arrestin-2 plays critical roles in the pancreas and liver to regulate metabolism.
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Research Update
June 26, 2017
Levels of a protein in the blood can help predict whether kidney function will deteriorate in people with high-risk genetic variants of the gene APOL1.
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Research Update
June 20, 2017
An Internet-based weight loss intervention produces greater weight loss in these women than a standard care program alone.
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Research Update
June 15, 2017
Scientists developed a new method for calculating the average rate that a single kidney nephron filters blood—an important measure of kidney health.
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Research Update
June 12, 2017
Discovery of a rare genetic mutation in a boy with Diamond-Blackfan anemia helped in developing a personalized treatment plan for a younger sibling with DBA.
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News Release
June 7, 2017
Children born to women with gestational diabetes whose diet included high proportions of refined grains may have a higher risk of obesity by age 7, compared to children born to women with gestational diabetes who ate low proportions of refined grains, according to results from a National Institutes of Health study. These findings, which appear online in the American Journal of Clinical Nutrition, were part of the Diabetes & Women’s Health Study, a research project led by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
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News Release
June 6, 2017
Children born to women who had gestational diabetes and drank at least one artificially sweetened beverage per day during pregnancy were more likely to be overweight or obese at age 7, compared to children born to women who had gestational diabetes and drank water instead of artificially sweetened beverages, according to a study led by researchers at the National Institutes of Health. Childhood obesity is known to increase the risk for certain health problems later in life, such as diabetes, heart disease, stroke and some cancers. The study appears online in the International Journal of Epidemiology.
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Research Update
June 1, 2017
Two recent reports have revealed important new information about pain patterns and detecting future pain trends through noninvasive brain imaging.
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News Release
June 1, 2017
A small study by researchers at the National Institutes of Health suggests that mutations in the gene CABLES1 may lead to Cushing syndrome, a rare disorder in which the body overproduces the stress hormone cortisol. The study appears online in Endocrine-Related Cancer.
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Research Update
May 29, 2017
Researchers discovered that a deficiency of the enzyme prohormone convertase 1, contributes to disease symptoms in Prader-Willi Syndrome, a genetic disorder.
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Research Update
May 26, 2017
Researchers have identified a group of brain cells that can induce rapid binge eating and weight gain in mice.