The mission of the VISN 20 NW MIRECC is to improve the health and well-being of Veterans by developing, evaluating, and disseminating novel effective treatments for military posttraumatic stress disorder (PTSD) and its complex comorbidities. The most prominent of these comorbidities is repetitive blast mild traumatic brain injury (mTBI); others are alcohol use disorder (AUD), chronic pain (in particular, post-concussive headaches), cognitive impairment, and increased risk for neurodegenerative disorders (chronic traumatic encephalopathy [CTE] and Alzheimer’s disease [AD]).