Toxicology

The objective of this workshop [was] to explore progress to date in implementing new, revised and alternative toxicological test methods across regulatory evaluation frameworks and decision-making programs in the U.S., identify barriers to progress and explore potential bridges to facilitate overcoming such barriers. These barriers may be technical, regulatory, economic or societal. Slides and speakers notes for all presentations are also available.

June 2012- Includes guidance regarding the use of alternatives to the rabbit pyrogen test (RPT) and the bacterial endotoxins test (BET) for detecting pyrogens in pharmaceuticals and other products. Examples of alternative assays cited include the recombinant horseshoe crab Factor C assay and monocyte activation type pyrogen tests (MATs).

The first step in a European research initiative to address the long term strategic target of "Safety Evaluation Ultimately Replacing Animal Testing (SEURAT)".

A searchable citation database and links to full-text documents on alternative methods in toxicology.

A tool to provide information on the status of alternative methods as they progress from scientific protocols to validation for being used in a regulatory context.

Access: free online

Provides internationally agreed testing methods used by government, industry and independent laboratories to characterize potential hazards of new and existing chemical substances.

Describes how to use in vitro cytotoxicity tests to estimate starting doses for acute oral lethality assays.

Links to information about the reviews of alternative test methods, the respective categories of toxicity, and/or the ICCVAM Working Group assigned to the assays.

The goal of this web site is to advance non-animal methods of toxicity testing through online discussion and information exchange.

 EPA’s ToxCast uses high-throughput screening methods and computational toxicology approaches to generate data and predictive models on chemicals.