Amy Hauck Newman, Ph.D., has been appointed the Scientific Director of the National Institute on Drug Abuse’s (NIDA) Intramural Research Program (IRP) in Baltimore. NIDA is part of the National Institutes of Health (NIH). Dr. Newman has served as NIDA’s IRP Acting Scientific Director for the past two years. She is also Chief of NIDA’s… [Read More]
National Institute on Drug Abuse - Intramural Research Program
Hot Off the Press! - Nature
Evolving schema representations in orbitofrontal ensembles during learning
Zhou, Jingfeng; Jia, Chunying; Montesinos-Cartagena, Marlian; Gardner, Matthew P H; Zong, Wenhui; Schoenbaum, Geoffrey
Learning what to learn about and generalizing from one situation to another is arguably one of the most fundamental abilities that distinguishes higher intelligence. The effects of the resultant schemas can be seen in simple motor or sensory processing, in which learning one skill facilitates acquisition of another—knowing how to ski helps us learn to snowboard—but they are also evident in experience-based improvements in more abstract problem-solving skills.
Hot Off the Press
In a Rat Model of Opioid Maintenance, the G Protein-Biased Mu Opioid Receptor Agonist TRV130 Decreases Relapse to Oxycodone Seeking and Taking and Prevents Oxycodone-Induced Brain Hypoxia
Hot Off the Press – November 17 , 2020 Bossert et al. used a rat model of opioid agonist maintenance therapy to study the effect of the novel G-protein-biased mu opioid receptor (MOR) agonist TRV130 on relapse oxycodone seeking and taking during abstinence. They showed that TRV130 decreased oxycodone seeking and taking during abstinence in… [Read More]
Reviews To Read
Advances in the science and treatment of alcohol use disorder.
Reviews To Read – March 2020. In this review, the authors critically report the scientific and clinical evidence supporting alcohol use disorder as a treatable disease using medications and/or behavioral treatments. Approved treatments and promising new interventions are reviewed and discussed, with a special emphasis on personal treatment approaches. The authors also note the critical… [Read More]
Featured Papers
Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D3R Bitopic Agonists
Featured Paper of the Month – December 2020 In this study, starting from our highly selective and potent D3R agonist 5 , we further investigated the chemical space around the linker portion of the molecule, via insertion of a hydroxyl substituent and ring-expansion of the trans cyclopropyl moiety into a trans -cyclohexyl scaffold. Moreover, inspired… [Read More]
