Volunteer for COVID-19 Clinical Trials

If you have never had a positive COVID-19 diagnostic test at any time in the past, you may qualify to volunteer for one of these studies. If you have had a positive COVID-19 test in the past—including if you had no symptoms but tested positive—you may qualify for studies that are seeking volunteers who have recovered from COVID-19.

These studies are seeking volunteers who may be exposed to SARS-CoV-2, the virus that causes COVID-19, in their everyday activities:

Study of COVID-19 Vaccines in Individuals With and Without Immune Deficiencies

• Study Goal: to evaluate the immune response to COVID-19 vaccination and any vaccine-associated adverse events that may be experienced in individuals with different immune disorders.
• Locations: All samples may be collected remotely; in-person visits at the NIH are optional.
• Sign up to Volunteer: To see if you may be eligible, please email NIAIDCovidVaccineStudy@niaid.nih.gov
• Official Study Title: Analysis of the Immune Response to COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and Dysregulations

Systemic Allergic Reactions to SARS-CoV-2 Vaccination

• Study Goal: To determine whether highly allergic people or people with mast cell disorders (a buildup of the white blood cells that release substances causing symptoms similar to an allergic reaction) are more likely to have an allergic reaction to the new Pfizer-BioNTech and Moderna COVID-19 vaccines than other people.
• Locations: Clinical research sites are located throughout the United States.
• Sign up to Volunteer: Go to http://www.covidvaccine-allergy.org/ for more information and information about how to contact a site near you.
• Official Study Title: Systemic Allergic Reactions to SARS-CoV-2 Vaccination

A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients

• Study Goal: The goal of this study is to evaluate the safety and efficacy of BIO 300 Oral Suspension to improve lung function in patients that were previously hospitalized with COVID-19 related pulmonary complications.
• Locations: New York, NY, Aurora, CO, Pearland, TX
• Sign Up to Volunteer: Visit A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 for eligibility and contact information.
• Official Study Title: BIO 300 Oral Suspension in Discharged COVID-19 Patients

COVID-19-Recovered Specimen Collection Study

• Study Goal: To further define and understand specific immune responses from blood samples donated by volunteers who are fully recovered from a confirmed COVID-19 infection.
• Locations: NIH Clinical Center in Bethesda, Maryland
• Sign Up to Volunteer: Visit the COVID-19-Recovered Specimen Collection Study page for eligibility and contact information.
• Official Study Title: Apheresis and Specimen Collection Procedures to Obtain Plasma, Peripheral Blood Mononuclear Cells (PBMCs) and Other Specimens for Research Studies

Study of COVID-19 Vaccines in Individuals With and Without Immune Deficiencies

• Study Goal: to evaluate the immune response to COVID-19 vaccination and any vaccine-associated adverse events that may be experienced in individuals with different immune disorders.
• Locations: All samples may be collected remotely; in-person visits at the NIH are optional.
• Sign up to Volunteer: To see if you may be eligible, please email NIAIDCovidVaccineStudy@niaid.nih.gov
• Official Study Title: Analysis of the Immune Response to COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and Dysregulations

Study of How COVID-19 Affects Blood Cells and the Immune System

• Study Goal: To study how SARS-CoV-2, the virus that causes COVID-19, affects the body, specifically how it affects blood cells and the immune system.
• Locations: Washington, DC Metro Area
• Sign Up to Volunteer: Visit the Study of How COVID-19 Affects Blood Cells and the Immune System page for eligibility and contact information
• Official Study Title: COVID-19–associated Lymphopenia Pathogenesis Study in Blood (CALYPSO)

Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery

• Study Goal: To study the long-term medical problems experienced by people who recover from COVID-19 and whether people who recover develop long-term immunity to SARS-CoV-2, the virus that causes COVID-19.
• Locations: The NIH in Bethesda, Maryland
• Sign Up to Volunteer: Visit the Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery page for eligibility and contact information
• Official Study Title: Longitudinal Study of COVID-19 Sequelae and Immunity (RECON_19)

Study of the Immune Response to the Seasonal Influenza Vaccine and How Previous Infection With SARS-CoV-2 May Change That Response

• Study Goal: To assess the response of the immune system, the part of the body that helps fight infections, to the seasonal influenza vaccine in healthy individuals and investigate whether prior SARS-CoV-2 infection may change that response.
• Locations: The NIH in Bethesda, Maryland
• Sign Up to Volunteer: Visit our Study of Long-Term Medical Problems and Long-Term Immunity After COVID-19 Recovery page for eligibility and contact information.
• Official Study Title: Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine

These studies are seeking volunteers who have had a confirmed diagnostic test for COVID-19 but are not sick enough to need hospitalization.

Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Persons

• Study Goal: To learn how coronavirus affects different organs of the body and the function of the body's immune system.
• Locations: The NIH in Bethesda, Maryland
• Sign Up to Volunteer: Visit our Cardiopulmonary Inflammation and Multi-System Imaging During COVID-19 Infection in Asymptomatic and Symptomatic Person page for eligibility and contact information.
• Official Study Title: Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons (COVIDARC19)

Drug Treatment Study of Individuals With Mild COVID-19

• Study Goal: To find out if an experimental drug called NT-I7 is safe for people with COVID-19. We also want to see if it might help treat COVID-19 by supporting the immune system.
• Locations: The NIH in Bethesda, Maryland
• Sign Up to Volunteer: Visit our Drug Treatment Study of Individuals With Mild COVID-19 page for eligibility and contact information.
• Official Study Title: A double-blind, randomized, placebo-controlled, phase 1, single-dose, dose-escalating trial of long-acting recombinant human IL-7 (NT-I7) for COVID-19 (SPESELPIS)

Genetics of COVID-19 Susceptibility and Manifestations

• Study Goal: To learn more about how genetics play a role in the severity of COVID-19 in different people. We hope to use this information to develop therapies to reduce the severity of symptoms of COVID-19 in some people.
• Locations: Participants will complete the health survey over the phone. Local participants may come to the NIH Clinical Center in Bethesda, Maryland, for the blood draw, while others may visit their local Quest lab for the blood draw. For either option, we cover the cost of the blood draw.
• Sign Up to Volunteer: Visit our Genetics of COVID-19 Susceptibility and Manifestations page for eligibility and contact information.
• Official Study Title: Genetics of COVID-19 Susceptibility and Manifestations (COVIDcode)

Outpatient Treatment With Anti-Coronavirus Immunoglobulin (OTAC)

• Study Goal: To test an experimental COVID-19 treatment called anti-coronavirus hyperimmune intravenous immunoglobulin (hIVIG).
• Locations: Visit ClincialTrials.gov to find an OTAC trial site near you.
• Sign Up to Volunteer: Email dcrcombatcovidhelp@mail.nih.gov
• Official Study Title: An International Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Safety and Efficacy of Anti-Coronavirus Hyperimmune Intravenous Immunoglobulin for the Treatment of Adult Outpatients in Early Stages of COVID-19

Study of How COVID-19 Affects Blood Cells and the Immune System

• Study Goal: To learn how SARS-CoV-2, the virus that causes COVID-19, affects the body—specifically how it affects blood cells and the immune system.
• Locations: Washington, DC, Metro Area
• Sign Up to Volunteer: Visit our Study of How COVID-19 Affects Blood Cells and the Immune System page for eligibility and contact information.
• Official Study Title: COVID-19-Associated Lymphopenia Pathogenesis Study in Blood (CALYPSO)

These studies are occurring in specific hospitals and seeking volunteers with severe COVID-19. Volunteers will typically be connected to the studies through their medical care providers.

A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients

• Study Goal: The goal of this study is to evaluate the safety and efficacy of BIO 300 Oral Suspension to improve lung function in patients that are ready to be discharged from the hospital with COVID-19 related pulmonary complications.
• Locations: New York, NY, Aurora, CO, Pearland, TX
• Sign Up to Volunteer: Visit A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 for eligibility and contact information.
• Official Study Title: BIO 300 Oral Suspension in Discharged COVID-19 Patients

Big Effect Trial (BET) for Finding Promising Treatments of COVID-19

• Study Goal: To evaluate the success of different investigational treatments for adults hospitalized for severe COVID-19.
• Locations: This study will be conducted in up to 40 sites throughout the United States.
• Sign Up to Volunteer: Visit our Big Effect Trial (BET) for Finding Promising Treatments of COVID-19 for eligibility and contact information.
• Official Study Title: Big Effect Trial for the Treatment of COVID-19 (ACTIV-5/BET-B)

Study of How COVID-19 Affects Blood Cells and the Immune System

• Study Goal: To study how SARS-CoV-2, the virus that causes COVID-19, affects the body—specifically how it affects blood cells and the immune system.
• Locations: Washington, DC, Metro Area
• Sign Up to Volunteer: Visit our Study of How COVID-19 Affects Blood Cells and the Immune System page for eligibility and contact information.
• Official Study Title: COVID-19-Associated Lymphopenia Pathogenesis Study in Blood (CALYPSO)