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See the list of featured NIAID clinical trials below or view the complete list of NIAID studies recruiting participants on ClinicalTrials.gov.

109 Results

Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)

Researchers at the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) seek healthy volunteers for a study looking at how common antibiotics affect the trillions of good microbes that live on and in our body, also known as our microbiome.

Allergic Diseases and Eczema (Atopic Dermatitis)

Online Survey About Eczema

This 10- to 20-minute survey is available for patients with eczema or parents of patients with eczema.  These questions will help us learn more about patient experiences to improve current research and guide future research. 

Arthritis

Rheumatoid Arthritis Studies

NIAID is committed to advancing the understanding of how and why autoimmune diseases such as rheumatoid arthritis occur.

Asthma

A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children (MUPPITS-2)

The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.

Airway Temperature (RATE)

Airway irritation, cough and bronchial spasm are common symptoms in patients with airway inflammatory diseases such as asthma. The primary focus of this exploratory study is to determine if there is an increase in tissue temperature in airway mucosa during asthma exacerbation.

Cockroach Immunotherapy in Children and Adolescents (CRITICAL)

Scientific evidence has shown that, over the past two decades, the combination of cockroach allergy and cockroach exposure is one of the most important factors contributing to the dramatic increase in asthma morbidity seen in inner city children with asthma.

Lung-Resident Memory Th2 Cells in Asthma

Determining how memory T helper type 2 (Th2) initiate recall responses to aeroallergens has the potential to change the therapeutic approach to allergic asthma, the most common asthma subtype.

Preventing Asthma in High Risk Kids (PARK)

This trial is a randomized, double-blind, placebo controlled trial designed to test whether two years treatment of preschool children aged 2-3 years of age at high risk for asthma with omalizumab (anti-IgE) for two years will prevent the progression to childhood asthma, as reflected by a reduction in the prevalence of active asthma in the Final 12 months during 2 year observation period off study drug.

Registry for Asthma Characterization and Recruitment 2 (RACR2)

There is a need for people to take part in research studies to learn more about diseases and how to treat them.

Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study) (SEARCH)

This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls involving a baseline characterization visit and a research bronchoscopy visit.

Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatics (ACE)

This protocol describes a single site mechanistic study to investigate microRNAs (miRNAs) that are differentially expressed in the airway epithelium of patients with asthma at baseline and in response to allergen challenge.

Upper Airway Microbial Development During the First Year of Life

This study tests the hypothesis that an increase in pathogenic bacteria within the infant airway leads to increased airway inflammation, decreased airway function and ultimately airway obstruction throughout the first one to two years of life.

Autoimmune Diseases

EPIC Study

The primary objective of this NIAID study is to further characterize the natural history of idiopathic CD4 lymphocytopenia (ICL).

Autoimmune Diseases and Immunodeficiency

NIAID Centralized Sequencing Protocol

This study serves as a centralized sequencing protocol for NIH human subjects research studies to facilitate standardization and consolidate accrual of genotype and phenotype data for participating programs.

Chronic Granulomatous Disease (CGD)

Evaluation of Patients With Immune Function Abnormalities

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.

Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations

To learn more about when and why IBD may develop in some people with primary immune dysregulation.

Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995

This study will determine the long term medical condition and daily functioning of participants with CGD after a transplant and if possible, compare these results to participants who do not undergo a transplant.

Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease

To see if RFA is a safe and effective treatment for CGD-related liver abscesses.

Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease

This study is a prospective non-controlled, non-randomized Phase I/II clinical trial to assess the safety, feasibility and efficacy of cellular gene therapy in patients with chronic granulomatous disease.

Use of G-CSF to Obtain Blood Cell Precursors

This protocol is designed to study the techniques needed to develop gene therapy or other treatments for certain inherited immune system diseases.

Chronic Granulomatous Disease (CGD) and Hyper-Immunoglobulin M (Hyper-IgM) Syndromes and Primary Immune Deficiency Diseases (PIDDs) and Wiskott-Aldrich Syndrome (WAS) and X-Linked Agammaglobulinemia (XLA) and X-Linked Lymphoproliferative Disease (XLP)

Participation in a Research Registry for Immune Disorders

To collect data on people with primary immune deficiency disorders.

Coronaviruses

Pediatric SARS-CoV-2 and MIS-C Long-term Follow-up (PECOS)

This is a multisite prospective observational study to evaluate the clinical sequelae of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the pediatric population, including coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C), and characterize the immune response associated with these clinical presentations.

A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients

The goal of this study is to evaluate the safety and efficacy of BIO 300 Oral Suspension to improve lung function in patients that were previously hospitalized with COVID-19 related pulmonary complications.

Coronaviruses and Immunodeficiency

Study of the Immune Response to and Safety Profile of COVID-19 Vaccines in Individuals With and Without Immune Deficiencies

Currently, people with immune disorders fall outside of guidance for COVID-19 vaccination, as they are typically excluded from vaccine trials.

Coronaviruses and Allergic Diseases

Assess the Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose

Randomized, placebo-controlled, crossover study to assess risk of recurrence of allergic reactions in individuals who had an immediate systemic allergic reaction after 1st dose of an mRNA COVID-19 vaccine and aiming to explore the underlying mechanism(s) of these reactions.