Welcome to the collection of resources at NCBI specifically designed to support the research of retroviruses.

The family Retroviridae comprise a variety of enveloped RNA viruses, such as endogenous retroviruses, leukemia viruses, or HIV-1, the replicative strategy of which includes as essential steps reverse transcription of the virion RNA into linear double-stranded DNA and the subsequent integration of this DNA into the genome of the cell. The virion RNA is 7 to 12 kb long, and it is linear, single-stranded, nonsegmented, and of positive polarity. All retroviruses contain genes for the proteins gag, pol, env, and (often) pro, whereas more complex retroviruses, such as HIV-1, contain additional regulatory proteins.

Complete reference genomes   [Common tree]

Retroviridae [ 51]

Alpharetrovirus [ 5] Avian type C retroviruses [ 2] Betaretrovirus [ 4] Deltaretrovirus [ 6] Epsilonretrovirus [ 2] Gammaretrovirus [ 5] Intracisternal A-particles Lentivirus [ 12] Mammalian type C retroviruses [ 7] Spumavirus [ 6] Type D retroviruses unclassified Retroviridae [ 2]

The resource also includes:

• Set of retrovirus complete genomes reference sequences
[Genome]  [GenBank]  [FASTA]
[Protein]  [GenPept]  [FASTA]
• Genotyping tool - uses the BLAST algorithm to identify the genotype of a query sequence
• Alignment tool - global alignment of multiple sequences
• Short sequence BLAST for primer design BLAST

Please send questions and comments to info@ncbi.nlm.nih.gov