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Homo sapiens Official Gene Symbol
and Name (HGNC) |
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PTPRD: protein tyrosine phosphatase, receptor type, D | | | LocusID: 5789 |
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RefSeq Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported. | | Locus Type: |
gene with protein product, function known or inferred | | Product: |
protein tyrosine phosphatase, receptor type, D isoform 1 precursor
protein tyrosine phosphatase, receptor type, D isoform 2 precursor
protein tyrosine phosphatase, receptor type, D isoform 3 precursor
protein tyrosine phosphatase, receptor type, D isoform 4 precursor
| | Alternate Symbols: |
HPTP, PTPD, HPTPD, HPTP-DELTA, R-PTP-DELTA | | Alias: |
protein tyrosine phosphatase delta
protein tyrosine phosphatase, receptor type, delta polypeptide
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Please note: As a consequence of our transition to Entrez Gene, GeneRIFs will only be displayed in the Entrez Gene record for this locus.
| NCBI Reference Sequences (RefSeq) | ? |
Please note: Conserved protein domain information will only be displayed in Entrez Gene. You may find the information for this locus here:
| 1. | mRNA: |
NM_002839 |
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| | Protein: |
NP_002830 protein tyrosine phosphatase, receptor type, D isoform 1 precursor |
BL |
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| | Transcript Variant: This variant (1) encodes the longest isoform (1). |
| | GenBank Source: |
L38929 |
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| 2. | mRNA: |
NM_130391 |
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| | Protein: |
NP_569075 protein tyrosine phosphatase, receptor type, D isoform 2 precursor |
BL |
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| | Transcript Variant: This variant (2) lacks two separate internal segments within the coding region. It thus encodes a protein that lacks a 9 aa, and a 4 aa internal fragments, as compared to isoform 1. |
| | GenBank Source: |
L38929 |
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| 3. | mRNA: |
NM_130392 |
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| | Protein: |
NP_569076 protein tyrosine phosphatase, receptor type, D isoform 3 precursor |
BL |
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| | Transcript Variant: This variant (3) lacks an internal segment within the coding region. It thus encodes a protein that lack a 9 aa internal fragment, as compared to isoform 1. |
| | GenBank Source: |
L38929 |
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| 4. | mRNA: |
NM_130393 |
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| | Protein: |
NP_569077 protein tyrosine phosphatase, receptor type, D isoform 4 precursor |
BL |
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| | Transcript Variant: This variant (4) lacks an internal segment within the coding region. It thus encodes a protein that lacks a 411 aa internal fragment, and has one amino acid change, as compared to isoform 1. |
| | GenBank Source: |
L38929 |
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Category: NCBI Genome Annotation |
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Category: NCBI Genome Annotation |
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