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This is the beginning of a simple schematic depicting the longest mRNA-encoding exon/intron structure of the gene regionupsream of gene picturenon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regiondownstream of gene picture
Click to Display mRNA-Genomic Alignments (spanning 19796 bps)
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   Homo sapiens Official Gene Symbol and Name (HGNC)
  PTPRN: protein tyrosine phosphatase, receptor type, N
 LocusID: 5798
Overview ?
RefSeq Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Locus Type: gene with protein product, function known or inferred
Product: protein tyrosine phosphatase, receptor type, N precursor
Alternate Symbols: IA2, IA-2, ICA512, R-PTP-N, IA-2/PTP
Alias: islet cell antigen 2
islet cell antigen 512
islet cell autoantigen 3
protein tyrosine phosphatase-like N precursor
FunctionSubmit GeneRIF(All Pubs)?

Please note: As a consequence of our transition to Entrez Gene, GeneRIFs will only be displayed in the Entrez Gene record for this locus. EntrezGene

 EC Number:  3.1.3.48                                                       
      Gene OntologyTM:  
     Term Evidence Source Pub
     
  • integral to plasma membrane
    		•  TAS GOA pm
     
  • protein amino acid dephosphorylation
    		•  NR GOA  
     
  • receptor activity
    		•  IEA GOA  
     
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  TAS GOA pm
    Relationships ?
      Mouse, Rat Homology Map Viewer  

    Map Information ?
      Chromosome:2   mv
      Cytogenetic:2q35-q36.1  RefSeq 
      Markers: Chr. -RH69021  
       Chr. -RH70260  
       Chr. -RH80862  
       Chr. -RH80635  
       Chr. -PTPRN_1350  

    NCBI Reference Sequences (RefSeq)?

    Please note: Conserved protein domain information will only be displayed in Entrez Gene. You may find the information for this locus here: EntrezGene

    Category: REVIEWED
     mRNA: NM_002846    
     Protein: NP_002837  protein tyrosine phosphatase, receptor type, N precursor BL
     GenBank Source: AF042285,BC007713,L18983    

    Category: NCBI Genome Annotation
    1.Genomic Contig: NT_005403   gb sv mv ev mm
     Haplotype reference    
      Annotation for this locus:
     Evidence: supported by alignment with mRNA   
     mRNA: NM_002846    
     Protein: NP_002837   BL

    Category: NCBI Genome Annotation
    2.Genomic Contig: NT_086634   gb sv mv ev mm
     Haplotype Celera    
      Annotation for this locus:
     Evidence: supported by alignment with mRNA   
     mRNA: NM_002846    
     Protein: NP_002837   BL

    Related Sequences ?
    Nucleotide Type Protein   
    AF042285 g      
    BC007713 m AAH07713   BL
    BC070053 m AAH70053   BL
    BT006975 m AAP35621   BL
    L18983 m AAA90974   BL
    X62899 m CAA44688   BL
    None p Q16849   BL
    AK054765 u      

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