NIDDK-Sponsored Distribution Programs

Liver Tissue Procurement and Distribution System (LTPADS)

The Liver Tissue Procurement and Distribution System (LTPADS) is a National Institutes of Health (NIH) service contract to provide human liver from regional centers for distribution to scientific investigators throughout the United States. These USA regional centers have active liver transplant programs with human subjects' approval to provide portions of the resected pathologic liver for which the transplant is performed. Frozen or fresh tissue is available from subcontractors for the usual forms of childhood and adult cirrhosis, fulminant liver failure, chronic rejection, and certain inborn errors of metabolism. Human pathologic liver prepared according to the investigator's specifications provides the opportunity to verify if animal liver investigations are relevant to human liver pathophysiology. The preparation of these livers has been excellent for the usual molecular biologic techniques for the past 10 years.

"Normal" liver specimens may be requested; however, the supply is appropriately much more limited and completion of proposal requests takes a longer time than for most pathologic liver specimens.

A new service is in the planning stage to provide isolated liver cells; thus we encourage new proposals requesting hepatocytes from "normal" and/or pathologic human liver obtained at the time of transplantation. NIH investigators are always given preference for requests. Supporting letters for NIH new or renewal grant requests can be provided.

Further information, proposal forms, and requests for supporting letters can be obtained from:

Harvey L. Sharp, M.D.
Principal Investigator, LTPADS
c/o Bobbie Randolph, Box 185 FUMC
University of Minnesota
Department of Pediatrics
Gastroenterology and Nutrition
420 Delaware Street S.E.
Minneapolis, MN 55455
Phone: (612) 624-1133
Fax: (612) 626-0639
Email: sharp001@tc.umn.edu

For more information, visit the LTPADS website.

Availability of Biologic Samples from Diabetic Study Population

(Notice released July 13, 1999)

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces that a portion (1/3) of all stored non-renewable samples (plasma, serum, urine) from subjects enrolled in the Diabetes Control and Complications Trial (DCCT) is available for use by the scientific community to address questions for which these samples are uniquely invaluable.

For further information contact Catherine Cowie, Director, Type 1 Diabetes Clinical Trials Program, phone: (301) 594-8804, fax: (301) 480-3503, email: cowiec@extra.niddk.nih.gov.

A complete list of NIDDK patient recruitment activities is available on the clinical trials page.

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