NIDDK Recent Advances and Emerging Opportunities (2004)

• The NIH Roadmap
  • Roadmap Initiatives–New Technology Development
  • Roadmap Initiatives–Molecular Libraries
  • The Future
• Visualizing Life's Proofreaders: Structural Studies of DNA Repair Proteins
• DNA Mismatch Repair
• Determining the Three-Dimensional Structure of Proteins
• Three-Dimensional Structural Studies of MutS
• Implications
• Potential and Plasticity of Stem Cells–An Evolving Picture
  • Bone Marrow Adult Stem Cells Take Different Paths to Become Liver Cells and Islets
  • "Niche" Control of Adult Stem Cell Fate
  • Beta Cell Biology Consortium (BCBC)
  • Progenitor Cell Genome Anatomy Projects (GAPs)
• Scientific Presentation: Dr. Catherine Verfaillie
• Scientific Presentation: Dr. David Altshuler

• Advances in Preventing Vascular Complications of Diabetes
  • Reduction in Atherosclerosis from Intensive Blood Glucose Control
  • Medicating the Microvasculature
• Continued Insights from the Diabetes Prevention Program: Sustained Benefits of Metformin
• Novel Use of Microarray Technology for Identifying Genes Involved in Type 2 Diabetes
• Dual Mechanism of Action of Type 2 Diabetes Drug Candidate
• New Insights into Endocrine Pancreas Gene Expression
• Modulating Autoimmunity–Implications for Type 1 Diabetes
• Removing Barriers to Islet and Organ Transplantation
  • Encapsulation–A Biological Cloak of Invisibility
  • Modeling Mice into Men
  • New Strategies for Immunosuppression
• Clinical Efforts to Fight Diabetes in Youth
• Using Small Molecules to Correct Cystic Fibrosis
• Bone Health and Osteoporosis
  • Novel Assay for Measuring Protein Involved in Phosphate-Wasting Disorders
  • Hormone Treatment for Osteoporosis
• Sustained Benefits of Insulin-Sensitizing Drug Therapy in HIV-Positive Individuals with Metabolic Complications and Fat Redistribution
• Story of Discovery: Preventing or Delaying Complications of Diabetes: 20 Years of Study by the DCCT/EDIC Research Group
• Patient Profile: Dan Lamb–For Dan Lamb and Many Others, Participating in the DCCT/EDIC Has Been a Life-Altering Experience
• The National Diabetes Education Program
• Patient Profile: Krystle Kelly–Living with Type 2 Diabetes as a Teen

• Strengthening Efforts in Liver Disease
• Liver Disease Research Branch
• Adult Liver Transplantation–New Hope from Living Donors
• Facilitating Research on Pediatric Liver Disease–The Biliary Atresia Research Consortium
• Comprehending the Complexity of Inflammatory Bowel Disease
• "Trading Spaces"–Modulating Gut Bacteria to Reduce Inflammation
• Insights Into Inflammatory Mechanisms
• The IBD5 Gene Confers Susceptibility to Inflammatory Bowel Disease
• "Good" Bacteria–How Do They Help?
• A Different Kind of Food Fight–Making Progress in Celiac Disease
• Treating Functional Bowel Disorders
• Comparing Psychological Treatment Strategies for Women with Bowel Disorders
• Sex Differences in Neurological Responses to Bowel Distension in IBS Patients
• Story of Discovery: The Art of Liver Transplantation
• Patient Profile: The Traffs–Celiac Disease–A Family Affair

• Organizational Enhancements
• New Research Initiatives
• Scientific Meetings–Setting the Stage for the Future
• NIH Obesity Research Task Force
• Examples of Recent NIDDK-Supported Obesity Research Advances
• Basic Research
• Hunger Pangs in the Brain? A Potential New Brain Circuit for Appetite Regulation
• Animal Model To Study the Metabolic Syndrome
• Obesity, Diet and Activity–Examples of Studies With Adult Volunteers
• Low Carbs versus Low Fat–Is Either Diet Better?
• Increased Risk of Obesity and Type 2 Diabetes from TV Watching and Other Sedentary Behaviors
• Exercise and Weight Management
• Obesity in Children and Adolescents
• Effects of Diet Macronutrient Content on Weight Loss in Obese Adolescents
• Obesity–Environmental Influences and Long-Term Health Effects
• Years of Life Lost Due to Obesity
• A Few Less Bites and a Few Extra Steps–Dealing with Obesity in Our Current Environment
• WIN: The Weight-control Information Network

• Building Insights in PKD and Other Cystic Kidney Diseases
• Cilia and Cystic Kidney Disease
• Potential Therapeutic Target for PKD and NPHP
• Fundamental Insights Into Kidney Disease
• sFlt1 Antagonism of Angiogenic Factors May Underlie Symptoms of Preeclampsia
• Deficiency in Podocyte Protein May Increase Susceptibility to Kidney Disease
• Regression to Normal Kidney Function Is Common in Type 1 Diabetes Patients
• Eliminating Health Disparities in Kidney Disease
• Testing the Effects of Lowered Blood Pressure on Kidney Disease in African Americans
• Nurse-Directed Diabetes Care Is Beneficial to Minorities with Diabetes
• Encouraging Kidney Donation
• Efforts To Halt Pediatric Renal Disease
• Improving Outcomes on Dialysis
• Progress on Treating Prostate Disease
• Invasion of the Bladder Snatchers–Bacterial Pods in Acute Urinary Tract Infections
• Nitrite Improves Blood Flow
• Seeking New Ways to Measure Bodily Iron
• Story of Discovery: Evolving Therapies for Benign Prostatic Hyperplasia
• The National Kidney Disease Education Program
• Basic Research on Interstitial Cystitis–Advancing Toward Clinical Tools
• Patient Profile: Alicia Somma–Living with Cooley's Anemia
• Patient Profile: Jennifer Klann–Life With Polycystic Kidney Disease: Experiencing Hope Through Research

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