Home | | | Search | | | Browse | | | Resources | | | Help | | | What's New | | | About |
---|
Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
This study has been completed.
Sponsored by: | National Eye Institute (NEI) |
---|---|
Information provided by: | Warren G Magnuson Clinical Center (CC) |
Purpose
This study will investigate congenital or developmental eye abnormalities that affect the iris, cornea and lens, and are usually accompanied by elevated pressure within the eye. These disorders can cause vision loss, and the increased eye pressure can lead to glaucoma, a condition that may also cause loss of eyesight.
Patients with eye anterior chamber eye disease, such as Axenfeld's syndrome, Rieger's anomaly, Peter's anomaly, iridocorneal endothelial syndrome, megalocornea, ocular hypertension, and others, are eligible for this study. Participants will have a medical examination, family history, and comprehensive eye examination. Tests and procedures may include photographs of the cornea, iris, and the structure through which fluid that normally circulates behind the cornea drains out of the eye. Some patients may undergo indentation tonography to measure how easily this fluid drains. In this procedure, the patient lies on an examination table and both eyes are numbed with eye drops. A small instrument (tonometer) is placed on the surface of one eye, and with the other eye, the patient looks at an overhead light. Other tests may include photographs of the back of the eye and ultrasound imaging of the structures of the eye. A blood sample may be drawn to study the genetic disorder responsible for the disease. Patients will have follow-up examinations every 6 months for the duration of the study.
Medical or surgical therapy will be recommended, as appropriate, for patients who develop elevated eye pressure or vision loss.
Condition |
---|
Aniridia Eye Abnormality Ocular Hypertension Open Angle Glaucoma |
MedlinePlus related topics: Birth Defects; Eye Diseases; Genetic Disorders; Glaucoma
Study Type: Observational
Study Design: Natural History
Official Title: Anomalies of the Anterior Chamber, Angle, Iris, Cornea and Lens with or without Glaucoma or Ocular Hypertension
Expected Total Enrollment: 100
Study start: July 1, 1977;
Study completion: August 19, 2002
This study will concentrate on abnormalities of the anterior chamber with or without elevated intraocular pressure. The purpose of the study will be to determine if there is a common pathogenesis shared by these conditions. A natural history study of 40 individuals with these diseases will utilize clinical measurements and photographs for documentation of this hypothesis. In addition, surgical specimens, when available, will be studied.
Eligibility
Genders Eligible for Study: Both
Criteria
Location Information
More Information
Publications
U.S. National Library of Medicine, Contact NLM Customer Service | ||||||||||||||
National Institutes of Health, Department of Health & Human Services | ||||||||||||||
Copyright, Privacy, Accessibility, Freedom of Information Act |