May 2003 Director's Status Report


Budget and Appropriations

FY 2003 Appropriation for NIA

The FY 2003 Appropriation for NIA (including AIDS) is $993,598,000 (post rescission) an increase of 11.1 percent over the FY 2002 actual amount of $891,302,000. Funding for AIDS related research increases from $4,985,000 in FY 2002 to $5,344,000 in FY 2003 an increase of 7.2 percent.

FY 2003 Appropriation for NIH

The FY 2003 Appropriation for NIH (including AIDS) increases from $23,478,083,000 in FY 2002 to $27,171,000,000 in FY 2003, an increase of 15.7 percent.

Overall Budget Policy

One of NIH’s highest priorities is the funding of medical research through research project grants (RPGs). Support for RPGs allows NIH to sustain the scientific momentum of investigator-initiated research while providing new research opportunities. The FY 2003 NIA appropriation provides an average cost increase for competing RPGs at 4.0 percent.

Promises for advancement in medical research are dependent on a continuing supply of new investigators with new ideas. With the FY 2003 Appropriation, NIA will support 571 pre- and post-doctoral trainees in full-time training positions, the same Number as in FY 2002.

NIA FY 2003 Appropriation - Mechanism Discussion

The FY 2003 appropriation includes funding for 1,458 research project grants, compared to 1,315 in FY 2002. Of these 1,458 awards, 480 will be competing research project grants and 978 will be noncompeting awards. In addition, the appropriation includes funding for 73 SBIR/STTR grants.

Funding for the Centers mechanism increases by 5.2 percent over the FY 2002 level.

The FY 2003 Appropriation includes an increase of 4.5 percent over FY 2002 for Other Research.

Funding for Contracts in FY 2003 increases by 27 percent over FY 2002 due to the large Program Evaluation assessment in FY 2003.

The FY 2003 Appropriation includes an 11 percent increase above FY 2002 for Intramural Research and a 10 percent increase above FY 2002 for Research, Management, and Support (RMS).

(Contact: Mr. Kevin Laser, BO, Ph: 301-496-9147)

Legislative Update

I. Significant Legislative Action

  • P.L. 108-7 – On February 20, 2003, the President signed into law H.J. Res. 2, the Consolidated Appropriations Resolution, 2003, as P.L. 108-7. This legislation provided funding for FY 2003 for the 11 appropriations bills not yet enacted. The bill provided $27.2 billion for NIH, a $3.8 billion increase over FY 2002, and completes the doubling of the NIH budget over five years. Bill language included a statement urging NIH to honor Florence S. Mahoney by designating one of two outdoor courtyards in the Mark O. Hatfield Clinical Research Center, now under construction, as the “Florence S. Mahoney Plaza (or Courtyard)” with a stone marker, plaque or sculpture.

  • S. 333 – On February 10, 2003, Senator John Breaux (D-LA) introduced S. 333, the Elder Justice Act. S. 333 would establish an Intra-Agency Elder Justice Steering Committee and an Advisory Board on Elder Abuse, Neglect, and Exploitation. NIA would be required to participate in both of these entities. The bill would also give NIA the authority to establish up to five centers of excellence for research on elder abuse, neglect, and exploitation. The bill has 16 cosponsors and was referred to the Senate Committee on Finance.

  • H.R. 1138/S. 566 – On March 6, 2003, Representative Edward Markey (D-MA) introduced H.R. 1138, the Alzheimer's Disease Research, Prevention, and Care Act. Also on March 6, Senator Barbara Mikulski (D-MD) introduced the companion measure, S. 566, to amend the Public Health Service Act to provide for Alzheimer’s disease research and demonstration grants. H.R. 1138 has one cosponsor and was referred to the House Committee on Energy and Commerce. S. 566 has five cosponsors and was referred to the Senate Committee on Health, Education, Labor and Pensions.

II. Congressional Hearings

  • On March 11, 2003, the Senate Special Committee on Aging (Senator Larry Craig [R-ID], Chairman) held a hearing on “Fitness and Nutrition: The Prescription for Healthy Aging.” Dr. Judy Salerno, Deputy Director of NIA, testified.

  • On April 1, 2003, the Senate Appropriations Subcommittee on Labor, HHS, and Education (Senator Arlen Specter [R-PA], Chairman) held a hearing on Alzheimer’s Disease. Dr. Richard Hodes, Director of NIA, testified.

  • On April 2, 2003, the House Appropriations Subcommittee on Labor, HHS, and Education (Representative Ralph Regula [R-OH], Chairman) held a hearing as part of its review of the FY 2004 NIH budget. Dr. Elias Zerhouni, Director of NIH, provided an NIH Overview.

  • On April 8, 2003, the Senate Appropriations Subcommittee on Labor, HHS, and Education (Senator Arlen Specter [R-PA], Chairman) held a hearing as part of its review of the FY 2004 NIH budget. Dr. Elias Zerhouni, Director of NIH, provided an NIH Overview.

  • On April 8, 2003, the House Appropriations Subcommittee on Labor, HHS, and Education (Representative Ralph Regula [R-OH], Chairman) held a second hearing as part of its review of the FY 2004 NIH budget. Dr. Elias Zerhouni, Director of NIH, provided an NIH Overview.

III. Outreach Activities

  • Alzheimer’s Association Public Policy Forum - On March 31, 2003, NIA Director, Dr. Richard Hodes gave a scientific presentation to the Alzheimer’s Association Public Policy Forum on the latest advances in Alzheimer’s disease research.

  • On April 14, 2003, NLM and NIA participated in events at the Jupiter Medical Center and University of Miami, School of Medicine at the request of Representative Mark Foley (R-FL). Dr. Richard Hodes, Director of NIA, made a presentation on aging research at the University of Miami, School of Mediciine.

Staff Changes

Ranjan Sen, Ph.D., was approved for tenure and will leave Brandeis University to join the Intramural Research Program (IRP) as the Chief, Laboratory of Cellular and Molecular Biology in September 2003. Ranjan Sen, Ph.D., received his doctoral degree in 1982 from Columbia University. During postdoctoral work with Dr. David Baltimore at the Massachusetts Institute of Technology, Dr. Sen discovered the NF-kB transcriptional regulator, a discovery that has spawned a field of research. Since then, he has become a leader in the field of the transcriptional regulation of immunoglobulin genes and a continuous contributor to studies of the NF-kB proteins. His recent work has defined the mechanism of regulation of the precise gene rearrangements involved in immunoglobulin production. He demonstrated the role of sequential hyperacetylation in the ordered D- to BJ region recombination followed by V to DJ recombination. In addition, he has defined unique properties of distinct members of the IkB family in the nuclear import and export of distinct rel family dimers.

Ms. Elayne Heisler joined the Behavioral and Social Research (BSR) program in April 2003. Ms. Heisler, a social science analyst, is providing scientific and administrative assistance to the Population and Social Processes Branch. Ms. Heisler is completing her PhD dissertation at Duke University in Durham, NC, in the Department of Sociology, where she was an NIA pre-doctoral trainee in the medical demography of aging. She completed her masters degree at Duke in the fall of 2001 with a concentration in health policy. In 1998, she received her B.S. degree from Cornell University, with honors in human development and a concentration in gerontology.

Ms. Tammy K. Rowe, M.S., joined the Neuroscience and Neuropsychology of Aging Program (NNA) on February 24 of this year working as a Research Program Analyst. Her position entails assisting Health Scientist Administrators (HSAs) on various assignments. She received her M.S. degree in Psychology from Shippensburg University of Pennsylvania. She started her Federal career in 1990 working as a Biologist for NIH in Frederick, MD. During her time as a Biologist, she has been co-author on over 10 publications and abstracts. In 1998, she moved to the Veterans Administration-Yale Trauma Research Program in Connecticut. Upon returning to NIH, she began working in the extramural arena as a Program Analyst at the National Center for Research Resources (NCRR).

Samuel G. Speciale, Ph.D., joined the NNA program, April 20, as a Research Program Specialist. Dr. Speciale has been a Research Assistant Professor within the Department of Psychiatry at the University of Texas Southwestern Medical School (UTSMS) in Dallas, Texas, since 1978. Prior to his tenure at UTSMS, he received his Ph.D. in Pharmacology at the Loyola University of Chicago in 1973 and then held fellowships at the National Institute of Mental Health (NIMH) and at the University Claude-Bernard in France. He has a broad range of neuroscience interests and experience, ranging from genetics, stress, sleep/wakefulness, and pharmacology to neurochemical and anatomical substrates of neurodegenerative disorders and neurotoxicology. In the NNA he will provide scientific and administrative assistance related to molecular and cellular neurobiology.

Institute-Sponsored Meetings, Workshops, and Conferences, and Public Information Activities

I. Meetings Held

Dietary Supplements and the Elderly. The NIA Office of Nutrition in conjunction with the NIH Office of Dietary Supplements held a two-day advisory meeting on January 14-15 in Bethesda on “Dietary Supplements Use in the Elderly.” The purpose of the meeting was to review the current state of knowledge and to suggest future research directions. Based on a survey conducted in 1999, it was estimated that at least 40 percent of older Americans had used some form of herbal or specialty supplement during that year. Reasons for their use include maintenance of overall health, increase of energy, improving memory, preventing or treating illness, and slowing the aging process. The Number of scientific studies on safety or efficacy of these products is limited because FDA approval is not required. Presentations covered three major areas: the what and why of dietary supplement use in the elderly; special physiological/metabolic conditions of the elderly that might affect DS use; and evidence-based studies on use of DS to maintain health in various organ systems, and to prevent or ameliorate diseases and impairments of the elderly. Other NIH Institutes and Offices that contributed to this conference included National Center for Complementary and Alternative Medicine (NCCAM), the National Eye Institute (NEI), the National Cancer Institute (NCI), the National Institute of Neurological Disorders and Stroke (NINDS), and the NIH Office of Behavioral and Social Science Research (OBSSR), as well as the US Department of Agriculture (USDA); extramural support was contributed through the Foundation of the NIH. A summary of the conference is available through the NIA website at: http://nacanet.nia.nih.gov/meetings.htm, and further recommendations can be obtained from the program contact. (Contact: Dr. Judith A. Finkelstein, NNA, Ph: 301-496-9350)

Research Needs in the Evaluation of Executive Functions from Cognitive Aging to Dementias Workshop. This advisory workshop was held on January 27-28 in Bethesda to seek expert opinion on the comparability of executive functions across different populations, species, and cognitive levels, and the feasibility of using brain imaging to improve measurement. The aging of executive functions was viewed as a public health issue that needs attention in terms of measurement and development of adequate interventions. Discussions highlighted the need for better definitions of the components of executive functions in normal aging and age-related diseases across species, the importance of evaluating the adequacy of existing instruments, the need for population studies of executive functions in older persons and in middle-age individuals, as well as the need for imaging studies to identify neural network reorganizations involved in executive functions. Recommendations from this meeting will be used in the formulation of an initiative on executive functions and aging by the NIA. Recommendations also will be presented at the trans-NIH conference on Executive Functions spearheaded by NINDS to form the basis for future research collaborations. A report of the meeting is forthcoming. (Contacts: Dr. Elisabeth Koss or Dr. Molly V. Wagster, NNA, Ph: 301-496-9350)

Defining and Measuring Environments for Genetic Studies of Aging, an exploratory workshop, took place on February 26-27, 2003, in Bethesda. The Purpose of This meeting was to explore issues related to incorporating environmental factors from the behavioral and social sciences into genetically informative studies of aging. Development of this area is critical to understanding central issues surrounding gene expression including gene-environment interactions, gene-environment covariation, and how social contexts and behaviors affect gene expression. The meeting congregated scientists from diverse backgrounds who have already done critical work related to the workshop theme. The presentations and discussions addressed issues related to methodological, conceptual and substantive approaches to defining and measuring environments, gene-environment interplay, most fruitful study designs, and how to foster the required interdisciplinary research. A special journal issue based upon the paper presentations is being considered. (Contact: Dr. Jennifer Harris, BSR, Ph: 301-402-8771)

Workshop on Microarray Technology and Aging. On March 14-15, the Biology of Aging Program (BAP) sponsored this satellite exploratory workshop after the Biology of Aging Gordon Conference in Ventura , CA. The workshop focused on technology development and progress made so far using microarray technology in aging research, mostly by NIA grantees. (Contacts: Dr. Huber Warner, BAP, Ph: 301-496-4996; Dr. Kevin Becker, IRP, NIA, Ph: 410-558-8360)

Apoptosis and Aging Tissues. This exploratory meeting was held March 24-25, 2003. It was the second annual meeting for grantees of the Systems Branch, BAP, and followed on the first meeting that addressed the topic of GH/IGF I and Aging Tissues. The meeting brought together investigators supported by the Branch and selected additional experts with the goal of sharing information across tissue lines on apoptosis in aging, bringing young investigators into contact with experienced investigators in the field, stimulating collaborations, and updating staff on current research issues. (Contact: Dr. Jill Carrington, BAP, 301-496-6402)

The Congress on Sleep, Health and Aging was held March 30 and 31 at the National Academy of Sciences, Washington, DC, and cosponsored by the National Sleep Foundation and the NIA. There is a wide gulf between the science of what is known about sleep in the elderly, and the application of this knowledge in clinical practice. Invited speakers and attendees reviewed the knowledge base about sleep, its disorders and impact on health in the elderly, and will develop strategies to bridge the gap between science and the bedside. (Contact: Dr. Andrew A. Monjan, NNA, Ph: 301-496-9350)

IOM Study on Testosterone Replacement. The second meeting of the NIA/National Cancer Institute (NCI)-sponsored Institute of Medicine (IOM) Study on Testosterone Replacement was held March 30-April 1, 2003, in Phoenix, Arizona. The topics of discussion were: Testosterone Levels and Aging; Bone-Related Outcomes, Body Composition and Strength; Prostate Outcomes, Cognitive, Sexual Function, Mood and Quality of Life Outcomes; Hemotologic and Cardiovascular Outcomes; Perspectives from Studies on Post-Menopausal Hormone Therapy; and Perspectives from the Pharmaceutical Industry. The third meeting was held on May 19, 2003, in Washington, D.C., with the final report due on November 7, 2003. The final report will address the current state of knowledge of testosterone treatment, and will provide advice as to the need for further clinical trials of testosterone. (Contact: Dr. Stanley Slater, GCG, Ph: 301-496-6761)

Genetics of Late Onset Alzheimer’s Disease Case Control Advisory Workshop. Studies of Alzheimer’s disease have demonstrated that there is a genetic component. Three of four genes shown to be associated with the disease are linked to the early onset form, are autosomal dominant, and account for only a small Number of all AD cases. Studies on the more common late onset form of AD have shown that a fourth gene, the APOE gene, is a susceptibility factor for sporadic late onset AD. Recent reports have suggested that there are additional risk factor genes for late?onset AD, and new AD-related regions in the human genome and gene candidates have been identified that may modify the risk for AD.

The NIA has expanded its Alzheimer’s Disease Genetics Initiative. A workshop on the Genetics of Late Onset Alzheimer’s Disease (LOAD) held in the spring of 2002, resulted in mechanisms to more rapidly collect and share large Numbers of samples for genetic analysis through the National Cell Repository for Alzheimer’s Disease (NCRAD). A major component of the AD Genetics Initiative is the collection of two types of samples: a family based sample set and a case-control sample set. This national case-control set of cell lines will serve as a gold standard against which risk factor genes for LOAD can be evaluated. An advisory workshop was convened on May 5 to plan for the acquisition of the case-control sample set. The purpose of the meeting was: to determine the goals for a national case-control study for late onset Alzheimer’s Disease; to discuss the study design for a national case-control study for late onset Alzheimer’s Disease; and to discuss criteria for inclusion of cases and controls. (Contact: Dr. Marilyn Miller, NNA, Ph: 301-496-9350)

Immunology and Aging. A BAP-sponsored exploratory workshop was held on May 7 during the annual American Association of Immunology (AAI) meeting in Denver, Colorado. The purpose of the workshop was to allow attendees at the national meeting the opportunity to become familiar with recent progress in research on aging-related defects in immunity and to allow an opportunity for researchers working in different areas of immunology to interact. Three speakers presented overviews of the current state of research into age-related defects in lymphopoiesis, T cell compartments and B cell compartments. This was followed by a presentation by NIA program staff highlighting NIA interests and current funding opportunities. (Contact: Dr. Rebecca Fuldner, BAP, Ph: 301-496-6402)

Biology of Adult Stem Cells in Aging. The first annual meeting for grantees of the NIA RFA “Biology of Adult Stem Cells in Aging” (exploratory) was held May 12-13, 2003. The meeting, which brought together investigators funded through the RFA, other NIA grantees, and outside experts, was a combined project of the NIA Stem Cell Working Group. The goals were to promote information exchange in this fast-moving area of research, to stimulate discussion of exciting research directions, and update staff on current research issues to be considered for future initiatives in stem cell research. (Contact: Dr. Jill Carrington, BAP, Ph: 301-496-6402)

II. Meetings Planned

Workshop on Werner’s Syndrome. BAP will co-sponsor this exploratory workshop with the NIA IRP, Geriatrics and Clinical Gerontology Program (GCG), the NIA International office, and the NIH Office of Rare Diseases (NIH ORD) on May 28–31. The meeting will address recent success in understanding the molecular basis of Werner’s syndrome (WS), a premature aging syndrome characterized by increased risk of cancer and osteoporosis, slow wound healing, and premature onset of cataracts and loss of subcutaneous fat. Understanding the causes of WS may inform us about the basic mechanisms associated with development of aging phenotypes during normal aging. The meeting will be held in Leesburg, VA. (Contacts: Dr. Vilhelm Bohr, IRP, Ph: 410-558-8223; Dr. Evan Hadley, GCG, Ph: 301-496-6761; and Dr. Huber Warner, BAP, Ph: 301-496-4996)

Workshop on Hutchinson-Gilford Syndrome. On July 28-29, BAP will sponsor a second advisory Workshop on Hutchinson-Gilford syndrome (HGS) to discuss promising new avenues of research on this syndrome, based on the forthcoming report in Nature that HGS is due to a specific T to C transition mutation in codon 608 of the gene for lamin A. Six other pathologies are associated with mutations in the lamin A gene. The various phenotypes of these other six laminopathies overlap the overall phenotype observed in HGS patients. The identification of this gene thus suggests research avenues for (1) understanding the molecular basis of HGS, (2) the development of therapeutic interventions for HGS, and (3) understanding the role that the nuclear envelope, and nuclear structure in general, could play in the development of aging phenotypes during normal aging. The workshop is co-sponsored by the National Human Genome Research Institute (NHGRI), the NIH Office of Rare Diseases, and the Progeria Research Foundation. The meeting will be held in Bethesda. (Contact: Dr. Huber Warner, BAP, Ph: 301-496-4996)

Advances in Aging Research 2003. The National Institute on Aging Intramural Research Program (IRP) and the Nathan W. and Margaret T. Shock Foundation are cosponsoring a one-day Nathan Shock Symposium entitled “Advances in Aging Research 2003” on September 17, 2003. (Contact: Ms. Peggy Grothe, NIA IRP, Ph: 410-558-8110)

General Information/Staff Awards

New Publications

Behavior Genetics, Special Issue: Aging, Vol. 33, No. 2, March 2003. Jennifer R. Harris, Special Expert in the BSR Program, served as guest editor.

Berch, D.B. and Wagster, M.V. Future directions in cognitive aging research: Perspectives from the National Institute on Aging. In R.A. Dixon, L. Backman, and L. Nilsson (eds.), New Frontiers in Cognitive Aging. New York: Oxford University Press, in press.

Updated Publications

  • NIA Publications List (also in Braille)
  • Alzheimer’s Disease: Unraveling the Mystery – Updated, redesigned edition presenting the latest findings and basic science behind Alzheimer’s disease (AD). Includes a CD-ROM with 2-minute animated video showing the progression of AD in the brain, and the report’s graphics and text files for ready use.
  • ADC Program Directory
  • AD Caregiver Guide
  • Alzheimer’s Disease Fact Sheet
  • Alzheimer’s Disease Genetics Fact Sheet
  • Medicamentos para la enfermedad de Alzheimer (Alzheimer’s Disease Medications Fact Sheet)
    (Contact: Jane E. Shure, Director, OCPL, Ph: 301-496-1752)

Exercise Guide Promotion
The Office of Communications and Public Liaison (OCPL) has produced a print public service announcement promoting the NIA exercise guide for display on Washington Metropolitan Area Transit Authority (WMATA) buses and in metro rail stops during Older American's Month, May 2003. The ads feature photos of diverse, healthy active older people engaging in physical activity. WMATA has donated ad space for this public service promotion. (Contact: Jane E. Shure, Director, OCPL, Ph: 301-496-1752)

Florence Mahoney Lecture and Tribute
Dr. Elizabeth Blackburn (University of California, San Francisco) presented, "Telomeres: No End in Sight" at the 17th Florence Mahoney Lecture on Aging on March 12, 2003. A video of this lecture is archived on the NIH CIT website. Prior to the lecture, Dr. Richard J. Hodes, NIA Director, and Dr. Robert Butler, President/ CEO, International Longevity Center in New York, paid tribute to Mrs. Mahoney who died Nov. 29, 2002, at the age of 103. (Contact: Jane E. Shure, Director, OCPL, Ph: 301-496-1752)

NIH SeniorHealth.gov
In June, NIA’s new senior-friendly web site, NIH SeniorHealth.gov, will be officially launched. The site, the result of a three-year collaboration between OCPL and the National Library of Medicine (NLM), is based on NIA’s cognitive aging research and is tailored to meet the cognitive and visual requirements of adults 60 and older. The site went “live” last year with three aging-related health topics: Alzheimer’s disease, Caring for someone with Alzheimer’s disease, and Exercise for older adults. OCPL is working with three other NIH Institutes to develop six new topics including breast, prostate, colorectal, and lung cancer; arthritis; and hearing/ balance disorders. Contributing institutes are the National Cancer Institute, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and the National Institute on Deafness and Other Communication Disorders. New design features are being added to the website, notably a “talking” function that allows users to listen to the information that appears on screen. (Contact: Jane E. Shure, Director, OCPL, Ph: 301-496-1752)

ADEAR Website Improvements
The ADEAR website has been redesigned to make it easier to navigate. The initial response has been very positive--in two months there have been 230,000 unique visitors to the site, that's an increase from 60,000-75,000 monthly. The website also now allows visitors to order publications online via a “shopping cart” system. (Contact: Jane E. Shure, OCPL Director, Ph: 301-496-1752)

Publication Award
The AD Caregiver Guide won a “2002 APEX Award for Publication Excellence." (Contact: Jane E. Shure, OCPL Director, Ph: 301-496-1752)

Awards

The National Association of Government Communications has awarded OCPL several notable Blue Pencil awards. The publication, Aging Under the Microscope, won first place in the category of soft cover books 50+ pages; Portfolio for Progress won second place and Home Safety for People with AD won honorable mention in the category of soft cover books under 50 pages. OCPL public service announcements (PSAs) received Gold Screen Awards as well. The television PSA, “Senior Dance” won first place in the category of TV PSAs and Ejercicio: Ideal a Toda Edad won honorable mention in audio PSAs. In addition, the AD Caregiver Guide won a “2002 APEX Award for Publication Excellence." (Contact: Jane E. Shure, OCPL Director, Ph: 301-496-1752)

New Publications from the NIA

Aging Under the Microscope: A Biological Quest - booklet focusing on the biology of aging.

Alzheimer's Disease: Unraveling the Mystery- booklet on Alzheimer's disease research including an animated CD showing the development of AD in the brain, as well as a pdf and other formatted versions of the full text.

Updated and/or Reprinted Publications

  • Age Page: Aging and Your Eyes
  • Age Page: Alcohol Use and Abuse
  • Age Page: Dietary Supplements
  • Age Page: Exercise: Feeling Fit for Life
  • Age Page: Good Nutrition
  • Age Page: Health Quackery
  • Age Page: Menopause
  • Age Page: Older Drivers
  • Age Page: Osteoporosis
  • Age Page: Sexuality in Later Life
  • Age Page: Urinary Incontinence
  • Making Your Website Senior Friendly
  • AD Caregiver Guide
  • AD Fact Sheet
  • AD Medications Fact Sheet
  • Holiday Hints

Publications Newly Translated Into Spanish

The following titles have been translated into Spanish.

  • Age Page: Alcohol Use and Abuse
  • Age Page: Choosing a Doctor
  • Age Page: Depression
  • Age Page: Health Quackery
  • Age Page: Hearing Loss
  • Age Page: Menopause
  • Age Page: Sexuality in Later Life
  • Home Safety for People with Alzheimer's Disease

(For more information on these publications contact: Jane E. Shure, Director, OCPL, ph: 301-496-1752.)

Other New Materials and Promotions

  • Radio Public Service Announcements (PSAs) (English)- Produced six different 60-second PSAs to promote Unraveling the Mystery and a new package of materials, the AD Caregiver Kit.
  • Radio Public Service Announcements (Spanish)- Produced two PSAs (one 30-second and one 60-second spot) in Spanish and English translation to promote the Spanish AD Caregiver Kit and the Spanish AD Fact Sheet.

New Exhibits

  • ADEAR Center Display-Booth-sized panel display for exhibiting at national meetings and conferences and NIH events.
  • NIA Display-Booth-size display, with panels that have high visual impact, for exhibiting at national, State, and local meetings and conferences and NIH events.

Publication Awards

  • NIA's Spanish-language radio public service announcements (PSAs) Ejercicio: Ideal A Todo Edad (Exercise: Good at Any Age) were honored with the 2002 Aesculapius Award of Excellence. This annual award, named for the Greek God of healing, was established by the nonprofit Health Improvement Institute to promote excellence in informing consumer lifestyle choices and health care decisions.
  • AD Caregiver Guide, won a "2002 National Mature Media Award," in the category of Brochure/Booklet.

New Notices and Initiatives Relevant to the National Institute on Aging (NIA)

From the NIH GUIDE - From September 5, 2002 – April 22, 2003
Published since the last National Advisory Council on Aging Meeting.
Also check our NIA website “Funding Opportunities
(Shown here are selected Notices relevant to NIA and selected Initiatives)

Notices

  1. Conference for Institutional Biosafety Committees
    Release Date: January 3, 2003
    Notice: NOT-OD-03-016
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-03-016.html

    The NIH Office of Biotechnology Activities, the NIH Office of Laboratory Animal Welfare, the American Biological Safety Association, and the Applied Research Ethics National Association are partnering to sponsor a conference titled, "The Future Face of IBCs: Evolving Roles and Responsibilities, Upcoming Challenges and Opportunities." This event will take place February 20-22, 2003 at the Town and Country Resort Hotel in San Diego, California. Registration is now open. The main conference will take place February 21-22 and is intended for Institutional Biosafety Committee (IBC) members, staff, and others who have an interest in the oversight of recombinant DNA research.

  2. Spring PRIM&R/ARENA Annual IACUC Conference and Arena IACUC 101 Training In San Diego
    Release Date: December 17, 2002
    Notice: NOT-OD-03-015
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-03-015.html

    The Office of Laboratory Animal Welfare is pleased to participate in the 2003 Annual IACUC Conference sponsored by Public Responsibility in Medicine and Research (PRIM&R) and the Applied Research Ethics National Association (ARENA), entitled "IACUC Actions: Making Ethically and Scientifically Informed Decisions." The conference will be held March 30 to April 1, 2003 at the Town & Country Resort & Convention Center in San Diego, California. An ARENA IACUC 101 training opportunity will be offered March 29 at the same location. This one-day course is cosponsored by OLAW and the University of California, San Diego.

  3. Announcing 2003 NIH Regional Seminars in Program Funding and Grants Administration
    Release Date: December 13, 2002
    Notice: NOT-OD-03-014
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-03-014.html

    Looking to learn about obtaining and managing NIH grant awards? Two regional seminars covering topics related to NIH extramural program funding and grants administration have been planned for 2003. The regional seminars provide information about the entire funding process, from opportunity identification and application preparation through post award administration. April 24-25, 2003 hosted by Stanford University in Palo Alto, California. The seminar program, on-line registration, cost and logistical information are available at: http://www.stanford.edu/dept/ORA/training/nihconf03/index.html June 11-12, 2003 hosted by University of Maryland in Baltimore, Maryland. A website with program, registration, cost and logistical information is in development at http://www.ord.umaryland.edu/nih/. If unable to access the website, please send a message to nih-conference@ordmail.umaryland.edu to be placed on a mailing list for further information.

  4. NIH Extramural Loan Repayment Program Regarding Clinical Researchers
    Release Date: December 4, 2002
    Notice: NOT-OD-03-012
    Application Receipt Date: 5 PM EST, January 31, 2003
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-03-012.html

    The National Institutes of Health (NIH) announces the extension of the deadline for the 2003 Extramural Loan Repayment Program for Clinical Researchers (LRP-CR). The original Notice was Notice: NOT-OD-03-004. The LRP-CR provides for the repayment of educational loan debt of qualified health professionals who agree to conduct clinical research for two years. The program provides for the repayment of up to $35,000 of the principal and interest of the educational loans. The program covers the Federal taxes on the loan repayments, which are considered taxable income to program participants. This year's program is not limited to NIH grantees as was the fiscal year 2002 requirement. The new deadline is now January 31, 2003. A full description of the Extramural Loan Repayment Program for Clinical Researchers (LRP-CR) is available at http://www.lrp.nih.gov.

  5. Laboratory Animal Management and Technology Conference, February 2003
    Release Date: November 26, 2002
    Notice: NOT-OD-03-010
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-03-010.html

    The Office of Laboratory Animal Welfare is joining the American Association for Laboratory Animal Science (AALAS), Florida State University, and Florida A&M University in co-sponsoring the AALAS Management and Technology Conference 2003. The conference will be held February 5-8, 2003, in Orlando, Florida.

  6. Publication of "Proactive Compliance Site Visits 2000 – 2002: A Compendium of Findings and Observations"
    Release Date: November 26, 2002
    Notice: NOT-OD-03-011
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-03-011.html

    The National Institutes of Health (NIH) is pleased to announce the publication of "Proactive Compliance Site Visits 2000 - 2002: A Compendium of Findings and Observations" (http://grants.nih.gov/grants/compliance/compendium_2002.htm). This newly updated document is available on the Grants Compliance and Oversight website (http://grants.nih.gov/grants/compliance/compliance.htm), which is linked on the Office of Extramural Research (OER) homepage (http://grants.nih.gov/grants/oer.htm) under Grant Topics.

  7. Addendum to – RFA-TW-03-006, Global Health Research Initiative Program for New Foreign Investigators (R01)
    Release Date: November 20, 2002 (see RFA-TW-03-006)
    Notice: NOT-TW-03-003
    Application Receipt Date: February 18, 2003
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-TW-03-003.html

    The Purpose of This addendum is to include language regarding the Office of Dietary Supplements (ODS), Office of the Director, National Institutes of Health. The following information regards the Authority and Regulations of the ODS. The Office of Dietary Supplements (ODS) was mandated by Congress in 1994 and established within the Office of the Director, National Institutes of Health (NIH). The Dietary Supplement Health and Education Act (DSHEA) [Public Law 103-417, Section 3.a] amended the Federal Food, Drug, and Cosmetic Act "to establish standards with respect to dietary supplements." This law authorized the establishment of the ODS.

  8. NIH Extramural Loan Repayment Program Regarding Clinical Researchers
    Release Date: October 10, 2002
    Notice: NOT-OD-03-004
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-03-004.html
    Application Receipt Date: 5 PM EST, November 30, 2002
    (new deadline 5 PM EST, January 31, 2003 – See Notice NOT-OD-03-012)

    The National Institutes of Health (NIH) announces the 2003 Extramural Loan Repayment Program for Clinical Researchers (LRP-CR). The LRP-CR provides for the repayment of educational loan debt of qualified health professionals who agree to conduct clinical research for two years. The program provides for the repayment of up to $35,000 of the principal and interest of the educational loans. The program covers the Federal taxes on the loan repayments which are considered taxable income to program participants.

  9. Reminder—Ruth L. Kirschstein National Research Service Award (NRSA) Stipends and Unallowable Charges
    Release Date: October 9, 2002
    Notice: NOT-OD-03-003
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-03-003.html

    NRSA recipients receive a stipend—a subsistence allowance to help defray living expenses during the research training experience. It is not provided as a condition of employment with either the Federal Government or the institution. Since NRSA awards are not provided as a condition of employment, it is inappropriate and unallowable for institutions to seek funds for or to charge individual fellowships and institutional training grant awards for costs that would normally be associated with employee benefits (for example FICA, workman's compensation and unemployment insurance). NIH occasionally receives information that FICA and/or other unallowable costs have been inappropriately charged to NRSA stipends. This Notice should serve as a reminder that such charges are unallowable at all times.

  10. Notice of Limited Competition Integrating Cancer and Aging Research in NCI-Designated Cancer Centers
    Release Date: September 20, 2002
    Notice: NOT-CA-02-027
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-CA-02-027.html

    The National Institute on Aging and the National Cancer Institute announces a limited competition for Planning Grants (P20s) for developing aging/cancer "Programs" (or equivalently effective models) that will become incorporated as stable components of Cancer Center Support Grants (CCSGs).

  11. Clinical Research Curriculum (K30) Award Announcement
    Release Date: September 13, 2002
    Notice: NOT-OD-02-070
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-02-070.html

    The National Institutes of Health is extending for one year the Clinical Research Curriculum (K30) Awards that were originally made in 1999. These awards, which were due to terminate in summer, 2004, will be extended at the same level of funding as currently exists. As a result of this extension, the K30 awards made in 1999 will end in the summer, 2005, approximately the same time that the K30 awards made in 2000 are scheduled to end. Next year, NIH plans to solicit competitive applications for the K30 award, which will be scheduled to begin in the summer, 2005. All domestic, non-Federal institutions with clinical research programs will be eligible to apply. That is, those who currently have a K30 award (those institutions that originally received an award in 1999 and those that originally received an award in 2000), and those that do not have an award may apply.

  12. Correction to Gene Discovery for Complex Neurological and Neurobehavioral Disorders Program Announcement (PAS-03-092)
    Release Date: April 22, 2003
    Notice: NOT-NS-03-013
    http://grants.nih.gov/grants/guide/Notice-files/NOT-NS-03-013.html

    This is a change to the Program Announcement "Gene Discovery for Complex Neurological and Neurobehavioral Disorders". The text in the Supplemental Instructions and Specific Instructions for Modular Grant Applications sections has been replaced.

  13. Temporary NIA Policy on Funding Human Testosterone Intervention Studies
    Release Date: April 21, 2003
    Notice: NOT-AG-03-001
    http://grants.nih.gov/grants/guide/Notice-files/NOT-AG-03-001.html

    This Notice is to inform you of the National Institute on Aging (NIA) policy decision that will temporarily affect the funding status of applications for clinical intervention studies involving the use of testosterone. As of this date, the NIA has decided to defer funding decisions on these applications. The reasons for this decision are described below. The NIA has held a long interest in hormone therapies for both men and women, as well as the pharmacologic and physiologic effects of such therapies on aging and aged populations of the United States. Testosterone has been the topic of scientific studies supported for some years by this Institute, with regard to risks and benefits of testosterone therapy. Recently, at NIA's request, the Institute of Medicine (IOM) of the National Academy of Sciences convened a panel of experts to make recommendations and assessments on the need for clinical trials of testosterone therapy and related issues. This IOM study was inaugurated in November 2002. The panel's final report is expected in November of this year.

  14. Revision of March 7, 2003 Notice About Ruth L. Kirschstein National Research Service Award (NRSA) Stipend Increase And Other Budgetary Changes Effective for Fiscal Year 2003
    Release Date: March 21, 2003
    Notice: NOT-OD-03-036
    http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-03-036.html

    National Institutes of Health (NIH)
    Agency for Healthcare Research and Quality (AHRQ)
    Health Resources Services Administration (HRSA)
    This Notice supercedes a Notice released on March 7, 2003 related to stipends and other budgetary issues associated with FY 2003 Ruth L. Kirschstein National Research Service Awards (NRSA). This Notice updates stipend levels associated with the Minority Access to Research Career (MARC) and the Career Opportunities in Research (COR) programs that operate out of the National Institute of General Medical Sciences and the National Institute of Mental Health, respectively. All other components of the Notice that appeared on March 7 remain unchanged.

  15. Salary Limitation on Grants, Cooperative Agreements, and Contracts
    Release Date: March 18, 2003
    Notice: NOT-OD-03-034
    http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-03-034.html

    This Notice provides updated information regarding the salary limitation for NIH grant and cooperative agreement awards and extramural research and development contract awards. On January 25, 2002, the Fiscal Year (FY) 2002 information on the salary limitation was published in the NIH Guide for Grants and Contracts. A Notice on the continuing resolutions for FY 2003 regarding the salary limitation was published February 10, 2003. For fourteen consecutive years, Congress has legislatively mandated a provision for the limitation of salary. For FY 2003,the Consolidated Appropriations Resolution 2003, Public Law 108-7, which includes appropriations for the Department of Health and Human Services, restricts the amount of direct salary of an individual under an NIH grant or cooperative agreement (referred to here as a grant) or applicable contract to Executive Level I of the Federal Executive Pay scale. The Executive Level I annual salary rate was $166,700 for the period January 1 through December 31, 2002. Effective January 1, 2003, the Executive Level I salary level increased to $171,900.

  16. Ruth L. Kirschstein National Research Service Award (NRSA) Stipend Increase and Other Budgetary Changes Effective for Fiscal Year 2003
    Release Date: March 7, 2003
    Notice: NOT-OD-03-033 (Superceded by NOT-OD-03-036)
    http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-03-033.html

    National Institutes of Health (NIH)
    Agency for Healthcare Research and Quality (AHRQ)
    Health Resources Services Administration (HRSA)
    The budgetary changes described below for Fiscal Year 2003 Kirschstein-NRSA awards affect the stipend levels for predoctoral and postdoctoral trainees and fellows. In addition, for informational purposes only, the stipend levels for undergraduate trainees, the Training Related Expenses for trainees and the Institutional Allowance for individual fellows are shown. These budget categories are not being increased. Only predoctoral and postdoctoral stipends are increased this fiscal year.

  17. Reminder to Applicants About Requirement to Submit Complete and Up-To-Date Other Support Information
    Release Date: February 13, 2003
    Notice: NOT-OD-03-029
    http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-03-029.html

    NIH requires submission of complete and up-to-date "other support" information before an award can be made. Other support includes all financial resources, whether Federal, non-Federal, commercial or institutional, available in direct support of an individual's research endeavors, including but not limited to research grants, cooperative agreements, contracts, and/or institutional awards. Training awards, prizes, or gifts are not included. Applicants should not include information on other support in the PHS 398 competitive grant application submission, but should be prepared to follow "just-in-time" procedures to submit current other support information upon the request of NIH Institute/Center staff when the application is under consideration for funding. Grantees must also report any changes in other support as a part of the annual progress report.

  18. Impact of the HIPAA Privacy Rule on NIH Processes Involving the Review, Funding, and Progress Monitoring of Grants, Cooperative Agreements and Research Contracts
    Release Date: February 5, 2003
    Notice: NOT-OD-03-025
    http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-03-025.html

    The Purpose of This GUIDE Notice is to provide an overview of how the HIPAA Privacy Rule may affect NIH processes involving the review, funding, and progress monitoring of grants, cooperative agreements and research contracts. The Privacy Rule is a federal regulation under the Health Insurance Portability and Accountability Act (HIPAA) of 1996 that governs the protection of individually identifiable health information. The Rule was enacted to increase the privacy protection of health information identifying individuals who are living or deceased, and to regulate known and unanticipated risks to privacy that may accompany the use and disclosure of personal health information. The Privacy Rule is not an NIH regulation. It is administered and enforced by the DHHS Office for Civil Rights (OCR). Those who must comply with the Privacy Rule, including some grantees and contractors, must do so by April 14, 2003 (with the exception of small health plans which have an extra year to comply). The OCR website (http://www.hhs.gov/ocr/) provides information on the Privacy Rule, including a complete Regulation Text for the Privacy Rule.

  19. Homepage and Listserv for Mind-Body Interactions and Health Research RFAS
    Release Date: January 22, 2003
    Notice: NOT-OB-03-001
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OB-03-001.html

    National Institutes of Health (NIH)
    The Office of Behavioral and Social Sciences Research (OBSSR) has created an electronic mailing list (listserv) and an Internet HomePage for the RFAs on Mind-Body Interactions and Health Research (RFA-OB-03-004 and RFA-OB-03-005). Included on the HomePage are "Frequently Asked Questions." Instructions for joining the listserv and the hyper link to the Frequently Asked Questions are posted at http://obssr.od.nih.gov/RFA_PAs/MBFY04/Start.htm.

  20. Addendum to Brain Disorders in the Developing World: Research Across the Lifespan (RFA-TW-03-007)
    Release Date: January 22, 2003 (see RFA-TW-03-007)
    Notice: NOT-TW-03-005
    http://grants.nih.gov/grants/guide/Notice-files/NOT-TW-03-005.html

    Clarification of Institutional Eligibility:
    Financial institutions and international intergovernmental organizations are not eligible, unless pre-approved by FIC, to apply for FIC research or training programs, whether these are related to an RFA or are investigator-initiated. However, staff of such institutions may, if invited by eligible applicants, serve as unpaid collaborators or consultants on such projects. International research organizations that are the recipient of grants or other external funding and are not themselves funding agencies are also eligible to apply for FIC grant support as well as serve as collaborators/consultants for other applicants.

  21. Resubmission of Unpaid RFA Applications and Resubmission of Applications With A Changed Grant Activity Mechanism
    http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-03-019.html
    Release Date: January 16, 2003
    Notice: NOT-OD-03-019
    http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-03-019.html

    Background and Rationale: The majority of grant applications submitted to NIH each year are investigator-initiated. However, the Institutes and Centers of NIH also solicit grant applications on specific topics through the use of Requests for Applications (RFAs). With this Notice the NIH is changing its practice regarding resubmissions of three categories of grant applications. Those categories include: 1. Applications that were originally submitted in response to an RFA and then resubmitted as an investigator-initiated application.2. Applications that were originally submitted as investigator-initiated applications and subsequently resubmitted in response to an RFA. 3. Applications that were originally submitted using one grant mechanism and subsequently resubmitted using a different grant mechanism (for example, an application that was originally an R01 and then is resubmitted as an R21).

Initiatives

(Sorted by most recent Release Date)
If the application dates are not listed then the standard NIH receipt dates apply. See Standard Receipt Dates.

  1. Development and Application of Pet and Spect Ligands (R21/R33) for Brain Imaging Studies (Phased Innovation Award)
    Release Date: April 21, 2003
    This PA is a reissue of RFA MH-02-003

    PA Number: PA-03-112
    http://grants.nih.gov/grants/guide/pa-files/PA-03-112.html

    Purpose of This PA
    This initiative requests research grant applications for the development of novel radioligands for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging in human brain, and that incorporate pilot or clinical feasibility evaluation in pre-clinical studies, model development, or clinical studies. This initiative is intended to facilitate the development of: 1) PET and SPECT probes for molecular targets (e.g., receptors, intracellular messengers, disease-related proteins) that are of broad interest to the neuroscience research community, and 2) new technologies for radiotracer development.

    Direct your questions about scientific/research issues to:
    Molly Wagster, Ph.D. and Neil Buckholtz, Ph.D.
    Neuroscience and Neuropsychology of Aging Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 350
    Bethesda, MD 20892
    Telephone: (301) 496-9350
    FAX: (301) 496-1494
    Email: wagsterm@nia.nih.gov; buckholn@nia.nih.gov

  2. NIH Exploratory/Developmental Research Grant Award (R21)
    Release Date: April 18, 2003
    PA Number: PA-03-107
    http://grants.nih.gov/grants/guide/pa-files/PA-03-107.html

    Purpose of This PA
    This announcement redefines the National Institutes of Health (NIH) Exploratory/Developmental Research Grant Award (R21) mechanism, and extends its use as an investigator-initiated mechanism to the Institutes and Centers (ICs) listed above. The R21 is intended to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. The characteristics, requirements, preparation, and review criteria for the R21 application are described.

    Direct your questions about scientific/research issues to:
    Dr. Robin Barr
    Deputy Associate Director, Office of Extramural Affairs
    National Institute on Aging
    7201 Wisconsin Avenue, Room 2C218
    Bethesda, MD 20892-9205
    Phone: (301) 496-9322
    FAX: (301) 402-2945
    E-mail: rb42h@nih.gov

  3. NIH Small Research Grant Program (R03)
    Release Date: April 18, 2003
    PA Number: PA-03-108
    http://grants.nih.gov/grants/guide/pa-files/PA-03-108.html

    Purpose of This PA
    This announcement redefines the National Institutes of Health (NIH) Small Grant (R03) mechanism, and extends its use to investigator-initiated applications at the Institutes and Centers (ICs) listed above. The R03 award supports small research projects that can be carried out in a short period of time with limited resources. The characteristics, requirements, preparation, and review criteria for the small grant application are described in this document.

    Direct your questions about scientific/research issues to:
    Dr. Robin Barr
    Deputy Associate Director, Office of Extramural Affairs
    National Institute on Aging
    7201 Wisconsin Avenue, Room 2C218
    Bethesda, MD 20892-9205
    Phone: (301) 496-9322
    FAX: (301) 402-2945
    E-mail: rb42h@nih.gov

  4. Innovations in Biomedical Computational Science and Technology (R01, R21/R33)
    Release Date: April 17, 2003
    PA Number: PAR-03-106
    http://grants.nih.gov/grants/guide/pa-files/PAR-03-106.html

    Application Receipt Dates: June 24, 2003; October 24, 2003; February 24, 2004; June 24, 2004; October 24, 2004; February 24, 2005; February 24, 2005; October 24, 2005; February 26, 2006

    Purpose of This PA
    This PA invites applications for innovative research in biomedical computational science and technology to promote the progress of biomedical research. There exists an expanding need to speed the progress of biomedical research through the power of computing to manage and analyze data and to model biological processes. The NIH is interested in promoting research and developments in computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here, biomedical computing or biomedical information science and technology includes database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational and mathematical research including the development of structural, functional, integrative, and analytical models and simulations.

    Direct your questions about scientific/research issues to:
    David B. Finkelstein, Ph.D.
    Biology of Aging Program/Cardiovascular Biology
    National Institute on Aging
    7201 Wisconsin Avenue, Room 2C231 MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-6402
    FAX: (301) 402-0010
    Email : finkelsd@nia.nih.gov

  5. Gene Discovery for Complex Neurological and Neurobehavioral Disorders (U01)
    Release Date: March 31, 2003
    PA Number: PAS-03-092
    http://grants.nih.gov/grants/guide/pa-files/PAS-03-092.html

    Purpose of This PA
    The goal of this Program Announcement (PA) is to promote the identification of susceptibility genes for complex neurological and neurobehavioral disorders. For this PA, complex disorders are defined as those caused by the interaction of multiple genes, or by a combination of genetic and environmental risk factors. Many of these disorders are relatively common and clinically heterogeneous. Projects focusing on any phase of the gene discovery process, from initial patient ascertainment to positional cloning, are appropriate. Novel approaches, including the use of intermediate phenotypes that potentially underlie complex disorders, are also encouraged.

    Direct your questions about scientific/research issues to:
    Winifred K. Rossi, M.A.
    Special Assistant for Planning
    Geriatrics and Clinical Gerontology Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 3C3O7 MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-3836
    Email: rossiw@nia.nih.gov

  6. The National Institute on Aging Multicenter Study on Exceptional Survival in Families (U01)
    Release Date: February 25, 2003
    RFA: AG-03-004
    http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-03-004.html

    Application Receipt Date: June 24, 2003

    Purpose of This RFA
    The National Institute on Aging (NIA) invites applications for cooperative agreements (UO1s) to participate in the design and implementation of a Multicenter Study on Exceptional Survival in Families (ESF). This study will determine the degree and patterns of familial transmission and aggregation of exceptional longevity and healthy survival to advanced age as characterized by a variety of phenotypic measures. This Request for Applications (RFA) solicits proposals for: (1) Study Centers to design and implement the ESF study, and (2) a Data Management and Coordinating Center (DMCC) that will interact with the Study Centers, a Steering Committee, a Monitoring Board, and NIA staff by providing administrative, logistical, and data management support for the ESF Study.

    Direct your questions about scientific/research issues to:
    Winifred K. Rossi, M.A.
    Special Assistant for Planning
    Geriatrics and Clinical Gerontology Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 3C3O7 MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-3836
    Email: rossiw@nia.nih.gov

  7. Clinical Research Education and Career Development (CRECD) in Minority Institutions (R25)
    Release Date: February 12, 2003
    RFA: RR-03-007
    http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-03-007.html

    Application Receipt Date: April 29, 2003

    Purpose of This RFA
    This PA invites minority institutions with professional schools offering doctoral degrees in one or more of the health care disciplines to apply for a Clinical Research Education and Career Development (CRECD) grant. Current CRECD awardee institutions may not apply for a second award.

    Direct your questions about programmatic issues to:
    Dr. Andre J. Premen
    Geriatrics and Clinical Gerontology Program
    National Institute on Aging
    Gateway Building, Room 480
    7201 Wisconsin Avenue, MSC 9205
    Bethesda, MD 20892-9205
    Telephone: 301-496-6761
    Fax: 301-402-1784
    E-mail: premena@nia.nih.gov

  8. The Biological Basis of Hutchinson-Gilford Syndrome (HGS): Relationship to Mutations in the Lamin A/C Gene (LMNA) And to Other Known Laminopathies
    Release Date: February 10, 2003
    PA Number: PA-03-069
    http://grants1.nih.gov/grants/guide/pa-files/PA-03-069.html

    Purpose of This PA
    This Program Announcement (PA) is a new initiative to support research to understand how mutations in the gene for lamin A/C affect nuclear structure, thus leading to both dysfunction of the nuclear envelope, and depending on the mutation, Hutchinson-Gilford syndrome in humans (Eriksson et al., manuscript in preparation). Lamins A and C are coded by a single developmentally regulated gene designated LMNA; lamin C is a splice variant and lacks the carboxyl terminus present in lamin A. At least 6 other rare human disorders due to lamin A/C mutations (known collectively as laminopathies) besides HGS have been described so far: Emery–Dreifuss muscular dystrophy (Bonne et al., 1999), dilated cardiomyopathy (Fatkin et al., 1999), familial partial lipodystrophy (Shackleton et al., 2000), limb girdle muscular dystrophy (Muchir et al., 2000), Charcot-Marie-Tooth disorder type 2 (De Sandre-Giovanni et al., 2002), and mandibuloacral dysplasia (Novelli et al., 2002).

    Direct your questions about scientific/research issues to either of the following:
    Dr. Felipe Sierra
    Biology of Aging Program
    National Institute on Aging
    Gateway Building, Room 2C231
    Bethesda, MD 20892
    Telephone: (301) 496-6402
    FAX: (301) 402-0010
    Email: sierraf@nia.nih.gov

  9. Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (F32)
    Release Date: February 6, 2003
    PA Number: PA-03-067
    http://grants1.nih.gov/grants/guide/pa-files/PA-03-067.html

    Purpose of This PA
    The Congress of the United States enacted the National Research Service Act (NRSA) Program in 1974 to help ensure that a diverse pool of highly trained scientists will be available in adequate Numbers and in appropriate research areas to carry out the Nation's biomedical and behavioral research agenda. In 2002, the National Research Service Award Program was renamed the Ruth L. Kirschstein National Research Service Award Program as a tribute to Dr. Kirschstein's years of exceptional service to the Nation. Additional details related to this legislative change are available at http://grants.nih.gov/training/news.htm. Under this congressional authority, the National Institutes of Health (NIH) awards individual postdoctoral fellowships (F32) to promising applicants with the potential to become productive, independent investigators in fields related to the mission of the NIH constituent institutes and centers.

    Direct your questions about scientific/research issues to:
    Robin Barr, Ph.D.
    Deputy Associate Director, Office of Extramural Affairs
    National Institute on Aging
    7201 Wisconsin Avenue, Room 2C218
    Bethesda, MD 20892-9205
    Phone: (301) 496-9322
    FAX: (301) 402-2945
    Email: rb42h@nih.gov

  10. Epidemiology of Alcohol Consumption and Alcohol-Related Problems in Older Persons (R01, R03, R21)
    Release Date: January 22, 2003
    PA Number: PA-03-061
    http://grants1.nih.gov/grants/guide/pa-files/PA-03-061.html

    Purpose of This PA
    The National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Aging (NIA) invite applications for research on the epidemiology of alcohol consumption and alcohol-related problems in older persons with the goal of enhancing our understanding of patterns of alcohol consumption and the epidemiology of alcohol-related problems in older populations.

    Direct your questions about scientific/research issues to:
    Angie Chon-Lee, MPH
    Behavioral and Social Research Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 533, MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-3138
    FAX: (301) 402-0051
    Email: ac176r@NIH.GOV (e-mail correspondence is preferred)

  11. NIA Pilot Research Grant Program (R03)
    Release Date: January 16, 2003
    PA Number: PAR-03-056
    http://grants1.nih.gov/grants/guide/pa-files/PAR-03-056.html

    Application Receipt DateS: March 17, 2003; July 15, 2003; November 17, 2003

    Purpose of This PA
    The National Institute on Aging (NIA) is seeking small grant (R03) applications in specific areas to: (1) stimulate and facilitate the entry of promising new investigators into aging research, and (2) encourage established investigators to enter new targeted, high priority areas in this research field. This Small Grant (R03) Program provides support for pilot research that is likely to lead to a subsequent individual research project grant (R01) that is focused on aging and/or a significant advancement of aging research. This PA supercedes PAR-02-049.

    Direct your questions about scientific/research issues with primary emphasis on the biology of aging to:
    Dr. David B. Finkelstein
    Biology of Aging Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 2C231, MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-6402
    FAX: (301) 402-0010
    Email: BAPQuery@nia.nih.gov

    Direct your questions about scientific/research issues with primary emphasis on behavioral and social research on aging to:
    Ms. Angie Chon-Lee
    Behavioral and Social Research Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 5C533, MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 594-5943
    FAX: (301) 402-0051
    Email: BSRQuery@nia.nih.gov

    Direct your questions about scientific/research issues with primary emphasis on the neuroscience and neuropsychology of aging to:
    Dr. Judy Finkelstein
    Neuroscience and Neuropsychology of Aging Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 350, MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-9350
    FAX: (301) 496-1494
    Email: NNAQuery@nia.nih.gov

    Direct your questions about scientific/research issues with primary emphasis on geriatric and clinical gerontological research to:
    Mr. Michael Bone
    Geriatrics and Clinical Gerontology Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 480, MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-6913
    FAX: (301) 402-1784
    Email: bonem@nia.nih.gov

  12. Exploratory/Developmental (R21) Bioengineering Research Grants (EBRG)
    Release Date: January 16, 2003
    PA Number: PA-03-058 (see NOT-HL-03-007 for update)
    http://grants1.nih.gov/grants/guide/pa-files/PA-03-058.html

    Purpose of This PA
    This PA invites applications for Exploratory/Developmental Bioengineering Research Grants (EBRG) to support innovative, high risk/high impact bioengineering research in new areas that are lacking preliminary testing or development. This research can explore approaches and concepts new to a particular substantive area; research and development of new technologies, techniques or methods; or initial research and development of data upon which significant future research may be built.

    Direct your questions about scientific/research issues to:
    Winifred K. Rossi, M.A.
    Special Assistant for Planning
    Geriatrics and Clinical Gerontology Program
    National Institute on Aging
    7201 Wisconsin Avenue - Room 3E327
    Bethesda, MD 20892-9205
    TEL: 301-496-3836
    FAX: 301-402-1784
    Email: rossiw@nia.nih.gov

  13. Social And Demographic Studies of Race And Ethnicity in The United States (R01)
    Release Date: January 16, 2003
    PA Number: PA-03-057
    http://grants1.nih.gov/grants/guide/pa-files/PA-03-057.html

    Purpose of This PA
    This PA invites qualified researchers to submit research grant applications on the demography and social science of race and ethnicity in the United States. The goal of this program announcement is to encourage research that will improve understanding of race and ethnicity in social science and demographic research. Demographic and social aspects of race and ethnicity include issues related to understanding how the changing composition and conceptualization of race and ethnicity are affecting the U.S. socially, economically, and demographically, including how increasing racial and ethnic diversity are affecting population health and health disparities; issues related to the development of racial and ethnic identity and to interactions between racial/ethnic identification and demographic, health, and other outcomes; and issues related to the measurement of race and ethnicity, including racial and ethnic self-identification.

    Direct your questions about scientific/research issues to:
    Georgeanne E. Patmios, M.A.
    Behavioral and Social Research Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 533, MSC 9205
    Bethesda, MD 20892-9205
    Telephone: (301) 496-3138
    Fax: (301) 402-0051
    Email: patmiosg@nia.nih.gov

  14. Maintenance of Long Term Behavioral Change
    Release Date: January 15, 2003 (see NOT-OB-03-002)
    RFA Number: OB-03-003
    http://grants1.nih.gov/grants/guide/rfa-files/RFA-OB-03-003.html

    Application Receipt Date: April 11, 2003

    Purpose of This RFA
    This RFA invites applications for research projects that (a) examine biopsychosocial processes and test interventions designed to achieve long-term health behavior change and (b) a Resource Center to provide coordination for this set of research projects. Past research has typically focused on short term behavioral change, yielding little information on how change, once achieved, is maintained over the long term. This Request for Applications (RFA) encourages investigators to expand on the current theoretical base of change processes and intervention models, as well as to consider new conceptualizations from basic research in the social and behavioral sciences. Applications must focus on important health-related behaviors already demonstrated amenable to short-term change, such as tobacco use, exercise, eating habits, alcohol and drug use, inoculation obtainment, disease screening, stress reduction, adherence to health care regimens, human immunodeficiency virus (HIV)or sexually transmitted infection (STI) risk practices, bullying and abuse of others, sun exposure, and failure to use safety equipment.

    Direct your questions about scientific/research issues to:
    Sidney M. Stahl, Ph.D.
    Behavioral and Social Research Program
    National Institute on Aging
    7201 Wisconsin Avenue, Room 533/Gateway
    Bethesda, MD 20892-9205
    Telephone: (301) 402-4156
    Fax: (301) 402-0051
    Email: StahlS@nia.nih.gov

  15. Academic Research Enhancement Award (R15)
    Release Date: January 9, 2003
    PA Number: PA-03-053
    http://grants1.nih.gov/grants/guide/pa-files/PA-03-053.html

    Application Receipt Dates: January 25, May 25, September 25
    AIDS-Related Application Receipt DateS: May 1, September 1, January 2

    Purpose of This PA
    The National Institutes of Health (NIH) is continuing to make a special effort to stimulate research in educational institutions that provide baccalaureate or advanced training for a significant Number of the Nation's research scientists but that have not been major recipients of NIH support. Since Fiscal Year (FY) 1985, Congressional appropriations for the NIH have included funds for this initiative, which NIH has implemented through the Academic Research Enhancement Award (AREA) program. Based on the expectation that funds will continue to be available each year, the NIH invites applications for AREA grants (R15) through a standing, an ongoing Program Announcement (PA). These grants are intended to create a research opportunity for scientists and institutions otherwise unlikely to participate extensively in NIH programs to support the Nation's biomedical and behavioral research effort.

    Direct your questions about scientific/research issues to:
    Dr. Miriam Kelty
    Associate Director, Office of Extramural Affairs
    National Institute on Aging
    7201 Wisconsin Avenue, Room 2C218
    Bethesda, MD 20892-9205
    Phone: (301) 496-9322
    FAX: (301) 402-2945
    E-mail: mk46u@nih.gov

  16. Mind-Body Interactions and Health: Exploratory/Developmental Research Program (R21)
    Release Date: January 9, 2003
    RFA: OB-03-005
    http://grants1.nih.gov/grants/guide/rfa-files/RFA-OB-03-005.html

    Application Receipt Date: July 16, 2003

    Purpose of This RFA
    The National Institutes of Health (NIH), through the participating Institutes, Centers, and Offices listed above, invite applications for infrastructure grants in support of research on mind-body interactions and health. "Mind-body interactions and health" refers to the relationships among cognitions, emotions, personality, social relationships, and health. Applicant institutions may request funds to support infrastructure and research designed to (1) enhance the quality and quantity of mind-body and health research and (2) develop new research capabilities to advance mind-body and health research through innovative approaches. These activities must reflect a research theme that is driven by scientific questions within the context of "Mind-body interactions and health" research. A central goal of this program is to facilitate interdisciplinary collaboration and innovation in mind-body and health research while providing essential and cost-effective core services in support of the development, conduct, and translation into practice of mind-body and health research based in centers or comparable administrative units.

    Direct your questions about scientific/research issues to:
    Richard Suzman, Ph.D.
    Associate Director
    Behavioral and Social Research (BSR)
    National Institute on Aging
    Gateway Building, Room 533
    7201 Wisconsin Avenue, MSC 9205
    Bethesda, MD 20892-9205
    Phone: 301-496-3131
    Fax: 301-402-0051
    E-mail: SuzmanR@nia.nih.gov

  17. Mind-Body Interactions and Health: Research Infrastructure Program (R24)
    Release Date: January 9, 2003
    RFA: OB-03-004
    http://grants1.nih.gov/grants/guide/rfa-files/RFA-OB-03-004.html

    Application Receipt Date: July 16, 2003

    Purpose of This RFA
    This RFA invites applications for infrastructure grants in support of research on mind-body interactions and health. "Mind-body interactions and health" refers to the relationships among cognitions, emotions, personality, social relationships, and health. Applicant institutions may request funds to support infrastructure and research designed to (1) enhance the quality and quantity of mind-body and health research and (2) develop new research capabilities to advance mind-body and health research through innovative approaches.

    Direct your questions about scientific/research issues to:
    Richard Suzman, Ph.D.
    Associate Director
    Behavioral and Social Research (BSR)
    National Institute on Aging
    Gateway Building, Room 533
    7201 Wisconsin Avenue, MSC 9205
    Bethesda, MD 20892-9205
    Phone: 301-496-3131
    Fax: 301-402-0051
    E-mail: SuzmanR@nia.nih.gov

  18. Pathways Linking Education to Health (R01)
    Release Date: January 8, 2003
    RFA: OB-03-001
    http://grants1.nih.gov/grants/guide/rfa-files/RFA-OB-03-001.html

    Application Receipt Date: March 26, 2003

    Purpose of This RFA
    A substantial Number of epidemiological and social science research studies have consistently found a moderate to strong association between educational attainment and a wide variety of illnesses, health problems, health behaviors and indices of overall health. The goal of this RFA is to increase the level and diversity of research directed at elucidating the causal pathways and mechanisms that may underlie the association between education and health.

    Direct your questions about scientific/research issues to:
    Georgeanne E. Patmios
    Behavioral and Social Research Program
    National Institute on Aging
    Gateway Building Room 533
    Bethesda, MD 20892
    Telephone: (301) 496-3138
    FAX: 301-402-0051
    Email: PatmiosG@nia.nih.gov

Budget Table

National Institute on Aging
FY 2002 Actual / FY 2003 Appropriation / FY 2004 President's Budget
(Dollars in Thousands)

Includes Aids FY 2002 Actual* FY 2003 Appropriation** FY 2004
President's Budget*
Research Grants No. Amount No. Amount No. Amount
Research Projects
Noncompeting 916 425,093 978 465,419 969 476,403
Admin. Suppl. (127) 14,645 (110) 8,126 (110) 8,126
Competing 399 134,144 480 167,575 460 161,832
Subtotal 1,315 573,882 1,458 641,120 1,429 646,361
SBIR/STTR 65 20,220 73 22,525 74 23,606
Subtotal, RPG 1,380 594,102 1,531 663,645 1,503 669,967
Research Centers 65 79,687 67 83,826 67 86,275
Other Research
Research Careers 174 20,882 181 23,043 181 23,371
Cooperative Clin Rsch 5 2,208 5 2,296 5 2,431
MBRS 0 1,240 0 1,290 0 1,338
Other 32 6,590 21 5,667 27 5,578
Subtotal, Other 211 30,920 207 32,296 213 32,718
Total Rsch Grants 1,656 704,709 1,805 779,767 1,783 788,960
Training FTTP   FTTP   FTTP  
Individual 59 2,400 59 2,589 59 2,581
Institutional 512 18,684 512 20,075 512 20,092
Total, Training 571 21,084 571 22,664 571 22,673
R&D Contracts (SBIR/STTR) 72 48,401 101 61,458 101 54,646
Subtotal, EXTRAMURAL   774,194   863,889   866,279
Intramural Research   86,842   96,798   95,699
RMS   29,780   32,911   32,433
TOTAL   890,816   993,598   994,411

* As presented in the FY 2004 Congressional Justification.
**Reflects FY 2003 Appropriation (post recission)