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Current Issue:April 2004, Volume 4, Issue 1: "Influence of Body Weight, Diet, and Stress on Aging, Survival and Pathological Endpoints in Rodents: Implications for Toxicity Testing and Risk Assessment" Text Version, PDF Version, Past Issues Subscribe to the Regulatory Research Perspectives (RRP) E-Mail List Issue 1 of Volume 4 of the Regulatory Research Perspectives: Impact on Public Health. Dietary restriction in rodents increases life span and protects against the formation of both chemically induced and spontaneous cancer. The protective effects of dietary restriction are associated with adaptive biochemical and physiological responses and with diminished growth. In recent years, the selective breeding of rodent populations used in toxicity testing, as well as improvements in their nutrition and animal husbandry, has resulted in larger animals with diminished life spans and increased incidences of background lesions. This phenomenon complicates the comparison of recent toxicity results with those from earlier studies. To overcome such problems, this paper proposes the rational use of dietary restriction to control body weight gain to within preset guidelines. The objective of the Regulatory Research Perspectives journal is to provide a vehicle for FDA scientists to communicate important scientific information to each other with the hope of generating collaborations and to communicate to the global community science that is important to the Agency. It is hoped that each center will submit manuscripts for publication through their respective editorial board members. Initially, we plan to publish quarterly. See the "Instructions to Authors" provided on this site. Some of these documents are in Portable
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