NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Heart, Lung and Blood Institute (NHLBI)

83 Protocols (66 Active Accrual of new subjects, 17 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 04-H-0268:
Effect of Nitric Oxide Donor on Endothelial Progenitor Cells in Patients with Coronary Artery Disease

* 04-H-0213:
Cytokine Gene Polymorphisms in Bone Marrow Failure

* 04-H-0211:
Specimen Procurement From Individuals With Hereditary Pulmonary Fibrosis

* 04-H-0202:
Human Diseases with Mutation of Non-muscle Myosin Heavy Chain Genes

* 04-H-0179:
Peripheral Blood Hematopoietic Progenitor Cell Mobilization Using Granulocyte Colony Stimulating Factor (G-CSF) Combined With AMD3100 in Healthy Volunteers

* 04-H-0143:
Modulation of Vascular Endothelial Growth Factor (VEGF) Using an Engineered Zinc-Finger Transcription Factor to Treat Lower Limb Intermittent Claudication

* 04-H-0112:
Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation Followed by T Cell Add-Back for Hematological Malignancies - Effect of Peritransplant Cyclosporine on Chimerism

* 04-H-0090:
A Pilot Study of the Safety and Efficacy of Imatinib in Reducing Monocytosis or Leukocytosis in Patients with Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia, Respectively

* 04-H-0082:
Technical Development of Strain Rate Echocardiography

* 04-H-0078:
Peripheral Blood Hematopoietic Progenitor Cell Mobilization with AMD3100 in Healthy Volunteers Previously Mobilized with G-CSF

* 04-H-0062:
The Role of Atrio-Ventricular Coupling in Exercise Tolerance in Non-Obstructive Hypertrophic Cardiomyopathy

* 04-H-0026:
A Randomized Trial of Recombinant Humanized Anti-IL-2 Receptor Antibody (Daclizumab) Versus Antithymocyte Globulin (ATG) to Treat the Cytopenia of Myelodysplastic Syndrome (MDS)

* 04-H-0012:
Collection of Blood, Bone Marrow, Urine, and/or Tissue Samples from Patients with Solid Tumors, Hematological Malignancies or Non-Malignant Hematologic Disorders or HLA Compatible Family Members

* 03-H-0312:
Dietary Nitrate/Nitrite as Sources of Bioactive Nitric Oxide in Patients with Coronary Artery Disease

* 03-H-0282:
Characterization of Cardiac Function in Patients with Hereditary Hemochromatosis Who Are New York Heart Association Functional Class I

* 03-H-0250:
Technical Development of Interventional Cardiovascular Magnetic Resonance Imaging

* 03-H-0249:
A Randomized Trial of Rabbit ATG/CsA vs Campath-1H in Aplastic Anemia Patients with Refractory Pancytopenia or Suboptimal Hematologic Response After h-ATG/CsA Treatment

* 03-H-0217:
Attenuating Insulin Resistance as a Therapeutic Target in the Management of Heart Failure

* 03-H-0209:
Pilot Study of T-Cell-Depleted Peripheral Blood Stem Cell Transplantation from Partially Matched Related Donors for Patients with High-Risk Leukemia

* 03-H-0193:
A Randomized Trial of a Novel Immunosuppressive Combination of ATG, CsA, and Sirolimus (Rapamune® (Registered Trademark)) vs a Slow Taper Cyclosporine Regimen in Subjects with Severe Aplastic Anemia

* 03-H-0105:
The Determination Of Genetic Basis Of Immunodeficiency

* 03-H-0086:
Stem Cell Mobilization For Improvement in Vascular Function and Myocardial Perfusion in Patients Undergoing Cardiac Rehabilitation

* 03-H-0051:
Collection of Blood, Stool, Bone Marrow and/or Tissue Samples from Subjects with Hepatitis-Associated Aplastic Anemia

* 02-H-0250:
A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1H

* 02-H-0227:
A Pilot Study to Determine if Transfer of Gpi-Linked Proteins Occurs Following Transfusion of Red Cells to Patients with Paroxysmal Nocturnal Hemoglobinuria

* 02-H-0059:
Evidence of Procedural Embolism Complicating Renal Artery Stenting

* 02-H-0050:
Technical Development of Cardiovascular MRI in Patients

* 01-H-0223:
Inhaled Nitric Oxide and Transfusion Therapy for Patients with Sickle Cell Anemia and Secondary Pulmonary Hypertension

* 01-H-0163:
Tissue Collection Protocol for Individuals with Cystic Fibrosis

* 01-H-0162:
Ex Vivo Selective Depletion of Alloreactive Donor T-Lymphocytes Utilizing RFT5-SMPT-dgA, a Specific Anti-Interleukin-2 Receptor Immunotoxin: Reducing GVHD Risk Associated with HLA-Matched Nonmyeloablative Peripheral Blood Stem Cell Transplantation

* 01-H-0097:
Investigation of G-CSF-Induced Stem Cell Mobilization Potential in Patients with Diamond-Blackfan Anemia

* 01-H-0083:
A Pilot Study of G-CSF Induced Stem Cell Mobilization Potential in Patients with Relapsed Severe Aplastic Anemia

* 01-H-0010:
Low Intensity Preparative Regimen Followed by HLA-Matched, Mobilized Peripheral Blood Stem Cell Transplantation for Systemic Mastocytosis

* 00-H-0147:
Treatment with Octreotide in Patients with Lymphangioleiomyomatosis

* 00-H-0051:
Cutaneous Tumorigenesis in Patients with Tuberous Sclerosis

* 00-H-0029:
A Pilot Study of Recombinant Humanized Anti-IL-2 Receptor Antibody (Daclizumab) in Patients with Moderate Aplastic Anemia, Pure Red Cell Aplasia, Diamond Blackfan Anemia, Relapsed Aplastic Anemia, or Refractory Aplastic Anemia

* 99-H-0076:
Fiberoptic Bronchoscopy in Patients with Asthma

* 99-H-0069:
Pulmonary Fibrosis Associated with Rheumatoid Arthritis: Identification of Genetic Polymorphisms

* 99-H-0068:
Specimen Procurement for Individuals with Pulmonary Fibrosis Associated with Rheumatoid Arthritis

* 99-H-0064:
Exploratory Study of Non-Myeloablative Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusions for Metastatic Neoplasms Refractory to Standard Therapy

* 99-H-0056:
Pulmonary Fibrosis with Rheumatoid Arthritis: Definition of the Natural History of Disease

* 99-H-0050:
Non-myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients with Debilitating Hematologic Diseases

* 99-H-0048:
Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy

* 99-H-0037:
Apheresis of Family Members of Patients Undergoing Allogeneic Bone Marrow Transplantation. A Pre-Clinical Study of Selective Depletion of Donor Lymphocytes to Prevent Acute Graft-Versus-Host Disease

* 98-H-0144:
Treatment of Diamond Blackfan Anemia with Antithymocyte Globulin and Cyclosporine A

* 98-H-0062:
Role of Exotoxins in the Pathogenesis of Pseudomonas Aeruginosa

* 97-H-0204:
Cardiovascular Magnetic Resonance Imaging

* 97-H-0196:
A Phase II Study of HLA-Matched Peripheral Blood Stem Cell Transplantation for Metastatic Renal Cell Carcinoma as Adoptive Allogeneic Immunotherapy

* 97-H-0154:
High-Dose Cyclophosphamide with CD34+ Selected Autologous Hematopoietic Cell Support for Treatment of Refractory Chronic Autoimmune Thrombocytopenia

* 97-H-0130:
Collection of Blood and Bone Marrow from Normal Volunteers and Patients for Research Purposes

* 97-H-0061:
Evaluation and Treatment of Pulmonary Patients not Participating in Research (Training Protocol)

* 97-H-0041:
Screening Protocol for Subjects Being Evaluated for Hematology Branch Protocols

* 97-H-0026:
Magnetic Resonance at 1.5 and 3 Tesla

* 97-H-0022:
Segmental Bronchoalveolar Lavage

* 96-H-0100:
Role of Genetic Factors in the Pathogenesis of Lung Disease

* 96-H-0049:
Use of Granulocyte Colony Stimulating Factor (G-CSF) Mobilized Leukapheresis Collections from Normal Volunteers to Develop Improved Methods of Stem Cell and Lymphocyte Selection for Allogeneic Transplantation

* 95-H-0186:
Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)

* 95-H-0167:
Effect of Hypoxia and Smoking on Oxidation of Proteins and Nucleic Acids in Human Volunteers

* 95-H-0047:
Evaluation of Patients with Heart Disease Not Eligible for Research Protocols

* 94-H-0010:
Evaluation, Treatment and Training Protocol for Patients with Bone Marrow Failure States, Isolated or Multilineage Cytopenias, Metastatic Solid Tumors, or Hematologic Malignancies

* 92-H-0189:
Evaluation of Patients with Known or Suspected Heart Disease (Screening Protocol)

* 86-H-0088:
Lymphocytapheresis of Patients with Pancytopenia

* 85-H-0105:
Cardiovascular Evaluation of Patients with Familial Hypercholesterolemia and Normal Individuals

* 82-H-0032:
Comprehensive Evaluation of the Etiology and Pathogenesis of Chronic Lung Disease (Screening Protocol)

* 79-H-0100:
Teaching Protocol for the Evaluation of Plasma Lipoproteins

* 76-H-0051:
Lipoprotein Metabolism in Normal Volunteers and Hyperlipoproteinemic Patients

Active Follow-up, Protocols NOT Recruiting New Patients 

* 04-H-0154:
Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI

* 03-H-0219:
A Genome-Wide Scan for Quantitative Trait Loci of Hematocrit - A Framingham Study

* 03-H-0192:
Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation Followed by T Cell Add-back for Hematological Malignancies - Effect of Irradiated Donor Lymphocytes on Chimerism

* 02-H-0264:
Stem Cell Mobilization as Therapy for Chronic Myocardial Ischemia in Patients with Coronary Artery Disease

* 01-H-0031:
National Heart, Lung, and Blood Institute Data Distribution

* 00-H-0169:
A Phase II Study of Antithymocyte Globulin (ATG) and Cyclosporine to Treat the Cytopenia of Myelodysplastic Syndrome (MDS)

* 00-H-0032:
Treatment of Severe Aplastic Anemia with Combined Immunosuppression: Antithymocyte Globulin (ATG) and Cyclosporine A (CSA), and Mycophenolate Mofetil (MMF)

* 00-H-0025:
MRI Evaluation of Chest Pain Compatible with Myocardial Ischemia

* 99-H-0140:
A Clinical Trial of TNFR:Fc in a Segmental Allergen Challenge Model of Asthma

* 99-H-0046:
Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation Followed by T-Cell Add-Back for Hematological Malignancies - Role of Cyclosporine

* 97-H-0202:
Low Intensity Preparative Regimen Followed by HLA-Matched, Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in Older Adults

* 97-H-0117:
A Randomized Trial of Antithymocyte Globulin and Cyclosporine versus Cyclophosphamide and Cyclosporine in the Treatment of Severe Aplastic Anemia

* 97-H-0099:
HLA-Matched Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation Followed by T Cell Add-Back for Hematological Malignancies

* 94-H-0033:
Retroviral Mediated Gene Transfer of the Fanconi Anemia Complementation Group C Gene to Hematopoietic Progenitors of Group C Patients

* 94-H-0001:
Obstructive Hypertrophic Cardiomyopathy (HCM) in Children: Natural History and Results of Dual Chamber (DDD) Pacemaker Therapy

* 85-H-0087:
Clinical Course of Patients with Transfusional Hemochromatosis on Deferoxamine

* 84-H-0029:
Effect of Hydroxyurea on Fetal Hemoglobin Synthesis in Patients with Sickle Cell Anemia

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