NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

68 Protocols (61 Active Accrual of new subjects, 7 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 04-DK-0193:
Identification and Mechanistic Investigations of Tolerant Kidney Transplant Patients

* 04-DK-0161:
Studies of the Natural History of Sickle Cell Disease and Other Hemolytic Disorders

* 04-DK-0140:
The Effects of Thyroid Hormone on Cytochrome P450 and P-Glycoprotein Activity in Thyroid Cancer Patients

* 04-DK-0099:
Depletional Induction with Rabbit Anti-Thymocyte Globulin, Followed by Two Approaches Toward Monotherapy Immunosuppression in Kidney Transplant Recipients

* 04-DK-0061:
Free Fatty Acid Flux in African Americans

* 04-DK-0057:
Renal Transplantation in Recipients with Nephropathic Cystinosis

* 04-DK-0021:
Urinary Vitamin C Loss in Diabetics

* 03-DK-0257:
Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance

* 03-DK-0256:
Inhibition of Intestinal Glucose Absorption by the Bioflavonoid Quercetin in the Obese and in Obese Type 2 Diabetes

* 03-DK-0245:
Effect of AC2993 (Synthetic Exendin-4) - Administered Alone or in Combination with Rapamycin and FK506 - On Islet Function in Patients with Type I Diabetes

* 03-DK-0233:
Treatment of Nonalcoholic Steatohepatitis with Metformin

* 03-DK-0226:
Pulse Dexamethasone Over 48 Weeks for Podocyte Disease

* 03-DK-0212:
Long-Term Treatment of Nonalcoholic Steatohepatitis With Pioglitazone

* 03-DK-0204:
Induction of Donor Specific Immunologic Hyporesponsiveness with Thymoglobulin, Sirolimus and Donor Bone Marrow Infusion

* 03-DK-0170:
Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Anemia, Thalassemia, and Diamond Blackfan Anemia

* 03-DK-0168:
Peripheral Blood Granulocyte Mobilization and Gene Expression Profiling in Adult Individuals of African Descent, With and Without Benign Ethnic Neutropenia

* 03-DK-0136:
Low Dose Peginterferon and Ribavirin Therapy for Patients with Chronic Hepatitis C Infected with Genotype 2 or 3

* 03-DK-0132:
The Expression of Connective Tissue Growth Factor and Other Mediators in the Pathogenesis of Chronic Allograft Nephropathy

* 03-DK-0098:
Study of Thyrotropin Releasing Hormone in Normal Volunteers and in Patients with Thyroid or Pituitary Abnormalities

* 03-DK-0071:
Sirolimus Therapy in Idiopathic and Lupus Membranous Nephropathy

* 02-DK-0160:
Peripheral Blood Stem Cell Collection from Adult Volunteers

* 02-DK-0107:
Investigation of Neurodegeneration in Glycosphingolipid Storage Disorders

* 02-DK-0065:
Combination of Pegylated Interferon and Ribavirin as Therapy for Patients with Chronic Hepatitis C with and without Renal Disease

* 02-DK-0022:
Long-Term Efficacy of Leptin Replacement in Treatment of Lipodystrophy

* 01-DK-0249:
Ingested Interferon Alpha: Prolongation or Permanence of the "Honeymoon" Phase in Newly Diagnosed Diabetes Mellitus

* 01-DK-0247:
Treatment of Chronic Delta Hepatitis with Pegylated Interferon

* 01-DK-0246:
Combination of Lamivudine and Adefovir Dipivoxil for Treatment of Chronic Hepatitis B

* 01-DK-0122:
Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease Therapy

* 01-DK-0088:
Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients with Sickle Cell Anemia

* 01-DK-0062:
Genetic Analysis of Familial Keloids

* 01-DK-0053:
Permeability Factor in Focal Segmental Glomerulosclerosis

* 00-DK-0221:
Evaluation of the Immune Response in Humans After Exposure to Hepatitis C Virus

* 00-DK-0152:
Use of Laparoscopy for Localization and Resection of Insulinomas of the Pancreas

* 00-DK-0125:
Immunogenetics of Hepatitis C Virus Infection

* 00-DK-0107:
Search for Novel Methods to Detect Acute Renal Failure

* 00-DK-0042:
Pirfenidone in Focal Segmental Glomerulosclerosis Phase II Study

* 99-DK-0120:
Screening Protocol for Patients Needing a Kidney, Kidney-Pancreas, or Islet Cell Transplant

* 99-DK-0119:
Monitoring for Donor-Specific Hyporesponsiveness Following Renal and Pancreatic Allotransplantation

* 99-DK-0107:
Live Donor Renal Donation for Allotransplantation

* 99-DK-0042:
Long-Term Therapy with Ribavirin for Chronic Hepatitis C

* 99-DK-0002:
Heart Disease Risk Factors in African Americans

* 94-DK-0195:
Use of Hypocalcemic Intraarterial Infusion Into the Thyroid/Parathyroid Bed to Localize Occult Parathyroid Adenomas

* 94-DK-0133:
Genetic Markers for Focal Segmental Glomerulosclerosis

* 94-DK-0127:
Pathogenesis of Focal Segmental Glomerulosclerosis

* 93-DK-0127:
Family Studies in Metabolic Diseases and Mineral Metabolism

* 92-DK-0156:
Studies of Immunologically-Mediated Kidney Diseases

* 92-DK-0033:
Pharmacokinetics and Biodistribution of Ascorbic Acid in Healthy Human Subjects

* 91-DK-0085:
Studies of Hyperparathyroidism and Related Disorders

* 91-DK-0066:
Fasting Hypoglycemia: Diagnosis and Treatment

* 90-DK-0137:
Evaluation of the Gastrinoma in Patients with Zollinger-Ellison Syndrome

* 89-DK-0173:
Studies of States with Resistance to Vitamin D and Parathyroid Hormone

* 89-DK-0152:
Determination of Glomerular Filtration Rate, Effective Renal Plasma Flow and Glomerular Capillary Wall Permselectivity

* 89-DK-0015:
Medical Therapy of Zollinger-Ellison Syndrome

* 88-DK-0194:
Evaluation of Treatment with Interferon, Octreotide, or their Combination in Patients with Zollinger-Ellison Syndrome and Progressive Metastatic Non-B Islet Cell Neoplasm

* 87-DK-0029:
Diagnosis and Treatment of Patients with Cystic Fibrosis and Other Disorders of the Respiratory System or Pancreas

* 85-DK-0082:
Acromegaly Treatment and Natural History

* 83-DK-0018:
The Use of Oral Omeprazole and Intravenous Pantoprazole in Patients with Hypersecretion of Gastric Acid

* 77-DK-0096:
Studies on Thyroid Nodules and Thyroid Cancer

* 77-DK-0002:
Evaluation of Patients with Thyroid Function Disorders

* 76-DK-0081:
Studies with 1,25-Dihydroxycholecalciferol

* 76-DK-0006:
Studies of Molecular Genetics of Insulin Secretion, Insulin Action, and Diabetes Mellitus

Active Follow-up, Protocols NOT Recruiting New Patients 

* 02-DK-0235:
Sirolimus for Focal Segmental Glomerulosclerosis

* 01-DK-0036:
Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression

* 00-DK-0196:
Sirolimus Monotherapy to Optimize Activation Induced Cell Death (AICD) in Renal Transplants Following Lymphocyte Depletion Induction with Thymoglobulin

* 00-DK-0186:
The Hep C Antiviral Long-Term Tx Against Cirrhosis (HALT-C) Trial: A Randomized Controlled Trial to Evaluate the Safety & Efficacy of Long-Term Peginterferon Alpha2A for Tx of Chronic Hep C in Patients Who Failed to Respond to Previous Interferon Therap

* 00-DK-0100:
Pulse Dexamethasone in Focal Segmental Glomerulosclerosis

* 00-DK-0013:
Tolerance Induction Following Human Renal Transplantation Using Treatment with a Humanized Monoclonal Antibody Against CD52 (Campath-1H)

* 95-DK-0199:
Lamivudine for Chronic Hepatitis B

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