NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Mental Health (NIMH)

106 Protocols (102 Active Accrual of new subjects, 4 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 04-M-0270:
Investigating the Role of Serotonin in Emotional Processing Through the Use of Tryptophan Depletion

* 04-M-0247:
Treatment Study for Frontotemporal Dementia

* 04-M-0227:
Combining a Dopamine Agonist and Selective Serotonin Reuptake Inhibitor for Treatment of Depression: A Double-Blind, Randomized Study

* 04-M-0222:
Investigation of the Rapid (Next Day) Antidepressant Effects of an NMDA Antagonist

* 04-M-0221:
The Treatment of Menstrually-Related Mood Disorders with Extended Versus Interrupted Oral Contraceptives

* 04-M-0208:
PET Evaluation of Serotonin Transporters Using [C-11] DASB in Alcoholism

* 04-M-0204:
PET Whole Body Biodistribution and Test Retest Brain Imaging Studies Using a Dopamine Transporter Ligand [18F]FECNT

* 04-M-0189:
Evaluation of Substance P Neurotransmission in Panic Disorder by PET Imaging of NK1 Receptors with [18F] SPA-RQ

* 04-M-0183:
Association Between Adenosine Receptor Gene Polymorphisms and Phsyiological Responses to Caffeine in Subjects with Panic Disorder and Healthy Controls

* 04-M-0180:
PET Evaluation of Monoamine Transporters in Obsessive-Compulsive-Related Disorders

* 04-M-0170:
Whole Body Study of [11C]NNC-112 PET Imaging of Dopamine D1 Receptors

* 04-M-0160:
Neural Correlates of Depressive Symptoms and Reward Related Mechanisms Following AMPT Depletion in Remitted Depressed Patients Off Treatment and Healthy Controls

* 04-M-0139:
The Effects of Dutasteride on Mood, HPA Axis, and Serum Allopregnanolone Levels in Women with Menstrual-Related Mood Disorders and Controls

* 04-M-0136:
Neurocardiac Control in Major Depression

* 04-M-0091:
An Investigation of a Pharmacologic Strategy to Bring About Rapid (Next Day) Antidepressant Effects

* 04-M-0075:
FMRI Study of Performance During a Probabilistic Reversal Learning Task in Depression

* 04-M-0002:
The Functional Neuroanatomy of Emotion Regulation in Major Depressive Disorder (MDD)

* 03-M-0297:
Cerebral Structure and Function Before and After Pharmacological and Psychological Treatment for PTSD

* 03-M-0296:
Propranolol For the Treatment of Acute Stress Disorder

* 03-M-0292:
Psychobiological Mechanisms of Resilience to Trauma

* 03-M-0211:
Family Study of Affective and Anxiety Spectrum Disorders

* 03-M-0186:
The Psychobiology of Temperament: An fMRI Study

* 03-M-0185:
Generalized Anxiety Disorder and Social Anxiety Disorder: Their Impact on the Processing of Social Emotional Information and Instrumental Learning

* 03-M-0175:
The Effects of Acute Withdrawal of Estradiol on Mood Symptoms in Women with Perimenopausal Depression

* 03-M-0161:
The Efficacy of 17Beta-Estradiol in Postpartum-Related Depressive Illness

* 03-M-0159:
Kinetic Studies in Whole Body and Brain of [11C]DASB PET Imaging of Serotonin Transporters

* 03-M-0149:
Functional MRI Study of Brain Mechanism Mediating Anhedonia in Major Depression

* 03-M-0143:
Randomized, Double-Blinded, Placebo Controlled Study of the Effects of Modafinil on Cognitive Function in Patients With Schizophrenia and Normal Controls Based on COMT Genotype

* 03-M-0138:
A Screening Protocol to Evaluate Women with Postpartum-Related Mood and Behavioral Disorders

* 03-M-0108:
Cholinergic Modulation of Cognition and Emotion in Mood Disorders: Functional Neuroimaging Studies

* 03-M-0104:
PET Imaging of Dopamine D2 Receptors and Extracellular Dopamine with (18F)Fallypride, D-amphetamine, and Alpha-Methyl-Para-Tyrosine in Healthy Subjects

* 03-M-0102:
Effects of Hydrocortisone Infusion on Processing of Facially Expressed Emotion During Functional Magnetic Resonance Imaging

* 03-M-0093:
Predictability and Aversive Expectancies in Anxiety Disorders

* 03-M-0092:
An Investigation of the Antidepressant Efficacy of an Antiglutamatergic Agent in Bipolar Depression

* 03-M-0035:
Screening and Follow-Up for Childhood Onset Psychotic Disorders

* 03-M-0014:
Neural Circuitry and Risk for Depression in Adolescents: A Study Using Functional Magnetic Resonance Imaging

* 03-M-0001:
Muscarinic Cholinergic Receptor Imaging in Depression

* 02-M-0321:
fMRI Investigation of Explicit Cue and Contextual Fear

* 02-M-0317:
Glucocorticoid and Mineralocorticoid Receptor Function in Post Traumatic Stress Disorder

* 02-M-0305:
The Effect of Short-Term Statin and NSAID Treatment on CSF Beta-amyloid

* 02-M-0281:
The Characterization of Childhood Onset Obsessive Compulsive Disorder and the PANDAS Subgroup

* 02-M-0263:
Effect of Alprazolam on Fear-Potentiated Startle in Humans

* 02-M-0251:
Antiglucocorticoid Therapy in Bipolar Depression with Mifepristone (RU486)

* 02-M-0239:
Randomized, Double-Blinded, Placebo Controlled Study Of The Effects Of Tolcapone On Cognitive Function In Patients With Schizophrenia And Normal Controls Based On COMT Genotype

* 02-M-0231:
An Investigation of the Antidepressant Efficacy of Memantine, an NMDA Antagonist with Neurotrophic Properties in Major Depression

* 02-M-0176:
A Double-Blind Randomized Placebo-Controlled Trial of Felbamate in Treatment Resistant Bipolar Depression

* 02-M-0162:
Tryptophan Depletion and PET Scanning in Remitted Depressed Patients Off Treatment and Healthy Controls

* 02-M-0155:
The Effects of Cortisol and Norepinephrine Modulation on Emotional and Nonemotional Processing

* 02-M-0136:
Combined Treatment With A Benzodiazepine (Clonazepam) And A Selective Serotonin Reuptake Inhibitor (Paroxetine) For Rapid Treatment Of Panic Disorder With Depression

* 02-M-0120:
The Efficacy of Phytoestrogens and Selective Estrogen Receptor Modulators in Perimenopause-Related Depression

* 02-M-0095:
MRI Contrast Imaging in the Evaluation and Follow-up of Patients with Memory Disorder and Healthy Controls

* 02-M-0092:
Reward-Related Processes and Brain Function

* 02-M-0089:
Alpha(2)-Adrenoreceptor (AR) Subtype Polymorphisms and Physiological Responses to Alpha(2)-AR Agonist and Antagonist Drugs

* 02-M-0085:
A Double Blind Study Examining the Efficacy of Clozapine and a Study of the Pathophysiology in Treatment Resistant Mania

* 02-M-0047:
Serotonin1A Receptor and Serotonin Transporter Imaging In Mood Disorders

* 02-M-0037:
A Double-Blind Study Examining the Efficacy of the Protein Kinase C Inhibitor Tamoxifen in the Treatment of Acute Mania

* 02-M-0036:
A Behavioral and Functional Neuroimaging Study of Inhibitory Motor Control

* 02-M-0021:
Severe Mood and Behavioral Dysregulation in Children: Pathophysiology and Treatment with Lithium

* 02-M-0018:
An Investigation of the Antidepressant Efficacy of a Dopamine Agonist with Neurotrophic Properties in Bipolar Disorder

* 02-M-0007:
Adolescent Medial Temporal Lobe Function in Health and Illness

* 02-M-0003:
Fear Conditioning Using Computer-Generated Virtual Reality

* 02-M-0002:
Serotonin 1A Receptor Imaging and Benzodiazepine Receptor Imaging in Panic Disorder and Posttraumatic Stress Disorder

* 01-M-0192:
Fluoxetine's Effects on Attention and Emotional Memory in Anxious and Depressed Youth

* 01-M-0185:
Effects of Arousal and Stress on Classical Conditioning

* 01-M-0175:
Treatment of Winter Depression with Pharmacological Suppression of Melatonin Secretion

* 01-M-0152:
Adolescence, Puberty, and Emotion Regulation: An fMRI Study

* 01-M-0128:
Pilot Study of Immunomodulatory versus Antiinflammatory Therapy in Alzheimer's Disease

* 01-M-0064:
Anatomic MRI Brain Imaging of White Matter in Children

* 00-M-0203:
The P.O.W.E.R. STUDY (Premenopause, Osteopenia/Osteoporosis, Women, Alendronate, Depression)

* 00-M-0198:
The Phenomenology and Neurophysiology of Affective Dysregulation in Children and Adolescents with Bipolar Disorder

* 00-M-0177:
Transcranial Magnetic Stimulation Studies of Visual Attention

* 00-M-0103:
The Treatment of Menstrually-Related Mood Disorders with Continuous Gonadal Steroid Replacement

* 00-M-0085:
Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 3.0 Tesla MRI and Magnetoencephalography

* 00-M-0067:
The Evaluation and Follow-up of Patients with Obsessive-Compulsive Disorder and OC Spectrum Disorders

* 00-M-0049:
Factors in Susceptibility to Ischemic Heart Disease in Major Depression: Documentation of Insulin Resistance in Patients with Major Depression Utilizing the Hyperinsulinemic Euglycemic Glucose Clamp

* 99-M-0172:
Integrating EEG/MEG and fMRI: Activity Correlation Between Frontal and Temporal Lobe Structures in Schizophrenic Patients, Their Siblings and Unrelated Normal Volunteers

* 99-M-0166:
Investigation of Brain Function During Eyeblink Responding in Normal Volunteers and Patients with Schizophrenia (A Study of Behavior and Evoked Potentials)

* 99-M-0073:
M2 Receptor Measurements in Aging and in Alzheimer's Disease

* 97-M-0126:
Childhood Onset Psychotic Disorders: Characterization and Treatment with Atypical Neuroleptics

* 96-M-0124:
Genetics of Obsessive-Compulsive Disorder: A Collaborative Study

* 95-M-0150:
A Neurobiological Investigation of Patients with Schizophrenia Spectrum Disorders and Their Siblings

* 95-M-0097:
An Endocrine Model For Postpartum Mood Disorders

* 95-M-0096:
The Evaluation and Follow-up of Patients with Memory Disorder and Normal Controls

* 94-M-0121:
Bone Mineral Density in Patients with Major Depression with Melancholic and Atypical Features: Relation to Stress-System Neurohormonal Function

* 93-M-0170:
Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

* 93-M-0122:
A Trial of Prophylaxis for the PANDAS Subgroup

* 92-M-0262:
Neuropsychiatric Evaluation of Normal Subjects and Psychiatric and Neurologic Contrast Groups

* 92-M-0174:
The Central Nervous System Effects of Pharmacologically Induced Hypogonadotropic Hypogonadism with and without Estrogen and Progesterone Replacement

* 91-M-0230:
Mechanisms of Individual Variation of Dextroamphetamine Effects in Normal Human Subjects

* 91-M-0124:
Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 1.5 Tesla MRI

* 90-M-0142:
Brain Procurement for the Neuropathology Section, CBDB

* 90-M-0088:
The Treatment of Menstrually-Related Mood Disorders with the Gonadotropin Releasing Hormone (GnRH) Agonist, Depot Leuprolide Acetate (Lupron)

* 90-M-0014:
Studies of Frontal Lobe Function During Cognitive Stimulation as Measured with Oxygen-15 Water Positron Emission Tomography in Normal Subjects and Neuropsychiatric Patients

* 89-M-0160:
Inpatient Evaluation of Neuropsychiatric Patients

* 89-M-0006:
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Controls

* 88-M-0131:
A Screening Protocol to Evaluate Women with Perimenopause-Related Mood and Behavioral Disorders

* 86-M-0096:
Studies of Genetic Heterogeneity in Patients with Lysosomal Storage Disorders

* 85-M-0115:
Biological Markers in Childhood Psychiatric Disorders

* 84-M-0050:
Biochemical, Physiological, and Psychological Measures in Normal Controls and Relatives of Psychiatric Patients

* 83-M-0176:
Neuropsychological Evaluation of Psychiatric and Neurological Patients

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