NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Neurological Disorders and Stroke (NINDS)

180 Protocols (169 Active Accrual of new subjects, 11 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 05-N-0001:
Propranolol for Syncope with Sympathoadrenal Imbalance in Children

* 04-N-0287:
Efficacy of Rituximab in Patients with Stiff Person Syndrome with Anti-GAD Antibodies: A Randomized Placebo-Controlled Trial

* 04-N-0278:
Neural Correlates of Observation of Tactile Stimulation in Healthy Subjects

* 04-N-0258:
Transcutaneous Lisuride Therapy for Parkinson's Disease

* 04-N-0244:
A Phase III Multicenter Study of Intratumoral/Interstitial Therapy with TransMID Compared to Best Standard of Care in Patients with Progressive and/or Recurrent, Non-Resectable Glioblastoma Multiforme

* 04-N-0243:
Glycogen Synthetase Kinase 3 (GSK-3) Inhibition in Alzheimer's Disease

* 04-N-0236:
Investigation of Biomarkers in Parkinson's Disease

* 04-N-0225:
5HT2A/C Serotonin Blockade in Parkinson's Disease

* 04-N-0220:
Measuring the Brain Effects of DC Polarization with O-15 PET

* 04-N-0212:
Enhancement of Rehabilitative Treatment-Dependent Functional Recovery After Stroke by Transcranial Direct Current Stimulation (tDCS)

* 04-N-0210:
Towards the Establishment of Standards of Practice and the Initiation of Multi-Center, Multi-National Clinical Trials for Neonates and Children With Stroke

* 04-N-0209:
Human Herpesvirus-6 and Its Effect on the GABA/glutamate Balance in the Cerebrospinal Fluid and in the Brain from Patients with Epilepsy

* 04-N-0207:
An Open Label Clinical Trial of Replagal Enzyme Replacement Therapy In Children With Fabry Disease Who Have Completed Study TKT023

* 04-N-0203:
Neural Correlates of Observational Motor Learning in Chronic Stroke Patients

* 04-N-0192:
The Role of the Prefrontal Cortex in Economic Decision-Making in Reciprocal Trust Games Using Functional Hyperscanning Neuroimaging

* 04-N-0188:
Neurophysiological Markers in Patients with Craniofacial Dystonia and Their Relatives

* 04-N-0159:
Functional MRI (fMRI) and Diffusion Tensor Imaging (DTI) in Temporal Lobe Epilepsy

* 04-N-0156:
Central Motor Physiology in Polio Survivors

* 04-N-0153:
Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder Using EEG and Surface EMG

* 04-N-0151:
Timing of Voluntary Movement in Patients with Schizophrenia Using EEG and Surface EMG

* 04-N-0147:
Treatment Efficacy of 1-Octanol Compared to Placebo in Adults with Essential Tremor

* 04-N-0146:
fMRI Study on Mechanism of Rhythm Perception and Generation

* 04-N-0133:
Effects of a T Cell-Depleting Monoclonal Antibody, Alemtuzumab, in Patients with Inclusion Body Myositis: A Pilot Clinicopathological Study

* 04-N-0129:
Phase 1B Clinical Trial to Establish the Safety and Tolerability of a Multiple-Dose Regimen of Idebenone Administered to Patients With Friedreich's Ataxia

* 04-N-0122:
Direct Current Brain Polarization in Frontotemporal Dementia

* 04-N-0117:
Modulation of the Visual Information Processing in the Human Parieto-Frontal Network as Studied by a Frequency Tagging Technique During Visuomotor Tracking

* 04-N-0113:
Examining Associative Relations in Structured Event Complexes Using Functional Neuroimaging

* 04-N-0110:
Enhanced Tactile Memory in the Blind

* 04-N-0107:
Motor Skill Learning: Spinal Reflexes

* 04-N-0103:
Changes in Intracortical Inhibitory Processes are Associated With the Development of Implicit Learning of a Motor Task

* 04-N-0101:
Levetiracetam Treatment of L-dopa Induced Dyskinesias

* 04-N-0100:
Role of the Right Hemisphere in Recovery of Language Function in Chronic Stroke

* 04-N-0098:
Brain Reorganization in Cerebral Palsy

* 04-N-0073:
A Phase I-II Pharmacokinetic/Pharmacodynamic Study of Replagal to Assess the Effects of Alternative Dose and Regimen in Patients with Fabry Disease

* 04-N-0066:
A Prospective, Randomized Trial Comparing Surgery Versus Radiosurgery for the Treatment of Metastatic Brain Tumors

* 04-N-0059:
Sensorimotor Gating Studies in Restless Legs Syndrome

* 04-N-0054:
Intraspinal Plasticity Associated with Locomotor Learning

* 04-N-0042:
Improvement of Use Dependent Plasticity in Chronic Stroke Patients

* 04-N-0041:
The Physiology of Tricks

* 04-N-0034:
Classification of Cerebral Palsy Subtypes

* 04-N-0033:
MRI in Autosomal Dominant Partial Epilepsy with Auditory Features

* 04-N-0029:
A Clinical Trial of Replagal Enzyme Replacement Therapy in Children Ages 7 - 17 Years with Fabry Disease

* 04-N-0019:
Zenapax (daclizumab) Administered to Patients with Multiple Sclerosis (ZAP MS): Effect of Intravenously Administered Humanized Monoclonal Antibody Against the Interleukin-2 Receptor Alpha Subunit (Daclizumab) on Inflammatory Activity in the Central Nerv

* 04-N-0017:
Movement Related Cortical Potentials in Primary Lateral Sclerosis

* 04-N-0016:
Non-Invasive Seizure Localization in Patients with Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings

* 04-N-0015:
Activating Effects of Sleep Deprivation On Synchronized MEG-EEG Recordings Of Epilepsy Patients with Non-Diagnostic EEG

* 04-N-0005:
Analysis of Brain Metastasis in Patients with Breast Cancer, with and without Over-Expression of HER-2

* 03-N-0276:
Modafinil In the Treatment of Fatigue in Post-Polio Syndrome

* 03-N-0273:
Bi-hemispheric Plasticity Elicited By Unilateral Finger Motor Training

* 03-N-0272:
Cooling of the Head and Neck to Reduce Seizure Frequency: A Pilot Study

* 03-N-0267:
Improvement of Motor Learning in Chronic Stroke Patients By Transcranial DC Stimulation

* 03-N-0266:
Dopamine Release in Use-Dependent Plasticity in Health and Disease

* 03-N-0260:
Functional Brain Mapping of Laryngeal Sensorimotor Control in Voice Disorders

* 03-N-0236:
A Neuroimaging Study of Automatic Movements in Patients with Parkinson's Disease

* 03-N-0231:
Noninvasive Stimulation of Human Deep Brain Regions With a Magnetic Stimulator

* 03-N-0230:
Event-Related fMRI Analysis of Patients with Ideomotor Apraxia During Transitive and Intransitive Hand Gesturing

* 03-N-0224:
Remote Effects of Stroke on Cerebral Metabolism. Evaluation with Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy

* 03-N-0220:
Safety Study of the Super Rapid Transcranial Magnetic Stimulation in Patients with Parkinson's Disease

* 03-N-0203:
SMN Levels in Peripheral Blood Samples of SMA Patients and the Effects of Pharmacological Compounds In Vitro

* 03-N-0197:
Reasoning About Social and Economic Knowledge: Identifying the Role of the Human Prefrontal Cortex Using Functional Neuroimaging

* 03-N-0196:
Social Knowledge Representation in the Human Prefrontal Cortex

* 03-N-0195:
Functional Neuroimaging of Social Cognitive and Emotional Processing: Technical and Cognitive Issues

* 03-N-0183:
Self-Perception of Postural Stability: Event-Related fMRI Study

* 03-N-0178:
Functional Neuroimaging of Calculus Problem Solving

* 03-N-0171:
Reperfusion of Stroke Safety Study Imaging Evaluation-2 (ROSIE 2) Adjunctive Treatment to Standard Alteplase Therapy of Ischemic Stroke

* 03-N-0165:
Cortical Control of Postural Stability in the Elderly

* 03-N-0164:
Evaluation and Treatment of Neurosurgical Disorders

* 03-N-0163:
Cross-Modal Plasticity of Verbal Memory in the Blind

* 03-N-0160:
EGF Polymorphisms and Gliomagenesis

* 03-N-0147:
Effects of AMPA Receptor Blockade on Human Cortical Excitability - A Pilot Study

* 03-N-0142:
Development of 7 Tesla MRI Methodology for Anatomical Functional and Spectroscopic Imaging of the Brain

* 03-N-0135:
Improved Function in the Paretic Hand of Chronic Stroke Patients by Transient Deafferentation of the Intact Upper Extremity

* 03-N-0134:
Neurophysiological Studies in Patients With Paroxysmal Hyperkinetic Movement Disorders

* 03-N-0126:
Spatiotemporal Dynamics of Cortical Connectivity Involved in Tics and Voluntary Movements in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder: An EEG Study

* 03-N-0120:
Spinal Substrates of Training-Dependent Improvements in Locomotor Function

* 03-N-0119:
The Effects of an NMDA-Receptor Antagonist in Idiopathic Voice Disorders

* 03-N-0116:
Transcranial Electrical Polarization for the Treatment of Bradykinesia and Rigidity in Patients with Parkinson's Disease.

* 03-N-0112:
Role Of Multimodal Areas For Sensory-To-Motor Processing

* 03-N-0106:
Registry of Fabry Disease: A Multicenter, Longitudinal Observational Study

* 03-N-0089:
Survey of Sensory and Motor Tricks in Focal Dystonia

* 03-N-0081:
Role of the Prefrontal Cortex in Successful Memory Encoding

* 03-N-0075:
Effects of Dopaminergic Agonist Treatment on Spinal Cord Excitability in Restless Legs Syndrome

* 03-N-0074:
Encoding a Motor Memory by Action Observation

* 03-N-0072:
The Physiology of Paroxysmal Hyperkinetic Movement Disorders: A SPECT Study

* 03-N-0057:
Safety, Tolerability, and Efficacy of Rituximab in Patients with Anti-Glycoconjugate Antibody-Mediated Demyelinating Neuropathy: A Double-Blind Placebo-Controlled Randomized Trial

* 03-N-0049:
Repetitive Transcranial Magnetic Stimulation in Chronic Stroke Patients. Dose Effect on Motor Cortex Excitability, Motor Performance, and Safety Using Different Stimulation Parameters.

* 03-N-0048:
The Effect of Peripheral Heterotopic Stimulation on Cortical Excitability in Dystonia

* 03-N-0024:
Drug-Refractory Neocortical Epilepsy: rTMS Treatment

* 03-N-0017:
A Phase I Trial of Focal DC Brain Polarization

* 03-N-0007:
Characterization and Identification of Paroxysmal Hypertensive/Hypercatcholamine Syndromes Among Patients with Pseudopheochromocytoma

* 03-N-0006:
SPECT Evaluation of Nicotinic Cholinergic Receptors in Parkinson's Disease

* 03-N-0004:
Clinical Laboratory Evaluation of Primary Chronic Autonomic Failure

* 02-N-0314:
Assessing the Risk of New Ischemic Brain Lesions With On- versus Off-Pump Coronary Artery Bypass Grafting

* 02-N-0301:
ReoPro Retavase Reperfusion of Stroke Safety Study-Imaging Evaluation with Computed Tomography (ROSIE-CT)

* 02-N-0256:
Role of Serum Gonadal and Neuroactive Steroids in the Seizure Susceptibility of Women with Catamenial Epilepsy

* 02-N-0243:
A Phase I/II Randomized, Controlled Study of OGT 918 in Patients with Neuronopathic Gaucher Disease

* 02-N-0236:
Alpha-2 Adrenergic Antagonist Treatment of Parkinson's Disease

* 02-N-0223:
fMRI Languages Studies In Young Children

* 02-N-0216:
Dopaminergic Modulation of Cerebral Connectivity During Sequential Finger Movements: A Combined fMRI-PET Study

* 02-N-0199:
Functional Coupling Of Cortico-Cortical and Cortico-Muscular Connections during Motor Movements: An Electrocorticographic Study of Ipsilateral Motor Control

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