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General Clinical Research Center
UAMS/CAVHS
4301 West Markham Street
Mail Slot VA 111J-1
Little Rock, AR 72205
Grant No. M01 RR14288 |
For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Jennifer Shinn, M.A.
501-257-5890; Fax: 501-257-5817
E-mail:
jsshinn@uams.edu
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Program Director
Steven C. Elbein, M.D.
501-257-5811; Fax: 501-257-5389
E-mail:
elbeinstevenc@uams.edu
Principal Investigator
E. Albert Reece, M.D., Ph.D., M.B.A.
501-686-5681
E-mail:
albert.reece@fcmstp.edu
Associate Program Director
Philip A. Kern, M.D.
501-257-4816; Fax: 501-257-4821
E-mail:
kernphilipa@uams.edu
Research Subject Advocate
Donald M. Mock, M.D., Ph.D.
501-526-4201; Fax: 501-603-1146
E-mail:
mockdonaldm@uams.edu
Nurse Manager
Cynthia Witkowski, R.N., B.S.N.
501-257-5868; Fax: 501-257-5389
E-mail:
witkowskicynthial@uams.edu
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Metabolic Core Director
Donald Bodenner, M.D., Ph.D.
501-526-5705; Fax: 501-526-5710
E-mail:
bodennerdonald@uams.edu
Biostatistician
Paula Roberson, Ph.D.
501-296-1556; Fax: 501-686-8297
E-mail:
robersonpaulak@uams.edu
Biostatistician
Trey Spencer, M.S.
501-296-1556 ; Fax: 501-686-8297
E-mail:
evansrichardb@uams.edu
Computer Systems Manager
Paula Graham, B.S.
501-257-5878; Fax: 501-257-5389
E-mail:
grahampaulai@uams.edu
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Special Assays, Services, or Tests
Anthropometrics: Standardized techniques for measurements
of whole body mass, height, and various skinfold thickness and body
circumference
Bioelectrical impedance: Allows for in vivo prediction of total body water,
extracellular water and intracellular water
Body composition: Whole density, total body water, whole body muscle
mass, intracellular and extracellular body, skinfold and circumference
measurements
Computed tomography: Sensitive measurement of regional adipose and lean
tissue area; high speed CT/i computed tomography system
Deuterium oxide dilution: Total body measurement using Nicolet 360 Avatar
spectrophotometer
Dual energy X-ray absorptiometry (DEXA): Hologic
24-Hour urinary creatinine excretion: Muscle mass calculated assuming
an equivalence of 18.5 kg of muscle per gram of urinary creatinine;
percentage of muscle estimated using the calculated muscle mass and
body mass
Muscle analysis: Mounting, freezing, and analysis of human muscle tissue
obtained by biopsy technique; sodium dodecyl sulfate-polyacrylamide gel
electrophoresis silver staining; histochemistry; immunohistochemistry;
assessment of total protein; Western blot analysis of specific proteins;
activities of a limited number of metabolic enzymes
Sample processing core: Expertise and processing of all
human samples collected for approved GCRC projects
Whole body plethysmography: Whole body mass and volume measurements used to
estimate whole body density; relative proportions of body fat and lean body
mass calculated using population-specific equations that relate body density
to body fat and lean tissue mass using the Bod Pod
Allergy and Immunology: Food allergens.
Dermatology: Intralesional skin test antigens.
Geriatrics: Hormone therapy in debilitated elderly; dietary protein
requirements in the elderly; myocellular basis of sarcopenia and reduced
muscle function; senescent muscle and exercise training.
Infectious Diseases: Tuberculosis in HIV-negative
adults.
Neurology: Parkinson's disease; auditory evoked
potentials on depression; Huntington's disease.
Nutrition and Metabolism: Diabetes and obesity; molecular genetics of
insulin resistance; translational regulation of lipoprotein lipase; genetics
of nephropathy; genetics of non-insulin-dependent diabetes; exercise and
high carbohydrate diet; gene expression in obesity; dioxin and insulin
resistance.
Oncology: Colon polyps and colon cancer; prostate
cancer; breast cancer; multiple myeloma.
Pulmonary Medicine: Sleep apnea.
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