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General Clinical Research Center
Harbor–UCLA Medical Center, Box 16
1000 West Carson Street
Torrance, CA 90509-2910
E-mail:
info@gcrc.rei.edu
Grant No. M01 RR00425
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
David Warren, M.P.W.
310-222-2503; Fax: 310-533-6972
E-mail:
dwarren@gcrc.rei.edu
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Program Director
Christina Wang, M.D.
310-222-2503; Fax: 310-533-6972
E-mail:
wang@gcrc.rei.edu
Principal Investigator
Gail V. Anderson Jr., M.D., M.B.A.
310-222-2901; Fax: 310-782-8599
E-mail:
gaanderson@dhs.co.la.ca.us
Associate Program Director
Eli Ipp, M.D.
310-222-2503; Fax: 310-533-6972
E-mail:
ipp@gcrc.rei.edu
Assistant Program Director
Lynne Smith, M.D.
310-222-1968; Fax: 310-222-3887
E-mail: smith@gcrc.rei.edu
Research Subject Advocate
Roger J. Lewis, M.D., Ph.D.
310-222-6741
E-mail:
roger@emedharbor.edu
Nurse Manager
Linda Lillington, D.N.Sc., R.N.
310-222-2501; Fax: 310-533-6972
E-mail:
llillington@gcrc.rei.edu
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Nurse Manager
Chris Mori, R.N., M.S.N.
310-222-2489; Fax: 310-533-6972
E-mail:
mori@gcrc.rei.edu
Nurse Manager
Merlyn Dubria, R.N.
310-781-3613; Fax: 310-972-2959
E-mail:
dubria@gcrc.rei.edu
Core Laboratory Manager
Stephanie Griffiths, B.S.M.T.
310-222-1890; Fax: 310-533-0627
E-mail:
griffiths@gcrc.rei.edu
Nutrition Research Manager
Rachelle Bross, Ph.D., R.D.
310-222-2505; Fax: 310-533-6972
E-mail:
rbross@gcrc.rei.edu
Biostatistician
Peter Christenson, Ph.D.
310-222-1874; Fax: 310-533-0627
E-mail:
pchristenson@gcrc.rei.edu
Computer Systems Manager
Angel Ferreiro, M.S.
310-781-3601; Fax: 310-972-2959
E-mail:
angel@gcrc.rei.edu
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Special Assays, Services, or Tests
Plasma and urine analysis of amino acids and
3-methyl-histidine
Preparation of lymphocytes for storage and transport to
satellite center for immortalization for human genetic
studies
Radioimmunoassay of gonadotropins, testosterone, and free
testosterone, growth hormone, insulin-like growth factor
(IGF)-I, IGF-II, glucagon, somatostatin, IGF binding
proteins, catecholamines, and cytokines Special Resources,
Instruments, or Services
Biomedical spectrometry core facility with gas
chromatography/mass spectrometer, isotope ratio mass
spectrometer, liquid chromatography/tandem mass
spectrometry
Body composition core offering anthropometry, total-body
water, bioelectrical impedance, and dual-energy X-ray
absorptiometry (DEXA)
Sleep laboratories
Endocrinology and Metabolism: National and international center
leading in the development of hormonal methods for male contraception;
multifaceted studies to delineate the effects of androgens on bone and
muscle mass and strength, sexual function, sleep apnea, mood, and
cognitive behavior in hypogonadal men and in wasting states including
HIV-associated cachexia, chronic lung diseases; investigation of new
androgen delivery systems; nutritional influences on androgen metabolism;
role of androgens in multiple sclerosis; semen quality and exposure to
environmental toxicants; role of oscillation of hormones in glucose
regulation; pathogenesis of hypoglycemia; early beta cell dysfunction
prior to type 2 diabetes; islet cell transplantation for type 1 diabetes;
regulation of gluconeogenesis using stable isotope tracers; studies of
type 2 diabetes of the young; studies of role of immunological functions
of fibroblasts and thyrocytes in Graves' disease and other autoimmune
diseases.
Infectious Diseases: Molecular mechanisms of
Candida adherence to endothelial cells; natural
history and significance of Candida in urine.
Maternal-Fetal Medicine: Treatment of oligohydramnios
with desmopressin acetate (DdAVP); mechanisms of fetal swallowing and
fluid control; use of magnesium in pregnancy.
Nephrology: Pathogenesis and genetics of diabetic
nephropathy; role of exercise training in end-stage renal
disease and during dialysis; protein balance in end-stage renal
disease: inflammatory and nutritional influences in end-stage renal
disease; significance of coronary artery calcifications in renal
disease.
Neurology and Psychiatry: Multidisciplinary team approach to studies
of brain structure and function in patients with sex chromosome
aneuploidy; ethnic differences in the metabolism of
neuropsychological agents; neuroendocrinology of sleep in
patients with depression; genotype-phenotype studies of
psychopharmacology; brain structure and function of infants
born of mothers who use drugs during pregnancy.
Respiratory Medicine and Cardiology: Effects of androgen treatment in
chronic obstructive airway disease; exercise testing in pulmonary
hypertension; long-term studies on the role of coronary calcification
in heart disease; oxidative function in HIV subjects on highly active
antiretroviral treatment (HAART).
Women's Health: Women's Health Initiative Center to
evaluate effects of diet, lifestyle changes, and hormones
on women's health; leading center to study dietary
modulation in the Women's Intervention Study for breast
cancer; weight loss in patients with cancer.
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General Clinical Research Center Satellite
Cedars-Sinai Medical Center, Room 1738
8700 Beverly Boulevard
Los Angeles, CA 90048
Grant No. M01 RR00425
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For information
about this satellite and how to access its resources, please
contact:
Administrative Manager
Debby Peterson, B.S.
310-423-8969; Fax: 310-423-5705
E-mail:
petersond@cshs.org
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Associate Program Director
John S. Adams, M.D.
310-423-8970; Fax: 310-423-0440
E-mail:
john.adams@cshs.org
Assistant Program Director
Leslie Raffel, M.D.
310-423-6451; Fax: 310-423-0237
E-mail:
leslie.raffel@cshs.org
PCRC Director
Deborah Krakow, M.D.
310-423-6451; Fax: 310-423-0236
E-mail:
deborah.krakow@cshs.org
Research Subject Advocate
Brian Kan, M.D.
310-423-8590; Fax: 310-423-0436
E-mail:
brian.kan@cshs.org
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Nurse Manager
Arlene Verne, R.N.
310-423-8968; Fax: 310-423-5705
E-mail:
arlene.verne@cshs.org
Genotyping Core Director
Kent Taylor, Ph.D.
310-423-6695; Fax: 310-423-0237
Email:
kent.taylor@cshs.org
Bionutritionist
Marie Chrabaszewski, R.D.
310-423-6426; Fax: 310-423-5705
E-mail:
marie.chrabaszewski@cshs.org
Biostatistician
Janet Elashoff, Ph.D.
310-423-3867 Fax: 310-423-0305
E-mail: e
janet.elashoff@cshs.org
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Special Assays, Services, or Tests
Genotyping/phenotyping core provides assistance in the
development and successful completion of well-designed genetic
studies; access to adequate amounts of DNA for both candidate
gene and genome scan studies; access to molecular methodology
for the performance of both candidate gene and genome scanning;
access to expert mathematical genetic analysis; and access to
genomic bioinformatic expertise for the performance of a wide
variety of computer-based searches
Human tissue repository to provide for the long-term
storage of human tissues and immortalized B lymphocytes
Lymphocyte immortalization facility created to establish an eternal
source of human subject-specific DNA, especially for large-scale human
genetic studies
Sample acquisition and processing facility for regional, national, and
international collection and triage of disease-associated human tissues
and biological fluids
AIDS: Evaluation of therapeutic approaches to reduce
morbidity and mortality of HIV-infected men, women, and
children.
Cellular Transplantation: Experimental programs to
define the utility of hepatocyte and stem cell (fetal and
adult) transplantation for treatment of terminal human
diseases of the liver and hematopoietic system.
Endocrinology, Paracrinology, and Autocrinology of Human
Neoplasia: Molecular definition of circulating and
locally produced factors that modulate the expression of
malignant and nonmalignant human neoplasms.
Epidemiology: Multidepartmental—pediatrics,
nursing, public health, medicine—effort to create
effective immunization schemes for children and prenatal
care for mothers in the urban environment.
Genetics of Common Diseases: National and
multinational consortia assembled to define genes
responsible for diabetes, atherosclerosis, obesity,
inflammatory bowel disease, hypertension, osteoporosis, and
blindness.
Genetics of Myocardial Development: Multifaceted
approach to the definition of genes important in the
development of the human heart.
Mitochondrial Genetics: Studies of inherited human
diseases caused by mutations in mitochondrial genes.
Skeletal Dysplasia: Worldwide repository for human
tissues and cells useful in defining the genetics of
inherited skeletal dysplasias affecting children and
adults.
Women's Health: Studies to understand long-term
effect of diet, lifestyle modification, and specific
therapeutic intervention on female malignancies, bone
diseases, cardiovascular health, and pregnancy outcomes.
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General Clinical Research Center, Room 311N
Green Hospital of Scripps Clinic
10550 North Torrey Pines Road
La Jolla, CA 92037
URL:
http://gcrc.scripps.edu
Grant No. M01 RR00833
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Elizabeth A. Bieger
858-554-2281; Fax: 858-554-2252
E-mail:
bieger@scripps.edu
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Program Director
Francis V. Chisari, M.D.
858-784-8228; Fax: 858-784-2160
E-mail:
fchisari@scripps.edu
Principal Investigator
Ernest Beutler, M.D.
858-784-8040; Fax: 858-784-2083
E-mail:
beutler@scripps.edu
Associate Program Director
Bruce L. Zuraw, M.D.
858-784-9585; Fax: 858-784-2131
E-mail:
zuraw@scripps.edu
Research Subject Advocate
David A. Gilder, M.D.
858-784-7346; Fax: 858-784-7349
E-mail:
dgilder@scripps.edu
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Nurse Manager
Sherry Mirkis, R.N., M.S.N.
858-554-4742; Fax: 858-554-2252
E-mail:
smirkis@scripps.edu
Core Laboratory Director
Daniel R. Salomon, M.D.
858-784-9381 Fax: 858-784-2121
E-mail:
dsalomon@scripps.edu
Biostatistician
James A. Koziol, Ph.D.
858-784-2704; Fax: 858-784-2664
E-mail:
koziol@scripps.edu
Computer Systems Manager
Clark V. Grininger
858-784-7347; Fax: 858-784-7348
E-mail:
clark@scripps.edu
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Special Assays, Services, or Tests
Affymetrix gene chip analysis
Collection and immediate freezing of surgical specimens for
future DNA and RNA analysis
Collection of normal blood specimens for Institutional
Review Board-approved research protocols
DNA bank of normal donor specimens
Fluorescence-activated cell sorter analysis for lymphocyte
subsets and other peripheral blood populations
Genotyping
Isolation of peripheral blood lymphocytes, T cell, B cell,
or monocyte populations
Platelet function assays
Allergy and Immunology: : Bronchial asthma; aspirin and analgesic
sensitivity in asthma.
Autoimmune Diseases: Angioedema syndromes;
pathogenetic autoantibodies.
Genetic Diseases: Aspirin resistance; complement and histamine in
urticaria and angioedemas.
Hematology and Oncology: Chemotherapy regimens in
acute leukemia and hematopoietic malignancies; studies in
idiopathic thrombocytopenic purpura.
Infectious Diseases: Immunopathogenesis of hepatitis
B and C virus infection; human immunodeficiency virus.
Neurology: Familial amyloid polyneuropathy; dopaminergic effects
in Parkinson's disease and restless legs syndrome.
Neuropharmacology: Electroencephalogram markers of
alcoholism risk; fetal alcohol syndrome; depression.
Sleep Disorders: Narcolepsy; HIV infection; apnea;
alcohol and nicotineintake; menopause.
Vascular Diseases: Systemic lupus erythematosus; rheumatoid
arthritis; venous thrombosis.
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General Clinical Research Center
SHS H-1
Stanford University
300 Pasteur Drive, Mail Code 5251
Stanford, CA 94305-5251
URL:
www.med.stanford.edu/gcrc/
Grant No. M01 RR00070
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Renee Rittler
650-723-7496; Fax: 650-725-6698
E-mail:
rittler@stanford.edu
Administrative Services Manager, Pediatrics
Siv Modler
650-725-6575; Fax: 650-723-2829
E-mail:
bkoenig@stanford.edu |
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Program Director
Branimir I. Sikic, M.D.
650-725-6427; Fax: 650-725-1420
E-mail:
brandy@stanford.edu
Principal Investigator
Philip A. Pizzo, M.D.
650-724-5688; Fax: 650-725-7368
E-mail:
philip.pizzo@stanford.edu
Associate Program Director
Charles Prober, M.D.
650-723-5682; Fax: 650-725-8040
E-mail:
cprober@stanford.edu
Associate Program Director
David K. Stevenson, M.D.
650-723-5711; Fax: 650-725-8351
E-mail:
dstevenson@stanford.edu
Associate Program Director
Julie Parsonnet, M.D.
650-725-4561, 650-724-8074; Fax: 650-725-7368
E-mail:
parsonnt@stanford.edu
Associate Program Director
Terrence Blashke, M.D.
650-725-4632; Fax: 650-725-8020
E-mail:
blaschke@stanford.edu
Research Subject Advocate
Bryan D. Meyers, M.D.
650-723-6248
E-mail:
bryan.meyers@stanford.edu
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Nurse Manager
Debra Mattmann, R.N., M.S.
650-723-6973; Fax: 650-725-6698
E-mail:
dmattmann@stanford.edu
Core Laboratory Manager
Ben Varasteh
650-723-7641; Fax: 650-725-6698
E-mail:
varasteh@stanford.edu
Nutrition Research Manager
Patricia Schaaf, M.S., R.D., C.D.E.
650-725-2558; Fax: 650-725-6698
E-mail:
pschaaf@stanford.edu
Biostatistician
Byron William Brown Jr., Ph.D.
650-725-5352; Fax: 650-725-6951
E-mail:
brown@stat.stanford.edu
Biostatistician
Bradley Efron, Ph.D.
650-725-5877; Fax: 650-725-2206
E-mail:
brad@stat.stanford.edu
Biostatistician
Richard A. Olshen, Ph.D.
650-725-8666; Fax: 650-725-6951
E-mail:
olshen@stat.stanford.edu
Informatics Core Manager
Mike Vining
650-723-6242; Fax: 650-725-6698
E-mail:
mvining@stanford.edu
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Special Assays, Services, or Tests
Chylomicron turnover
Glucose turnover
HbA1c
HDL turnover
Insulin binding
Insulin internalization in adipocytes and monocytes
Lipoprotein profile
RIA method—insulin, aldosterone, atrial natriuretic
peptide, angiotensin II
Triglyceride turnover Special Resources,
Instruments, or Services
Anthropometric measurement
Bioelectrical impedance analysis (BIA)
Facilities for conducting sleep studies
Laminar flow room
Nutrient database; computerized diet planning
AIDS and HIV: Immunization with HIV-1 antigen-pulsed
allogeneic dendritic cells in HIV patients; HIV-specific
CD8+ cytotoxic T-lymphocytes; liposomal amikacin (mikasome)
in HIV-seropositive patients; activity of saquinavir
(SQVsgc) with ritonavir or nelfinavir and combinations of
delavirdine and/or adefovir dipivoxil in HIV-infected
subjects.
Cystic Fibrosis: Maxillary sinus treatments in
patients with antrostomies; adeno-associated virus
(AAV)-mediated gene transfer of cystic fibrosis
transmembrane regulator in maxillary sinus of patients with
antrostomies; DMP-777 in cystic fibrosis.
Dermatology: Epidermolysis bullosa registry.
Endocrinology: Insulin resistance in
non-insulin-dependent diabetes mellitus; lipemia:
carbohydrate and glyceride metabolism; dietary cholesterol
and cholesterol concentration; relationship between insulin
resistance and early events in development of
atherogenesis; postprandial lipemia.
Epilepsy: Reproductive function in women with
epilepsy; bone health in antiepileptic-drug-exposed women
with epilepsy.
Hematology: Gene therapy for hemophilia.
Infectious Diseases: Development of enteropathogenic
E. coli (EPEC) vaccine: virulence determinant of
bundle-forming pilus and site of EPEC infection in the
intestine; Helicobacter pylori transmission.
Neonatology: Thermoregulation, breathing, and sleep
in infants; infant heme catabolism and carbon monoxide;
long-term follow-up of infants and children treated with
extracorporeal membrane oxygenation; prenatal child abuse
and pregnancy outcome; in utero magnesium sulfate exposure
and cerebral palsy; minimal ventilator support and
corticosteroid therapy to increase survival without chronic
lung disease.
Nephrology: Delayed function of renal allograft;
therapeutic intervention in IgA nephropathy; recombinant
human insulin-like growth factor-I to reverse ischemic
damage to transplanted kidney; pathophysiology of
pregnancy-induced injury to glomerular endothelial cells.
Oncology: Mitoxantrone for recurrent non-Hodgkins
lymphoma (NHL); PSC 833, vincristine, mitoxantrone, cyclophosphamide,
etoposide, prednisone (ONCEP-PSC) for NHL; doxorubicin,
paclitaxel, and PSC833; IDEC-C2B8 with/without interferon
alpha for B-cell lymphoma; Women's Healthy Eating and
Living Trial; vitamin D treatment of prostate cancer;
IDEC-C2B8 for low-grade or follicular B-cell lymphoma;
vaccination with autologous dendritic cells pulsed with idiotype
protein for B-cell lymphoma; paclitaxel and PSC 833 in metastatic
colorectal carcinoma; idiotype vaccination after bone marrow
transplantation for B-cell malignancies; dendritic cell-based
vaccination for multiple myeloma; lutetium-texaphyrin (PCI-0123)
photodynamic treatment of recurrent or metastatic breast cancer;
dendritic cell therapy for non-small-cell lung cancer.
Pediatric Endocrinology: Type 1 diabetes prevention;
insulin and recombinant human IGF-I combined in
insulin-dependent diabetes mellitus; growth hormone
replacement therapy.
Pediatric Immunology: Human CD4+ lymphocytes; asthma
intervention using SuperNintendo.
Pediatric Infectious Diseases: Cell-mediated immune
response to varicella zoster virus; Oka/Merck varicella
vaccine.
Pediatric Nephrology: Glomerular permaselectivity
and hemodynamics in steroid-resistant idiopathic nephrotic
syndrome.
Pediatric Oncology: Tiazofurin and 6-thioguanine in
acute leukemia; mitoxantrone, etoposide and PSC-833
(PSC-ME) in acute leukemia; doxil for solid tumors;
thymidylate synthase inhibitor ZD1694 for acute leukemia;
irinotecan for solid tumors; interleukin-4 for acute
leukemia; topotecan for refractory leukemia.
Psychiatry: Hypothalamic-pituitary-adrenal
axis/dopamine interactions in psychotic depression; rapid
reversal of psychotic major depression using RU 486;
hypothalamic-pituitary-adrenocortical activity and
cognitive function in HIV-positive individuals.
Radiation Oncology: 131I anti-B1 (murine)
in low-grade NHL; 90Yttrium-DOTA-biotin
pretargeted by murine NR-LU-10/streptavidin in
hormone-independent prostate cancer, advanced colon cancer,
and small-cell lung cancer.
Transplantation: Fetal pancreas transplantation.
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General Clinical Research Center
UCLA Medical Center, CHS 27-066
10833 LeConte Avenue
Los Angeles, CA 90095
Grant No. M01 RR00865
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Helen Williams-Bayne, M.B.A.
310-825-7117; Fax: 310-206-9440
E-mail:
hwbayne@mednet.ucla.edu
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Program Director
Isidro B. Salusky, M.D.
310-206-6987; Fax: 310-206-9440
E-mail:
isalusky@mednet.ucla.edu
Principal Investigator
Gerald S. Levey, M.D.
310-825-5687; Fax: 310-825-4955
E-mail:
glevey@deans.medsch.ucla.edu
Associate Program Director
Julio Licinio, M.D.
310-206-6207; Fax: 310-206-6715
E-mail:
licinio@ucla.edu
Associate Program Director
Ronald T. Mitsuyasu, M.D.
310-206-8359; Fax: 310-206-3311
E-mail:
rmitsuya@medl.medsch.ucla.edu
Associate Program Director
Mohammed Saad, M.D.
310-794-6200; Fax: 310-794-6206
E-mail:
msaad@medl.medsch.ucla.edu
Core Laboratory Director
Ma-Li Wong, M.D.
310-206-6123; Fax: 310-206-6715
E-mail:
mali@ucla.edu
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Research Subject Advocate
Laurie Shaker-Irwin, Ph.D.
310-794-7504
E-mail:
lshakerirwin@ucla.edu
Nurse Manager
Carolyn Borne, R.N.
310-825-5225; Fax: 310-206-9440
E-mail:
nsmcb@mednet.ucla.edu
Nutrition Research Manager
Patricia De Miranda, M.S., R.D.
310-825-5768; Fax: 310-206-9440
E-mail:
pmiranda@mednet.ucla.edu
Biostatistician
Robert M. Elashoff, Ph.D.
310-825-5250 ; Fax: 310-267-2113
E-mail:
elashoff@biomath.medsch.ucla.edu
Computer Systems Manager
Martin Lai, M.S.
310-794-9396; Fax: 310-206-9440
E-mail:
mylai@mednet.ucla.edu
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Special Assays, Services, or Tests
ACTH-IRMA (immunoradiometric assay)
Assays in development: Prolactin, TSH, sex-hormone-binding
globulin (SHBG), urocortin, ghrelin, adiponectin, bone-specific
alkaline phosphatase
Bone laboratory: Bone histomorphometry; database on
bone histology in normal children after double tetracycline
labeling; calcitriol; osteocalcin; parathyroid hormone
Brain imaging core: MRI, PET, transcranial magnetic stimulation
studies, optical intrinsic signal imaging studies, cryosections
Cortisol
Creatinine
DHEA
DHEAS
Estradiol
Estrone
Free testosterone, total testosterone
FSH
Leptin
LH
Neuropeptide Y
17OH Progesterone
Progesterone
Using Nichols advantage (volume 500 l): ACTH, cortisol, parathyroid
hormone (RIA)
Using RIA kit: Quality control: Intrassay variability is much lower
than 15% in most assays; interassay variability is lower than 15%
Adult Endocrinology
AIDS and HIV
Cardiovascular Diseases
Clinical Nutrition:
Hematology and Oncology
Immunology and Rheumatology
Neurology
Obstetrics and Gynecology
Pediatric Endocrinology and Metabolism
Pediatric Nephrology
Pulmonary Physiology
Psychiatry
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General Clinical Research Center, Room 8203
University of California Medical Center
200 West Arbor Drive
San Diego, CA 92103-8203
URL:
http://gcrc.ucsd.edu/
Grant No. M01 RR00827
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Coordinator
Cheryl B. Ward
619-543-6180; Fax: 619-543-5536
E-mail: cward@ucsd.edu
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Program Director
Michael Ziegler, M.D.
619-543-6180; Fax: 619-543-5536
E-mail:
mziegler@ucsd.edu
Principal Investigator
Edward W. Holmes, M.D.
858-534-1501; Fax: 858-534-6573
E-mail:
ewholmes@ucsd.edu
Associate Program Director
Jerrold M. Olefsky, M.D.
619-534-6651; Fax: 619-534-6653
E-mail:
jolefsky@ucsd.edu
Assistant Program Director
Ravindra L. Mehta, M.D.
619-543-7310; Fax: 619-543-7420
E-mail:
rmehta@ucsd.edu
Core Laboratory Director
Paul J. Mills, Ph.D.
619-543-6796; Fax: 619-543-7716
E-mail:
pmills@ucsd.edu
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Research Subject Advocate
Bruce A. Barshop, M.D., Ph.D.
619-543-5279
E-mail:
bbarshop@ucsd.edu
Nurse Manager
Cecilia Echon, R.N., M.S.N.
619-543-6013; Fax: 619-543-5536
E-mail:
cechon@ucsd.edu
Nutrition Research Manager
Eva Brzezinski, M.S., R.D.
619-543-6795; Fax: 619-543-5536
E-mail:
ebrzezinski@ucsd.edu
Biostatistician
Reena Deutsch, Ph.D.
619-543-6898; Fax: 619-543-5536
E-mail:
rdeutsch@ucsd.edu
Computer Systems Manager
Paul Shragg, M.A.
619-543-3687; Fax: 619-543-5536
E-mail:
pshragg@ucsd.edu
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Special Assays, Services, or Tests
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Aldosterone
Alpha/beta-adrenergic receptors
Cortisol
Creatinine
Cyclic AMP
DHEA
DHEAS
Dihydrotestosterone
Endothelin
Estradiol
Estrone
Epinephrine and norepinephrine
Flow cytometry
Free fatty acids
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FSH
Glucose
Glucose-specific activity
IL-6
Insulin
Leptin
Nitric oxide
Plasma renin
Progesterone
Prolactin
Sex-hormone-binding globulin
Testosterone
Tumor necrosis factor alpha
Urinary albumin, protein, uric acid
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Cardiovascular Diseases: Hypertension; norepinephrine pharmacokinetics;
orthostatic hypotension; endocrine effects on the cardiovascular system;
role of stress in hypertension; sleep apnea and congestive heart
failure.
Endocrinology: Regulation of hypothalamic pituitary function;
regulation of hypothalamic function; etiology and prevention of diabetes.
Epidemiology: Osteoporosis, dietary intervention in
cancer.
Gastroenterology: Immunology of the gastrointestinal tract.
Genetic Diseases: : Cystinosis; disorders of amino acid metabolism,
purine metabolism, ammonia metabolism, and organic acid metabolism;
Lesch-Nyhan syndrome; lactic acidemia; hyperuricemia; mitochondrial
disorders.
Infectious Diseases: Development of antiviral agents.
Metabolism: In vivo insulin action;
insulin-resistant states; pathogenesis of type 2 diabetes;
dietary therapy in diabetes; diabetic complications;
pathophysiology and therapy of hyperlipidemic states.
Neurology: Alzheimer's disease; Parkinson's disease;
Leigh's disease.
Oncology: Use of monoclonal antibodies; gene therapy for chronic
lymphocytic leukemia and prostate cancer.
Psychiatry: Role of phototherapy in the management
of depression; depression and immunity; pain management;
neurochemistry.
Pulmonary Medicine: Ventilation and perfusion
distribution using inert gases; asthma.
Renal Disease: Aminothiols to treat cystinosis;
renal transplantation and benign prostatic hyperplasia.
Reproductive Endocrinology: Polycystic ovary
syndrome; biological rhythms of hormones and
dehydroepiandrosterone.
Rheumatology: Rheumatoid arthritis.
Sleep Disorders: Sleep apnea; depression and sleep;
dementia and sleep.
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General Clinical Research Center Satellite
Building 25, 2nd Floor
University of California, Irvine Medical Center
101 The City Drive
Orange, CA 92868
URL:
www.ucihs.uci.edu/gcrc
Grant No. M01 RR00827
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For information
about this satellite and how to access its resources, please
contact:
Administrative Manager
Keri Zabokrtsky
714-456-2313; Fax: 714-456-2321
E-mail: kzabo@uci.edu
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Associate Program Director
Dan M. Cooper, M.D.
714-456-2317; Fax: 714-456-2321
E-mail:
mailto:dcooper@uci.edu
Associate Program Director
Ruth A. Mulnard, R.N., D.N.Sc.
949-824-7016; Fax: 949-824-2071
E-mail:
mailto:ramulnar@uci.edu
Research Subject Advocate
Julie M. Boyle, R.N.
714-456-8029; Fax: 714-456-2240
E-mail:
mailto:jmboyle@uci.edu
Nurse Manager
Lupe Ettinger, R.N.
714-456-2308; Fax: 714-456-2321
E-mail:
lettinge@uci.edu
Applied Physiology Human Performance Lab Director
Vincent J. Caiozzo, Ph.D.
949-824-5571; Fax: 949-824-3278
E-mail:
vjcaiozz@uci.edu
Applied Physiology Human Performance Lab Manager
Christie R. Gottron, M.S.
714-456-2312; Fax: 714-456-2321
E-mail:
crosegot@uci.edu
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Neuroimaging Core Director
Steven C. Cramer, M.D.
714-456-6876; Fax: 714-456-8805
E-mail:
scramer@uci.edu
F-BIRN Principal Investigator
Steven G. Potkin, M.D.
949-824-8040; Fax: 949-824-7873
E-mail:
sgpotkin@uci.edu
Metabolic-Bionutrition Research Unit Director
Pietro R. Galassetti, M.D., Ph.D.
714-456-5357; Fax: 714-456-2934
E-mail:
pgalasse@uci.edu
Metabolic-Bionutrition Research Unit Manager
Andria M. Pescatello, M.S., R.D.
714-456-2309; Fax: 714-456-2321
E-mail:
apesca@uci.edu
Informatics Systems Manager
Fu Joseph Wu, M.S.
714-456-3621; Fax: 714-456-2934
E-mail:
wuf@uci.edu
Biostatistician
Robert L. Newcomb, Ph.D.
949-824-5366; Fax: 949-824-1683
E-mail:
rnewcomb@uci.edu
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Special Assays, Services, or Tests
Applied physiology/human performance testing
Exhaled breath marker testing
Metabolic testing
Neuroimage analysis
Alzheimer's Disease: Clinical trials (simvastatin, vitamin E
and denepezil HCl, estrogens), validation of an informed consent method;
amyloid precursor protein processing in platelets; assessment
measures.
Asthma: Treatment with ginkgo biloba; mechanism of
exercise-induced asthma; influences of particulate air
pollution and NO2.
Attention Deficit-Hyperactivity Disorder: Pharmacokinetic and
pharmacodynamic evaluation of methylphenidate; MRI assessment
of effects of medication on ADHD children.
Autism: Neurobiology and genetics; exercise and stress response
in children with autism.
Basic Science: Molecular mechanisms of ion channels in cell
membranes; calcium ions and lymphocyte activation; migration of
neutrophils in chemokine gradients; monocyte-derived dendritic
cell biology; cellular and molecular interactions in aging humans;
endothelial cell co-stimulation of T cell activation.
Biomedical Engineering: Robotics (adaptive control of reaching
movement in children; development of a training device for teaching the
spinal cord to walk); exhaled nitric oxide in inflammatory lung
disease; human leukocyte gene profiling in response to exercise.
Cancer Measurements of breast tissue optical properties; monitoring
the response of chemotherapy in breast cancer tumors by photon migration
spectroscopy; enhanced single-visit cervical cancer screening program;
clinical treatment and prevention trials (colon, colorectal,
leukoplakia, prostate).
Cochlear Implants: Perception in acoustic and electric hearing.
Exercise Physiology: Health consequences of schizophrenia; mechanisms
of exercise modulation; countermeasures to microgravity; exercise,
cytokines, and growth factors (cystic fibrosis, overweight children);
delayed-onset muscle soreness; anabolic/catabolic mediators in children
born prematurely; exercise and Parkinson's disease.
HIV/AIDS: Training intervention to enhance adherence to highly
active antiretroviral therapy; California NeuroAIDS Tissue Network;
selection of R5 HIV-1 (basic science).
Mitochondrial Genetics: Human genetic variation; mitochondrial
inborn errors of metabolism and ANT defects in mitochondrial
diseases.
Neonatology: Noninvasive measurements of anemia and physiological
response in very-low-birthweight infants using NIRS; ultrasound
evaluation of bone strength in infants; correlation of
growth/inflammatory mediators with measures of body
composition (anthropometrics, bone, muscle, and fat mass).
Pediatrics: Osteoporosis prevention in sedentary adolescent
females; fitness and cardiovascular disease risk factors in healthy
children; tuberculosis immunity in children; hypoglycemia and exercise
in children and adolescents with type 1 diabetes.
Stress Response: Psychological states and cancer; influence of
prenatal maternal stress and maternal neuroendocrine responses on fetal
behavior and infant development.
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General Clinical Research Center–Ward 5B
San Francisco General Hospital, UCSF Box 1353
San Francisco, CA 94143-1353
URL: http://medicine.ucsf.edu/gcrc/sfgh/html/
Grant No. M01 RR00083
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Debra Greenblat
415-206-3324; Fax: 415-826-3381
E-mail:
debgcrc@sfghgcrc.ucsf.edu
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Program Director
Morris Schambelan, M.D.
415-206-3351; Fax: 415-826-3381
E-mail:
morrie@sfghgcrc.ucsf.edu
Principal Investigator
David A. Kessler, M.D.
415-476-2342; Fax: 415-476-0689
E-mail:
kesslerd@medsch.ucsf.edu
Associate Program Director
Andrew B. Bindman, M.D.
415-206-6095; Fax: 415-206-5586
E-mail:
bindman@itsa.ucsf.edu
Associate Program Director
David J. Erle, M.D.
415-514-4370; Fax: 415-514-4278
E-mail:
erle@itsa.ucsf.edu
Associate Program Director
Mark Jacobson, M.D.
415-476-4082 x407; Fax: 415-206-5586
E-mail:
mjacobson@php.ucsf.edu
Associate Program Director
Joseph M. McCune III, M.D., Ph.D.
415-695-3828; Fax: 415-826-8449
E-mail:
mmccune@gladstone.ucsf.edu
Research Subject Advocate
Michael H. Humphreys, M.D.
415-476-4101
E-mail:
mhhsfgh@itsa.ucsf.edu
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Research Subject Advocate
Shirley Tsunoda, Pharm.D.
415-206-4780; Fax: 415-206-4377
E-mail:
stsunoda@sfghgcrc.ucsf.edu
Nurse Manager
Mary Lake, R.N.
415-206-3317; Fax: 415-206-8614
E-mail:
mlake@sfghgcrc.ucsf.edu
Core Laboratory Director
Barry Bredt, M.A.
415-206-5210; Fax: 415-206-8200
E-mail:
barryb@itsa.ucsf.edu
Bionutrition Research Manager
Doris Dare, M.S., R.D.
415-206-3322; Fax: 415-826-3381
E-mail:
ddare@sfghgcrc.ucsf.edu
Biostatistician
Peter Bacchetti, Ph.D.
415-476-9844; Fax: 415-476-6014
E-mail:
peter@biostat.ucsf.edu
Epidemiologist
Dennis Osmond, Ph.D.
415-597-4966; Fax: 415-597-9125
E-mail:
dosmond@psg.ucsf.edu
Computer Systems Manager
Su Yang
415-206-4885; Fax: 415-206-5148
E-mail:
syang@sfghgcrc.ucsf.edu
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Special Assays, Services, or Tests
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ACTH–chemiluminescence
Affymetrix GeneChip analysis
Aldosterone–HPLC, RIA
Androstenedione–EIA
Corticosterone–HPLC
Cortisol, serum-RIA; urinary free-HPLC, RIA; salivary -
EIA
C-peptide-RIA
C-reactive protein-EIA
Cytokines-EIA
Deoxycorticosterone-HPLC
11-Deoxycortisol-HPLC
DHEA-EIA; DHEA sulfate-RIA
Estradiol-RIA
FSH-IRMA
Genomic DNA extraction and banking
Genotyping (RFLP and PCR-based)
Glucose-YSI
Glucagon-RIA
HGH-chemiluminescence
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18-hydroxydeoxycorticosterone-HPLC
17-hydroxyprogesterone-HPLC
IGF-1 - IRMA;IGF-BP3 - RIA
Immunophenotyping-flow cytometry
Insulin-RIA
Intracellular cytokines-flow cytometry
Lactate-YSI
Leptin-RIA
LP(a)-EIA
Luteinizing hormone-RIA
Lymphoproliferation-flow cytometry
Neopterin-EIA
Natural killer cell function-flow cytometry
Proinsulin-EIA
Prolactin-chemiluminescence
Progesterone-EIA
Renin activity and concentration-RIA
SHBG-RIA
Testosterone-RIA
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Special Resources, Instruments, or Services
Affymetrix GeneChip system
Bioelectrical impedance analysis
Dual-energy X-ray absorptiometry
Flow cytometry
High-performance liquid chromatography
Indirect calorimetry
Treadmill, exercise physiology
Endocrinology and Metabolism: Effects of antiretroviral therapy and HIV on metabolic parameters; treatment of metabolic complications of HIV disease; hyperlipidemia in non-insulin-dependent diabetes mellitus; hypertensive, electrolyte, and acid-base disorders; endocrine aspects of HIV infection; zinc intake and absorption; kinetics of spermatogenesis; MR spectroscopy to evaluate hepatic lipid metabolism; HCV infection and insulin resistance; genetics of obesity.
General Internal Medicine: Improving health literacy among
diabetics.
Immunology and Infectious Diseases: Virologic and immunologic consequences of antiretroviral treatment and drug resistance; treatment strategies for persistent immune activation in HIV disease; HIV superinfection; cardiovascular complications of HIV disease; evaluation of thymic mass in HIV disease; use of growth hormone to enhance thymopoeisis; lymphocyte depletion following HIV infection; synthesis and removal (turnover) of T cells in HIV infection; treatment intensification for drug-resistant HIV; cerebrospinal fluid pleocytosis in HIV; IL-12 adjuvant activity in cytomegalovirus vaccination; efficacy of antiretroviral therapy in women; scheduled treatment interruption to improve HIV immune responses; epidemiology and treatment of drug-resistant gram-positive bacterial infection.
Nephrology: Metabolic derangements and their
treatment in hemodialysis patients.
Neurology: Response to antiretroviral therapy for HIV in the cerebrospinal fluid compartment; effect of marijuana on neuropathic and cancer pain; genetic risk factors for hemorrhagic stroke; hypothermia treatment for traumatic brain injury.
Oncology: Measurement of breast epithelial turnover; natural history and treatment of post-mastectomy arm pain.
Pharmacology: Drug interactions and pharmacokinetics in treatment of HIV and mycobacterial infection; protease inhibitor pharmacokinetics and drug interactions in treatment of HIV; nicotine metabolism; mechanisms and safety of diet control and performance-enhancing substances; effect of genetic factors and dipyridamole on ribavirin pharmacokinetics and toxicity; pharmacogenetics of multidrug resistance transporters; pharmacogenetics of cholesterol metabolism; marijuana pharmacokinetics and pharmacodynamics; pharmacogenetics of anti-hypertensive drugs, gaba-hydroxybutyrate pharmacokinetics.
Pulmonary Medicine: Effects of ozone, nitrogen dioxide, and atmospheric particulates on asthma and airway responsiveness; genetics and pathogenesis of asthma in ethnically diverse populations.
Rheumatology: New treatments for osteoporosis.
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General Clinical Research Center, Room 1202
UCSF Moffitt Hospital
505 Parnassus Avenues
San Francisco, CA 94143–0126
Grant No. M01 RR00079
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Cathleen Tierney
415-476-9232; Fax: 415-476-0986
E-mail:
tierneyc@gcrc.ucsf.edu
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Program Director
Joel Palefsky, M.D.
415-476-1574; Fax: 415-476-0986
E-mail:
joelp@medicine.ucsf.edu
Principal Investigator
David A. Kessler, M.D.
415-476-2342; Fax: 415-476-0689
E-mail:
kesslerd@medsch.ucsf.edu
Associate Program Director
Lynda Frassetto, M.D.
415-476-6143; Fax: 415-476-0986
E-mail:
frassett@gcrc.ucsf.edu
Associate Program Director
Lindsey Criswell, M.D., M.P.H.
415-476-9026; Fax: 415-476-9370
E-mail:
lac@itsa.ucsf.edu
Associate Program Director
Deborah E. Sellmeyer, M.D.
415-597-4982; Fax: 415-597-9213
E-mail:
dsellmeyer@psg.ucsf.edu
Associate Program Director
Ronald H. Jensen, Ph.D.
415-476-3383; Fax: 415-476-8218
E-mail:
rjensen@cc.ucsf.edu
Research Subject Advocate
Julie Hambleton, M.D.
415-476-9608
E-mail:
jsh@medicine.ucsf.edu
Research Subject Advocate
Gary McCart, Pharm.D.
415-476-1733
E-mail:
gmccart@itsa.ucsf.edu
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Nurse Manager
Deanna Sheeley, R.N.
415-353-1330; Fax: 415-476-0986
E-mail:
dsheeley@gcrc.ucsf.edu
Nutrition Research Manager
Karen Todd, M.S., R.D.
415-476-9234; Fax: 415-476-0986
E-mail:
ktodd@gcrc.ucsf.edu
Biostatistician
Chuck McCulloch, Ph.D.
415-476-8336; Fax: 415-476-6014
E-mail:
chuck@biostat.ucsf.edu
Biostatistician
Mark R. Segal, Ph.D.
415-476-4553; Fax: 415-476-6014
E-mail:
mark@biostat.ucsf.edu
Biostatistician
Sue-Chun Cheng, Ph.D.
415-514-2975; Fax: 415-476-6014
E-mail:
scheng@biostat.ucsf.edu
Informatics Core Manager
Mark Ayres
415-502-7563; Fax: 415-476-0986
E-mail:
ayresm@gcrc.ucsf.edu
Core Lab Manager
Elise Olmsted, M.A.
415-476-2509; Fax: 415-476-0986
E-mail:
olmstede@gcrc.ucsf.edu
Exercise Physiology/Body Composition Lab Manager
Patricia Painter, Ph.D.
415-476-6108; Fax: 415-476-8899
E-mail:
painter@itsa.ucsf.edu
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Special Assays, Services, or Tests
Body composition and bone density testing
Complex, specialized specimen processing
ELISA assays
Exercise testing with respiratory gas analysis
Lactic acid analysis
Limb blood flow
Muscle function testing
Specimen shipping, ambient and frozen
TaqMan analysis
Special Resources, Instruments, or
Services
Aerosolized portable treatment station
Circadian studies
Dual energy X-ray absorptiometer (DEXA)
Food processor plus nutrient analysis software
Isokinetic muscle function testing system
Metabolic cart
Minnesota Nutrition Data System
Monitored negative pressure room
Osmometer
Overnight sleep study monitoring
Portable respiratory gas analysis system
Programmable plate reader
Stress ECG system
Temperature-controlled centrifuges (4°–37° room temp)
–80° Temporary specimen storage
Acid-Base Physiology and Pathophysiology: Effect of
diet on systemic acid-base equilibrium; acid-base effects
on the skeleton, on nitrogen.
Aging: Renal function; acid-base metabolism; treatment and prevention
of osteoporosis; hypertension, drug metabolism.
AIDS: Natural history of AIDS in women; anal neoplasms in HIV disease;
cell-mediated immune response to human papillomavirus in HIV+
and HIV- men.
Autoimmune Diseases: Testing for candidate loci in
systemic lupus erythematosus; genetic and nongenetic risk factors
for rheumatoid arthritis.
Cancer: Treatment of malignant brain tumors, anal
neoplasia in HIV disease and transplantation; pancreatic, hepatic,
bladder, prostate and ovarian carcinoma; recurrent lymphomas;
neuroendocrine tumors; cytokines in cancer; diet, lipids, and breast
cancer; treatment of premalignant and malignant skin diseases.
Cardiovascular Diseases: Lipoprotein chemistry and metabolism;
treatment of genetic disorders of hyperlipidemia; antimicrobials in
prevention of vascular disease; cardiac function in cerebrovascular
disease; new methods for diagnosis of ischemic heart disease.
Clinical Pharmacology: Pharmacokinetics of antiretrovirals and
antibiotics, transplant immunosuppressives, antihypertensives, psychotropic
drugs, and cancer chemotherapeutic drugs; genetic polymorphisms of membrane
transporter-metabolizing enzyme interactions.
Endocrinology: Glucose control in obesity, complete androgen
insensitivity; uses of selective estrogen-receptor antagonists,
role of female reproductive hormones in temporomandibular joint
disease; adrenal function in post-traumatic stress disorder;
reproducibility of vitamin D assay results.
Exercise Physiology: Effects of exercise in treatment of dyspnea,
cancer, renal insufficiency and dialysis, and liver transplant patients;
exercise in insulin sensitivity; yoga for treatment of back pain.
Gastroenterology: Treatment of primary biliary cirrhosis; acute
liver failure; neural mediators of non-ulcer dyspepsia and irritable
bowel syndrome.
Genetic Diseases: Obesity; genetic factors in neurologic diseases
including ALS, Parkinson's disease, Alzheimer's and rapidly
progressive dementias.
Infectious Diseases: AIDS treatment and prevention trials; treatment
of hepatitis B and C virus infections; pain control in herpes zoster.
Metabolism: Glucose, lipids and leptin levels in obesity, smoking
and tissue oxygen tension.
Nephrology: Renal hemodynamics in essential hypertension, cohort study
of chronic renal insufficiency, prevention of progression of chronic renal
failure.
Neurology: Sleep disturbances in Parkinson's disease and post-traumatic
stress disorders; prion diseases in rapidly progressive dementias and
aging; nicotinic receptor modulation of pain perceptions; radiosurgery for
temporal epileptic disorders.
Nutrition: Folic acid in progression of cardiovascular disease in
transplant patients; potassium, salt sensitivity, and hypertension in
African American and elderly persons; protein, potassium, and calcium effects
on bone health and bone density; vegan diets for obesity.
Psychiatry: Study and treatment of drug abuse; structural and functional
basis of post-traumatic stress disorder; effects of neurosteroids on
alcohol intoxication.
Pulmonary Disorders: Pathophysiology and treatment of airway disease in
asthma, chronic obstructive pulmonary disease and interstitial lung disease;
antibiotic levels in lung tissue.
Transplantation: Solid organ transplantation in HIV+ subjects,
islet cell transplantation in type 1 diabetes mellitus.
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Pediatric General Clinical Research Center
University of California, San Francisco
Department of Pediatrics
San Francisco, CA 94143
Grant No. M01 RR001271
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Danielle Thouvenin
415-476-2654; Fax: 415-476-3466
E-mail:
thouvend@peds.ucsf.edu
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Program Director
Diane W. Wara, M.D.
415-476-2865; Fax: 415-476-3466
E-mail:
wara@peds.ucsf.edu
Principal Investigator
Haile T. Debas, M.D.
415-476-2342; Fax: 415-476-0689
E-mail:
hdebas@medsch.ucsf.edu
Associate Program Director
Bertram Lubin, M.D.
510-450-7601; Fax: 510-450-7910
E-mail:
blubin@mail.cho.org
Associate Program Director
Ronald I. Clyman, M.D.
415-476-4462; Fax: 415-476-0676
E-mail:
ric@itsa.ucsf.edu
Associate Program Director
Anna-Barbara Moscicki, M.D.
415-476-5139; Fax: 415-476-6106
E-mail:
annam@itsa.ucsf.edu
Research Subject Advocate
Selna Kaplan, M.D., Ph.D.
415-476-0518
E-mail:
skaplan@peds.ucsf.edu
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Nurse Manager
Jean Addis, R.N., M.S.
415-502-2683; Fax: 415-476-3466
E-mail:
addisj@peds.ucsf.edu
Biostatistician
David Glidden, Ph.D.
415-476-9523; Fax: 415-476-6014
E-mail:
david@biostat.ucsf.edu
Computer Systems Manager
Kari Mazurek, B.S.
415-502-4298; Fax: 415-476-3466
E-mail:
mazurekk@peds.ucsf.edu
Dietician
Christie S. McGovern, R.D.
415-353-1565
E-mail:
Christie.McGovern@ucsfmedctr.org
Core Laboratory Director
Mark Scott, M.D.
415-476-3260; Fax: 415-502-1222
E-mail:
mscott@itsa.ucsf.edu
Core Laboratory Director
Selna Kaplan, M.D., Ph.D.
415-476-0518
E-mail:
skaplan@peds.ucsf.edu
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Special Assays, Services, or Tests
Cytokine and adhesion molecule levels in serum and other
body fluids
Cytokine production by T-cells in culture
Epstein-Barr virus transformation of peripheral blood B
cells
Genomic DNA isolation
IgA anti-HIV dot blot assay
Long-term cell culture of T and B cells
Lymphocyte phenotyping
Lymphocyte responses to mitogens and soluble antigen
Lymphocyte signaling assays
Natural killer cell activity
Adolescent Medicine: Natural history of human
papilloma virus from early infection to the development of
cervical intraepithelial neoplasia 1.
Endocrinology: Various issues related to diabetes mellitus,
including screening and prevention of type 1 diabetes mellitus; use
of continuous glucose sensors; characterization of type 2 diabetes
in children; insulin pump therapy in children; disorders of growth
and their treatment with human GH; treatment of sexual precocity with
luteinizing hormone-releasing factor agonists.
Epidemiology: Five-year outcome of severe neonatal
jaundice and dehydration.
Gastroenterology: Effect of growth hormone in
Crohn's disease.
Genetic Diseases: Natural history, pathophysiology,
and experimental treatment of lysosomal storage diseases;
identification and delineation of human defects in copper
transport; identification of modifier genes and biologic
pathways affecting pathophysiology in galactosemia.
Immunology: Immunological reconstitution; molecular defects in
severe combined immunodeficiency and hypogammaglobulinemia;
immunological and neurodevelopmental consequences of DiGeorge
syndrome and congenital heart disease; gene therapy for adenosine
deaminase deficiency; cellular and molecular analyses of primary
immunodeficiencies.
Neonatology: Controlled trials: Fetal surgery for diaphragmatic
hernia; inhaled nitric oxide to prevent chronic lung disease; LNMA for
permanent closure of patent ductus arteriosus; premature skin flora.
Observational studies: Brain oxygenation during resuscitation, during
extracorporeal circulation membrane oxygenation (ECMO), during polycythemia
correlation of brain imaging with neurodevelopmental outcome in preterm
infants and infants with intrapartum asphyxia.
Neuro-oncology: : Phase I-II studies of therapies in pediatric
patients with recurrent or progressive poor-prognosis brain tumors.
Nutrition: Dietary intervention in children and adolescents with
genetic lipid disorders at high risk for premature coronary
heart disease.
Oncology: Iodine-labeled meta iodobenzylguanidine with bone marrow
transplant rescue for treatment of advanced neuroblastoma; phase I-II trials
in children with relapsed or refractory cancer.
Pediatric AIDS: Risk factors associated with
perinatal transmission; AIDS Clinical Trials Group Phase
I-II trials with emphasis on pharmacokinetics,
antiretroviral agents, immunomodulators, and vaccines;
effects of school entry stress on HIV-affected children;
caregiving and mental health in mothers of HIV-infected
children.
Radiation Therapy: Role of P53 in radiosensitivity
and prognosis in malignant gliomas.
Rheumatology: Bone mineral density in pediatric
systemic lupus erythematosus; risk factors for
atherosclerosis in children and adolescents with systemic
lupus erythematosus; influenza vaccination in pediatric
patients with rheumatic diseases; molecular defects in
pediatric autoimmune diseases.
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Pediatric Clinical Research Center Satellite
Children's Hospital and Research Center at
Oakland Research Institute
747 52nd Street
Oakland, CA 94609
Grant No. M01 RR001271
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For information
about this satellite and how to access its resources, please
contact:
Assistant Program Director/Administration
Laurie Schumacher, M.P.H., Ph.D.
510-428-3885, x 5366; Fax: 510-450-5809
E-mail:
lschumacher@mail.cho.org
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Associate Program Director
Bertram Lubin, M.D.
510-450-7601; Fax: 510-450-7910
E-mail:
blubin@mail@mail.choi.org
Associate Program Director
Paul Harmatz, M.D.
510-428-3058; Fax: 510-450-5809
E-mail:
pharmatz@mail.cho.org
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Research Subject Advocate, Nurse Manager
Nancy Sweeters, R.N., P.N.P.
510-428-3885 x4151
E-mail:
nsweeters@mail.cho.org
Core Laboratory Director
Elizabeth Trachtenberg, Ph.D.
510-450-7685
E-mail:
etrachtenberg@mail.cho.org
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Hematology laboratory: Serum nitric oxide; exhaled breath
nitric oxide, secretory phospholipase A2; ektacytometry;
hemoglobin concentration and red cell volume
HLA laboratory: PCR/sequence-specific oligonucleotide: Format I human
leukocyte antigen (HLA) typing and format II immobilized oligonucleotide
probe analysis; microsatellite analysis
Asthma: Associations between environmental factors and
allelic variation in predisposition to asthma, assessing biologically
plausible gene-gene and gene-environment interactions; comparing drug
interventions; role of arginase activity in asthma, and its association
with cytokine activity involved in inflammation; pharmacological
activation of chloride ion transport by vitamin C in asthmatics.
Bioiron Basic research activities in iron metabolism and iron
toxicity and clinical variability in hepatic iron concentration in
secondary hemochromatosis; secondary hemochromatosis in beta
thalassemia and sickle cell disease; cross-sectional study of the
cellular localization of iron, structure and function of ferritin,
and differences in oxidative injury in sickle cell and thalassemia;
validity studies comparing the ferritometer and liver biopsy, examination
of cardiac iron and liver iron.
Critical Care: Acute lung injury; prone positioning; sepsis,
unexplained pneumonia.
Endocrinology: HLA typing in diabetic children; drug therapies in
pediatric patients with type 2 diabetes; stress response and risk factors
for disease in caregivers; genetic determinants and clinical implications
of obesity; frequency of mutations and identification of biological markers
associated with genetic defects causing severe obesity; Therapeutic
Development Network (TDN) Immune Tolerance Network: comparison study of
five T cell assay techniques to quantitate differences in GAD65
antigen-specific T cells from normal versus new onset type 1
diabetics.
Gastroenterology: Variation in hepatic iron concentration measurements
in patients with secondary hemochromatosis; molecular pathology of
inflammatory diseases of the intestine; biomarkers of genetic damage and
disease activity; cellular mechanisms for iron storage and oxidative injury;
lysosomal storage disease; enzyme replacement therapies for patients with
mucopolysaccharidosis.
Hematology-Sickle Cell Disease: Site of the North California
Sickle Cell Center; membrane phospholipid asymmetry; multicenter trials
of hydroxyurea in sickle cell disease, avascular necrosis of the hip in
sickle cell disease, complement regulatory proteins in sickle cell anemia;
mixed chimerism after bone marrow transplantation; stroke prevention trial
in sickle cell disease; secretory phospholipase A2 in acute chest syndrome;
nitric oxide as a marker of degree of vaso-occlusion in sickle cell disease;
arginine therapy in sickle cell disease; myocardial injury in
iron-overloaded chronically transfused patients with beta thalassemia and
sickle cell disease; assessment of nutritional status in sickle cell
disease; HLA association with stroke in sickle cell disease; erythrocyte
isozyme biomarkers of low lead overburden; DEXA studies in osteoporosis.
Hematology-Thalassemia: Participating member in the Thalassemia
Clinical Research Network; studies of novel therapies for hepatitis C;
mitochrondrial dysfunction with iron chelators; phase II study of an
iron chelator; clinical trials on darbepoetin alfa for treating anemia.
Medical Genetics: Candidate genes involved in cytokine production
and inflammatory response pathways; lysosomal storage disease studies:
trials of enzyme replacement therapy for mucopolysaccharidosis type VI
(aryl sulfatase B deficiency); phase II/III confirmatory trial of enzyme
replacement therapy for MPS type II (Hunter disease); phase II enzyme
replacement clinical trial for a rare disease, glycogen storage disease
type II (GSD-II Pompe disease).
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General Clinical Research Center
LA County and USC Medical Center
1200 North State Street, Room 6602
Los Angeles, CA 90033
URL:
www.usc.edu/hsc/gcrc/
Grant No. M01 RR00043
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Denise Walters
323-226-4632; Fax: 323-226-2796
E-mail:
dwalters@usc.edu
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Program Director
Thomas A. Buchanan, M.D.
323-226-4632; Fax: 323-226-2796
E-mail:
buchanan@usc.edu
Principal Investigator
Joseph P. Van Der Meulen, M.D.
323-442-2077; Fax: 323-442-3043
E-mail:
vanderme@usc.edu
Associate Program Director
Fred R. Sattler, M.D.
323-343-8288; Fax: 323-226-2083
E-mail:
fsattler@usc.edu
Associate Program Director
Richard M. Watanabe, Ph.D.
323-442-2053; Fax: 323-442-2349
E-mail:
rwatanab@usc.edu
Research Subject Advocate
Robert A. Larsen, M.D.
323-226-7556
E-mail:
rlarsen@hsc.usc.edu
Nurse Manager
Susie L. Nakao, R.N., M.N.
323-226-8026; Fax: 323-226-2796
E-mail:
nakao@usc.edu
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Core Laboratory Director
Carole A. Spencer, Ph.D., M.T.
323-224-7132; Fax: 323-224-7134
E-mail:
cspencer@usc.edu
Bionutrition Research Manager
Carmen L. Martinez, M.S., R.D.
323-226-4993; Fax: 323-226-6921
E-mail:
cmartine@usc.edu
Biostatistician
Colleen G. Azen, M.S.
323-226-8025; Fax: 323-226-2796
E-mail:
azen@usc.edu
Informatics/Systems Manager
Justo Diaz, M.I.S.
323-226-4634; Fax: 323-226-6921
E-mail:
jadiaz@usc.edu
Molecular Medicine Core Director
Juergen Reichardt, Ph.D.
323-442-1529; Fax: 323-442-2764
E-mail:
reichard@usc.edu
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Special Assays, Services, or Tests
Calcium and magnesium (serum, urine, diet) by atomic
absorption
Diet ashing, lymphocyte preparation
DNA extraction
Establishment of Epstein-Barr virus-immortalized cell lines
Genotyping and sequencing
Hemoglobin A1C by HPLC
Inulin (plasma, urine)
Microalbumin (urine) by RIA
Para-aminohippurate (plasma, urine)
Variety of peptide assays–ELISA
Sodium and potassium (urine, diet) by flame photometry
Special Resources, Instruments, or Services
DEXA scanner for body composition analysis
Dietary analysis of food records and dietary histories
Exercise testing for fitness (VO2max)
Indirect calorimetry for assessment of metabolic rates
Shared equipment for genetic analysis
Database construction
Diabetes and Metabolism: Pathogenesis and genetics of type 2 diabetes
in adults and children; prevention of type 1 and type 2 diabetes; diabetes
and atherosclerosis; diabetes in pregnancy; muscle metabolism and wasting
in aging.
Endocrinology: Thyroid hormone metabolism; goiter and thyroid
malignancy; metabolic bone disease; magnesium metabolism and
deficiency.
Gastroenterology: Therapy of chronic viral hepatitis.
Infectious Diseases: Wasting in AIDS; drug treatment of HIV
infection and opportunistic infections; mechanisms and prevention of
maternal-child HIV transmission; HIV infection and obesity; diabetes and
insulin resistance.
Neurology: Immunotherapy for multiple sclerosis, treatment of
seizure disorders.
Obstetrics and Gynecology: Fetal complications of gestational
diabetes.
Oncology: Clinical pharmacology of chemotherapeutic agents; novel
combination chemotherapy, immunotherapy of cancer; treatment of
AIDS-related malignancies.
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General Clinical Research Center Satellite
Children's Hospital of Los Angeles
Mail Stop 62
4650 Sunset Boulevard
Los Angeles, CA 90027
Grant No. M01 RR00043
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For information
about this satellite and how to access its resources, please
contact:
Associate Administrative Manager
William Terrell, B.S.
323-669-5615; Fax: 323-671-1547
E-mail:
wterrell@chla.usc.edu
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Associate Program Director
Kenneth Weinberg, M.D.
323-669-2213; Fax: 323-660-8736
E-mail:
kweinberg@chla.usc.edu
Assistant Program Director
John Wood, M.D.
323-669-5470; Fax: 323-669-7317
E-mail:
jwood@chla.usc.edu
Research Subject Advocate
Alan Lewis, M.D.
323-669-2265; Fax: 323-671-1513
E-mail:
alewis@chla.usc.edu
Nurse Manager
Deborah Tumbarello, R.N., B.S.N.
323-669-5644; Fax: 323-668-7904
E-mail:
dtumbarello@chla.usc.edu
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Informatics Director
Thomas Coates, M.D.
323-669-2352; Fax: 323-660-9321
E-mail:
tcoates@chla.usc.edu
Gene Therapy Core Laboratory Director
Donald Kohn, M.D.
323-669-4617; Fax: 323-667-1021
E-mail:
dkohn@chla.usc.edu
Biostatistician
Colleen G. Azen, M.S.
323-660-2450 x4221; Fax: 323-671-1547
E-mail:
cazen@chla.usc.edu
Neuropsychologist
Karen Epport, Ph.D.
323-669-5636 ; Fax: 323-671-1542
E-mail:
kepport@chla.usc.edu
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Special Assays, Services, or Tests
Gene therapy/bone marrow transplant laboratory
Neuropsychology services: Design of neuropsychological
components, evaluation measures, and age-appropriate
assessments
PCR analysis of in vitro colonies and patient specimens
Transduction of CD34+ cells; isolation of CD34+ bone marrow
cells; growth of lymphoid and hematopoietic colonies from
peripheral blood and bone marrow specimens
AIDS: Clinical trial of gene therapy for HIV-infected children with
autologous cord blood or bone marrow cells.
Bone Marrow Transplantation: Transplantation for both autologous
and allogeneic bone marrow in genetic, immunological, hematological, and
oncological diseases; evaluation of long-term effects of bone marrow
preparative regimens and their long-term effects.
Diabetes: Investigations of the neuropsychological effects of diabetes;
evaluation of new therapies.
Gene Therapy: Clinical trials for immunodeficiency diseases,
pediatric brain tumors, and HIV.
Hematology and Oncology: New therapy modalities
including gene therapy for brain tumors and neuroblastoma;
differentiating agents and immunotherapy.
Immunology: Investigations into primary
immunodeficiency diseases and establishment of new
therapeutic modalities.
Neurology: Evaluation and treatment of seizures in
children and infants through integration of clinical and
basic research; development of novel therapies for
pediatric seizures.
Radiology: Development of new imaging modalities and paradigms to
derive functional and biochemical data in children with metabolic disorders.
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General Clinical Research Center Satellite
City of Hope National Medical Center
1500 East Duarte Road
Duarte, CA 91010
Grant No. M01 RR00043
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For information
about this satellite and how to access its resources, please
contact:
Associate Administrative Manager
Irene Tomeck
626-256-8749; Fax: 626-256-8748
E-mail:
itomeck@coh.org
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Associate Program Director
John A. Zaia, M.D.
626-301-8434; Fax: 626-301-8458
E-mail: jzaia@coh.org
Assistant Program Director
Fouad Kandeel, M.D.
626-359-8111 x2689; Fax: 626-301-8489
E-mail:
fkandeel@coh.org
Research Subject Advocate
Kim Margolin, M.D.
626-359-8111, x62307
E-mail:
kmargolin@coh.org
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Nurse Manager
Brenda K. Williams, R.N.
626-256-8747; Fax: 626-256-8748
E-mail:
bwilliams@coh.org
Core Laboratory Director
Joy Fridey, M.D.
626-359-8111, ext. 68380; Fax: 626-301-8820
E-mail:
jfridey@coh.org
Biostatistician
David Ikle, Ph.D.
626-359-8111 x64446; Fax: 626-301-8802
E-mail: dikle@coh.org
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Cancer Chemotherapy: Phase I and phase II studies in cancer
chemotherapy with and without stem cell support.
Diabetes and Atherosclerois: Genetic studies in Hispanic populations;
treatment of diabetic polyneuropathy; islet transplantation for
type 1 diabetes.
Radioimmunotherapy: Use of Y-90 labeled monoclonal antibodies
for treatment of neoplastic disease.
Stem-Cell-Based Gene Therapy: Application of retrovirus and
adeno-associated virus vectors and other novel viral vectors for stem cell
transplantation in AIDS lymphoma.
T Cell-Based Gene Therapy: Application of hybrid T cell receptor
methods for cellular therapy for lymphoma, leukemia, glioblastoma
and neuroblastoma.
Vaccine Development Development of a peptide-based vaccine for human
cytomegalovirus; development of a vaccine for breast cancer.
Other Studies Molecular pathogenesis of therapy-related leukemia;
evaluating the hypothalamic-pituitary axis after hematopoeitic cell
transplantation (HCT).
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