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General Clinical Research Center
University of Colorado Health Sciences Center
4200 East 9th Avenue, B141
Denver, CO 80262
URL:
www.uchsc.edu/gcrc/
Grant No. M01 RR00051
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Tim Lockie, M.S., M.B.A.
303-372-8801; Fax: 303-372-5866
E-mail:
tim.lockie@uchsc.edu
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Program Director
Robert H. Eckel, M.D.
303-315-8443; Fax: 303-315-4525
E-mail:
robert.eckel@uchsc.edu
Principal Investigator
Richard D. Krugman, M.D.
303-315-7565; Fax: 303-315-8494
E-mail:
richard.krugman@uchsc.edu
Associate Program Director
E. Chester Ridgway, M.D.
303-315-8443; Fax: 303-315-4525
E-mail:
chester.ridgway@uchsc.edu
Associate Program Director
Bryan Haugen, M.D.
303-315-3486; Fax: 303-315-4525
E-mail:
bryan.haugen@uchsc.edu
Research Subject Advocate
Alison Lakin, R.N., L.L.B., L.L.M., Ph.D.
303-372-8810; Fax: 303-372-5866
E-mail:
alison.lakin@uchsc.edu
Research Subject Advocate
Troy Donahoo, M.D.
303-372-8802; Fax: 303-372-5866
E-mail:
william.donahoo@uchsc.edu
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Nurse Manager
Carol Losh, R.N., M.S., C.C.R.N.
303-372-8814 Fax: 303-372-8819
E-mail:
carol.losh@uchsc.edu
Core Laboratory Director
Maureen Garrity, Ph.D.
303-372-8798; Fax: 303-372-5866
E-mail:
maureen.garrity@uchsc.edu
Bionutrition Research Manager
Coni Francis, Ph.D., R.D.
303-372-8838; Fax: 303-372-5866
E-mail:
coni.francis@uchsc.edu
Biostatistician
John Kittelson, Ph.D.
303-315-5279; Fax: 303-315-3183
E-mail:
john.kittelson@uchsc.edu
Biostatistician
Lorri Ogden, Ph.D.
303-315-0508; Fax: 303-315-3183
E-mail:
lorri.ogden@uchsc.edu
Informatics Manager
Thomas Yaeger, B.S.
303-372-8803; Fax: 303-372-5866
E-mail:
thomas.yaeger@uchsc.edu
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Adiponectin
Aldosterone
Angiotensin II
Arginine vasopressin
Atrial natriuretic peptide
Beta-hydroxybutyrate
Cholesterol
C-peptide
Creatinine (serum/plasma, urine)
DHEA
DHEAS
Endothelin I
Epinephrine–HPLC
Estradiol, estradiol-us
Estrone
Follicle-stimulating hormone
Free fatty acids
Galactose
Glucagon
Glucose
Glycerol
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High-density lipoprotein total (direct), HDL-C subfraction 3 (precipitation),
HDL-C total (precipitation)
IGF-I
IGF-BP3 (binding protein-3)
IL-6
Insulin
Ketones (urine)
Lactate
Leptin
Lipid fractionation by fast protein liquid chromatography (FPLC)
Luteinizing hormone
Norepinephrine– HPLC (urinary)
Oxidized low-density lipoprotein
Progesterone
Reduced glutathione
Renin
Sex-hormone-binding globulin
Superoxide dismutase (SOD-1)
Total antioxidate status (TAS)
Thiobarbituric acid reactive substances (TBARS)
Triglycerides
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Cardiology: Congestive heart failure.
Clinical Pharmacology: Aging; blood pressure
regulation.
Endocrinology: Thyroid hormone action.
Gastroenterology: Bile acid metabolism.
Immunology: AIDS.
Metabolism and Nutrition: Obesity; diabetes
mellitus; energy balance; exercise; micronutrients;
electrolytes in food (flame photometry).
Nephrology: Edematous diseases; polycystic kidney
disease; hypertension.
Oncology: Biological modifiers; cancer screening;
malignant melanoma; CNS tumors.
Psychiatry: Schizophrenia, drug action; stress; alcoholism.
Pulmonary Diseases: Primary pulmonary hypertension.
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General Clinical Research Center Satellite
National Jewish Medical and Research Center
Room K-341
1400 Jackson Street
Denver, CO 80206
Grant No. M01 RR00051
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For information
about this satellite and how to access its resources, please
contact:
Administrative Manager
Helga Jacobs-Koehn
303-398-1717; Fax: 303-270-2207
E-mail: jacobsh@njc.org
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Associate Program Director
Donald Y. M. Leung, M.D.
303-398-1186; Fax: 303-270-2182
E-mail:
leungd@njc.org
Research Subject Advocate
Henry Milgrom, M.D.
303-398-1999
E-mail:
milgromh@njc.org
Nurse Manager
Trudi Madigan, R.N.
303-398-1434; Fax: 303-270-2207
E-mail:
madigant@njc.org
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Core Laboratory III Director
Lee Newman, M.D., M.S.
303-398-1983; Fax: 303-398-1452
E-mail:
mailto:newmanl@njc.org
Core Laboratory IV Director
Frederick Wamboldt, M.D.
303-398-1135; Fax: 303-270-2115
E-mail:
wamboldtf@njc.org
Biostatistician
James Murphy, Ph.D.
303-398-1686; Fax: 303-270-2131
E-mail:
murphyj@njc.org
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Special Assays, Services, or Tests
Cytokine analysis
Inflammation markers
Psychosocial assessment
T cell phenotyping
T cell receptor gene usage
Allergy: Food allergy; respiratory allergy.
Dermatology: Atopic dermatitis; psoriasis.
Genetic Diseases: Atopic gene-linkage abnormalities.
Infectious Diseases: Tuberculosis; mycoplasma.
Occupational Medicine: Beryllium toxicity; air
pollution.
Pharmacology: Pharmacokinetics of asthma and
tuberculosis drugs.
Psychiatry: Adherence; outcome studies.
Pulmonary Disease: Asthma; interstitial lung disease; pulmonary
fibrosis; sarcoidosis; berylliosis; inflammatory mediators.
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General Clinical Research Center Satellite
Wardenburg Health Center, Room 376
University of Colorado
18th Street & Wardenburg Drive
Boulder, CO 80309-0119
Grant No. MO1 RR00051
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For information
about this satellite and how to access its resources, please
contact:
Assistant Administrative Manager
Emily Edwards, M.S.
303-735-2521; Fax: 303-735-1968
E-mail:
emily.baker@colorado.edu
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AssistantProgram Director
Douglas R. Seals, Ph.D.
303-492-5305; Fax: 303-492-6778
E-mail:
seals@spot.colorado.edu
Research Subject Advocate
William Byrnes, Ph.D.
303-492-5301; Fax: 303-492-6778
E-mail:
mailto:william.byrnes@colorado.edu
Core Laboratory Director
Robert Mazzeo, Ph.D.
303-492-1509; Fax: 303-492-6778
E-mail:
robert.mazzeo@colorado.edu
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Bionutritionist
Kathleen Farrell, M.S.
303-735-2125; Fax: 303-735-1968
E-mail:
kathleen.farrell@spot.colorado.edu
Biostatistician
Gregory Carey, Ph.D.
303-492-1658; Fax: 303-492-2967
E-mail:
gregory.carey@colorado.edu
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Special Assays, Services, or Tests
Baroreflex responsiveness
DEXA scans
Exercise prescriptions, monitoring and compliance
Muscle sympathetic nerve activity
Pulse wave velocity and applanation tonometry
Resting and exercise oxygen consumption
Whole-limb blood flow
Cardiac output during exercise
Aging: Endothelial function; autonomic nervous
system; steadiness training.
Alcohol Addiction: Pharmacological mechanisms.
Cardiovascular Physiology: Vascular endothelial
biology; large artery compliance.
Exercise Intervention: Hypertension; aging.
Immunology: Physical activity and immune function.
Skeletal Muscle Physiology: Exercise-induced muscle
injury; muscle fatigue of motor steadiness.
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General Clinical Research Center
Children's Hospital, B218
1056 East 19th Avenue
Denver, CO 80218
URL: www.uchsc.edu/pedsgcrc
Grant No. M01 RR00069
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Puff Stevens
303-837-2957; Fax: 303-764-8407
E-mail:
stevens.puff@tchden.org
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Program Director
Ronald J. Sokol, M.D.
303-861-6669; Fax: 303-764-8407
E-mail:
sokol.ronald@tchden.org
Principal Investigator
Richard D. Krugman, M.D.
303-315-7565; Fax: 303-315-8494
E-mail:
richard.krugman@uchsc.edu
Associate Program Director
William W. Hay, Jr. M.D.
303-724-1600; Fax: 303-724-0898
E-mail:
bill.hay@uchsc.edu
Associate Program Director
Philip S. Zeitler, M.D., Ph.D.
303-861-6128; Fax: 303-864-5670
E-mail:
zeitler.philip@tchden.org
Assistant Program Director
Nancy Krebs, M.D.
303-315-5304; Fax: 303-315-3273
E-mail:
nancy.krebs@uchsc.edu
Research Subject Advocate
Theresa A. O'Lonergan, M.A.
303-764-8538; Fax: 303-764-8407
E-mail:
o'lonergan.theresa@tchden.org
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Nurse Manager
Diane L. Branham, R.N., B.S.N
303-869-3195; Fax: 303-764-8125
E-mail:
branham.diane@tchden.org
Core Laboratory Medical Director
Frank J. Accurso, M.D.
303-837-2522; Fax: 303-764-8159
E-mail:
accurso.frank@tchden.org
Core Lab Technical Director
Iris Osberg, M.T.
303-764-8205; Fax:303-764-8159
E-mail:
osberg.iris@tchden.org
Nutrition Research
Janine Higgins, Ph.D.
303-837-2955; Fax: 303-764-8187
E-mail: higgins.janine@tchden.org
Biostatistician
Joseph Coll, Ph.D.
303-869-3157; Fax: 303-764-8407
E-mail: coll.joseph@tchden.org
Informatics Core
Bob DiLaura, D.B.A., M.B.A.
303-764-8373; Fax: 303-764-8407
E-mail:
dilaura.bob@tchden.org
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Special Assays, Services, or Tests
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Adrenocorticotropic hormone
Alpha-1-antitrypsin
Anti-Pseudomonas aeruginosa
Bile acids, total
Bone-specific alkaline phosphatase
Bromide
C-reactive protein, high sensitivity
Caffeine (serum and saliva)
Calcitonin
Carbohydrate antigen 19-9 (CA 19-9)
Carotene, alpha and beta
Carotenoids (micro): beta cryptoxanthin; lutein/zeaxanthin;
lycopene, total
Coenzyme Q-10
Cortisol (urine and saliva)
Cyclic guanosine monophosphate (c-GMP)
DNA total
2,3 Diphosphoglyceric acid (DPG)
Deoxypyridinoline crosslinks
Elastase free; elastase, polymorphonuclear (PMN)
Endothelin-1
Eosinophil cationic protein (ECP)
E-selectin
Galactose
Glutathione peroxidase; glutathione reductase
Granulocyte colony stimulating factor (GCSF)
Granulocyte macrophage colony stimulating factor (GM-CSF)
Immunoglobulin-A (IgA)
Immunoreactive trypsinogen (IRT)
Insulin-like growth factor 1 (IGF-I/somatomedin C)
Insulin-like growth factor binding protein 3 (IGFBP-3)
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Interferon Gamma (IFN-gamma)
Interleukin-1 alpha and beta; -1ra; -2; -3; -6; -6
receptor; -8; -10; -11; -12
Intracellular adhesion molecule (ICAM)
Lactoferrin
Lactulose
Lipids, total
Lysozyme
Mannitol
Microalbumin
Micro total protein
Myeloperoxidase
N-telopeptide
Nitrite and nitrate
Nitrogen
Osteocalcin
Pancreatic elastase-1 (fecal)
Parathyroid hormone (PTH) N-tact
Pit count, red cell
Polyethylene glycol
Prealbumin
Procollagen type I and II
Pyridinium crosslinks
Retinol-binding protein
Retinyl palmitate
Secretory leukocyte protease inhibitor (SLPI)
Transforming growth factor beta (TGF-beta)
Tumor necrosis factor, alpha and beta (TNF-alpha, -beta)
Urea, bronchoalveolar lavage (BAL) and urine
Vascular endothelial growth factor (VEGF)
Vitamin A (retinol)
Vitamin D, 25-hydroxy
Vitamin E (alpha and gamma tocopherol)
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Special Resources,Instruments, or Services
DEXA
Indirect calorimetry
Specialized anthropometric equipment
Specialized neonatal equipment
Diabetes and Endocrinology: Prediabetes and autoimmunity; prevention
of type 1 diabetes; genetics of type 1 diabetes; treatment of type 2
diabetes; polycystic ovary syndrome.
Gastroenterology and Hepatology: Celiac disease; biliary atresia;
childhood cirrhosis; alpha-1 antitrypsin deficiency; liver disease in
cystic fibrosis; nonalcoholic steatohepatitis; short bowel syndrome.
Genetics and Metabolism: Inborn errors of metabolism; congenital
hypothyroidism.
Hematology: Hemophilia joint disease; congenital thrombotic disease;
sickle cell disease.
Immunology: Childhood vaccine immunology.
Infectious Diseases: HIV; sexually transmitted diseases; respiratory
syncytial virus; childhood vaccine development.
Neonatology: Nitric oxide and steroid therapy to prevent
bronchopulmonary dysplasia; nutrition in growth-restricted neonates;
glucose metabolism in low-birthweight infants; amino acid and protein
metabolism; neonatal infection.
Nephrology: Polycystic kidney disease; hyperlipidemia in chronic
renal disease.
Neurocognitive Development: Autism; sensory integration disorders;
effects of intrauterine nicotine exposure; adolescent psychosis.
Neurology and Rehabilitation Medicine: Muscular dystrophy; spina bifida;
neurotrauma.
Nutrition: Childhood obesity; energy metabolism; trace metal
metabolism; nutrition in the premature infant; cystic fibrosis; liver
disease; osteoporosis in pediatric diseases.
Oncology: Sarcomas; CNS tumors.
Pulmonary Medicine: Early detection and therapy of cystic fibrosis (CF);
genomics of airway epithelium in CF; aminoglycoside treatment in CF;
nitric oxide therapy in CF; gene therapy in CF.
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