 |
|
|
|
|
|
General Clinical Research Center
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030-3805
URL:
http://gcrc.uchc.edu/
Grant No. M01 RR006192
|
For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Priscilla Adler, M.B.A.
860-679-2880; Fax: 860-679-1454
E-mail:
adler@nso.uchc.edu
|
|
|
|
Program Director
Herbert Bonkovsky, M.D.
860-679-4145; Fax: 860-679-1454
E-mail:
bonkovsky@uchc.edu
Principal Investigator
Richard Berlin, M.D.
860-679-2413; Fax: 860-679-1371
E-mail:
berlin@nso.uchc.edu
Associate Program Director
Henry Kranzler, M.D.
860-679-4151; Fax: 860-679-1316
E-mail:
kranzler@psychiatry.uchc.edu
Associate Program Director
Lawrence Raisz, M.D.
860-679-3851; Fax: 860-679-1454
E-mail:
raisz@nso.uchc.edu
Research Subject Advocate
Lisanne Circullo, A.P.R.N.
860-679-2819; Fax: 860-679-1454
E-mail:
circullo@uchc.edu
|
Core Laboratory Director
Jonathan Covault, M.D., Ph.D.
860-679-3681; Fax: 860-679-4077
E-mail:
covault@psychiatry.uchc.edu
Nurse Manager
Robin Leger, R.N., Ph.D.
860-679-4932; Fax: 860-679-1454
E-mail:
rleger@uchc.edu
Biostatistician
Stephen Walsh, Sc.D.
860-679-5471; Fax: 860-679-5464
E-mail:
walsh@nso.uchc.edu
Informatics Director
Khamis Abu-Hasaballah, Ph.D.
860-679-8141; Fax: 860-679-1454
E-mail:
khamis@nso.uchc.edu
|
|
Special Assays, Services, or Tests
Bone marker immunoassays: Free deoxypyridinoline
crosslinks, crosslinked C-telopeptide, and N-telopeptide of
type I collagen, osteocalcin, bone-specific alkaline
phosphatase, N-terminal propeptide of type I collagen
Hormones, growth factors, cytokines
Molecular biology: RNA and DNA extraction from tissue and blood; quantitative
PCR; microarrays; quantitative reverse-transcriptase PCR
Cardiology: Atrial fibrillation; hypertension;
congestive heart failure.
Endocrinology: Oncogenes of adrenal and thyroid
tumors; effect of sex hormones on calcium and bone turnover
in older women and men; bone loss and its treatment in men
with prostate cancer.
Gastrointestinal Diseases: Acute intermittent porphyria;
hepatitis C.
Genetic Diseases: Primary cortisol resistance; genetic abnormalities
in glaucoma; osteoporosis; osteogenesis imperfecta; lysosomal storage
disorders.
Infectious Diseases: Lyme and other tick-borne
diseases; AIDS; influenza.
Obstetrics and Gynecology: Smoking cessation and pregnant
women.
Oncology: National Surgical Adjuvant Breast and Bowel Project
prevention and treatment trials; treatment of chronic myelogenous leukemia,
breast cancer, cervical disease with heat shock protein immunotherapy.
Pediatrics: AIDS, Children's Cancer Group protocols;
tick-borne diseases; Crohn's disease and bone, asthma.
Psychiatry: Etiology and pathophysiology of alcohol, cocaine, and
opioid dependence, including neuroendocrinologic, neuropsychological,
and molecular genetic studies; pharmacological treatment of alcohol
dependence; physiological measures of risk and molecular genetic studies
of schizophrenia; psychotherapy of alcohol and drug dependence and
pathological gambling.
Rheumatology: Sjogren's syndrome; scleroderma.
|
 |
|
|
|
|
General Clinical Research Center
East Pavilion, Yale-New Haven Hospital
Yale University School of Medicine
P.O. Box 208019
333 Cedar Street
New Haven, CT 06510
URL: http://info.med.yale.edu/crc/welcome.html
Grant No. M01 RR000125
|
For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Sonja Beamon
203-785-4424; Fax: 203-688-3100
E-mail:
sonja.beamon@yale.edu
|
|
|
|
Program Director
Robert S. Sherwin, M.D.
203-785-4183; Fax: 203-785-6015
E-mail:
robert.sherwin@yale.edu
Principal Investigator
Dennis Spencer, M.D.
203-785-4672; Fax: 203-785-7437
E-mail:
dennis.spencer@yale.edu
Associate Program Director
William V. Tamborlane Jr., M.D.
203-785-4646; Fax: 203-737-1998
E-mail:
william.tamborlane@yale.edu
Associate Program Director
James F. Leckman, M.D.
203-785-5580; Fax: 203-785-7611
E-mail:
james.leckman@yale.edu
Assistant Program Director
Douglas Rothman, M.D.
203-785-6202; Fax: 203-785-6643
E-mail:
douglas.rothman@yale.edu
Assistant Program Director
Barbara Gulanski, M.D.
203-785-2983; Fax: 203-737-5558
E-mail:
barbara.gulanski@yale.edu
|
Research Subject Advocate
Rosa Hendler, M.D.
203-785-5448; Fax: 203-688-3100
E-mail:
rosa.hendler@yale.edu
Research Protocol Coordinator
Gina D'Agostino, R.N., M.S.N.
203-688-6500; Fax: 203-785-3513
E-mail:
gina.d'agostino@ynhh.org
Nurse Manager
Tahiry Sanchez, R.N., M.S.
203-688-7598; Fax: 203-785-3513
E-mail:
tahiry.sanchez@ynhh.org
Nutrition Research Manager
Donna Caseria, R.D.
203-688-4731; Fax: 203-688-3100
E-mail:
donna.caseria@yale.edu
Biostatistician
James Dziura, Ph.D.
203-737-4468; Fax: 203-688-3100
E-mail:
james.dziura@yale.edu
Informatics Core Director
Cynthia A. Brandt, Ph.D.
203-764-6713; Fax: 203-688-3100
E-mail:
cynthia.brandt@yale.edu
|
|
Special Assays, Services, or Tests
|
Hormone Assays
ACTH
Adiponectin
Catecholamines
Cortisol
C-peptide
Glucagon
Growth horome
IGF-I and systolic blood pressure
Insulin
Leptin
Prolactin
Proinsulin
Substrate Assays
Amino acids
Ethanol
Free fatty acids
Glucose
Glutamate
Glycerol
Ketones
Lactate
Pyruvate
Triglycerides
Urea
|
Mineral Metabolism
IL-6, IL-6sR, IL-11
1,25(OH)23D
25OHD
Plasma cAMP
PTH
TNF-a
Urinary cAMP
Urinary NTX
Stable Isotopes
Glucose
Glycerol
KIC
Leucine
Palmitate
|
Special Resources, Instruments, or Services
Amino acid analyzer (Dionex) with digital computer
Bicycle ergometer
Bone densitometer
Calorimetry facility with ventilated hood system
Metabolic diet program
MAJOR-AREAS
AIDS: Drug interactions in patients with AIDS and
drug abuse.
Diagnostic Radiology: Genetic characteristics and history of hereditary
hemorrhagic telangiectasia.
Endocrinology: Effect of exercise on insulin absorption and hepatic
function; effects of catecholamines on fuel metabolism; protein metabolism
in obesity; genetic factors in hypertension; fuel metabolism in human brain
and skeletal muscle; NMR studies of glycogen metabolism; HIV gynecological
manifestations; gender differences in relationship of cardiac and metabolic
risk factors; temporal lobe epilepsy and glucose metabolism; IL-6 in skeletal
calcium during lactation; insulin resistance related to stroke.
Gastroenterology: Therapeutic studies of hepatitis C; novel treatments
for primary biliary cirrhosis; effect of protein on gastric pH.
Mineral Metabolism: Vitamin D metabolism; hypercalcemia associated with
malignancy; pathogenesis and treatment of metabolic bone disease (osteoporosis,
hypophosphatemic rickets, Paget's disease, and hepatic and renal
osteodystrophy); pathogenesis and treatment of secondary thyroid disease;
studies of parathyroid hormone-related protein; gene modifiers and natural
history of Gaucher's disease.
Neurology and Neurosurgery: Surgical treatment of epilepsy; dopamine
function in Parkinson's disease; autologous Schwann cell transplantation in
multiple sclerosis patients.
Obstetrics and Gynecology: Preterm delivery; polycystic ovary
syndrome.
Occupational Medicine and Environmental Health: Immunologic mechanisms
of isocyanate asthma.
Oncology: Pharmacokinetics of new antitumor drugs.
Psychiatry: Tourette's syndrome treatment with pimozide and with
clonidine; biological studies of autism, aphasia, and other developmental
disabilities; drug abuse; gender differences in metabolic studies of nicotine
dependence; use of single-photon-emission computed tomography (SPECT)
to delineate dopamine receptors; studies of post-traumatic stress syndrome;
therapy of Alzheimer's disease; cortical glutamate and gamma-aminobutyric
acid (GABA) levels in depressed patients; repetitive transcranial magnetic
stimulation in schizophrenia.
Surgery: Implantation of phrenic pacemaker, special
emphasis in pacing parameters in patients with total
respiratory paralysis; effect of weight reduction of gastric bypass
patients on hormone levels.
|
|
|
|
