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General Clinical Research Center
Mailing Address:
Box 571457
Washington, DC 20057
Location:
General Clinical Research Center
7 East, Main Hospital
Georgetown University Hospital
3800 Reservoir Road, NW
Washington, DC 20007
URL:
http://gcrc.georgetown.edu/
Grant No. M01 RR13297
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Carol Natale
202-444-2793; Fax: 202-444-4114
E-mail:
cbn3@georgetown.edu
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Program Director
Joseph G. Verbalis, M.D.
202-687-2818; Fax: 202-444-4114
E-mail:
verbalis@georgetown.edu
Associate Program Director
Robert Ratner, M.D.
301-560-7323; Fax: 301-560-7321
E-mail:
ratnermri@aol.com
Assistant Program Director
Jason G. Umans, M.D., Ph.D.
202-444-1202; Fax: 202-444-4114
E-mail:
jgu@georgetown.edu
Research Subject Advocate
Judith Baigis, Ph.D., R.N.
Pager: 202-542-9813; Fax: 202-687-5553
E-mail:
baigisj@georgetown.edu
Nurse Manager
Shaunagh Browning, R.C.F.N.P., C.D.E.
202-444-2639; Fax: 202-444-1505
E-mail:
brownins@georgetown.edu
Biostatistics Core Director
Edmund Gehan, Ph.D.
202-687-0825; Fax: 202-687-3821
E-mail:
gehane@georgetown.edu
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Biostatistician
Rochelle Tractenberg, Ph.D., M.P.H.
202-444-8748; Fax: 202-444-1505
E-mail:
ret7@georgetown.edu
Nutrition
Lauren Rhee, M.S., R.D.
202-884-2910; Fax: 202-444-1505
E-mail:
lrhee@cnmc.org
Genetics Core Laboratory Director
Lee Jun Wong, Ph.D.
202-444-0760; Fax: 202-444-1770
E-mail:
wonglj@georgetown.edu
Bioanalytical Core Laboratory Director
Steven Soldin, Ph.D.
202-687-7153; Fax: 202-884-2007
E-mail:
ssoldin@georgetown.edu
Informatics Director
Rahel Ketema
202-444-4713; Fax: 202-444-1505
E-mail:
rk3@georgetown.edu
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ABI 377 automated DNA sequencing machines for mutational analysis,
large scale genotyping systems for mutation and single nucleotide
polymorphisms discovery
ABI sequence detection system 7700 (real-time PCR)
Affymetrix hybridization station and laser scanner for
analysis of Affymetrix diagnostic gene chips
API-3000 tandem mass spectrometer
API-4000 tandem mass spectrometer
Capillary electrophoresis with UV and laser-induced
detection
Cognitive testing room with video monitoring
Gas chromatography with nitrogen, phosphorus, and
flame ionization detection
High performance liquid chromatography with UV and
fluorescence detection
HPLC
Immulite (Diagnostic Products Corp)
Liquid chromatograph with mass spectroscopy
SpectruMedix SCE9610 capillary-based automated
SNP discovery and DNA sequencing system
The GCRC provides outpatient and inpatient clinical
research support to both pediatric and adult research
subjects. Some procedures that nurses currently
perform or assist include:
Allergy testing
Bod Pod measurements
Chemotherapy administration
Cognitive testing
Complex medication administration with monitoring
Complex pharmacokinetic sampling and collection
Complex sample processing
Diabetes education
Exercise stress testing
Expert IV/phlebotomy services
Insulin clamp studies
Lumbar puncture
Pulse wave analysis
Six-minute walk testing
Telemetry
Vaccination
Aging and Alzheimer's Disease
AIDS and HIV Infection
Behavior
Cancer
Cardiovascular Diseases and Hypertension
Chronic Multisymptom Illnesses
Endocrinology
Genetics:
Neuroscience and Neurology
Rheumatology
Sex-based Biology
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Inpatient/Outpatient Pediatric Clinical Research Center Satellite
Children's National Medical Center
111 Michigan Avenue, NW
Washington, DC 20010
Grant No. MO1 RR13297
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For information
about this satellite and how to access its resources, please
contact:
Administrative Director
Kerstin Hildebrandt
202-884-3584; Fax: 202-884-6636
E-mail:
khildebr@cnmc.org
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Program Director
Mendel Tuchman, M.D.
202-884-2549; Fax: 202-884-6636
E-mail:
mtuchman@cnmc.org
Assistant Program Director
Jill G. Joseph, M.D., Ph.D.
202-884-5969; Fax: 202-884-6636
E-mail:
jjoseph@cnmc.org
Research Subject Advocate
Tomas Jose Silber, M.D., M.A.S.S.
202-884-3066
E-mail:
tsilber@cnmc.org
Nurse Manager
Marlene Lee, R.N.
202-884-2298; Fax: 202-884-6636
E-mail:
mlee@cnmc.org
Informatics/Biostatistics
Robert McCarter, Ph.D.
202-884-3140; Fax: 202-884-6636
E-mail:
rmccarte@cnmc.org
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Genetics Core Laboratory
Eric Hoffman, Ph.D.
202-884-6011; Fax: 202-884-6014
E-mail:
ehoffman@childrens-research.org
Bioanalytical Core Laboratory
Steven Soldin, Ph.D.
202-884-2096; Fax: 202-884-2007
E-mail:
ssoldin@cnmc.org
Neurobehavioral Evaluation Core
Gerard Gioia, Ph.D.
202-745-8860
E-mail:
ggioia@cnmc.org
Bionutrition Research
Lauren Rhee, M.S., R.D.
202-884-2910; Fax: 202-884-6636
E-mail:
lrhee@cnmc.org
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Affymetrix Genechip® profiling
Air displacement plethysmography (BodPod)
Automated amino acid analyzer
Automated sequencing
Denaturing high-performance liquid chromatography (DHPLC)
DNA arrays
Eye movement tracking camera
Gas chromatography/ mass spectrometry
HPLC with radioactivity detector
Liquid chromatography/mass spectrometry
Matrix-assisted laser desorption ionization–time–of–flight
mass spectrometry (MALDI-TOF/MS)
Neurobehavioral evaluation instruments
Pediatric quantitative muscle testing system (PQMT)
Quantitative PCR
Tandem mass spectrometry
Attention Deficit Hyperactivity Disorder (ADHD)/Autism: Cognitive
function in children with and without attention and memory disorders;
neuropsychological profiles in children with functioning autism.
Community-Based Research:Prevention of child neglect; obesity
intervention project for inner city Latino children and adolescents;
teen violence; ADHD; head trauma.
Dental Research: Educating nondental primary care providers about
early childhood caries; effects of severe early childhood caries and
comprehensive dental intervention on children's weight.
Endocrinology:Youth type 1 diabetes nonadherence prevention program;
polycystic ovary syndrome in adolescents with type 1 diabetes.
Genetics: In vivo nitrogen incorporation into urea: Correlation with
genotype and phenotype in late-onset ornithine transcarbamylase (OTC)
deficiency; molecular basis of OTC deficiency; N-acetylglutamate
synthase (NAGS) deficiency and treatment with carbamylglutamate; temporal
analysis of cells' innate immunity.
Hematology: Prospective study of transfusion-transmitted
diseases as assayed by molecular and immunologic assays; international,
randomized, controlled trial of immune-tolerance induction.
HIV and AIDS: Studies of pediatric late outcome; effect of
antiretroviral therapy on the recovery of immune function and body
composition of infected children; study of Lopinavir/Ritonavir in HIV-1
infected infants up to 6 months of age; prevalence of morphologic and metabolic
abnormalities in HIV-infected and uninfected young women; short-cycle
therapy in adolescents with established viral suppression; structured
treatment interruption as an autovaccination approach to enhance immune-based
HIV-1 control in an adolescent/young adult population; antiretroviral
therapeutic drug level monitoring comparison between total and free drug
concentration in plasma; chronic kidney disease in pediatric AIDS.
Muscular Dystrophy: Molecular pathophysiology of muscular dystrophy
by expression profiling; efficacy and safety of glutamine, CoQ10, and
creatine monohydrate in Duchenne muscular dystrophy.
Neurology: Functional magnetic resonance imaging (fMRI) studies of
remediation of developmental dyslexia; functional neuroanatomy of reading
in hyperlexic children studied with fMRI; plasticity of language networks
in childhood epilepsy, traumatic brain injury.
Oncology: Study of Flavopiridol in refractory childhood leukemia;
phase I study of hu 14.18-IL2 (humanized 14.18 antibody/IL2 fusion protein)
in GD2+ malignancies of childhood, specifically neuroblastoma; P9973
phase I study of ST1571 (anti-bcr/abl) in Philadelphia chromosome and acute
lymphoblastic leukemia (ALL) in relapse.
Psychiatry: Diagnostic classification of infantile anorexia; youth
violence: unmet need for mental health services; treatment of early age
mania; levothyroxine in the treatment of pediatric anorexia nervosa.
Psychology: Psychological sequelae of disturbed sleep in children;
early disruptive disorders in young children.
Pulmonary Medicine: : Improving pediatric asthma care in the District
of Columbia; refining techniques for isolation of mononuclear cells from
human respiratory washings; immunity and thrombosis in acute lung injury;
characterization of mucins in tracheal secretions.
Sickle Cell Anemia: Stroke prevention trial; pediatric
hydroxyurea phase III clinical trial; pleiotropic and epistatic
effects in sickle cell anemia.
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General Clinical Research Center
Howard University Hospital
Fourth Floor, 4 West
2041 Georgia Avenue, NW
Washington, DC 20060
Grant No. M01 RR10284
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Betty M. Deen
202-865-7272 or 1929; Fax: 202-865-1933
E-mail:
bdeen@howard.edu
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Program Director
Otelio S. Randall, M.D.
202-865-7272; Fax: 202-865-1933
E-mail:
orandall@fac.howard.edu
Principal Investigator
Floyd J. Malveaux, M.D., Ph.D.
202-806-6270; Fax: 202-806-7934
Associate Program Director
Victor R. Gordeuk, M.D.
202-806-9601; Fax: 202-806-4517
E-mail:
vgordeuk@howard.edu
Associate Program Director
Thomas O. Obisesan, M.D., M.P.H.
202-865-3397; Fax: 202-865-3777
E-mail:
tobisesan@howard.edu
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Research Subject Advocate
Jane A. Otado, Ph.D.
202-865-7272; Fax: 202-865-1933
Nurse Manager
Carl Tilghman, B.S.N., R.N.
202-865-7272; Fax: 202-865-5327
Informatics Manager
Shichen Xu, M.D.
202-865-7273; Fax: 202-865-1933
E-mail:
sxu@howard.edu
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Special Assays, Services, or Tests
Cytomegalovirus cultures
p24 HIV antigen by enzyme-linked immunosorbent assay
Lymphocyte subset studies
Western blot Special Resources, Instruments, or
Services
Body composition assessment
Brachial artery ultrasound for reactivity and carotid artery
ultrasound for intima-medial thickness and vascular function
Cardiac monitoring and telemetry
Echocardiography and Doppler studies
Exercise equipment with telemetric heart rate monitoring
24-hour ambulatory blood pressure monitoring
Metabolic cart to measure basal energy expenditure
Nutritional consultations, intervention, education, monitoring
Random-zero blood pressure measurement apparatus
Special diets
Alcoholism: Genetics of alcoholism, with neurophysiological
evaluations and behavioral psychological assessments of alcoholics;
alcohol preference and pharmacokinetics in African Americans.
Alternative Medicine: Studies involving the use of transcendental
meditation versus education and the effects of antioxidants versus
conventional or non-food-derived vitamin supplementation in the treatment
of cardiovascular disease in older African American women and older
African Americans, respectively.
Anxiety and Bipolar Disorders: Clinical treatment trials, imaging
trials for major depression, bipolar and anxiety disorders, and genetics
analyses.
Cardiovascular Diseases: Coronary artery disease (CAD) and the role of
risk factors in the minority population; left ventricular hypertrophy and its
effect on diastolic left ventricular function; effectiveness of CAD risk
factor reduction with diet and exercise on disease outcome; ability to
reduce and/or modify risk factors for CAD development in patients who have
not yet manifested clinical evidence of the disease; optimal treatment for
congestive heart failure; establishment of a better clinical index of
impedance as an estimate of afterload.
Endocrinology: Effect of diabetes on CAD with
specific emphasis on diabetes and coronary disease in
African American women.
Genetic Disorders: Investigation of genetic markers as a possible
reason for the excessive incidence of hypertension in African Americans;
studies of the role of hypertension and the type of antihypertensive therapy
on the progression of renal dysfunction in African Americans; the role of
left ventricular hypertrophy in morbidity and mortality; investigation of
obesity in the African diaspora, and its implications for an increased
susceptibility to breast cancer.
Geriatrics and Gerontology: Mechanisms and treatment of systolic
hypertension in the elderly population; Alzheimer's disease prevention
with estrogens; the treatment of incontinence in African American women
by behavioral intervention.
Hematology: Effects of iron overload in African Americans with
sickle cell disease; studies involving the use of hydroxyurea in the
treatment of sickle cell disease and the effect of exercise on cerebral,
peripheral, and cardiopulmonary function in sickle cell anemia patients at
steady state.
Neurology: : Management of hypertension in patients with
cerebrovascular accident; the relationship between proinflammatory
cytokines and neurobehavioral outcomes in stroke patients.
Pharmacology: Treatment adherence with HIV
protease inhibitors (PI), PI blood levels, and treatment failure;
the use of Ondansetron and Naltrexone in the treatment of
alcohol dependence.
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