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General Clinical Research Center
Feinberg Pavilion, Suite 10-760B
Northwestern Memorial Hospital
251 East Huron Street
Chicago, IL 60611
URL:
www.feinberg.northwestern.edu/gcrc
Grant No. M01 RR000489
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Barbara M. Bellg
312-926-3192; Fax: 312-926-8450
E-mail: bbellg@nmh.org
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Program Director
William L. Lowe Jr., M.D.
312-503-2539; Fax: 312-908-9032
E-mail:
wlowe@northwestern.edu
Principal Investigator
Lewis L. Landsberg, M.D.
312-503-0340; Fax: 312-503-7757
E-mail:
l-landsberg@northwestern.edu
Associate Program Director
Gerhard P. Baumann, M.D.
312-503-4128; Fax: 312-908-9032
E-mail:
gbaumann@northwestern.edu
Associate Program Director
Boyd E. Metzger, M.D.
312-503-7979; Fax: 312-908-9032
E-mail:
bem@northwestern.edu
Associate Program Director
Leon G. Epstein, M.D.
773-880-4757; Fax: 773-880-3208
E-mail:
lepstein@childrensmemorial.org
Research Subject Advocate
Lewis J. Smith, M.D.
312-503-0501; Fax: 312-503-0555
E-mail:
ljsmith@northwestern.edu
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Biostatistician
Borko D. Jovanovic.Ph.D.
312-503-2008; Fax: 312-908-9588
E-mail:
borko@northwestern.edu
Clinical Nurse Manager
Janet Cahill, R.N., B.S.N., M.B.A.
312-926-5895; Fax: 312-926-8450
E-mail:
jcahill@nmh.org
Core Laboratory Manager
Mariquita Sumaque, C.(A.S.C.P.)
312-926-3194; Fax: 312-926-8450
E-mail:
msumaque@nmh.org
Informatics Core Manager
Thomas M. McKibben II, Ph.D.
312-908-7923; Fax: 312-908-9588
E-mail:
tmckibben@northwestern.edu
Nutrition Research Manager
Meenakshi Rammohan, M.S., R.D., C.S., L.D.
312-926-4377; Fax: 312-926-8450
E-mail:
mrammoha@nmh.org
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Special Assays, Services, or Tests
C-peptide
D-xylose
Inulin
Leptin
Melatonin
Vasopressin Special Resources, Instruments, or
Services
Body composition analyzer, single and multifrequency
Cardiac monitoring and telemetry
Metabolic cart for basal energy expenditure measurement
Polysomnograph recording
Bone Marrow Transplantation: Bone marrow
transplantation as therapy for autoimmune disease:
multiple sclerosis, rheumatoid arthritis, Crohn's disease, scleroderma, and
systemic lupus erythematosus.
Cardiovascular Diseases: Antiarrhythmic therapy; therapy of congestive
heart failure; functional assessment; cardiac arrhythmias; circadian and
gender variation in electrical activity of the heart; cardiac memory and
diastolic function; peripheral arterial disease; parasympathetic tone
during exercise.
Endocrinology and Metabolism: Hyperglycemia and pregnancy outcome;
acanthosis nigricans and risk factors for type 2 diabetes (adolescents);
islet cell transplantation; phenotype and genotype in familial polycystic
ovary syndrome; pathogenesis of familial diabetes insipidus; treatment of
hyponatremia with a vasopressin antagonist; hormonal function in pituitary
hypothalamic disease; prevention of diabetes mellitus; vasopressin function
in nocturnal enuresis (adults and children); desmopressin regulation effects
on salt and water balance; growth disorders.
Gastroenterology: Antiviral treatment strategies in hepatitis C;
D-xylose kinetics in malabsorption; malabsorption in intestinal
transplantation; abnormal circadian rhythms in cirrhosis; short
bowel syndrome; ulcerative colitis.
Infectious Diseases: AIDS and AIDS-related complex
in adults and children; fat maldistribution and metabolic
changes in HIV-infected patients.
Nephrology: Effects of renal disease on the
pharmacokinetics of drugs; dopaminergic regulation of
aldosterone secretion; effects of potassium balance on
antidiuretic function; racial differences in sodium and
potassium metabolism.
Neurology: Alzheimer's disease; treatment of aphasia
and spatial neglect; effects of light and exercise on
circadian rhythms; effects of sleep on auditory and perceptual learning;
genetic studies of aneurysmal subarachnoid hemorrhage.
Oncology: Radiolabeled monoclonal antibodies in treatment of
cutaneous T cell lymphoma and adenocarcinoma of the lung; monoclonal
antibodies for radioimmunodetection and radioimmunoassay; monoclonal
antibody therapy; use of plasminogen activator therapy for antiangiogenic
therapy; chemopreventive agents.
Pediatrics: Vasculitis and connective tissue disease; type 2
diabetes in pediatric patients; HIV; partial external biliary diversion
for chronic cholestasis in Alagille syndrome; nutritional status and liver
function in children with biliary atresia; corticotropin-releasing factor
in cyclic vomiting; cystic fibrosis.
Pulmonary Medicine: Pseudomonas aeruginosa infection in cystic fibrosis;
ion transporters in bronchial epithelial cells in asthma; sleep apnea severity
and simulated driving performance; chronic obstructive pulmonary disease.
Rheumatology: Systemic lupus erythematosus; osteoarthritis treatment;
osteoporosis; neuromechanical factors in the progression of knee
osteoarthritis.
Transplantation: Pancreas, bone marrow, intestinal,
and islet cell transplantation.
Women's Health: Estradiol levels in the breast;
estrogen exposure from oral contraceptives; milk
availability and lactation status.
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General Clinical Research Center
University of Chicago Medical Center
MC 7100
5841 South Maryland Avenue
Chicago, IL 60637
URL:
http://gcrc.bsd.uchicago.edu
Grant No. M01 RR00055
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Andrea Acklin
773-702-6980; Fax: 773-702-6952
E-mail:
aacklin@medicine.bsd.uchicago.edu
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Program Director
Roy E. Weiss, M.D., Ph.D.
773-702-9266; Fax: 773-702-6940
E-mail:
rweiss@medicine.bsd.uchicago.edu
Principal Investigator
James Madara, M.D.
773-702-3004; Fax: 773-702-1897
E-mail:
jmadara@bsd.uchicago.edu
Associate Program Director
Robert L. Rosenfield, M.D.
773-702-6432; Fax: 773-702-0443
E-mail:
robros@peds.bsd.uchicago.edu
Associate Program Director, Bioinformatics
David Ehrmann, M.D.
773-702-9653; Fax: 773-834-7808
E-mail:
dehrmann@medicine.bsd.uchicago.edu
Research Subject Advocate
F. Gary Toback, M.D., Ph.D.
773-702-1476; Fax: 773-702-6952
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Nurse Manager
M. Julie Helms, B.S.N., R.N.
773-702-6977; Fax: 773-702-6952
E-mail:
jturgeon@mcis.bsd.uchicago.edu
Nutrition Research Manager
Linda S. Trumbore, M.S., R.D., L.D.
773-702-3012; Fax: 773-702-6952
E-mail:
ltrumbor@medicine.bsd.uchicago.edu
Biostatistician
Theodore Karrison, Ph.D.
773-702-9326; Fax: 773-702-3538
E-mail:
tkarrison@health.bsd.uchicago.edu
Informatics Core Director
Patrick Fleury, Ph.D.
773-702-0517; Fax: 773-702-6952
E-mail:
pfleury@medicine.bsd.uchicago.edu
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Special Assays, Services, or Tests
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Bone densitometry
Bioimpedance analysis
Computerized sleep scoring
Cortisol
DNA and lymphocyte separation
Insulin, proinsulin, C-peptide
Lymphoblastoid cell line facility
Mineral balance
25(OH)D3
1,25(OH)2D3
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Parathyroid hormone
Polysomnography with 24-hour remote sampling capability
Pulse oximeters
Sex steroid hormone intermediates
Serum osteocalcin
Serum bone-specific alkaline phosphatase
Video monitoring
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Endocrinology (Adult and Pediatric): Insulin secretion and clearance;
metabolic and genetic screening of families with non-insulin-dependent diabetes
mellitus; disorders of growth and pubertal progression in children and
adolescents; genetics and pathogenesis of polycystic ovary syndrome and
syndromes of insulin resistance; states of resistance to thyroid hormone;
Cushing syndrome; circadian and hormonal rhythmicity; nonhormonal treatment
of osteoporosis.
Gastroenterology: Genetics of inflammatory bowel
diseases; novel treatments for Crohn's disease.
Genetics: Diabetes, polycystic ovary syndrome,
thyroid disease, asthma, psychiatric disorders,
inflammatory bowel disease, cardiomyopathy, and cancer.
Interdisciplinary: Pharmacology and efficacy of
methylnaltrexone.
Oncology: Pharmacokinetics and pharmacodynamics of various
antineoplastic agents; genetic screening in cancer-prone families;
autologous immunization for melanoma; pharmacogenetics of antineoplastic
therapies.
Psychiatry: Menstrual cycle effects on response to psychoactive
drugs; interactions in smoking and alcohol use; impulsive aggression
and intermittent explosive disorder; pharmacogenetics of drugs for autism.
Pulmonary Medicine: Airway inflammation; genetics of asthma.
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General Clinical Research Center
University of Illinois at Chicago
M/C 521
1740 West Taylor
Chicago, IL 60612
URL:
www.gcrc.uic.edu
Grant No. M01 RR13987
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Irene Ziaya, L.C.S.W., M.M.
312-996-6248; Fax: 312-996-6781
E-mail: iziaya1@uic.edu
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Program Director
Arthur B. Schneider, M.D., Ph.D.
312-996-6060; Fax: 312-413-0437
E-mail:
abschnei@uic.edu
Principal Investigator
Gerald S. Moss, M.D.
312-996-3500; Fax: 312-996-9006
E-mail:
gmoss@uic.edu
Associate Program Director
Theodore Mazzone, M.D.
312-996-6060; Fax: 312-413-0437
E-mail:
igbrodsk@uic.edu
Associate Program Director
Philip G. Janicak, M.D.
312-413-4507; Fax: 312-413-4503
E-mail:
pjanicak@psych.uic.edu
Research Subject Advocate
Burton Andersen, M.D.
312-996-1596; Fax: 312-413-0437
E-mail:
BRAnders@uic.edu
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Core Lab Director
Samuel Levin, Ph.D.
312-996-6292; Fax: 312-996-6781
E-mail:
slevin@uic.edu
Patient Care Services Assistant Director
Mary Jane Strong, R.N., M.S., C.S.
312-413-4521; Fax: 312-413-4503
E-mail:
jstrong@psych.uic.edu
Bionutrition Research Manager
Cindy Carey, M.S., R.D.
312-996-4511; Fax: 312-996-6781
E-mail:
carey@uic.edu
Biostatistician
Marlos A. G. Viana, Ph.D.
312-996-8384; Fax: 312-413-7376
E-mail: viana@uic.edu
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Special Assays, Services or Tests
Collection and freezing of blood, urine, tissue, and
saliva specimens following guidelines of
institutional-review-board-approved protocols; sterile
isolation of cellular blood elements
Glucose assay (real-time processing and measurement
available); measurement of insulin levels; measurement of
osmolality
Indirect calorimetry; peak aerobic capacity testing;
iothalamate glomerular filtration rate measurement
Cardiology: Diabetic cardiomyopathy; cardiovascular risks in
adolescent diabetics; acute effects of alcohol in heart
failure patients.
Endocrinology: Diabetes and nutrition; 3-beta-hydroxy-steroid
dehydrogenase (HSD) deficiency; insulin sensitivity; exercise effects
in diabetes; radiation-induced thyroid cancer.
Geriatric Medicine: Chronic obstructive pulmonary disease (COPD)
and inspiratory muscle strength; vitamin E in aging persons with
Down syndrome.
Gynecology: Cognitive function and oral contraceptive use;
pharmacokinetics of antibiotics in pregnancy.
Immunology: : Function and regulation of eosinophilic proteins;
TSH receptor autoimmunity; peptide-based specific active (PSA)
immunotherapy.
Infectious Diseases: Hepatitis C treatment and viral kinetics;
women and HIV; early natural history of hepatitis C vaccine among
injecting drug users; two strategies for management of antiretroviral
therapy.
Nephrology: Chronic renal insufficiency cohort.
Nursing: COPD and inspiratory muscle strength; insulin sensitivity;
exercise effects in diabetes; comparison of bone mineral density between
men and women with COPD; pupillometric sleepiness in treated sleep disorders.
Nutrition: Lycopene and DNA oxidation in prostate cancer,
lycopene kinetics; regional adiposity and syndrome X in spinal
cord injury.
Pediatrics: 3-beta-HSD deficiency; pediatric bipolar disorder;
monoamine receptor function in children with mood disorders.
Pharmacology: Prevention of DNA oxidation; cytochrome P450
expression in multiple myeloma; effects of clotrimazole on cytochrome
P450 3A4 activity in healthy persons; racial determinants of the renal
effects of spironolactone.
Psychiatry: Neuroendocrine defects in schizophrenia; transcranial
magnetic resonance in depression; 5-HT-2a receptors in depression with
aggressive behavior; arousal and neuropsychological functioning in
schizophrenia; oculomotor and spatial cognition deficits in schizophrenia;
pediatric bipolar disorder; protein kinase C substrates and transcription
factors in mood disorders; monoamine receptor function in children with
mood disorders.
Psychology: Carbohydrate craving syndromes; obstructive
sleep apnea, cognitive function and functional cerebral studies;
effects of endogenous estrogen and sex on cognitive functioning.
Rehabilitation and Health Promotion: Vitamin E in aging persons
with Down syndrome; exercise and nutrition in paraplegia; exercise
therapies in Down syndrome.
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