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General Clinical Research Center
University Hospital, Room 5595
Indiana University School of Medicine
550 North University Boulevard
Indianapolis, IN 46202-5250
URL: www.gcrc.iupui.edu/default.htm
Grant No. M01 RR00750 |
For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Sharon Cromer
317-278-3446; Fax: 317-274-7346
E-mail:
scromer2@iupui.edu
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Program Director
Munro Peacock, M.D.
317-274-4356; Fax: 317-274-4361
E-mail:
mpeacock@iupui.edu
Principal Investigator
D. Craig Brater, M.D.
317-274-8157; Fax: 317-274-8439
E-mail:
dbrater@iupui.edu
Associate Program Director
Scott Denne, M.D.
317-274-4920; Fax: 317-274-2065
E-mail:
sdenne@iupui.edu
Associate Program Director
Kurt Kroenke, M.D
317-630-7447; Fax: 317-630-6611
E-mail:
kkroenke@regenstrief.org
Research Subject Advocate
Jim Croop, M.D., Ph.D.
317-274-8784; Fax: 317-278-8784
E-mail:
jcroop@iupui.edu
Research Subject Advocate
Paul Helft, M.D.
317-278-6942; Fax: 317-278-4190
E-mail:
phelft@iupui.edu
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Nurse Manager
Tiffany Fox, M.S.N., M.B.A., R.N.
317-278-3567; Fax: 317-274-7346
E-mail:
tifox@iupui.edu
Nutrition Research Manager
Laurie Trevino, M.S., R.D.
317-274-0952; Fax: 317-274-7346
E-mail:
lhackwar@iupui.edu
Core Lab Director
Stephen Dlouhy, Ph.D.
317-274-5747; Fax: 317-274-2387
E-mail:
sdlouhy@iupui.edu
Biostatistician
Chandan Saha, Ph.D.
317-278-4283; Fax: 317-274-2678
E-mail:
cksaha@iupui.edu
Biostatistician
Naomi Fineberg, Ph.D.
317-274-4334; Fax: 317-274-2678
E-mail:
nfineber@iupui.edu
Informatics Core Manager
Ken Anderson, M.S.
317-274-7931; Fax: 317-274-4361
E-mail:
kanders2@iupui.edu
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Special Assays, Services, or Tests
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Bone-specific alkaline phosphatase–serum
Deoxypyridinium crosslinks–urine
DNA preparation
Hydroxyproline–urine
Ionized calcium
Monitoring of gene vectors
N-telopeptide crosslinks–urine
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1,25(OH)2D–serum
25(OH)D–serum
Osteocalcin–serum
PTH–serum
Pyridinium crosslinks–urine
Tartrate-resistant acid phosphatase–serum
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Special
Resources, Instruments, or Services
Achilles ultrasound
Acoustically and electrically shielded room for alcohol
research
Dual-energy x-ray absorptiometers
Gamma radiation counter
HPLC
Liquid scintillation counter
Microplate reader
Open-circuit, indirect respiratory calorimetry system for
infants
Roche Cobas Mira chemistry analyzer
Thermal cycler for PCR
AIDS: Drug therapy in the management of patients
with AIDS and its complications.
Alcohol Studies: Alcohol utilization and elimination
rates determined by alcohol clamping; twin and family
studies on the acute effects of alcohol.
Amyloidosis: Presentation and prognosis of human
amyloidosis.
Bone Diseases: : Genetics of bone strength in men and of bone loss
in women; genetic determinants of peak bone mass in women; clinical and
genetic analysis of autosomal dominant hypophosphatemic rickets; clinical
and genetic studies of autosomal dominant osteopetrosis; bisphos-phonate
therapy for osteogenesis imperfecta and childhood osteoporosis; effects of
bisphosphonates, PTH on postmenopausal osteoporosis; effects of
calcimimetic agents in primary hyperparathyroidism; effect of isoflavones
on calcium metabolism in humans; calcium requirements in adolescence.
Cancer: Drug treatment of cancers including breast,
pancreatic, colorectal, lung and osteosarcoma.
Cardiology: Cardiac, neural, and conduction dysfunction in
myotonic dystrophy.
Diabetes: Insulin resistance; endothelial function;
obesity gene; early diabetes intervention program; diabetes
prevention trial in type 1 diabetes; HIV-related proteinuria
and endothelial dysfunction; HIV-1 protease inhibitors' effect
on endothelial function and glucose metabolism in normal,
HIV-uninfected subjects; early diabetes prevention program;
subcutaneous insulin infusion versus insulin injection therapy
in very young children with type 1; diabetes prevention trial
type 1 (pediatrics); prevention of diabetes progression trial.
Gene Therapy: Treatment of germ cell tumors, chronic
myelogenous leukemia, multiple myeloma, non-Hodgkin's lymphoma,
poor prognosis pediatric and adult brain tumors, x-linked chronic
granulomatous disease.
Genetics: Cardiovascular disease risk factors and brain
morphology in twins; pilot Huntington's disease (HD) at-risk
observational study; longitudinal studies among at-risk HD gene
carriers; identification of the gene causing spheroid body myopathy.
Hypertension: Longitudinal study of blood pressure regulation in
young people; the relation of race to renal hemodynamics; ascertainment of
hypertensive patients for genetic studies; salt sensitivity; cardiovascular
metabolic bone disease.
Infectious Diseases: Experimental human infection
with Hemophilus ducreyi.
Neonatology: Protein and carbohydrate metabolism and
regulation in newborns; glutamine supplementation for extremely
low birthweight infants; mechanically evoked reflexes and functional
oromotor skill acquisition in preterm infants; energy requirements and
expenditure in healthy and ill newborns; neonatal inhaled nitric oxide
study.
Neurology: Treatment of Huntington's disease;
treatment of Alzheimer's disease.
Pharmacology: Drug interactions in renal clearance; the role
of CYP3A on drug metabolism; effect of chloroquine on opiate receptors;
profiling Tamoxifen with pharmacogenetic predictors.
Psychiatry: Medical treatment of autistic disorders, schizophrenia,
mood disorders; treatment of hyperactivity and impulsiveness in pediatrics
with pervasive developmental disorders.
Transplantation: Medical treatment of rejection in renal
transplant patients; assessment of anitphiX174 antibody response in
previously treated dialysis patient.
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