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General Clinical Research Center
Johns Hopkins Bayview Medical Center
B3NW, Room 310
4940 Eastern Avenue
Baltimore, MD 21224
URL: http://gcrc.jhbmc.jhu.edu
Grant No. M01 RR02719
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Debra Grudzien
410-550-1880; Fax: 410-550-1227
E-mail: dgrudzi1@jhmi.edu
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Program Director
Pamela Ouyang, M.D.
410-550-0853; Fax: 410-550-1183
E-mail: pouyang@jhmi.edu
Principal Investigator
Michael J. Klag, M.D.
410-955-0496
E-mail: mklag@jhmi.edu
Associate Program Director
Suzanne Jan De Beur, M.D.
410-550-4229; Fax: 410-550-6864
E-mail: sjandebe@jhmi.edu
Research Subject Advocate
Michele Copersino, M.P.H., C.C.R.P.
410-550-1850; Fax: 410-550-1227
E-mail: mgoldsm1@jhmi.edu
Sleep Core Director
Alan Schwartz, M.D.
410-550-0545; Fax: 410-550-3374
E-mail: schwartz@jhmi.edu
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Patient Care Manager
Linda K. Weinberg, R.N., M.S.N., C.R.R.N.
410-550-1056; Fax: 410-550-1227
E-mail: lweinber@jhmi.edu
Clinical Dietitian
Lynn Moseley, M.P.H., R.D., L.D.
410-550-1768; Fax: 410-550-0650
E-mail: lmosele1@jhmi.edu
Core Laboratory Director
Neal S. Fedarko, Ph.D.
410-550-2632; Fax: 410-550-1227
E-mail: ndarko@mail.jhmi.edu
Exercise and Body Composition Director
Kerry J. Stewart, Ed.D.
410-550-0870; Fax: 410-550-1227
E-mail: kstewart@mail.jhmi.edu
Biostatistician
Matthew Tayback, Sc.D.
410-550-1248; Fax: 410-550-1227
E-mail: mtayback@jhmi.edu
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Special Assays, Services, or Tests
Bionutrition: Computerized nutrient analysis
Body composition: Anthropometry, body composition analysis–dual–energy
X-ray absorptiometry, bone-mineral density measurements
CV imaging: Brachial ultrasound, carotid imaging, cardiac echo/Doppler,
coronary flow reserve
Exercise testing and training facility: Strength and fitness testing and
exercise training, metabolic energy exchange analysis
Sleep core facility: Polysomnography
Core Laboratory Assays
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Basic fibroblast growth factor (bFGF)
Bone-specific alkaline phosphatase
cAMP/cGMP
Chondrex
Cortisol
C-peptide
Creatinine
Deoxypyridinoline crosslinks
Dehydroepiandrosterone sulfate
Epinephrine
Estradiol
Follicle-stimulating hormone
Free fatty acids (nonesterified)
Gastric inhibitory protein
Glucagon-like peptide
Glucose
Growth hormone
GH ultra sensitive
25-Hydroxyvitamin D
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Insulin
Insulin ultra sensitive
Insulin-like growth factor I
Leptin
Lipid panel (cholesterol, HDL, LDL, triglycerides)
Luteinizing hormone
Norepinephrine
Osteocalcin
Parathyroid hormone (intact)
Procollagen type I carboxyterminal propeptide
Proinsulin
Prolactin
N-telopeptides (urinary)
Testosterone free
Testosterone total
Thyroid-stimulating hormone
Triiodothyronine
Thyroxin
Tumor necrosis factor alpha
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Aging: Alzheimer's disease; calcium therapy in elderly
patients with hip fracture.
Cardiovascular Diseases: Sex hormone effects on the cardiovascular
system; benefits of exercise in older hypertensives; effect of status on
coronary flow reserve; interaction between heart failure and
sleep-disordered breathing.
Endocrinology: Physiology and cell biology of Trp64Arg beta-3
adrenergic receptor in obesity and non-insulin-dependent diabetes.
Immunology: Childhood asthma management program; in vitro approach
to problems of clinical allergy (bee and wasp sting allergy);
chronic sinusitis.
Metabolism: Hormone-metabolic and sympathoadrenal responses
to exercise.
Psychiatry and Behavioral Sciences: Subjective, behavioral,
physiological, and pharmacological responses to substance abuse;
individual differences in response to marijuana and alcohol;
neurotoxicity of recreational drug abuse; effects of exposure to
cigarettes or abstinence.
Pulmonary and Sleep Medicine: Mediators of bronchial
hyperreactivity; childhood asthma management; studies of sleep-disordered
breathing; restless leg syndrome.
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General Clinical Research Center
Johns Hopkins Hospital, Carnegie 446
600 North Wolfe Street
Baltimore, MD 21287
URL: http://gcrc.med.jhmi.edu/gcrc
Grant No. M01 RR00052
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Florence Perry
410-614-5383; Fax: 410-614-7610
E-mail:
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Program Director
Christopher D. Saudek, M.D.
410-955-2132; Fax: 410-955-0801
E-mail:
Principal Investigator
Michael J. Klag, M.D., M.P.H.
410-955-0496; Fax: 410-955-0889
E-mail:
Associate Program Director
Charles W. Flexner, M.D.
410-955-9712; Fax: 410-955-9708
E-mail:
Associate Program Director
Pamela Zeitlin, M.D., Ph.D.
410-955-2035; Fax: 410-955-1030
E-mail:
Research Subject Advocate
Susan Bonura, M.P.A., C.C.R.A.
410-614-6323; Fax: 410-614-7610
E-mail:
Nurse Manager, Adult Inpatient Unit
Erin Turner, R.N., M.S.N.
410-955-5875; Fax: 410-614-7236
E-mail:
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Research Nurse, Adult Outpatient Unit
Jared Christopher, R.N., B.S.N., B.A., C.C.R.C.
410-955-2760; Fax: 410-614-1828
E-mail:
Nurse Manager, Pediatrics
Mary Ann Sartain, R.N., M.S.N.
410-955-5245; Fax: 410-614-1477
E-mail:
Bionutrition Research Manager
Susan Oh, M.S., M.P.H., R.D.
410-955-5189; Fax: 410-955-3399
E-mail:
Biostatistical Core
Josef Coresh, M.D., Ph.D.
410-955-0495; Fax: 410-955-0476
E-mail:
Computer Systems Manager
David Holmack, B.B.A.
410-955-0409; Fax: 410-955-0689
E-mail:
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Anesthesiology and Critical Care: Aminocaproic acid and bleeding
in spinal surgery.
Cardiology: Risk predictors and interventions
in siblings of premature myocardial infarction patients; psychosocial
factors in heart disease; racial differences in lipoprotein(a) and other
risk factors for ischemic stroke; dyslipidemias and other risk factors;
carotid evaluation in siblings; ischemic heart disease.
Clinical Pharmacology: Drug development for AIDS treatments;
antiviral therapies.
Emergency Medicine: Evaluation of intravenous drug abusers
for bacterial endocarditis; outcomes in pneumonia among the
immunosuppressed.
Endocrinology: Calcium kinetics in postmenopausal women;
development of implantable insulin-delivery systems for use in
diabetics; use of glucose sensors to control insulin delivery; new
forms of thyroid hormone replacement; pituitary function in children
of alcoholics; estrogen and coronary heart disease in postmenopausal
diabetics; hormone resistance in pseudohypoparathyroidism; prevention
of diabetes mellitus in African Americans; disorders of sexual
differentiation.
Gene Therapy: Treatment of cystic fibrosis; treatment of
patients with exertional angina.
Genetic Diseases: Carnitine deficiency; hyperammonemia; urea
cycle enzymopathies; phenylketonuria; hereditary connective tissue
disorders; malformation syndromes; mucolipidoses and mucopolysaccharidoses;
neurological and mental retardation syndromes; gyrate atrophy;
achondroplasia; pseudoxanthoma elasticum; Marfan syndrome; immunologic
and therapeutic studies in patients with adrenoleukodystrophy; genetic
studies of craniofacial disorder (Treacher Collins syndrome).
Geriatrics and Gerontology: Markers of functional decline;
exercise lifestyles and training (heart rate variability); precursors
for physical disabilities in older adults.
Hematology: Treatment of sickle cell anemia with
hydroxy-urea and related approaches.
Hypertension: Primary prevention of hypertension; nonpharmacologic
therapy of hypertension; epidemiology and pathophysiology of essential
hypertension; diagnosis and treatment of renovascular hypertension; role of
nutritional factors in essential hypertension; high blood pressure care for
young urban black men.
Infectious Diseases Pediatric and adult HIV; phase III clinical
investigative drug studies; immunodeficiency; nutritional and viral and
immune status in HIV-infected children; treatment of HIV-related
tuberculosis; risk factors for extrapulmonary tuberculosis.
Liver Diseases: Responses to alpha-interferon therapy of
hepatitis C in hemophiliac children.
Musculoskeletal Disorders Calcium kinetics in young girls from
families with histories of osteoporosis.
Nephrology: Monoclonal antibody therapy in acute renal
allograft rejection.
Neurology: Degenerative disease; adrenoleukodystrophy;
seizure disorders; Rett syndrome; ketogenic diet; autism;
ataxia-telangiectasia; psychopathology of frontal lobe injury.
Nutrition: Metabolism of phenylalanine and related metabolic
intermediaries by use of double-stable-isotope turnover techniques.
Oncology: Phase I and phase II studies of new antineoplastic
drugs; lethally irradiated allogenic pancreatic tumor cells transfected
with GM-CSF gene in pancreatic adenocarcinoma; screening for early
pancreatic neoplasia/familial pancreatic cancer.
Psychiatry and Behavioral Sciences: Evaluation of schizophrenia by
positron emission tomography scanning.
Pulmonary Diseases: Asthma, critical pathway; cystic fibrosis.
Sleep Studies: Structural evaluation of children with
obstructive sleep apnea; sleep-disordered breathing in children.
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Neurobehavioral Research Unit (NBRU)
707 North Broadway, Suite 200J
Baltimore, MD 21205
URL: www.kennedykrieger.org
Grant No. M01 RR00052
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Bridget Johnson
443-923-2852; Fax: 410-502-8747
E-mail: johnsonb@kennedykrieger.org
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Associate Program Director
Michael Cataldo, Ph.D.
443-923-2850; Fax: 410-502-8747
E-mail: cataldo@kennedykrieger.org
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Research Subject Advocate
Susan Bonura, M.P.A., C.C.R.P.
410-614-6323; Fax: 410-614-7610
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Neurobehavioral Research Unit: Manages acute behavioral
and medical problems while accommodating patients (including children of all ages) with visual, auditory, communication, and behavioral disorders; provides neuroimaging and neurobehavioral assessment research resources, including structural and functional magnetic resonance imaging, spectral and diffusion analysis, fiber track mapping, fMRI protocol development and training of pediatric and brain-/behavior-disordered subjects.
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General Clinical Research Center
University of Maryland
22 South Greene Street, Room S10D13
Baltimore, MD 21201
URL: http://medschool.umaryland.edu/gcrc/
Grant No. M01 RR16500
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Sharon Andres, R.N., M.B.A.
410-328-7368; Fax: 410-328-8749
E-mail: sandres@medicine.umaryland.edu
Administrative Assistant
Sharon Wiggins
410-328-7369; Fax: 410-328-8749
E-mail: swiggins@medicine.umaryland.edu
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Program Director
Carol O. Tacket, M.D.
410-328-7367 or 410-328-8749
Fax: 410-328-8749
E-mail: ctacket@medicine.umaryland.edu
Principal Investigator
Donald E. Wilson, M.D. M.A.C.P.
410-706-7410; Fax: 410-706-0235
E-mail: deanmed@som.umaryland.edu
Assistant Program Director
Mary-Claire Roghmann, M.D., M.S.
410-706-0062; Fax: 410-605-7914
E-mail: Mroghman@epi.umaryland.edu
Assistant Program Director
Kristi D. Silver, M.D.
410-706-1628; Fax: 410-706-6146
E-mail: Ksilver@medicine.umaryland.edu
Research Subject Advocate
Kathleen Palmer, R.N., C.C.R.C.
410-328-7655; Fax: 410-328-8749
E-mail: kpalmer@medicine.umaryland.edu
E-mail: rsa@medicine.umaryland.edu
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Nurse Manager
Jennifer Post, R.N., B.S.N.
410-328-7365; Fax: 410-328-8749
E-mail: jpost@medicine.umaryland.edu
Biostatistical Core Director
Patricia Langenberg, Ph.D.
410-706-3251; Fax: 410-706-8013
E-mail: plangenb@umaryland.edu
Bioinformatics Core Director
L. Samuel Dongmo, Ph.D.
410-328-8008; Fax: 410-328-8749
E-mail: sdongmo@medicine.umaryland.edu
Genomics Core Director
O. Coline Stine, Ph.D.
410-706-1607; Fax: 410-706-1644
E-mail: ostin001@umaryland.edu
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Special Assays, Services, or Tests
Printing and reading of DNA micro arrays
Production of human DNA and custom arrays
Sequencing and genotyping
Special Resources, Instruments, or Services
Dual-energy X-ray absorptiometry
Endocrinology/Metabolism: Insulin sensitivity, fat metabolism,
body composition in diabetes; islet cell transplant for diabetes
Genetics of Chronic Disease: Genetic determinants of diabetes
mellitus, stroke, hypertension, osteoporosis.
Infectious Diseases: Pathogenesis of bacterial infections;
vaccine development including challenge studies of vaccine efficacy,
vaccine safety; interstitial cystitis.
Neurology: Early-onset stroke, stroke rehabilitation,
stroke management, prevention.
Oncology: New agents for treatment of prostate cancer,
renal carcinoma, hematologic malignancies, solid tumors.
Rheumatology: Osteoporosis in women and men; lupus erythematosus;
evaluation of traditional Chinese medicine for arthritis.
Psychiatry: Negative symptoms and cognitive impairment in schizophrenia.
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