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General Clinical Research Center
Beth Israel Deaconess Medical Center, GZ-800
330 Brookline Avenue
Boston, MA 02215
URL:
www.research.bidmc.harvard.edu/gcrc
Grant No. M01 RR01032
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Michelle Beck
617-667-4269; Fax: 617-667-5953
E-mail: mbeck1@bidmc.harvard.edu
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Program Director
Steven D. Freedman, M.D., Ph.D.
617-667-5576; Fax: 617-667-5953
E-mail: sfreedma@bidmc.harvard.edu
Principal Investigator
Jeffrey Flier, M.D.
617-667-9050; Fax: 617-667-9054
E-mail: jflier@bidmc.harvard.edu
Associate Program Director
Kaarkuzhali B Krishnamurthy, M.D.
617-667-4269; Fax: 617-667-5953
E-mail: bkrishna@bidmc.harvard.edu
Associate Program Director
Alvaro Pascual-Leone, M.D., Ph.D.
617-667-0203; Fax: 617-975-5322
E-mail: apleone@bidmc.harvard.edu
Research Subject Safety Office Director
Rabbi Terry R. Bard, D.D.
617-667-3354; Fax: 617-667-5953
E-mail: tbard@bidmc.harvard.edu
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Nurse Manager
Mary M. Williams, R.N., M.S.
617-667-1764; Fax: 617-667-5953
E-mail: mwillia2@bidmc.harvard.edu
Chief Bionutritionist
Jeanene Fogli, M.S., R.D., L.D.N.
617-667-1254; Fax: 617-667-5953
E-mail: jfogli@bidmc.harvard.edu
Core Laboratory Director
John Zeind, M.S.
617-667-3586; Fax: 617-975-5394
E-mail: jzeind@bidmc.harvard.edu
Biostatistician
Shiva Gautam, Ph.D.
617-667-0453; Fax: 617-667-5953
E-mail:
sgautam@bidmc.harvard.edu
Informatics Core Director
Paul Zotov, M.Ed.
617-667-4194; Fax: 617-667-5953
E-mail: pzotov@bidmc.harvard.edu
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Clinical Investigator Training Program: Two year,
multidisciplinary training program for postdoctoral
fellows. Cooperative venture with MIT/HST, Pfizer, and
FDA. Majority of time spent on patient-oriented research
project with strong didactic program addressing full range
of topics important to clinical investigators. Graduates
are eligible for Master of Science degree from Harvard
Medical School. Special Assays, Services, or
Tests
Catecholamines–urine, plasma
Inulin–urine, serum
Measurement of markers of cardiovascular reactivity and endothelial
dysfunction
Microelements in biological fluid using atomic absorption spectroscopy
Purification and determination of organic compounds, including free fatty
acids, using HPLC and gas chromatography
Radioimmunoassays: Core lab offers various RIA, FIA, EIA, and chemiluminescent
immunoassays
Special Resources, Instruments, or Services
Body composition analysis: bioelectrical impedance analysis, DEXA
Diode array spectrophotometer
Dental research methodology: Dental exam facility, Periotron 8000
DPC Immulite
ELISA plate reader and washer
Gas liquid chromatograph
High-pressure liquid chromatography
Nutrition research methodology: Nutrient analysis of various dietary intake
records with appropriate nutrient databases; anthropometric evaluation with
research quality tools; production of test formulas, constant nutrients,
and weighed research meals
Perkin Elmer 1470 Wizard Gamma Counter
Perkin Elmer atomic absorption spectrophotometer (double beam)
Thin-layer chromatography capabilities
Bone and Mineral Metabolism: Use of new therapies in treating
elderly osteoporosis.
Cardiology: MRI as a diagnostic tool; angiogenesis treatments in
ischemic myocardium; role of soy in coronary artery disease.
Endocrinology: Leptin physiology in obesity and
neuroendocrine/leptin interactions; HIV lipodystrophy; role
of omentectomy in treating obesity and resulting endocrine
changes; relaxation response in acute stress.
Gastroenterology: Molecular etiology of and therapy for chronic
pancreatitis; therapy for C. difficile colitis.
Gerontology: Mechanisms involved in syncope, falls, and
cerebral vasoregulation.
Infectious Diseases: Treatment of AIDS, HIV infection; AIDS Clinical
Trials Group; Phase I studies of AIDS-related Kaposi's sarcoma.
Nephrology: Islet cell transplantation in type 1 diabetes
subjects.
Neurology: Neural plasticity in learning Braille; sleep deficit
and immune function; mechanisms of orthostatic intolerance; genetics
of epilepsy in epilepsy and cognitive disorders; cognitive and
motor function in Parkinson's disease; prefrontal function in working
memory; transcranial magnetic stimulation.
Oncology: Use of biologic agents in the treatment of
advanced malignancy.
Psychiatry: Serotonin metabolism in eating disorders; psychobiology
in eating disorders; cognitive function, mentation, and sleep.
Pulmonary Physiology: Pathophysiology and treatment of sleep apnea
syndrome; sympathetic nervous system and sleep apnea; etiology
of sarcoidosis.
Rheumatology: Immune modulation in therapy of rheumatoid arthritis;
role of exercise in fibromyalgia; role of preoperative exercise in hip
and knee arthroplasty.
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General Clinical Research Center Satellite
The Forsyth Institute
140 The Fenway
Boston, MA 02215
URL: www.forsyth.org
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For information
about this satelite and how to access its resources, please
contact:
Administrative Manager
Elizabeth Regan, M.Sc.
617-262-5200, x456; Fax: 617-262-4021
E-mail: eregan@forsyth.org
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Associate Program Director
J. Max Goodson, D.D.S., Ph.D.
617-262-5200, x 266; Fax: 617-262-4021
E-mail: mgoodson@forsyth.org
Assistant Program Director
Philip Stashenko, D.M.D., Ph.D.
617-262-5200, x386; Fax: 617-262-4021
E-mail: pstashenko@forsyth.org
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Biostatistician
Ralph L. Kent Jr., Sc.D.
617-262-5200, x 291; Fax: 617-262-4021
E-mail: rkent@forsyth.org
Dental Clinic Manager
Marie Letteri, C.D.A., E.M.T.
617-262-5200, x 242; Fax: 617-262-4021
E-mail: mletteri@forsyth.org
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The Forsyth Institute is the world's oldest and largest independent
oral health research institution. Forsyth's clinical research program
focuses on identifying the underlying causes of oral disease and better
methods for effective treatment and prevention.
Microbial Genomics: Sequencing of periodontal pathogens.
Oral Microbiology: Biofilm development and ecology; species
identification; checkerboard DNA-DNA hybridization; oral cancer.
Periodontal Disease Therapy: Local antimicrobial delivery; supra
and subgingival plaque control; effects of combination therapies in smokers;
refractory disease condition.
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General Clinical Research Center Satellite
Joslin Diabetes Center
One Joslin Place
Boston, MA 02215
URL: www.joslin.org
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For information
about this satellite and how to access its resources, please
contact:
Daniel Soroko
617-735-1908; Fax: 617-732-2572
E-mail: dan.soroko@joslin.harvard.edu
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Assistant Program Director
Edward S. Horton, M.D.
617-732-2428; Fax: 617-732-2572
E-mail: edward.horton@joslin.harvard.edu
Nurse Manage and Research Subject Safety Officer
Joan Braley, R.N., M.S.M.
617-264-2749; Fax: 617-732-2572
E-mail: joan.braley@joslin.harvard.edu
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Nutrition Research Manager
Sharon Jackson, M.S., R.D., C.D.E.
617-264-2708 Fax: 617-732-2572
E-mail: sharon.jackson@joslin.harvard.edu
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Joslin Diabetes Center is one of the leading centers in diabetes
education, treatment, and research. Clinical research done at
the Joslin Diabetes Center focuses on diabetes mellitus and related
metabolic disorders. The Joslin satellite also plays a significant
role in training research fellows in endocrinology, diabetes,
and metabolism.
Section on Behavioral and Mental Health: Studies associated
with the epidemiology of diabetes and its complications, depression
and brain structure in type 1 diabetes, and cognitive therapy in
patients with type 1 and type 2 diabetes.
Section on Cellular and Molecular Physiology: Studies associated
with the genetics of diabetes, insulin action in humans, the role of
estrogen in vascular function in insulin-resistant women, the effects
of salicylate on glucose metabolism in insulin-resistant states, and
the role of insulin in the regulation of insulin secretion in B cells
and studies of the physiologic and molecular determinants of diabetes.
Section on Clinical Research: The Diabetes Prevention Program
Outcomes Study (DPPOS) continues to follow volunteers with impaired
glucose tolerance, including those who have converted to type 2
diabetes, to determine the impact of intervention strategies on the
development of cardiovascular disease and other long-term complications
of diabetes. The Look AHEAD Trial is actively recruiting patients with
established type 2 diabetes and randomizing them into an intensive
lifestyle program focusing on weight reduction and increased physical
activity or diabetes support and education group to determine the
effects of lifestyle modification on cardiovascular event rates and
other long-term complications of diabetes. In addition to these large
NIH-funded multicenter trials, this section is also studying the
effects of the angiotensin-converting enzyme inhibitor, quinipril,
on vascular reactivity and endothelial function in patients with
impaired glucose tolerance and type 2 diabetes with or without
microalbuminuria. Also being conducted is a double-blind, randomized,
placebo-controlled study of the effect of pioglitazone on vascular
reactivity and endothelial function and on pancreatic beta cell function
in patients with impaired glucose tolerance or established type 2
diabetes mellitus. Other studies are looking at the effects of weight
loss on vascular reactivity, endothelial function and circulating markers
of inflammation as well as visceral fat reduction by omentectomy as a
potential treatment for obesity-related type 2 diabetes.
Section on Immunology and Immunogenetics: Studies associated with
the Diabetes Prevention Trial for type 1 patients include studies of
the genetic determinants of pathogenesis of autoimmune disease and studies
of insulin receptor positive and autoantigen reactive T cells in
human type 1 diabetes.
Section on Pediatrics: Studies associated with the metabolic
and immunogenetic evaluation of relatives of patients with type 1
diabetes expressing "biochemical" anti-islet antibodies.
Section on Vascular Complications of Diabetes: Studies associated
with the relationship between insulin resistance and vascular function
in Chinese Americans.
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General Clinical Research Center Admin. Office
Boston University School of Medicine
715 Albany Street, M-1016
Boston, MA 02118
Research Unit, Boston Medical Center
88 East Newton, Evans 8, Boston, MA 02118
Grant No. M01 RR00533
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Janice Kopp, M.S., M.B.A.
617-638-4542; Fax: 617-638-8883
E-mail: jkopp@bu.edu
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Program Director
Michael F. Holick, Ph.D., M.D.
617-638-4545; Fax: 617-638-8882
E-mail: mfholick@bu.edu
Principal Investigator
Aram Chobanian, M.D.
617-638-5300; Fax: 617-638-5258
E-mail: achob@bu.edu
Associate Program Director, Pediatrics
Elizabeth Brown, M.D.
617-414-5461; Fax: 617-414-7297
E-mail: elizabeth.brown@bmc.edu
Associate Program Director, Biostatistics
Theodore Colton, Ph.D.
617-638-5174; Fax: 617-638-4458
E-mail: tcolton@bu.edu
Associate Program Director, Sleep Medicine
Daniel Gottlieb, M.D., M.P.H.
617-638-8693; Fax: 617-638-5298
E-mail: dgottlieb@lung.bumc.bu.edu
Associate Program Director, Career Development
Peter Merkel, M.D., M.P.H.
617-638-4312; Fax: 617-638-5226
E-mail: pmerkel@bu.edu
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Associate Program Director, Dental Medicine
Thomas E. Van Dyke, D.D.S., Ph.D.
617-638-4758; Fax: 617-638-4799
E-mail: tvandyke@bu.edu
Research Subject Advocate
Lori Gilmartin, R.N.
617-638-8876; Fax: 617-638-8890
E-mail: logilmar@bu.edu
Nurse Manager
Barbara Nayak, R.N., M.S.N.
617-414-1961; Fax: 617-414-1969
E-mail: barbara.nayak@bmc.org
Core Laboratory Director
Tai Chen, Ph.D.
617-638-4543; Fax: 617-638-8882
E-mail: taichen@bu.edu
Bioinformatics Director
Suzette Levenson, M.P.H.
617-638-5014; Fax: 617-638-5066
E-mail: sml@bu.edu
Nutrition Research Manager
Christine Gebeshian, R.N., M.S.
617-414-1963; Fax: 617-414-1969
E-mail: christine.gebeshian@bmc.org
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Special Assays, Services, or Tests
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Androstenedione
Beta-endorphin
cAMP
Cortisol
DHEA sulfate
Estrogens (estradiol, estrone)
FSH
GH
Human chorionic gonadotropin/LH
Human erythropoietin
Insulin
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8-Isoprostane
Norepinephrine and epinephrine
Osteocalcin
25(OH)D; 1,25(OH)2D
Progesterone
Prolactin
PTH
Testosterone
TSH
Vitamin A, C, D, E
Vitamin D metabolites
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Special Resources,
Instruments, or Services
Echocardiography
Hewlett Packard Series 60 real-time, phased-array imaging
system and accessories for Doppler
Hologic bone densitometer
Indirect caloriometer
Marquette microprocessor-based exercise stress test EKG monitoring systems
Polysomography testing equipment
Videotaping laboratory
Cardiovascular Diseases: Nitric oxide and the black vascular
diathesis; cardiac amyloidosis; identification of subgroups with
hypertension; oxidative stress and heart failure; glucose-insulin-potassium
in coronary artery bypass graft; risk factors such as tobacco and buproprion;
bypass angioplasty revascularization.
Child Development: Cocaine exposure in utero; secure environments;
infant feeding behavior; neonatal hyper-algesia; autism.
Dentistry: Oral health in veterans; periodontitis; cigar smoking and
periodontitis; cardiac events and periodontal prevention.
Endocrinology: Vitamin D3 and its
analogues in psoriasis and in cancer; osteoporosis and HIV;
multinodular goiter, diabetes.
Geriatrics: Lecithin in Alzheimer's disease; outreach programs
for the elderly; low muscle power and function in the elderly;
pathways of stress on health decline in aged caregivers.
Infectious Diseases: Pharmacokinetic and new drug studies in
adults with HIV; Lyme disease.
Men's Health: Violent injury in young black men; bone density
in aging men of race and diversity.
Pediatrics: Pharmacokinetic studies in HIV-infected children;
Williams syndrome; beta thalassemia.
Pulmonary Disease: Sleep apnea in children and people with
congestive heart failure; snoring; IL-16 in asthma; exercise endurance
in chronic obstructive pulmonary disease.
Rheumatology: Therapy for systemic lupus and scleroderma; amyloidosis;
Wegener's granulomatosis; osteoarthritis; vasculitis.
Substance Abuse: Coordination of treatment and primary care;
drug interactions in alcohol-dependent adults; treatment of cocaine
dependence; evaluation of bipolar disease.
Women's Health: Breast cancer and exercise; assessment of
estradiol-glucoside levels.
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General Clinical Research Center, Tower 9A
Brigham and Women's Hospital
75 Francis Street
Boston, MA 02115
Grant No. M01 RR02635
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Chris O'Byrne
617-732-7793; Fax: 617-732-7900
E-mail: cobyrne@partners.org
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Program Director
Gordon H. Williams, M.D.
617-732-5661; Fax: 617-732-5764
E-mail: gwilliams@partners.org
Principal Investigator
Victor Dzau, M.D.
617-732-6340; Fax: 617-732-6439
E-mail: vdzau@partners.org
Associate Program Director
Daniel Kuritzkes, M.D.
617-768-8371; Fax: 617-732-5764
E-mail: rgdluhy@bics.bwh.harvard.edu
Associate Program Director
Ann Stark, M.D.
617-732-7793; Fax: 617-732-5764
E-mail: astark@partners.org
Associate Program Director
Ellen W. Seely, M.D.
617-732-5661; Fax: 617-732-5764
E-mail: eseely@partners.org
Research Subject Advocate
Peter Stone, M.D.
617-732-5692; Fax: 617-732-7134
E-mail: pstone@partners.edu
Nurse Manager
Sheila M. Driscoll, M.S., R.N.
617-732-7764; Fax: 617-732-7900
E-mail: sdriscoll1@partners.org
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Core Laboratory Director
Vincent Ricchiuti, Ph.D.
617-732-5661; Fax: 617-732-5764
E-mail: vricchiuti@rics.bwh.harvard.edu
Ultrasound Core Laboratory Director
Marie Gerhard-Herman, M.D., M.M.Sc.
617-732-6632; Fax: 617-277-4782
E-mail: mgerhard@partners.org
Biostatistician
Shelly Hurwitz, Ph.D.
617-732-6467; Fax: 617-732-5764
E-mail: shurwitz@hms.harvard.edu
Informatics Core Director
Joseph Ronda, M.S.
617-732-6864; Fax: 617-732-5764
E-mail: jronda@partners.org
Bionutrition Manager
Janis Swain, M.S., R.D.
617-732-7783; Fax: 617-732-7900
E-mail: jswain@partners.org
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Special Assays, Services, or Tests
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Adrenocorticotropin
Aldosterone; aldosterone excretion rate
Angiotensin II immunoradiometric assay
Atrial natriuretic peptide
Calcium, ionized
Catecholamines: Norepinephrine, epinephrine, dopamine
Cortisol–plasma, saliva, urine
Creatinine
11-Deoxycortisol
Estradiol
Follicle-stimulating hormone
Free cortisol–urine
Glucose
Growth hormone
Insulin
Luteinizing hormone
Melatonin–plasma, saliva, urine
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Metanephrines, total
N-telopeptides
Na/Li countertransport
17-OH progesterone
1,25(OH)2 vitamin D; 25(OH) vitamin D
Parathyroid hormone (intact)
Potassium
Progesterone
Prolactin
Renin activity, renin profile (total renin, active renin, prorenin)
Sodium
Testosterone
Thyroid hormone binding ratio; thyroid peroxidase
antibodies; thyrotropin; total T3; total
T4
Vanillylmandelic acid
Vasopressin
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Special Resources, Instruments, or Services
DNA processing
Group dining facilities for outpatients and controlled
studies
Intensive physiological monitoring unit
Noninvasive cardiovascular ultrasound
Outpatient research kitchen
Cardiovascular Diseases: Deep vein thrombosis; percutaneous
transluminal coronary angioplasty and atherectomy; hypertension;
endothelial function; congestive heart failure; coronary laser
angioplasty; improving hormone profile during heart failure;
noninvasive measures of vascular function.
Circadian Physiology and Sleep Disorders: Insomnia and disruptive
sleep in the elderly; circadian rhythms in blind persons; circadian phase
estimation after scheduled and unscheduled routine; circadian rhythms in
shift rotation; homeostasis and circadian regulation of wakefulness during
jet lag; melatonin as a hypnotic; effect of bright light in men versus women;
effect of disruptive sleep on hormonal and renal responses to posture.
Endocrinology: Thyroid hormone secretion and
metabolism; hormones in hypertension; angiotensin;
parathyroid function; osteoporosis; racial differences in
metabolism; bone metabolism.
Genetic Diseases: Genetics of hypertension; genetic
epidemiology of early onset chronic obstructive pulmonary
disease; glucocorticoid-suppressible hyperaldosteronism;
risk intervention in sibling pairs; genetic predisposition
in hypertension and diabetic nephropathy; oral glucose
tolerance in aniridia; genetics of polycystic ovary
syndrome (PCOS).
Geriatrics and Gerontology: Improving geriatric urge
incontinence; cardiovascular and volume research in aging.
Hematology and Oncology: Bone marrow transplant;
ovarian failure in breast cancer patients.
Infectious Diseases: AIDS; chronic fatigue syndrome;
regulation of hormonal function in fibromyalgia; endotoxin,
immunoneuroendocrine response to tetanus toxoid.
Metabolism: Diabetes mellitus; hyperinsulinemia and
protein metabolism; hemodynamics and insulin-dependent
diabetes mellitus; vascular function in diabetes; vanadate
action in diabetes mellitus; lipoprotein and free fatty
acid in insulin-dependent diabetes mellitus; insulin
resistance; hypertension and diabetes.
Nephrology: Renal responses to angiotensin II;
racial influences on the development of renal disease.
Neurology: Linomide in multiple sclerosis; MRI
studies in multiple sclerosis; therapeutic treatment of
multiple sclerosis; oral toleration to myelin antigen in
multiple sclerosis; Parkinson's disease; Huntington's
disease; epilepsy.
Nutrition: Glycemic index and weight loss, diabetes, and
human physiology; effect of dietary patterns on blood pressure and
lipids; circadian physiology; dietary treatment in Crohn's disease;
endothelial function in renal disease; cocoa and polyphenols in
renal function.
Obstetrics: Cellular immunity in recurrent miscarriage;
insulin resistance and pregnancy-induced hypertension; sodium
regulation and hypertensive complications of pregnancy; preeclampsia;
HIV immunoglobulin for prevention of maternal-fetal HIV transmission
in pregnant women.
Psychiatry: Seasonal affective light treatment;
phototherapy.
Pulmonary Medicine: Aspirin-sensitive asthma;
chronic obstructive pulmonary disease; respiratory control
during extended wakefulness; glucocorticoid-induced
osteopenia in pulmonary patients.
Space Medicine: Neurobehavioral hormonal and
physiological adaptation to microgravity.
Women's Health: Preservation of gonadal function in
bone marrow transplant; mechanisms by which estrogen and
bone disorders affect bone mass; genetics of PCOS; premature
ovarian failure in breast cancer patients; estrogen and
vascular function in women; prevention of bone loss during
early menopause; treatment of postmenopausal women.
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General Clinical Research Center
The Children's Hospital, 7 East
300 Longwood Avenue
Boston, MA 02115
Grant No. M01 RR02172
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Kristine S. Jordan
617-355-7541; Fax: 617-730-0585
E-mail: kristine.jordan@tch.harvard.edu
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Program Director
Richard Grand, M.D.
617-355-2962; Fax: 617-730-0494
E-mail: richard.grand@tch.harvard.edu
Principal Investigator
James Mandell, M.D.
617-355-8555; Fax: 617-730-0630
E-mail: james.mandell@tch.harvard.edu
Associate Program Director
Mary Ellen Wohl, M.D.
617-355-6105; Fax: 617-730-0084
E-mail: maryellen.wohl@tch.harvard.edu
Associate Program Director
Stavroula Osganian, M.D., M.P.H., Sc.D.
617-355-2463; Fax: 617-355-2312
E-mail: stavroula.osganian@tch.harvard.edu
Associate Program Director
David Ludwig, M.D., Ph.D.
617-355-4878; Fax: 617-7730-0183
E-mail: david.ludwig@tch.harvard.edu
Research Subject Advocate
Walter Robinson, M.D., M.P.H.
617-432-3712; Fax: 617-730-1585
E-mail:
walter_robinson@hms.harvard.edu
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Informatics Manager
Joseph Rezuke, B.S.
617-355-7004; Fax: 617-355-2312
E-mail:
joseph.rezuke@tch.harvard.edu
Nurse Manager
Margaret McCabe, R.N., P.N.P., D.N.Sc.
617-355-7545; Fax: 617-730-0585
E-mail:
margaret.mccabe@tch.harvard.edu
Core Laboratory Director
Joseph Majzoub, M.D.
617-355-6421; Fax: 617-730-0244
E-mail: joseph.majzoub@tch.harvard.edu
Core Laboratory Associate Director
Rodica L. Emanuel, Ph.D.
617-355-4016; Fax: 617-730-0244
E-mail: rodica.emanuel@tch.harvard.edu
Biostatistician
David Wypij, Ph.D.
617-355-2641; Fax: 617-730-1585
E-mail:
david.wypij@tch.harvard.edu
Research Dietician
Christine Clark, M.S., R.D., L.D.N.
617-355-6423; Fax: 617-730-1585
E-mail:
christine.clark@tch.harvard.edu
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Special Assays, Services, or Tests
Analysis for genetic disorders: PCR and DNA sequence
analysis
ELISAs: E-selectin, L-selectin, P-selectin, vascular cell
adhesion molecule, intracellular adhesion molecule, IL-1ra,
IL-1 beta, IL-2, IL-6, IL-12, fibroblast growth factor,
vascular endothelial growth factor, tumor necrosis
factor-alpha, tumor necrosis factor-alpha RI,
interferon-gamma
Radioimmunoassays for metabolic disorders:
corticotropin-releasing hormone, leptin
Special Resources, Instruments, or Services
DEXA, indirect calorimetry, bioelectric impedance analysis
(BIA), anthropometry
Fully equipped sleep-study facility with lux spectrum
lighting, adjacent observation rooms, and the ability to
monitor patients in neighboring neonatal intensive care
unit.
AIDS: AIDS Clinical Trials Group studies; new
treatment regimens for children with HIV infection.
Cardiology: Central nervous system sequelae of
intraoperative perfusion techniques in infant cardiac
surgery; evaluation of Fontan pathway hemodynamics; growth
hormone for pediatric cardiac myopathy.
Endocrinology: Glycogen storage disease; obesity
studies; DHEA for bone loss in cystic fibrosis and anorexia nervosa;
dietary glycemic index and diabetes.
Gastroenterology: Nutritional failure in childhood
HIV; treatment of steroid-refractory Crohn's disease;
treatment of severe colitis; arginine metabolism in cystic
fibrosis; treatment of pouchitis with clotrimazole; genetics of
inflammatory bowel disease.
Genetic Diseases: Pregnancy outcomes of phenylketonuria (PKU)
patients; Smith-Lemli-Opitz syndrome.
Hematology and Oncology: Clinical studies in bone marrow
failure syndromes; clinical studies in thalassemia; studies of
novel iron chelating agents in patients with transfusional iron
overload; immunologic, genetic, and treatment studies in
hemophilia; treatment of vascular malformations and defects
in angiogenesis; sickle cell anemia.
Immunology and Rheumatology: Hereditary angioedema;
studies on the cellular basis of immune defects in patients
with antibody deficiency; primary immune deficiency studies.
Infectious Diseases: Women and infants HIV
transmission study; HIV treatment studies.
Metabolism: Maternal phenylketonuria;
dichloroacetate for mitochondrial disease; incidentally
found hypoglycemia; amino acid requirements in critically
ill patients; glutathione metabolism in children; growth
hormone effect in children with short bowel syndrome.
Neonatology: Energy expenditure in premature
neonates.
Nephrology: Induction therapy in renal
transplantation; safety of oral Sirolimus in children
undergoing hemodialysis.
Neurology: Developmental follow-up of premature infants.
Pulmonary Diseases: Gene therapy for cystic fibrosis; airway
inflammation in cystic fibrosis.
Surgery: Marimastat for vascular anomalies; genetics of congenital
diaphragmatic hernia.
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Mallinckrodt General Clinical Research Center
55 Fruit Street, White 13
Boston, MA 02114-2696
URL: www.mgh.harvard.edu/GCRC
Grant No. M01 RR01066
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Edwin Andrews, B.A., M.P.A.
617-726-6885; Fax: 617-724-3299
E-mail:
ebandrews@partners.org
Administrative Coordinator
Faith Fortune
617-726-6886; Fax: 617-724-3299
E-mail:
ffortune@partners.org |
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Program Director
David M. Nathan, M.D.
617-726-2875; Fax: 617-726-6781
E-mail: dnathan@partners.org
Principal Investigator
Peter L. Slavin, M.D.
617-724-9300; Fax: 617-724-3377
E-mail: pslavin@partners.org
Associate Program Director
Anne Klibanski, M.D.
617-726-3870; Fax: 617-726-5072
E-mail: aklibanski@partners.org
Research Subject Advocate
Laurence Katznelson, M.D.
617-726-3870
E-mail: lkatznelson1@partners.org
Nurse Manager
Bonnell Glass, R.N.
617-726-3295; Fax: 617-726-7563
E-mail: bglass@partners.org
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Core Laboratory Director
Enrico Cagliero, M.D.
617-724-7702; Fax: 617-726-1871
E-mail: ecagliero@partners.org
Nutrition Research Manager
Ellen J. Anderson, M.S., R.D.
617-724-2830; Fax: 617-726-7563
E-mail: eanderson1@partners.org
Biostatistics Director
David Schoenfeld, Ph.D.
617-726-6111; Fax: 617-724-9878
E-mail: dschoenfeld@partners.org
Computer Systems Manager
Melissa J. Cacace, B.A.
617-726-5320; Fax: 617-724-3299
E-mail: mcacace@partners.org
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Special Assays, Services, or Tests
Bone-specific alkaline phosphatase
Deoxypyridinoline
Frequent blood sampling for physiologic studies
Growth hormone
Insulin
N-telopeptide
Osteocalcin Special Resources, Instruments, or
Services
Controlled airflow isolation room for immunosuppressed and
transplant patients
Graduate nursing student clinical research fellowship
program
Nutrition services: Nutrient analysis of dietary intake;
computerized diet planning for weighed diets; bioelectrical
impedance analysis; anthropometry assessment; indirect
calorimetry; behavior modification for nutrition
intervention; DEXA for measurement of bone density and body
composition
Premedical and medical student fellowship program
Aging: Evaluation of physiology of aging, including
cardiovascular and metabolic changes in the very
elderly.
Anesthesiology: Innovative therapy of pain syndromes.
Diabetes: Innovative treatments with external and
implantable programmable insulin-infusion pumps and islet
transplantation, role of glycemic control in pathogenesis
of long-term complications; role of endogenous
insulinotropic hormones in pathogenesis and treatment of
type 2 diabetes mellitus; prevention of diabetes;
amelioration of cardiovascular risk factors in diabetes.
Endocrinology: Parathyroid hormone physiological
effects; hyperparathyroidism; thyroid-stimulating hormone
secretion and metabolism; vitamin D metabolism;
hypothalamic-pituitary axis in children; physiological
effects of hyperthyroidism and hypothyroidism; diagnostic
use of serum prolactin and somatomedin assays;
pathophysiology and treatment of osteoporosis and other
metabolic bone diseases.
Gastroenterology: Development and implementation of
treatments of hepatitis B and C; novel treatments of
inflammatory bowel disease.
Genetic Diseases: Treatment of Gaucher's disease
with enzyme replacement; gene therapy of cystic fibrosis.
Infectious Diseases: AIDS Clinical Trials Group
protocols; vaccine studies for typhoid, Listeria.
Neuroendocrinology: Hypogonadism and osteoporosis;
pathogenesis and regulation of ACTH-producing pituitary
adenomas; octreotide therapy of clinically nonfunctioning
pituitary adenomas; long-term effects of growth hormone in
adults with GH deficiency; AIDS wasting syndrome.
Neurology: Investigation of new drugs for
Parkinson's disease, Alzheimer's disease, amyotrophic
lateral sclerosis, and progressive supranuclear palsy.
Neuropsychiatry: Neuroendocrine effects of
antipsychotic drugs; depression and Cushing's disease;
neuroendocrine mechanisms in anxiety; mechanisms of and
treatments for addictive disorders; functional NMR studies
of addiction.
Oncology: Treatment of metastatic adenocarcinoma
with chimeric antibody and ovarian cancer with mullerian
inhibitory factor.
Pediatrics: Treatment of precocious puberty with
gonadotropin-releasing hormone analog; pubertal changes in
bone mass, and treatment of diabetes in children.
Psychiatry: Pharmacologic treatment of
obsessive-compulsive disorder; biochemical changes in
cerebrospinal fluid in tardive dyskinesia and in addictive
states; pharmacokinetics of psychotropic drugs.
Reproductive Endocrinology and Gynecology:
Exercise-induced reproductive disturbances; physiology of
gonadotropin release in normal women and patients with
reproductive disorders; treatment of idiopathic
hypogonadotropic hypogonadism; interaction of androgen,
estrogen, and insulin in women with polycystic ovary
syndrome and in women with insulin resistance.
Rheumatology: Novel therapies for rheumatoid
arthritis and other inflammatory joint diseases.
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General Clinical Research Center Satellite
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, MA 02139-4307
Grant No. M01 RR01066
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For information
about this satellite and how to access its resources, please
contact:
Administrative Manager
Susan D. Dalton, M.B.A.
617-258-6430; Fax: 617-258-5026
E-mail: sdalton@mit.edu
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Associate Program Director
Richard J. Wurtman, M.D.
617-253-6732; Fax: 617-253-6882
E-mail: dick@mit.edu
Assistant Program Director
Lee Schwamm, M.D.
617-724-1597; Fax: 617-724-6834
E-mail: braindoc@mit.edu
Assistant Program Director
Steven Grinspoon, M.D.
617-726-3890; Fax: 617-726-5072
E-mail: sgrinspoon@partners.org
Assistant Program Director
Roger Pitman, M.D.
617-726-5333; Fax: 617-262-7492
E-mail: pitman@psych.mgh.harvard.edu
Assistant Program Director
Ravi Thadhani, M.D.
617-724-1207; Fax: 617-726-2340
E-mail: rthadhani@partners.org
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Research Subject Advocate Director
Laurence Katznelson, M.D.
617-726-0541; Fax: 617-726-7563
E-mail: lkatznelson1@partners.org
Research Subject Advocate Associate Director
Joyce A. Saturley, R.N., M.S.
617-726-0541; Fax: 617-726-7563
E-mail: jsaturley@partners.org
Nurse Manager
Marguerite Parkman, B.S.
617-253-6332; Fax: 617-452-3054
E-mail: mparkman@mit.edu
Bionutrition Manager
Rita Tsay, M.S.
617-253-6337; Fax: 617-452-3054
E-mail: rtsay@mit.edu
Informatics Manager
Ann Kusch, B.S.
617-253-6560; Fax: 617-258-5026
E-mail: akusch@mit.edu
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Special Assays, Services, or Tests
Assays for melatonin; amino acids (including tryptophan)
Dual-energy X-ray absorptiometry (DEXA) for bone density
and body composition measurements
Facilities for quantifying intake of calories, proteins,
carbohydrates, and fats from meals and snacks by inpatients
and outpatients
Indirect calorimetry
Isotope ratio and GC/MS
Metabolic studies with stable isotopes, using mass
spectroscopy and neutron activation
Psychiatric and behavioral testing
Clinical Neuropharmacology: Behavioral effects of
neurotransmitter precursors (tryptophan, tyrosine,
lecithin), foods (carbohydrates, proteins); effects of
experimental drugs in memory disorders; clinical
pharmacology of seasonal depression and of premenstrual
syndrome; effects of drugs (e.g., citicoline, uridine) on memory in
aged and memory-impaired individuals; effects of
serotoninergic drugs in depression and weight gain.
Endocrinology: Metabolic alterations in women with prior
complications of pregnancy.
Geriatrics and Gerontology: Nutrient preferences of
the elderly; behavioral effects of nutrients in the
elderly; protein and energy metabolism.
Investigator-Initiated Programs: The program in nutrition and
metabolism investigates relationships among nutrition, body composition,
and hormonal function; the program in women's health studies
psychological aspects of premenstrual syndrome (PMS) and menopause;
the program in applied technology and communications in health care
seeks to develop new avenues for health care delivery through
strategic applications of novel technologies such as telerehabilitation
in stroke patients.
Neuroendocrinology: : Lipodystrophy syndrome in HIV-infected
individuals; effects of anorexia nervosa on development of peak bone
mass during pubertal development, effects on the growth hormone and
reproductive endocrine axes.
Neurology: Functional neuroimaging and biochemical
markers of acute stroke; cognitive impairment of acute stroke.
Neuropsychology: Effects of brain injury; effect of
dietary precursors of neurotransmitters on memory loss in
Alzheimer's disease; application of information technology in health care.
Nutrition: Protein and amino acid requirements of
humans; starvation and refeeding; protein-wasting states;
effects of infection on protein metabolism; treatment of
obesity; nutritional requirements in the elderly; protein
tolerance; protein-sparing diets; effects of exercise;
protein and glucose turnover in various nutritional states
and at various ages; new protein sources; energy
metabolism; factors influencing plasma branched-chain amino
acid levels in obesity; phenylalanine metabolism in
subjects on phenylalanine-rich diets; relationship among nutrition,
body composition, and hormonal function.
Obesity: Characterization of abnormal patterns of
nutrient intake (e.g., carbohydrate snacking) and of
responses to drugs; characterization of O2
consumption and CO2 production by ambulatory
subjects after particular foods or drugs; obesity in
adolescents.
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General Clinical Research Center
Tufts-New England Medical Center
750 Washington Street, Tufts-NEMC #831
Boston, MA 02111
URL: www.tufts-nemc.org/gcrc/
Grant No. M01 RR00054
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Directory
Lynda Burstein, M.S.W., L.C.S.W.
617-636-5973; Fax: 617-636-8397
E-mail: lburstein@tufts-nemc.org
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Program Director
Patricia L. Hibberd, M.D., Ph.D.
617-636-2215; Fax: 617-636-5506
E-mail: phibberd@tufts-nemc.org
Principal Investigator
Harry P. Selker, M.D.
617-636-5009; Fax: 617-636-8023
E-mail: hselker@tufts-nemc.org
Associate Program Director
David J. Greenblatt, M.D.
617-636-6997; Fax: 617-636-6738
E-mail: dj.greenblatt@tufts.edu
Associate Program Director
Cynthia H. Cole, M.D., M.P.H.
617-636-5322; Fax: 617-363-1456
E-mail: ccole@tufts-nemc.org
Research Subject Advocate
Deborah R. Zucker, M.D., Ph.D.
617-636-7235; Fax: 617-636-8023
E-mail:
dzucker@tufts-nemc.org
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Research Subject Advocate
Kathryn E. Lasch, Ph.D.
617-636-4589; Fax: 617-636-8351
E-mal:
klasch@tufts-nemc.org
Nurse Manager
Catherine Brown, R.N., M.S.N.
617-636-6148; Fax: 617-636-8397
E-mail: cbrown3@tufts-nemc.org
Core Laboratory Director
Roland R. Stewart, M.S.
617-636-6461; Fax: 617-636-8397
E-mail: rstewart@tufts-nemc.org
Director of Biostatistics
John Griffith, Ph.D.
617-636-4619; Fax: 617-636-5560
E-mail: jgriffith@tufts-nemc.org
Informatics Manager
Anne-Maria Fiorino, B.S.
617-636-2214; Fax: 617-636-5560
E-mail: afiorino@tufts-nemc.org
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Cardiology: Sestamibi for emergency department triage for
suspected cardiac ischemia; emergency department clinical trial
of ECG-based predictive instruments; glucose-insulin-potassium
immediate myocardial metabolic enhancement during initial
assessment and treatment of myocardial ischemia.
Clinical Pharmacology: Effects of ethnicity on
cytochrome P4503A4 using midazolam; effects of cytochrome P4503A4;
effect of medications on cytochrome (CYP3A) activity in HIV
infection.
Endocrinology and Metabolism: Effects of progressive
resistance training on glycemic control in Hispanic elders
with type 2 diabetes; exercise interventions in HIV-infected
adults with fat redistribution; effects of Atorvastatin on
the kinetics of apo B-100 and apo B-48 and on cholesterol
synthesis; lipodystrophy in HIV-seropositive persons;
protease inhibitor-related dyslipidemia; hormonal regulators
of muscle and metabolism in aging.
Gastroenterology: Syncytium-inducing virus: HIV, cytokine and
permeability profiles in HIV-infected intestinal mucosa.
Genetics: First and second trimester evaluation of risk
of aneuploidy
Hematology and Oncology: Epidemiology of multiple endocrine
neoplasia; weekly Taxotere and Herceptin in HER-2 expressing
metastatic breast cancer; escalating doses of Targretin with
DAB389 IL-2 in cutaneous T cell lymphoma, chronic lymphocytic
leukemia + low-grade non-Hodgkin's lymphoma; Depsipeptide in
cutaneous T cell lymphoma and relapsed peripheral T cell
lymphoma; ONTAK (DAB389 IL-2) in T cell lymphoma.
Infectious Diseases: Understanding and improving adherence
to medications in HIV disease; Lactobacillus rhamnosus (LGG) to
eliminate intestinal colonization by vancomycin-resistant enterococcus;
LGG to eliminate nasal colonization by Staphylococcus aureus.
Metabolism: Apolipoprotein metabolism in renal disease;
alterations in body shape; extended-release niacin vs. extended-release
niacin and lovastatin on apolipoprotein kinetics and cholesterol
synthesis; dietary treatment of metabolic syndrome; blood glucose
and appetite in healthy individuals.
Neonatology: Cardiovascular effects of physiologic
hydrocortisone therapy in extremely low birthweight infants;
molecular antecedents of brain damage in premature infants;
actual versus intended pulse oximetry saturation in premature
infants at risk for severe retinopathy of prematurity.
Neurology and Psychiatry: Stroke outcome prediction model;
micronutrients, cerebrovascular disease, and cognitive impairment
in the homebound elderly; contributing factors to low body weight
in Alzheimer's disease; insulin, cognitive impairment, and
Alzheimer's disease; antidepressant adherence in late-life
depression.
Nutrition: Nutrition and HIV; nutritional status in HIV-positive
Hispanic drug abusers; micronutrient metabolism in HIV-positive and
HIV-negative drug users; nutrition intervention in AIDS wasting;
acute weight loss and nutrition assessment in HIV; AIDS-associated
catabolism and weight loss treatment strategies; treatment of
HIV-induced lipodystrophy with diet; timed feeding and resistance
training to prevent muscle atrophy.
Obstetrics Fetal environmental toxicant exposures.
Organ Transplantation: Hypogammaglobulinemia in liver
transplant patients.
Pediatrics: Relationships between resting energy expenditure,
circulating serum cyokines, and severity of illness scores in
critically ill children; noninvasive positive pressure for
children in status asthmaticus.
Pulmonary and Sleep Medicine: Evaluation of patient ventilator
dyssynchrony and sleep fragmentation during weaning from mechanical
ventilation.
Renal Medicine: Kidney disease, volume status, and cognition
in aging; halting progression of polycystic kidney disease.
Rheumatology: Role of vitamin E in the control of symptoms
of rheumatoid arthritis; effect of Tai Chi on rheumatoid arthritis.
Women's Health: Body fat phenotypes, hormones and
breast cancer.
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