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General Clinical Research Center
University of Michigan Medical Center
A7007 UH
1500 East Medical Center Drive
Ann Arbor, MI 48109-0108
URL: www.med.umich.edu/gcrc
Grant No. M01 RR00042
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Violet Elder, M.P.P.
734-936-8078; Fax: 734-936-4024
E-mail: violet@umich.edu
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Program Director
John Wiley, M.D.
734-936-8080; Fax: 734-936-4024
E-mail: jwiley@umich.edu
Principal Investigator
Robert P. Kelch, M.D.
734-647-9351; Fax: 734-647-9739
E-mail: rkelch@umich.edu
Associate Program Director–Adult
David C. Smith, M.D.
734-764-2248; Fax: 734-647-9480
E-mail: dcsmith@umich.edu
Associate Program Director–Pediatrics
Carol M. Foster, M.D.
734-764-5175; Fax: 734-763-4208
E-mail: cmfoster@umich.edu
Associate Program Director–Education and Training
David E. Schteingart, M.D.
734-936-5035; Fax: 734-936-6684
E-mail: dschtein@umich.edu
Biomedical Imaging Core Director
Kirk Frey, M.D., Ph.D.
734-764-4212; Fax: 734-936-8182
E-mail: kfrey@umich.edu
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Human Applications Laboratory Director
Blake Roessler, M.D.
734-647-3413; Fax: 734-763-4151
E-mail: roessler@umich.edu
Research Subject Advocate
Louise Hahn, B.S.N., M.S.A.
734-936-8083
E-mail: lhahn@umich.edu
Nurse Manager
Patricia Powell, R.N.
734-936-8090; Fax: 734-936-4024
E-mail: ppowell@umich.edu
Biostatistician
John Kalbfleisch, Ph.D.
734-615-7067; Fax: 734-615-7068
E-mail: jdkalbfl@umich.edu
Informatics Core Manager
Nazar Eltahir, M.S.
734-936-5376; Fax: 734-936-4024
E-mail: nazar@umich.edu
Bionutrition Research Director
Cewin Chao, M.S.
734-936-8075; Fax: 734-936-4024
E-mail: cewinc@umich.edu
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Special Resources, Instruments, or Services
Biomedical imaging core: State-of-the-art imaging
services and tracer development for PET and MRI research
scanning
EEG monitoring
Human applications laboratory: FDA-compliant facility for
viral vector, cellular-based therapies and vaccine
development
Isolation room, radiation room, sleep study room
Leukapheresis
Allergy, Immunology, and Rheumatology: Systemic
lupus erythematosus; hyperuricemia and gout;
pharmacological studies using cytoxan; dialysis-induced
arthropathy; chronic fatigue syndrome.
Bioengineering: Bioartificial kidney.
Cardiovascular Diseases: Hypertension
pathophysiology and therapy; exercise and diet therapy;
tissue plasminogen activator; atrial natriuretic hormone.
Clinical Pharmacology: Molecular basis for
interindividual differences in response to certain drugs.
Endocrinology:Primary aldosteronism; pheochromocytoma;
obesity; carbohydrate metabolism; diabetes mellitus; multiple
endocrine neoplasia type II; Cushing's disease; neuroendocrinology
(pharmacology, sexual maturation, anorexia nervosa); nutrition and
reproductive function; gastrointestinal hormones; pancreatic tumors;
growth hormone deficiency treatment; regulation of menstrual cycle;
hypothyroidism; acromegaly; treatment with long-acting somatostatin
analogue.
Gastroenterology: Gastrointestinal polypeptide hormones;
visceral sensory pathways; viral hepatitis studies.
Gene Therapy: Use of gene transfer technology to treat cancer,
AIDS, and rheumatology diseases; cell-mediated vaccines and dendritic
cell studies.
Genetic Diseases: Treatment of cystinosis; immune
disorders associated with purine enzyme defects;
deficiencies of hypoxanthine-guanine
phosphoribosyltransferase; glucose-6-phosphatase
deficiency; Wilson's disease.
Hematology: Treatment of sickle cell disease;
monoclonal antibodies for imaging and treatment of
lymphomas.
Hypertension: Low-renin hypertension; regulation of
aldosterone secretion; renin–angiotensin disorders.
Neurology: Management of malignant brain tumors;
pharmacologic studies in epilepsy; management of
parkinsonism; pain control; sleep disorders, sleep apnea.
Nuclear Medicine: Adrenocortical and medullary
imaging agents; myocardial imaging; radiolabeled
microspheres for tumor imaging and therapy.
Nutrition: Effects of various food groups on the
body's ability to defend against cancer.
Oncology: Drug pharmacokinetics and metabolism;
regional chemotherapy; drug delivery systems;
antimetabolites; nucleosides; hepatic and central nervous
system cancers; head and neck cancers; use of monoclonal
antibodies for imaging and treatment; interleukin-2.
Pediatrics: Congenital adrenal hyperplasia; growth
hormone deficiency; growth disorders; delayed puberty;
cardiovascular studies; treatment of nutritional disorders
in newborns; hypoglycemia in infancy; childhood
arrhythmias.
Psychiatry: Neuroendocrinology of depression;
phobias; anxiety, human stress cognitive studies.
Sleep Research: Investigations in many areas of
sleep research are supported as the main focus of the
research or a facet of a disease, process or therapy under
investigation.
Surgery: Changes in body physiology as a result of organ transplantation.
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