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General Clinical Research Center
5-251 Domitilla Building
Mayo Foundation
Saint Mary's Hospital
200 First Street Southwest
Rochester, MN 55905
Grant No. M01 RR00585
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Marcia Andresen-Reid, M.S.
507-255-6122; Fax: 507-255-7445
E-mail: andresen@mayo.edu
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Program Director
K. Sreekumaran Nair, M.D., Ph.D.
507-255-2415; Fax: 507-255-4828
E-mail:
nair@mayo.edu
Principal Investigator
John C. Burnett Jr., M.D.
507-284-4838; Fax: 507-266-4710
E-mail: burnett.john@mayo.edu
Associate Program Director, Saint Mary's Inpatient Unit
Michael Joyner, M.D.
507-255-4288; Fax: 507-255-4288
E-mail: joyner.michael@mayo.edu
Associate Program Director, Charlton Outpatient Unit
Claudia Lucchinetti, M.D.
507-284-4349; Fax: 507-255-7445
E-mail: clucchinetti@mayo.edu
Associate Program Director, Research, Education,
Training
James Levine, M.D.
507-284-7636; Fax: 507-284-9744
E-mail: levine.james@mayo.edu
Associate Program Director, Oncology
Charles Erlichman, M.D.
507-284-3902; Fax: 507-284-1803
E-mail: erlichman.charles@mayo.edu
Research Subject Advocate
Shari K. Brumm, R.N.
507-255-6122; Fax: 507-255-7445
E-mail: brumm.shari@mayo.edu
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Nurse Manager, Saint Mary's GCRC
Jennifer Weis, R.N.
507-255-6122; Fax: 507-255-7445
E-mail: weis.jennifer@mayo.edu
Nurse Manager, Charlton GCRC
Joan Muhs, R.N.
507-266-2302; Fax: 507-266-2490
E-mail: muhs.joan@mayo.edu
Nutrition Research Manager
LaVonne Oenning, R.D.
507-255-2676; Fax: 507-255-7445
E-mail: oenning.lavonne@mayo.edu
Biostatistician
Peter C. O'Brien, Ph.D.
507-284-5573; Fax: 507-284-9542
E-mail: obrien.peter@mayo.edu
Computer Systems Manager
Michael Lin, M.B.A.
507-255-0162; Fax: 507-255-7445
E-mail: Lin.WoonTzuMichael@mayo.edu
Human Genomic, Proteomic, and Metabolic Core Laboratory
Director
Sreekumar Raghavakaimal, Ph.D.
507-255-0898; Fax: 507-255-7445
E-mail: nair@mayo.edu
Integrative Physiology Core Laboratory Director
Michael Joyner, M.D.
507-255-4288; Fax: 507-255-4288
E-mail: joyner.michael@mayo.edu
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Special Assays, Services, or Tests
Human genomic, proteomic, and metabolism core laboratory: GC/MS, GC/IR/MS
instrumentation; assays for stable-isotope-labeled tracers; muscle
protein turnover studies; glucose metabolism studies; energy
expenditure; microarray; DNA isolation; genotyping
Immunoassay and chemistry laboratory: Protein, peptide, and
substrate assays; bioamines; blood gases
Integrated physiology laboratory–body composition: Lunar DPX,
Hologic 4500, underwater tank; renal clearance; exercise studies:
treadmill; cycle ergometer; mass spectrometry; indirect calorimetry;
sleep studies; hemodynamic measurements; ambulatory blood pressure
monitoring; autonomic function: blood flow studies; sudorometry;
lower body negative pressure; gastrointestinal (GI) function and
motility: fluoroscope, gamma camera, endoscopy; GI imaging
Special Resources, Instruments, or Services
Cardiac telemetry monitoring
Lead-lined patient room
Negative airflow isolation rooms
Sleep studies room
Specimen-processing laboratory
Allergy: Asthma, peanut allergy.
Anesthesiology: Respiratory function; pain;
exercise; blood flow; sleep, mechanical ventilation, regulation
of blood flow in smokers.
Cardiology: Arrhythmias, antithrombotic therapy,
cardiomyopathy; coronary artery disease; bypass angioplasty
revascularization; beta-blocker evaluation of survival
study; congestive heart failure; cardiovascular disease
mechanisms in sleep apnea; atherogenesis.
Endocrinology: Epidemiology of diabetes intervention and
complications; diabetes mellitus; epidemiology and molecular
genetics of non-insulin-dependent diabetes mellitus; neuropathy;
bone disease and osteoporosis; hypercalcemia; carbohydrate metabolism;
free-fatty-acid metabolism in different types of obesity;
hyperlipidemia; parathyroid hormone secretion; muscle wasting
in aging; protein metabolism; hyperparathyroidism; exercise
and training effect on muscle metabolism; insulinoma.
Epidemiology: Molecular genetics in a highly
characterized community-based population (Olmsted County).
Gastrointestinal Disorders: Diabetic GI disorders; GI motility;
malabsorption; pancreatic insufficiency; serotonergic control of colon;
posthepatic transplantation; chronic ulcerative colitis; irritable bowel
syndrome; cirrhosis; Barrett's esophagus; Crohn's disease; celiac
disease; gluten-sensitive ataxia; colorectal cancer screening;
satiety testing.
Geriatrics and Gerontology: Muscle wasting;
osteoporosis.
Hematology: Leukemias and lymphomas (pediatric and adult);
hemophilia; dendritic-cell-based vaccines; menorrhagia in women with
bleeding disorders; primary amyloidosis.
Hypertension: Epidemiology and molecular genetics of
hypertension; exercise.
Immunology: Eosinophilia; mastocytosis; vaccine
research.
Infectious Disease: HIV; hepatitis C.
Nephrology: Autosomal dominant polycystic kidney disease;
renal failure and protein metabolism; Fabry's disease and progression
of renal disease; idiopathic membranous glomerulopathy; focal
segmental glomerulosclerosis.
Neurology: Multiple sclerosis; diabetic neuropathy; myasthenic
syndromes; neurogenic orthostatic hypertension; microneurographic
studies of autonomic failures and autonomic neuropathies; spasticity
in incomplete spinal cord injury; Alzheimer's disease; stroke
prevention; Parkinson's disease.
Obstetrics/Gynecology: Polycystic ovary syndrome.
Oncology: Pharmacokinetics; phase I and II studies
of cytotoxic agents (pediatric and adult); metabolic
effects of chemotherapy; melanomas; lymphomas; cancer-associated
anorexia.
Pediatrics: Oncology; vaccines; leukemia, lymphomas,
neuroblastomas; rhabdomyosarcoma; exercise in adolescent
patients with type 1 diabetes; evaluation of recurrent abdominal
pain with the use of novel tests of GI function and motility.
Rheumatology: Giant cell arteritis.
Smoking: Body image for smokers; exercise for depressed smokers;
cardiovascular responses to smoking.
Thoracic Disorders: Sleep apnea; ventilator
dependence.
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General Clinical Research Center
University of Minnesota
MMC 8504
420 Delaware Street, SE
Minneapolis, MN 55455
URL: www.gcrc.umn.edu
Grant No. M01 RR00400
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Joyce Melzer, B.S.
612-624-9159; Fax: 612-626-2456
E-mail: melze001@umn.edu
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Program Director
Elizabeth R. Seaquist, M.D.
612-626-4833; Fax: 612-626-3133
E-mail: seaqu001@umn.edu
Principal Investigator
Charles Moldow, M.D.
612-625-9626; Fax: 612-626-1900
E-mail: moldo002@umn.edu
Associate Program Director
John Bantle, M.D.
612-626-0462; Fax: 612-626-2456
E-mail: bantl001@umn.edu
Associate Program Director
Kelvin O. Lim, M.D.
612-273-9765; Fax: 612-273-9779
E-mail: kolim@umn.edu
Associate Program Director
Jeffrey S. Miller, M.D.
612-625-7409; Fax: 612-626-4915
E-mail: mille001@umn.edu
Research Subject Advocate
Michele Watrin, B.A.
612-624-2621; Fax: 612-624-4491
E-mail: watri001@umn.edu
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Nurse Manager
Nancy Flemmons, M.S.N., R.N.
612-624-4628; Fax: 612-626-2456
E-mail: flemm006@umn.edu
Bionutritionist
Susan K. Raatz, Ph.D.
612-624-6642; Fax: 612-626-2456
E-mail: raatz@mail.ahc.umn.edu
Biostatistician
J. William Thomas, Ph.D.
612-625-0651; Fax: 612-626-0660
E-mail: will@muskie.biostat.umn.edu
Laboratory Director
Timothy Walseth, Ph.D.
612-625-2627; Fax: 612-625-8408
E-mail: walseth@mail.ahc.umn.edu
Computer Systems Manager
Matt Beecher, B.S.
612-625-6409; Fax: 612-626-2456
E-mail: beecher@umn.edu
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Special Assays, Services, or Tests
Biomedical Imaging Core
Body composition lab: DEXA, indirect calorimetry,
anthropometric measures
Child and infant development core lab: Event-related potential,
autonomic nervous system, neuropsychological batteries; consultation
for selection of assessments for neurodevelopment
Developmental cell therapy core lab: Production of therapeutic cell
products for immune-based therapies, laboratory analyses on clinical
cell products for quality control and to analyze patient samples to
evaluate the impact of novel experimental therapies
GC/MS core lab: Analysis of stable isotope enrichment in
plasma and urine samples
Magnetic resonance core lab: Magnetic resonance
spectroscopy and imaging
Metabolic kitchen: Preparation and service of controlled
research diets
Molecular genetics core lab: DNA extraction and storage,
lymphocyte isolation and lymphoblastoid cell line production,
genetic mapping using short tandem repeat polymorphism (STRP)
markers, DNA sequencing and DNA polymorphism detection;
consultation for study design, sample selection, and database
analysis
Allergy: Molecular genetics of asthma.
Cardiovascular Diseases: Lytic therapy of deep venous thrombosis;
adolescent risk factors.
Genetic Diseases: Core laboratory determinations of
RFLPs in immunogenetics of families with both
insulin-dependent diabetes and non-insulin-dependent
diabetes; diabetic neuropathy; molecular screening of
distal X and Y chromosomes in children with familial and/or
idiopathic short stature; epidemiology of chronic/recurrent
otitis media.
Infectious Diseases: HIV infection.
Metabolic Disorders: Islet transplantation, intensive
treatment of type 1 diabetes; dietary treatment of diabetes;
cystic fibrosis and diabetes complications; effect of recurrent
hypoglycemia on cerebral glucose metabolism; action to control
cardiovascular risk in diabetes; renal and cellular studies in
type 1 diabetic patients.
Nephrology: Structural-functional relationships in
diabetic nephropathy; chronic allograft nephropathy.
Neurodevelopment: Effect of nutrition and stress on brain
development and behavior.
NMR Studies: Nuclear magnetic resonance studies of
glucose and glycogen metabolism in humans at 4 Tesla;
diffusion tensor imaging in schizophrenia.
Nutrition: Omega-3 lipid supplementation; fatty acid flux
in fasted and fed humans; resistance training to prevent increases
in body fat; adolescent obesity.
Oncology: Treatment and prevention of relapse of leukemia
after bone marrow transplant using donor peripheral blood mononuclear
cells; continuous infusion taxol for refractory malignancies;
vaccination with tetanus and keyhole limpet hemocyanin
(KLH) to assess immune responses; metastatic colorectal cancer
therapies.
Pharmacology: Epilepsy treatment; immunosuppressive therapy
after transplant.
Psychiatry: Addiction medicine; eating disorders; schizophrenia.
Pulmonary Diseases: Treatment of cystic fibrosis.
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