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General Clinical Research Center
Jack and Pearl Resnick Campus
Forchheimer Building, Room G47
1300 Morris Park Avenue
Bronx, NY 10461
URL:
http://gcrcweb.aecom.yu.edu/gcrc/
Grant No. M01 RR012248
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Margaret Arnim, M.B.A.
718-430-3607; Fax: 718-430-8998
E-mail: marnim@aecom.yu.edu
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Program Director
Harry Shamoon, M.D.
718-430-3382; Fax: 718-430-8873
E-mail: shamoon@aecom.yu.edu
Principal Investigator
Dominick P. Purpura, M.D.
718-430-2801; Fax: 718-430-8822
E-mail: purpura@aecom.yu.edu
Associate Program Director
Ronald Nagel, M.D.
718-430-2186; Fax: 718-824-3153
E-mail: nagel@aecom.yu.edu
Assistant Program Director
Sanjeev Gupta, M.D.
718-430-3309; Fax: 718-430-8975
E-mail: sanjvgupta@po1.net
Core Laboratory Director
Jullie Pan, M.D., Ph.D.
718-430-2416; Fax: 718-430-3399
E-mail: jpan@aecom.yu.edu
Assistant Core Laboratory Director
Daniel T. Stein, M.D.
718-430-2446; Fax: 718-430-8998
E-mail: dstein@aecom.yu.edu
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Research Subject Advocate (Medical Director)
Samuel S. Engel, M.D.
718-430-3765; Fax: 718-430-8557
E-mail: engel@aecom.yu.edu
Research Subject Advocate (Safety Monitor)
Nancy Moynihan, R.N., M.S.
718-430-2268; Fax: 718-430-8817
E-mail: nmoyniha@aecom.yu.edu
Nurse Manager
Gail Glenn, R.N., M.Ed.
718-430-8804; Fax: 718-430-8998
E-mail: gglenn@aecom.yu.edu
Biostatistician
Hillel Cohen, Dr.P.H.
718-430-3745; Fax: 718-430-8998
E-mail: hicohen@aecom.yu.edu
Informatics Core Manager
José Adames, B.S., M.C.P.
718-430-3609; Fax: 718-430-8998
E-mail: jadames@aecom.yu.edu
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Special Assays, Services, or Tests
Liquid chromatography/mass spectroscopy
Magnetic resonance core: High field anatomic and
spectroscopic imaging; functional magnetic resonance
imaging (fMRI).
Stable isotope measurements
Aging: Longevity.
Cancer: Colorectal cancer; cervical cancer; prostate cancer.
Diabetes: Type 1 and type 2 diabetes mellitus;
hepatic glucose metabolism; hypoglycemia; insulin resistance;
obesity; insulin pharmacokinetics; nutritional influences on
insulin sensitivity; intramyocellular lipid turnover;
cardiovascular risk; diabetes prevention; metabolic
syndrome risk factors in adolescents.
Hematology: Sickle cell anemia; detection of hypoxia
by magnetic resonance imaging/blood oxygenation level dependent.
Immunology: Systemic lupus erythematosus; rheumatoid arthritis;
HIV/AIDS; immunoglobulin deficiency.
Liver Disease: Inherited disorders of bilirubin
glucuronidation.
Neurology: Epilepsy; glucose and ketone metabolism by
magnetic resonance spectroscopy; dementia; aging.
Reproductive Endocrinology: Hyperestrogenemia; hyperandrogenism;
menopausal transition.
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General Clinical Research Center
Room PH10-305
Columbia–Presbyterian Medical Center
622 West 168th Street
New York, NY 10032-3784
Scatterbeds: St. Luke's/Roosevelt Hospital Center
Amsterdam Avenue at 114th Street
New York, NY 10025
Grant No. M01 RR00645
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Deborah Bell
212-305-9425; Fax: 212-305-3213
E-mail: deb2@columbia.edu
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Program Director
Henry N. Ginsberg, M.D.
212-305-2071; Fax: 212-305-3213
E-mail: hng1@columbia.edu
Principal Investigator
Harvey R. Colten, M.D.
212-305-7676; Fax: 212-305-6993
E-mail: hc2056@columbia.edu
Associate Program Director
Michael Rosenbaum, M.D.
212-305-9949; Fax: 212-769-3070
E-mail: mr475@columbia.edu
Associate Program Director
Elizabeth Shane, M.D.
212-305-6238; Fax: 212-305-6486
E-mail: es54@columbia.edu
Associate Program Director
Sudha Kashyap, M.D.
212-305-9034; Fax: 212-305-3213
E-mail: sk48@columbia.edu
Associate Program Director
Karen Marder, M.D.
212-305-9194; Fax: 212-305-2426
E-mail:
marderk@sergievsky.epmc.columbia.edu
Associate Program Director
Jeanine Albu, M.D.
212-523-4183; Fax: 212-523-7492
E-mail: jba1@columbia.edu
Clinical Research Advocate
Anne C. Knieriem, R.N., M.S.
212-342-1393; Fax: 212-305-3213
E-mail: knierie@nyp.org
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Nurse Manager—Adult Inpatient Services
Media Berghout, R.N., B.S.N
212-305-6633; Fax: 212-305-3213
E-mail: berghou@nyp.org
Nurse Manager—Pediatric Services
Jill Felter, R.N., M.A.
212-305-8355; Fax: 212-305-3213
E-mail: felterj@nyp.org
Nurse Manager—Adult Outpatient Services
Joan T. Duer-Hefele, R.N., M.A.
212-305-8355; Fax: 212-305-3213
E-mail: jd2171@columbia.edu
Core Laboratory Director
John O'Connor, Ph.D.
212-305-9287; Fax: 212-305-3213
E-mail: jfo1@columbia.edu
Nutrition Research Manager
Wahida Karmally, M.S.
212-305-6639; Fax: 212-305-3213
E-mail: wk2@columbia.edu
Biostatistician
Bruce Levin, Ph.D.
212-305-9401; Fax: 212-305-9408
E-mail: b16@columbia.edu
Biostatistician
Rajasekhar Ramakrishnan, Sc.D.
212-305-7989; Fax: 212-305-9408
E-mail: rr6@columbia.edu
Informatics Core Manager
Beverly E. Diamond, M.A., D.S.W.
212-305-9453; Fax: 212-305-3213
E-mail: bed1@columbia.edu
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Special Assays, Services, or Tests
Bone and mineral metabolism: Osteocalcin, PTH,
25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, urinary
calcium and creatinine, bone-specific alkaline phosphatase,
pyridinium crosslinks, N-telopeptide
Cancer therapeutic drug monitoring: Axol, ifosamide, taxotere,
mitoxantrone
Lipids: Total cholesterol, triglycerides, HDL and LDL
cholesterol, LP(a), apolipoprotein A-1, apolipoprotein B
Molecular biology: DNA isolation, Apo E genotyping
Other: Insulin-like growth-factor-binding protein-3
(IGFBP-3), atrial natriuretic peptide, brain natriuretic peptide,
angiotensin, endothelin-1, serotonin, norepinephrine,
TNF-alpha, homocysteine, nerve growth factor, free fatty acids,
C-reactive protein
Reproduction: Testosterone, androstanediol-3-glucuronide, SHBG
AIDS: Maternal-fetal transmission; malnutrition;
HIV-related dementia; clinical trials of new drugs; HIV-related
lipodystrophy.
Bone Disorders: Hyperparathyroidism; osteoporosis.
Cancer: Clinical and pharmacokinetic studies of new
agents and of combinations of agents that have shown
synergy in laboratory models.
Cardiovascular Diseases: Arrhythmias; congestive heart failure;
the relationship of lipids to atherosclerosis; primary pulmonary
hypertension; genetics of coronary artery disease; syncope;
noninvasive methods to predict atherosclerosis.
Metabolism: Lipoprotein metabolism; metabolic
regulation in obesity; insulin resistance; diabetes
mellitus; acromegaly; studies in children and adults.
Muscle Diseases: Mitochondrial abnormalities;
Duchenne muscular dystrophy.
Neurology and Aging: Risk factors for stroke;
Alzheimer's disease and dementias; Parkinson's disease;
Huntington's disease; essential tremor; epilepsy; cerebral
function following cardiac bypass surgery.
Nutrition: Diet effects on plasma lipids.
Pediatrics: Nutritional requirements of
low-birthweight newborns; cognitive development in children
with neonatal brain damage; attention deficit disorder; delayed puberty.
Psychiatry: Effects of substance abuse; depression;
suicidal behavior; schizophrenia.
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General Clinical Research Center, Room 149
1300 York Avenue
New York, NY 10021
Grant No. M01 RR00047
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Geraldine Amera, M.P.A.
212-746-4936; Fax: 212-746-4810
E-mail: gga9001@med.cornell.edu
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Program Director
Julianne Imperato-McGinley, M.D.
212-746-4745; Fax: 212-746-8922
E-mail: jimperat@med.cornell.edu
Principal Investigator
Antonio M. Gotto Jr., M.D., D.Phil.
212-746-6005; Fax: 212-746-8424
E-mail: dean@med.cornell.edu
Associate Program Director
David Brillon, M.D.
212-746-6318; Fax: 212-746-8527
E-mail: djbrillo@med.cornell.edu
Associate Program Director
Yuan-Shan Zhu, M.D., Ph.D.
212-746-8348; Fax: 212-746-8348
E-mail: yuz2002@med.cornell.edu
Research Subject Advocate
Cathleen Acres, R.N., M.A.
212-746-4781; Fax: 212-746-8352
E-mail: cacres@med.cornell.edu
Research Subject Advocate
Juan Cordero, M.D.
212-746-4781; Fax: 212-746-8352
E-mail: jcordero@med.cornell.edu
Research Subject Advocate Protocol Specialist
Rita Falbel
212-746-6291; Fax: 212-746-8352
E-mail: rfalbel@med.cornell.edu
Nurse Manager
Barbara Hormann, R.N.
212-746-5342; Fax: 212-746-8569
E-mail: bhormann@nyp.org
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Outpatient Nurse Clinician
Sandra Flynn, R.N.
212-746-6537; Fax: 212-746-8352
E-mail: saf2007@med.cornell.edu
Nutrition Research Manager
Charles Mueller, M.S., R.D., C.N.S.D.
212-746-4747; Fax: 212-746-8352
E-mail: cmmuelle@med.cornell.edu
Core Laboratory Director
Ivan Haller, Ph.D.
212-746-6535; Fax: 212-746-8352
E-mail: ihaller@med.cornell.edu
Molecular Core Supervisor
Neil Hackett, Ph.D.
212-746-5354; Fax: 212-746-8796
E-mail: nhackett@med.cornell.edu
Biostatistician
Martin L. Lesser, Ph.D.
516-240-8300; Fax: 516-240-8344
E-mail: marty@nshs.edu
Biostatistician
Cristina Sison, Ph.D.
516-240-8300; Fax: 516-240-8344
E-mail: marty@nshs.edu
Informatics Core Manager
Elizabeth Wood
212-746-4744; Fax: 212-746-8922
E-mail: eawood@med.cornell.edu
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Special Assays, Services, or Tests
Core laboratory services: Immunodiagnostic assays by RIA, ELISA,
and delayed fluorescence methods of steroid and peptide hormones,
cytokines, and disease markers; ACTH; salivary, urinary, and serum
cortisol; 11-deoxycortisol; insulin; C-peptide; leptin; urinary
microalbumin; DHEA; DHEAS; progesterone; 17-alpha-OH progesterone;
estrone; androstenedione; total and free testosterone;
dihydrotestosterone; IGF-1; ICFBP-1, IGFBP-3; oxytocin;
IL-1, -2, -6, -10; TNF-alpha; TGF-beta; E-selectin; prostaglandin E-2;
leukotriene B4; growth hormone, LH, FSH, SHBG, prolactin, and estradiol
Mass spectrometric and chromatographic measurements: GC/MS and LC-MS/MS
for assays of substances in bodily fluids, for in vivo kinetic studies
by stable isotope-labeled tracers, for total energy expenditure
measurements, for clinical proteomics
Molecular biology services: DNA and RNA purification;
quantitative PCR and RT-PCR by TaqMan method; sequencing,
genotyping, microarray analysis
Nutrition research methodology: Consultation for protocol
design, methodology; inpatient and outpatient research diets
including balanced, constant, and weighed diets for macro- and
micronutrient composition; computer-planned research diets with
analysis of food intake data, food records, food frequency
questionnaires, computerized diet analysis; estimation of body
composition, anthropometrics, and indirect calorimetry; formal
teaching programs on nutrition research methodology for
medical center professionals
Cardiovascular Diseases: Race, socioeconomic status, and
hypertension in African Americans; paroxysmal hypertension; statin
myopathy and ubiquinone; cardiac rehabilitation without walls
intervention trial in women.
Diabetes and Metabolism: Epidemiology of diabetes interventions
and complications; genetics of kidneys in diabetes; human islet cell
transplantation in type 1 diabetes.
Digestive Diseases: Viral kinetics and dynamics of
hepatitis C virus (HCV); pegylated interferon and ribavirin
therapy for hepatitis C.
Endocrinology: Disorders of sexual differentiation and
maturation; biology of androgens; effects of androgens on cognition.
Gene Therapy and Gene Expression: Direct administration of a
replication deficient adenovirus vector (VEGF121.1) containing the
VEGF121cDNA to the ischemic myocardium of individuals with diffuse
coronary artery disease; angiogenic gene therapy in conjunction
with operative bypass grafting for severe peripheral vascular
ischemia in individuals with insulin-dependent diabetes mellitus;
smoking and gene expression in lung career.
Geriatrics: Chronic pain in the elderly.
Hematology: Risk of thrombosis with systemic lupus
erythematosus (SLE) and antiphospholipid antibodies (APL).
Immunology and Infectious Diseases: AIDS immunotherapy and
anti-infectious therapy; IL-2 treatment for HIV and hepatitis C
disease; vaccine therapy for HIV; decreased bone mineral density
in HIV; anal dysplasia and anal HPV in HIV; long-term assessment
of metabolic, cardiovascular, and neurologic complications in
patients on highly active antiretroviral treatment (HAART);
HCV dynamics, evolution, and host gene expression.
Nephrology: Use of urinary PCR to detect rejection
in kidney transplant patients; the renin system in delayed function
of renal allograft.
Neurology and Neuroscience: Risk evaluation and education
for Alzheimer's disease; thrombophilia in cryptogenic stroke;
outcome assessment and follow-up of severe traumatic brain injury.
Nutrition: Comparative study of carbohydrate-controlled
versus fat-controlled weight loss diets on weight loss, serum
lipids, and dietary preference.
Oncology: Non-Hodgkin's lymphoma therapies; quality of
life and outcomes in older lymphoma patients; monoclonal
antibody therapy for prostate cancer and for solid tumors;
depsipeptide treatment for relapsed/refractory multiple myeloma;
therapies for high-risk primary breast cancer; peripheral
neuropathy in breast cancer patients.
Ophthalmology: Longitudinal study of cytomegalovirus
retinitis in AIDS.
Psychiatry: DHEA effects on mood in HIV-positive patients;
metyrapone challenge in major depression; ketoconazole for
obsessive-compulsive disorder in nonclassical chronic active
hepatitis; sex hormones and sleep in the elderly; functional
neuroanatomy of anorexia nervosa; pregnenolone in patients
with schizophrenia; effect of catecholamines on emotional memory;
medication treatment of severe depression; treatment of
depression in Parkinson's disease.
Surgery: Effect of selective cyclo-oxygenase-2 (COX-2) inhibitors on
burn injury; preoperative COX-2 inhibitors for stage IIA non-small-cell lung
cancer.
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General Clinical Research Center
Box 1027
Mount Sinai School of Medicine
One Gustave L. Levy Place
New York, NY 10029
URL: www.mssm.edu/gcrc/index.shtml
Grant No. M01 RR00071
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Vivian Mitropoulou, M.A.
212-241-6045; Fax: 212-348-5811
E-mail: vivian.mitropoulou@mssm.edu
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Program Director
Hugh Sampson, M.D.
212-241-5548; Fax: 212-426-1902
E-mail: hugh.sampson@mssm.edu
Principal Investigator
Kenneth L. Davis, M.D.
212-659-9000; Fax: 212-803-6772
E-mail: kenneth.davis@mssm.edu
Associate Program Director
Margaret M. McGovern, M.D., Ph.D.
212-241-9234; Fax: 212-860-3316
E-mail: margaret.mcgovern@mssm.edu
Associate Program Director
Mike Lipkowitz, M.D.
212-241-2264; Fax: 212-348-5811
E-mail: mike.lipkowitz@mssm.edu
Research Subject Advocate
Ilene Wilets, Ph.D.
212-241-2714; Fax: 212-348-5811
E-mail: ilene.wilets@mssm.edu
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Interim Nurse Manager
Margaret Garrett-Herry, F.N.P.
212-241-6041; Fax: 212-426-8313
E-mail:
margaret.garrett-herry@msnyuhealth.org
Core Laboratory Director
George A. Diaz, M.D., Ph.D.
212-659-6790; Fax: 212-849-2508
E-mail: george.diaz@mssm.edu
Research Dietician
Shideh Mofidi, M.S., R.D.
212-241-6045; Fax: 212-348-5811
E-mail: shideh.mofidi@mssm.edu
Biostatistician
Sylvan Wallenstein, Ph.D.
212-241-1526 Fax: 212-860-4630
E-mail: sylvan@camelot.mssm.edu
Computer Systems Manager
Angela Reznick
212-241-1804; Fax: 212-348-5811
E-mail: angela.reznick@mssm.edu
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Special Assays, Services, or Tests
DNA facility: Molecular mutation identification by DNA
sequence analysis; direct mutation detection; polymerase
chain reaction amplification; restriction enzyme digestion,
allele-specific oligonucleotide hybridization; linkage
analysis; Southern hybridization analysis; polymorphism
analysis; DNA isolation and banking; establishment of
immortalized cell lines
Endocrinology: Role of insulin in modulating
responsiveness to androgens in ovarian dysfunction;
evaluation of ethnic factors influencing bone mass in
female population.
Genetic Diseases: Molecular basis of phenotypic
variation in Fabry's and Gaucher's diseases; therapy of
inborn errors of metabolism (including enzyme deficiencies,
amino acid disorders, lipid storage diseases) by dietary,
cofactor, transplantation, enzyme replacement, and
recombinant DNA approaches; natural history of inborn
errors of metabolism and other genetic diseases
(such as Niemann-Pick disease).
Geriatrics: Drug metabolism; endogenous formation of
advanced glycation end products (AGEs) in diabetes.
Hematology: Growth and development in children with
hemophilia; beta-globin disorders.
Internal Medicine: Determinants of vasodilator
response in heart failure; effect of lowering cholesterol
on thrombotic markers; thrombus formation; lead
mobilization during pregnancy and lactation in young urban
women.
Neurology: Therapy of parkinsonism, myoclonus,
dysautonomia, and seizure disorders; HIV dementia;
peptide-T in HIV-positive patients.
Pediatrics: Immunopathogenic mechanisms of food
hypersensitivity in children with atopic dermatitis; cow
milk-induced hypersensitivities; peanut hypersensitivity.
Psychiatry: Role of glucose metabolism, cholinergic
neurotransmitters in memory function in Alzheimer's disease;
biochemical alterations in schizophrenia and schizophrenia
spectrum disorders; post-traumatic stress disorder; major
depression; panic and generalized anxiety disorders;
autism and autistic spectrum disorders; obsessive-compulsive,
dissociative, and impulse control disorders.
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General Clinical Research Center
New Bellevue Building, 8E36
New York University Medical Center
550 First Avenue
New York, NY 10016
URL: http://gcrc.med.nyu.edu
Grant No. M01 RR00096
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Jacqueline Abramoff Graap
212-263-6410; Fax: 212-263-8501
E-mail: jacqueline.graap@med.nyu.edu
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Program Director
William N. Rom, M.D., M.P.H.
212-263-6479; Fax: 212-263-8442
E-mail: william.rom@med.nyu.edu
Principal Investigator
Robert M. Glickman, M.D.
212-263-5372; Fax: 212-263-8622
E-mail: robert.glickman@msnyuhealth.org
Associate Program Director
William Borkowsky, M.D.
212-263-6513; Fax: 212-263-7806
E-mail: borkowsky@med.nyu.edu
Associate Program Director
Bruce Cronstein, M.D.
212-263-6404; Fax: 212-263-1048
E-mail: bruce.cronstein@med.nyu.edu
Associate Program Director for Informatics
Ross Smith, M.D., Ph.D.
212-263-5356; Fax: 212-263-7135
E-mail: phillip.smith@med.nyu.edu
Assistant Program Director
Michael Weiden, M.D.
212-263-7889; Fax: 212-263-8501
E-mail: michael.weiden@med.nyu.edu
Research Subject Advocate
Andrea Downey, R.N., M.A., A.O.C.N.
212-263-3942; Fax: 212-263-8501
E-mail: andrea.downey@med.nyu.edu
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Nurse Manager
Eleanor DeCandia, R.N., M.A., C.C.R.C.
212-263-6411; Fax: 212-263-8501
E-mail: eleanor.decandia@med.nyu.edu
Medical Director for the Protection of Human Subjects
Eric Leibert, M.D.
212-263-2623; Fax: 212-263-8442
E-mail: eric.leibert@med.nyu.edu
Core Laboratory Director
Frank Martiniuk, Ph.D.
212-263-7770; Fax: 212-263-8501
E-mail: frank.martiniuk@med.nyu.edu
Associate Core Laboratory Director
Kam-Meng Tchou-Wong, Ph.D.
212-263-7098; 212-263-8501
E-mail: tchouk02@med.nyu.edu
Informatics Core Manager
Steven Aponte, B.A.
212-263-7492; Fax: 212-263-8501
E-mail: steven.aponte@med.nyu.edu
Director of Biostatistics
Judith Goldberg, Sc.D.
212-263-6879; Fax: 212-263-8570
E-mail: jd.goldberg@med.nyu.edu
Biostatistician
Ilana Belitskaya, Ph.D.
212-263-6879; Fax: 212-263-8570
E-mail: ilana.belitskaya@med.nyu.edu
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Aging: Longitudinal studies of aging and dementia;
pharmacological therapies of Alzheimer's disease; effects
of glucose and cortisol on aging.
AIDS, Adult: Highly active antiretroviral therapy
(HAART) for adults; impact of discontinuing therapy for
opportunistic infections in subjects who have responded to
HAART; cytokine administration with HAART; clinical studies
for the treatment of cervical dysplasia, oral candidiasis,
cytomegalovirus retinitis and HIV-associated wasting;
multiple trials with new antiretroviral therapies;
immunomodulation and immune restoration with drugs and
cytokines; longitudinal study of AIDS.
AIDS, Pediatric: Highly active antiretroviral therapy (HAART)
for children; immunological and pharmacological studies to understand
and treat maternal-fetal transmission of HIV and AIDS; effects of
cytokines on HAART in children; recombinant growth hormone in
HIV-associated growth failure; pathogenesis of HIV infection
and the biology of hepatitis C infection in HIV-infected
mothers and children.
Endocrinology: New approaches to the treatment of
growth hormone deficiency; new agents in the treatment of
non-insulin-dependent diabetes mellitus.
Genitourinary Disorders: Medical therapy for benign
prostatic hyperplasia; chemoprevention of prostate cancer.
Imaging: Preoperative mapping of seizures using
magnetoencephalogram (MEG); MEG recordings of normal,
blind, and dyslexic subjects and patients with neurological
and psychiatric disorders.
Neurology: Diagnosis and treatment of Gaucher's
disease.
Obstetrics and Gynecology: Prediction of preterm
labor using sonogram and fibronectin levels; vasoactive
mediators in the pathogenesis of preeclampsia; novel
therapies for gynecological malignancies.
Oncology: Novel chemotherapy regimens with and without
radiation therapy for solid tumors; cell-mediated immunity for
metastatic malignant melanoma; prevention of breast cancer and
novel strategies for treatment of breast cancer using neoadjuvant
and antiepidermal therapies; intraperitoneal infusion of
chemotherapeutic agents for gastric and ovarian cancer;
protein kinase C modulators; phenethyl isothiocyanate (PEITC)
as a chemopreventive agent; thalidomide for unresectable
hepatocellular carcinoma; other new approaches for
treatment of solid tumors.
Otolaryngology: Novel monoclonal antibody therapy in
head and neck cancer; therapeutic approaches to autoimmune
inner-ear disease; evaluation of facial nerve dysfunction
following acoustic neuroma surgery.
Pediatric Oncology: Reducing cardiac dysfunction
after chemotherapy.
Psychiatry: New therapies for schizophrenia and
cocaine abuse; physiologic correlates of addiction.
Pulmonary Diseases: Bronchoalveolar lavage in normal
volunteers, asbestos-exposed workers, and pulmonary fibrosis
patients; new drug therapies for multidrug-resistant tuberculosis,
interstitial fibrosis, and pulmonary aspergilloma; mechanisms of
host response to tuberculosis/AIDS, including immunology,
cytokine expression, and transcription factor regulation;
novel approaches in treatment of asthma; gene therapy for
lung cancer and Pompe's disease; mechanisms of p53 cell
cycle deregulation in lung cancer; NYU Biomarker
Clinical and Epidemiologic Center for Lung Cancer;
chemoprevention of lung cancer.
Rheumatology: Pharmacologic mechanisms of
antirheumatic agents; safety of estrogens in systemic lupus
erythematosus (SLE); immunological study of serologically
active stable SLE.
Sleep Studies: Diagnosis and epidemiology of upper
airway resistance; mechanism and treatment of obstructive
sleep apnea syndrome; understanding carbon dioxide balance
during sleep; evaluation of disordered breathing in select
patient.
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General Clinical Research Center
350 Community Drive
Manhasset, NY 11030
URL: www.northshorelij.com
Grant No. M01 RR018535
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Sonia Kleiner
516-562-1012
E-mail: skleiner@nshs.edu
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Program Director
Kevin J. Tracey, M.D.
516-562-1012; Fax: 516-562-1006
E-mail: kjtracey@sprynet.com
Principal Investigator
Nicholas Chiorazzi, M.D.
516-562-1001; Fax: 516-562-1022
E-mail: nchizzi@nshs.edu
Associate Program Director
Jesse Roth, M.D.
718-470-8635; Fax: 718-437-7717
E-mail: jesserothmd@hotmail.com
Associate Program Director
Howard Trachtman, M.D.
718-470-3491; Fax: 718-470-0887
E-mail: htrachtm@lij.edu
Associate Program Director
Andrew Feigin, M.D.
516-869-9527; Fax: 516-869-9535
E-mail: asfeigin@aol.com
Assistant Program Director
Gwenn Smith, Ph.D.
718-470-8373; Fax: 718-343-1659
E-mail: gsmith@lij.edu
Research Subject Advocate
Erica Christen, B.S., R.N.
516-562-1021; Fax: 516-562-1006
E-mail: echriste@nshs.edu
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Nurse Manager
Migdalia Reid, R.N., M.P.H.
516-562-4874; Fax: 516-562-1006
E-mail: mreid@nshs.edu
Biostatistics Director
Martin L. Lesser, Ph.D.
516-240-8300; Fax: 516-240-8344
E-mail: marty@nshs.edu
Informatics Manager
James Tsang, M.P.H.
516-240-8300; Fax: 516-240-8344
E-mail: jtsang@nshs.edu
Molecular Biology and Immunology Core Director
Leslie Goodwin, Ph.D.
516-562-1037; Fax: 516-562-1022
E-mail: lgoodwin@nshs.edu
Imaging Core Director
David Eidelberg, M.D.
516-562-2498; Fax: 516-562-1008
E-mail: David1@nshs.edu
Biorepository and Tissue Donation Program Director
Peter Gregersen, M.D.
516-562-1542; Fax: 516-562-1153
E-mail: peterg@nshs.edu
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Biorepository core and tissue donation program: Tissues: site
initiation (find a source for samples), collection; access to
existing samples; Biorepository (stores biological fluids
long-term or short-term): plasma, serum, DNA
Imaging core: PET scans, MRI scans, fMRI
Molecular biology and immunology core: DNA synthesis of custom
oligonucleotides <120 bp in length; standard oligonucleotides;
single fluorescently labeled oligonucleotide; double fluorescently
labeled oligonucleotide; DNA sequencing; protein sequencing;
protein synthesis,15-20 amino acid residue oligomers; real-time
or quantitative PCR; confocal microscope; Hewlett-Packard
matrix-assisted laser desorption ionization-time of flight
(MALDI-TOF) mass spectrophotometer; gas chromatograph/mass
spectrophotometer; ProteinChip protein analysis system; Sorvall
centrifuges, scintillation counter; Bio-Rad gel system, lyophilizer,
Shimadzu biospectrophotometer, Savant; automated speed-vac system,
dark room, radioactive fume hood; flow cytometry; cytokine ELISA; RNA i
solation; silver nitrate immunoperoxidase (SNIP) analysis
Cardiology: Cardiac surgery; thyroid hormone therapy.
Endocrinology: Diabetes.
Gastroenterology: Inflammatory bowel disease.
Hematology: Diamond-Blackfan.
Immunology: Chronic lymphomic leukemia; rheumatoid arthritis.
Molecular Genetics: Rheumatoid arthritis;
systemic lupus erythematosus; cancer.
Nephrology: Congenital uropathies; diarrhea-related
hemolytic uremic syndrome (D-HUS).
Neuropsychiatry: Parkinson's disease; Alzheimer's disease.
Psychiatry: Schizophrenia; depression; post-traumatic disorder;
bipolar disorder; autism; obsessive compulsive disorder.
Sepsis: Cytokine responses; HMGB1; cholinergic
anti-inflammatory pathway.
Urology: Cystitis; urinary incontinence.
Vascular Disease: Abdominal aortic aneurysm; peripheral
vascular disease; carotid endardectomy.
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General Clinical Research Center
Rockefeller University Hospital, Box 327
1230 York Avenue
New York, NY 10021
URL: www.rucares.org
Grant No. M01 RR00102
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Susan Richer, M.P.A., F.A.C.H.E.
212-327-8433; Fax: 212-327-8450
E-mail: richers@mail.rockefeller.edu
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Program Director
James Krueger, M.D., Ph.D.
212-327-7730; Fax: 212-327-8232
E-mail: kruegej@mail.rockefeller.edu
Principal Investigator
Emil C. Gotschlich, M.D.
212-327-8157; Fax: 212-327-8960
E-mail: ecg@mail.rockefeller.edu
Associate Program Director
Robert B. Darnell, M.D., Ph.D.
212-327-7460; Fax: 212-327-7453
E-mail: darnelr@mail.rockefeller.edu
Research Subject Advocate
Rhonda G. Kost, M.D.
212-327-8408; Fax: 212-327-8450
E-mail: kostr@rockefeller.edu
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Nurse Manager
Kelly McClary, B.A., R.N.
212-327-8441; Fax: 212-327-8450
E-mail: mcclark@rockefeller.edu
Nutrition Research Manager
Janet Maturi, M.S., R.D.
212-327-8397; Fax: 212-327-8350
E-mail: maturij@rockefeller.edu
Biostatistician
Knut Wittkowski, Ph.D., D.Sc.
212-327-7175; Fax: 212-327-7157
E-mail: wittkok@mail.rockefeller.edu
Informatics Manager
Alexandre Peshansky, M.S.
212-327-8062; Fax: 212-327-7157
E-mail: pechtca@mail.rockefeller.edu
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Special Assays, Services, or Tests
Aaron Diamond AIDS Research Center
Diepoxybutane testing for Fanconi anemia
Fanconi anemia complementation group CAC mutation
testing for Fanconi anemia
Heme pathway enzymes
Metabolite and receptor determinations
National epidermolysis bullosa and Fanconi anemia registries
National reference porphyric testing center
Nutrition services: Bomb calorimetry testing of research diets; liquid
formula preparation; computerized nutrient analysis of dietary intake
records
Plasma and tissue intermediates and enzymes relating to
cholesterol and other lipids; cholesterol and triglyceride
determinations and fractionations
Porphyrin and heme precursors
Products of metabolism of steroid hormones and their
relevance to estrogen-dependent diseases
Starr Center for Human Genetics
Cystic Fibrosis: Gene therapy.
Dermatology: Psoriasis; Fanconi anemia; epidermolysis bullosa;
studies on human wound healing.
Gastrointestinal Disorders: Narcotic-induced disorders of
gastrointestinal hypomotility; gastrointestinal neoplasms: colon
cancer, colon polyps, polyposis syndromes; colon tumor
prevention by nutritional and pharmaceutical means.
Genetics: Identification of genes related to the development
of obesity, type 2 diabetes, schizophrenia, and other mental
disorders; onset of early cardiac disorders; hypertension;
color blindness; hearing loss and sleep disorders.
HIV/AIDS: Biology and therapy of HIV infections.
Immunology and Infectious Diseases: Children and young adults
with early acute rheumatic fever; glomerulonephritis, including
patients with poststreptococcal glomerulonephritis, chronic
idiopathic glomerulonephritis, rapidly progressive
glomerulonephritis; HIV infections; AIDS; immunology and
treatment of pulmonary tuberculosis; effects of cytokines.
Lipoprotein Disorders: Any genetic dyslipidemia, especially
familial type III and familial combined hyperlipidemia (type IIb);
patients with type I or type V hyperlipidemia; patients with
hypertriglyceridemia; men or women with high (>60 mg/dL) or
low (<35 mg/dL) HDL-C levels; children and adolescents with
dyslipidemias and/or family history of premature coronary
rtery disease.
Metabolic Disorders: Hepatic, erythropoietic, and cutaneous
porphyrias; toxicities from metals and other environmental chemicals.
Neuroendocrine Studies: Chemically induced stress in heroin and
cocaine addiction; opioid antagonists; endogenous opioids;
hypothalamic-pituitary-adrenal axis studies.
Neurology: Multiple sclerosis; paraneoplastic disease.
Obesity and Nutrition: Inpatient metabolic studies and weight
reduction studies in obese (not more than 175 percent of ideal weight)
patients between the ages of 20 and 40 who are free of diabetes,
hypertension, and other medical or psychiatric complications;
individuals who were formerly obese but have lost more than
50 pounds and are now maintaining normal body weight;
individuals with strong predilection to accumulate adipose
tissue primarily in abdominal or gluteal regions or with other
unusual accumulations of subcutaneous fat; obese individuals for
study of weight loss as outpatients; normal weight, healthy
volunteers for in-hospital studies of metabolic changes during
brief weight gain and weight loss.
Psychiatry: Schizophrenia; major depression; obsessive-compulsive
disorder; young adults with velocardiofacial syndrome for assessment
of psychiatric status.
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General Clinical Research Center
University Hospital, 12 South
Stony Brook, NY 11794
Grant No. M01 RR10710
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Nancy Wyllie
631-444-7737; Fax: 631-444-6930
E-mail: nwyllie@notes.cc.sunysb.edu
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Program Director
Marie C. Gelato, M.D., Ph.D.
631-444-1175; Fax: 631-444-8951
E-mail: mgelato@notes.cc.sunysb.edu
Principal Investigator
Norman H. Edelman, M.D.
631-444-2080; Fax: 631-444-6266
E-mail: nedelman@dean.som.sunysb.edu
Associate Program Director
Wadie Bahou, M.D.
631-444-2059; Fax: 631-444-7530
E-mail: wadie.bahou@sunysb.edu
Research Subject Advocate
Tracy Dourdounas, B.A, R.N., C.C.R.C.
631-444-4662
E-mail:
tdourdounas@notesmta2.cc.sunysb.edu
Nurse Manager
Stephanie Musso, R.N., M.S.N.
631-444-7759; Fax: 631-444-6930
E-mail: smusso@notes.cc.sunysb.edu
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Core Laboratory Director
Peter Garlick, Ph.D.
631-444-1790; Fax: 631-444-6039
E-mail: garlick@surg.som.sunysb.edu
Biostatistician
Eugene Komaroff, Ph.D.
631-444-7612; Fax: 631-444-8409
E-mail: ekomaroff@cc.sunysb.edu
Data Manager/Epidemiologist
Judith Greene, M.P.H.
631-444-6900; Fax: 631-444-6930
Informatics Manager/Core Codirector
David Cyrille
631-444-7399; Fax: 631-444-6930
E-mail: dcyrille@notes.cc.sunysb.edu
Outreach Program Director
Hector Sepulveda, M.A., M.P.H., M.D.
631-444-3244; Fax: 631-444-6930
E-mail: hsepulveda@notes.cc.sunysb.edu
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Biostatistics and informatics
Gas chromatography/mass spectrometry is available to measure
enrichment of stable isotopes in physiological samples derived
from metabolic tracer studies
Genetics core laboratory offers genetic testing for well-characterized
human genetic disorders. Quality assurance, sample handling and
processing, and compliance issues have been established. Isolation
and storage of DNA from patient peripheral blood leukocytes;
storage and tracking of patient material; assistance with
techniques of genetic mutation identification (oligonucleotide
primer generation); Epstein-Barr virus (EBV) transformation of
lymphocytes for rare human disorders, storage of lymphocytes;
DNA sequence analysis
Immuno- and radiometric assays for insulin-like growth
factors I and II; insulin-like growth factor binding
protein1, 2, 3 ; growth hormone, prolactin,
catecholamines, dopamine
Outreach program to recruit minorities and women
Aging: Regulation of muscle metabolism; effects of
GH on immune function.
Diabetes: Genetic studies in patients with type 2
diabetes mellitus; role of the kidney in glucose
metabolism.
Dupuytren's Disease: Medical therapy.
Genetics: Hematologic diseases and stroke.
HIV Disease: Pathogenesis of the metabolic
complications.
Metabolism: Regulation of muscle wasting in catabolic
illness; regulation of muscle metabolism by insulin and amino
acids in normal adults; effects of dietary arginine supplements
on metabolism in cancer patients; gut priming in neonatal adaptation
to enteral nutrition in micropreemies.
Neurology: Neurologic complications and development
of novel diagnostic testing for Lyme disease; cognitive
dysfunction in multiple sclerosis.
Osteoporosis: Development of new therapeutic agents.
Psychiatry: Substance abuse and its effects on the
brain dopamine system.
Renal Failure: Use of anabolic agents in children
with chronic renal failure; role of nitric oxide in defense
against infection in patients on peritoneal dialysis.
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General Clinical Research Center
University of Rochester Medical Center Box MED/CRC
601 Elmwood Avenue
Rochester, NY 14642
URL:
www.urmc.rochester.edu/smd/crc/crcweb.html
Grant No. M01 RR00044
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Kathleen M. Jensen, M.H.S.A.
585-275-6409; Fax: 585-461-4737
E-mail: kathleen_jensen@urmc.rochester.edu
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Program Director
John E. Gerich, M.D.
585-275-5295; Fax: 585-461-4737
E-mail: john_gerich@urmc.rochester.edu
Principal Investigator
David S. Guzick, M.D.
585-275-0017; Fax: 585-256-1131
E-mail: david_guzick@urmc.rochester.edu
Associate Program Director
Daniel B. Ornt, M.D.
585-275-8538; Fax: 585-756-5154
E-mail: daniel_ornt@urmc.rochester.edu
Associate Program Director
John Treanor, M.D.
585-275-5871; Fax: 585-442-9328
E-mail:
john_treanor@urmc.rochester.edu
Research Subject Advocate
Robert Betts, M.D.
585-275-5871; Fax: 585-442-9328
E-mail:
robert_betts@urmc.rochester.edu
Research Subject Advocate
Rebecca Hahn, M.P.H.
585-275-4675; Fax: 585-461-4737
E-mail:
robert_betts@urmc.rochester.edu
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Nurse Manager
Patricia Pincus, R.N., M.P.H., C.I.C., C.C.R.C.
585-275-2907; Fax: 585-461-4737
E-mail:
patricia_pincus@urmc.rochester.edu
Nutrition Research Manager
Patricia Stewart, Ph.D., R.D.
585-275-3918; Fax: 585-461-4737
E-mail:
patricia_stewart@urmc.rochester.edu
Biostatistician
Michael McDermott, Ph.D.
585-275-6685; Fax: 585-273-1031
E-mail: mikem@bst.rochester.edu
Biostatistician
Sue Messing, M.A., M.S.
585-275-0343; Fax 585-273-1031
E-mail:
susan_messing@urmc.rochester.edu
Informatics Director
William DiGrazio, B.S.
585-275-5783; Fax: 585-461-4737
E-mail:
will_digrazio@urmc.rochester.edu
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Special Assays, Services, or Tests
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Alanine
Amino acid profile
Asparagine
Beta-hydroxybutyrate
C-peptide
Cortisol
Creatinine
Enrichments and specific activities: Stable-isotope-based
turnover studies of glucose, amino acid, energy metabolism
Free fatty acids
Glargine insulin
Glucagon
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Glucose
Glutamine
Glycerol
Growth hormone
In vivo determination of whole body and skeletal muscle
protein synthesis rates
In vivo oxygen consumption, respiratory quotient
Insulin
Insulin-like growth factor I (IGF-I)
Lactate
3-Methyl-histidine
Para-aminohippuric acid (PAHA)
Proinsulin
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Special Resources, Instruments, or
Services
Aerosol exposure chamber with aerosol generator, aerosol
monitoring equipment, bicycle ergometer
DEXA
Filter- and monochromator-based fluorometers for
fluorometric analysis or substrate concentrations,
nucleotide purity, and more
GC/MS, isotope ratio mass spectrometer
Glucose/lactate analyzers
HPLC systems for protein and amino acid analysis
glucose, and free fatty acids
Plate reader for ELISA analysis
Quantitative myometry equipment
UV/Vis spectrophotometer with low-volume cell and sipper
sampler
Whole-body 40K counter
Behavioral: Smoker's health study; diabetes management adherence.
Cardiology: Long QT syndrome; myocardial damage in
acute illness in children.
Endocrinology and Metabolism: Neurotransmitter regulations
of growth hormone; energy balance and fuel homeostasis in diabetes,
aging, and obesity; protein turnover and regulation by hormones, aging,
and nutrition; renal substrate and glucose metabolism; gluconeogenesis;
fatty-acid metabolism and renal glucose uptake; treatments in type 2
diabetes mellitus; hypercholesterolemia treatments; diabetes database;
insulin resistance in post-myocardial infarction (MI) patients.
Geriatrics: Pharmacologic challenges in Alzheimer's and
Lewy body disease; function and quality of life in nursing home
patients.
Infectious Diseases: Pathophysiology and therapy of
herpes genitalis; herpes vaccine; pathobiology of HIV infection;
experimental therapeutics of AIDS; AIDS-related complex and
associated opportunistic infections in children and adults;
various AIDS Clinical Trials Group studies; studies of protease
inhibitors; varicella zoster treatment; immune response to
smallpox vaccine; human herpesvirus-6 infections in infants;
papillomavirus vaccine; measles, mumps, rubella, and varicella
vaccine in premature infants; respiratory syncytial virus
infections in infants.
Nephrology: Hypomagnesemia in renal transplant
recipients on Tacrolimus; Fabry's disease treatment.
Neurology: Insulin sensitivity in myotonic dystrophy
and neuromuscular diseases; pharmacodynamics and antioxidant
therapy in Parkinson's disease; muscle protein synthesis and
turnover in wasting disorders; natural history of fascioscapulohumeral
muscular dystrophy (FSHD); FSHD tissue bank; natural history of
oculopharyngeal MD; treatments in Duchenne dystrophy; inheritance
and genetic location of Tourette's syndrome; Andersen's syndrome;
treatment of muscular dystrophy; mood fluctuations in Parkinson's;
muscle strength in myasthenia gravis; cognitive impairment in
HIV/AIDS; sleep studies; treatment for amyotrophic lateral sclerosis.
Nursing: Psychoneuroimmune relationship across the
menstrual cycle; cardiovascular risk in former gestational diabetic women.
Nutrition: Nutritional aspect of HIV infection in infants/children.
Obstetrics and Gynecology: Polycystic ovary
syndrome; postmenopausal estrogen replacement therapy;
hot flash treatment.
Oncology: Pulse radiotherapy in inoperable lung cancer;
prostate cancer treatment; immunotherapy for lung cancer; breast
cancer treatment.
Pediatrics: Surfactant treatment in respiratory diseases
of newborns; long-term follow-up after treatment with surfactant
and inhaled steroids; Dtap-Hib vaccination; growth hormone studies;
treatment of AIDS in children; childhood stress and virologic
outcomes; treatment of mucopolysaccharidosis; treatment of
Crohn's disease in children; treatments for complications
in preterm infants.
Psychiatry: Heart-rate reactivity, neuroendrocrine
and immune function studies; neuropsychological findings in
adult muscular dystrophy; bone density and reproductive changes in bipolar
women.
Pulmonary Medicine: Effects of chemical aerosols on
pulmonary gas exchange and lung function; exposure-response
characteristics of ozone and solvents; ultrafine particles
and morbidity; EKG abnormalities in asthmatics; genetic
modification in cystic fibrosis.
Surgery: Treatment of critical leg ischemia; treatment of
abdominal infections in hospitalized patients.
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