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General Clinical Research Center
University Hospitals of Cleveland
11100 Euclid Avenue
Cleveland, OH 44106-5041
URL: http://gcrc.case.edu
Grant No. M01 RR00080
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Joyce P. Dearborn, B.S.
216-844-4902; Fax: 216-844-1522
E-mail: joyce.dearborn@case.edu
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Program Director
Jackson T. Wright Jr., M.D., Ph.D.
216-844-5174; Fax: 216-844-1522
E-mail: jxw20@case.edu
Principal Investigator
Ralph I. Horwitz, M.D.
216-368-2825; Fax: 216-368-3013
E-mail: ralph.horwitz@case.edu
Associate Program Director
William T. Dahms, M.D.
216-844-3661; Fax: 216-844-8900
E-mail: wxd2@case.edu
Research Subject Advocate
Baha M. Arafah, M.D.
216-844-3166; Fax: 216-844-1522
E-mail: bxa@case.edu
Nurse Manager
Terryl Homes Koeth, R.N., M.S.
216-844-4901; Fax: 216-844-1331
E-mail: terry1.koeth@uhhs.com
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Core Laboratory Manager
Paul Hartman, M.S.
216-844-1369; Fax: 216-844-1522
E-mail: phh@case.edu
GC/MS Lab Director
Satish C. Kalhan, M.D., M.B.B.S.
216-778-8643; Fax: 216-778-8644
E-mail: sck@case.edu
Nutrition Research Manager
Karen Y. Warman, M.S., R.D., L.D.
216-844-1221; Fax: 216-844-1522
E-mail: kyw@case.edu
Biostatistician
Mark D. Schluchter, Ph.D.
216-844-2391; Fax: 216-844-6265
E-mail: mds11@case.edu
Informatics Manager
Sheree A. Hemphill, M.S.
216-844-1546; Fax: 216-844-1522
E-mail: sah18@case.edu
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Special Assays, Services, or Tests
Cortisol (saliva)
Cytokines
Deoxypyridinoline
Fibroblast growth factor basic
Glucagon
Pituitary and reproductive biology hormone assays
Renin substrate
t(14,18) translocation
Vascular endothelial growth factor
Special Resources, Instruments, or Services
Body composition: skinfold and bioelectrical impedance
Computer analysis of diets
Gas chromatograph/mass spectrometer
HPLC with electrochemical detector
Indirect calorimetry, glucose clamp
Metabolic kitchen
AIDS: AIDS Clinical Trials Group studies.
Endocrinology: Growth hormone in children;
epidemiology of diabetes intervention and complications
study; drug therapies for hyponatremia; genetic regulation of puberty.
Epidemiology: Familial sleep apnea.
Gene Therapy: Human methylguanine methyltransferase (MGMT)
gene transfer into hematopoietic progenitors in therapy of advanced
solid tumors.
Genetic Diseases: Support of DNA banking; genetic
testing for familial breast cancer; osteogenesis
imperfecta; cystic fibrosis.
Hypertension: African American study of kidney disease; genetics
of salt sensitivity in hypertension; chronic renal insufficiency.
Neurodevelopment: Developmental assessment of
infants and children with various disorders (diabetes,
pulmonary hemosiderosis, very low birthweight, traumatic
head injury).
Oncology: Cancer therapies in various tumors; bone
marrow aspirations for hematopoietic stem cell core
facility; therapeutic approaches to antineoplastic drug
resistance; phase I and II cancer therapies, including
angiogenesis inhibitors.
Pediatrics: Sleep-disordered breathing in adolescents;
longitudinal studies of very-low-birthweight infants; infant
pulmonary hemosiderosis.
Pharmacology: Pediatric Pharmacology Research Unit
(PPRU) Network; pharmacokinetics of various drugs in
children.
Psychiatry: Pharmacokinetic studies of
antipsychotics; antidepressants in anxiety disorders;
serotonin in the pathophysiology of depression.
Psychology: Traumatic brain injury in children;
cocaine-exposed infants.
Pulmonary Medicine: Asthma; therapies of cystic
fibrosis; factors regulating immune mechanisms in the lung,
including HIV and tuberculosis.
Radiation Oncology: Thermal ablation of tumors under
magnetic resonance guidance.
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General Clinical Research Center Satellite
MetroHealth Medical Center
2500 MetroHealth Drive
Cleveland, OH 44109-1998
URL: www.metrohealth.org
Grant No. M01 RR00080
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For information
about this satellite and how to access its resources, please
contact:
Administrative Manager
Denise Kosty-Sweeney, R.N., M.S.N., C.N.A.
216-778-5462; Fax: 216-778-4691
E-mail: dkosty@metrohealth.org
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Associate Program Director
Brian M. Mercer, M.D.
216-778-8446; Fax: 216-778-4691
E-mail: bmercer@metrohealth.org
Research Subject Advocate
Satish Kalhan, M.D., M.B.B.S.
216-778-8643; Fax: 216-778-8644
E-mail: sck@po.cwru.edu
Nurse Manager
Denise Kosty-Sweeney, R.N., M.S.N., C.N.A.
216-778-5462; Fax: 216-778-4691
E-mail: dkosty@metrohealth.org
Core Laboratory Manager
Jacqueline Bjaloncik, M.S., N.R.C.C.
216-778-8899; Fax: 216-778-4691
E-mail: jbjaloncik@metrohealth.org
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GC/MS Director
Satish Kalhan, M.D., M.B.B.S.
216-778-8643; Fax: 216-778-8644
E-mail: sck@po.cwru.edu
Nutrition Research Manager
Alicia Thomas, M.S., R.D., L.D.
216-778-8929; Fax: 216-778-4691
E-mail: athomas@metrohealth.org
Computer Systems Manager
Sheree Hemphill, M.S.
216-844-1546; Fax: 216-844-1522
E-mail: sah18@po.cwru.edu
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Special Assays, Services, or Tests
Bone markers
C-peptide
Cytokines/growth factor
Insulin
Leptin
Reproductive biology hormone assays (RIA, ELISA)
Special Resources, Instruments, or Services
Agilent Technologies gas chromatography with mass
spectrometer
Body composition (skin fold thickness; bioelectrical impedance analysis;
underwater weighing hydrodensitometer)
Dual-energy X-ray absorptiometry (DEXA)
Metabolic kitchen
Metabolic laboratories (glucose clamp, indirect
calorimetry)
Total body electrical conductivity
Cardiology: Electrophysiology; cardiac rehabilitation; long QT
syndrome.
Genetic Diseases: Ankylosing spondylitis; asthma:
fibromyalgia syndrome; nephropathy and diabetes.
Immunology and Infectious Diseases: AIDS Clinical
Trial Group Studies.
Metabolism: Diabetes; abnormal fatty-acid metabolism in chronic
renal failure; gluconeogenesis in cirrhosis; effects of nutrition and
exercise on insulin in the elderly diabetic; fatty-liver disease in adults;
protein metabolism in neonates and very-low-weight infants; nutrition
in pregnancy; glucose intolerance in pregnancy; obesity in pregnancy.
Orthopedics: Functional electrical stimulation for hand/leg
in spinal cord injuries.
Pediatrics: Birth Control and bone density in adolescents;
protein metabolism in neonates and very-low-weight infants; fatty-liver
disease in children.
Pharmacology: Treatment of strokes; systemic lupus
erythematosus; atrial fibrillation and flutter.
Physical Medicine and Rehabilitation: Functional electrical
stimulation for bowel and bladder control in spinal cord injuries;
stroke electrostimulation.
Pulmonary Medicine: Sleep apnea; phrenic nerve diaphragmatic pacing
in spinal cord injuries.
Women's Health: Exercise physiology in pregnancy;
glucose and amino acid metabolism in pregnancy; feto-placental growth;
prematurity; polycystic ovarian syndrome.
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General Clinical Research Center
Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati, OH 45229-3039
URL:
www.cincinnatichildrens.org/gcrc
Grant No. M01 RR08084
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Andrea L. Smith
513-636-4273; Fax: 513-636-7874
E-mail: andrea.smith@chmcc.org
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Program Director
James E. Heubi, M.D.
513-636-8046; Fax: 513-636-4695
E-mail: james.heubi@chmcc.org
Principal Investigator
Thomas Boat, M.D.
513-636-4588; Fax: 513-636-8453
E-mail: boatt0@cchmcc.org
Associate Program Director
Robert Cohen, M.D.
513-558-4444; Fax: 513-558-8581
E-mail: robert.cohen@uc.edu
Research Subject Advocate
Frederick Samaha, M.D.
513-636-2754; Fax: 513-636-8453
E-mail: samt7q0@cchmcc.org
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Nurse Manager
Susan Allen, M.S.N.
513-636-8213; Fax: 513-636-7874
E-mail: alles0@cchmcc.org
Core Laboratory Director
Thomas L. Clemens, Ph.D.
513-558-4444; Fax: 513-558-8581
E-mail: thomas.clemens@uc.edu
Nutrition Research Manager
Suzanne Spang, R.D.
513-636-2734; Fax: 513-636-4695
E-mail: suzanne.spang@cchmcc.org
Biostatistician
Judy Bean, Ph.D.
513-636-3430; Fax: 513-636-7509
E-mail: judy.bean@cchmcc.org
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Special Assays, Services, or Tests
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Bone-specific alkaline phosphatase
Carboxyterminal propeptide of type I procollagen
Carboxyterminal telopeptide of type I collagen
Cross-linked N-telopeptide of type I collagen (NTx)
Dual-energy X-ray absorptiometry
Insulin
Leptin
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Nutrition services: Indirect calorimetry, anthropometry,
computerized dietary analysis
Osteocalcin
Peripheral quantitative computed tomography (pQCT) scans
PTH
Pyrilinks-D (D-PYD)
Vitamin D metabolites
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Allergy and Immunology: Allergen elimination diets
and severity of asthma; effect of intravenous mepolizumab on the outcome
and management of hypereosinophilic syndromes.
Cardiology: Cardiovascular risk tracking study;
blood pressure divergence in adolescent females; vitamin E
intake and oxidized low-density lipoprotein; effect of
pre-operative methylprednisolone on inflammatory response
following cardiopulmonary bypass; body mass index rebound
epidemiology; genetic epidemiology of energy metabolism; neurohormonal
activation in single ventricular physiology.
Critical Care Medicine: Adrenal dysfunction in
children with septic shock; nitric oxide in infants with
respiratory failure.
Developmental Disorders: Human synthetic secretin in children with
autism; effect of oral baclofen on function in cerebral palsy.
Endocrinology: Glucagon-like peptide-1 in diabetic and nondiabetic
humans, including effects on insulin secretion; mechanisms
and implications of discordant hemoglobin A1c;
rhIGF-1 in children with short stature and growth hormone
insensitivity syndrome; coronary atherosclerosis in early
insulin-dependent diabetes mellitus; sulfonylurea therapy
in patients with mutations in the Delta F508 CF
transmembrane conductance regulator gene; IGF-1 receptor
mutations in human uterine growth retardation; effects of ketogenic diet
on body weight/cardiovascular risk factors.
Gastroenterology and Nutrition: Cholera challenge
trial; bile acid therapy in treatment of childhood liver
disease, including cystic fibrosis, total parenteral
nutrition-related cholestasis, and peroxisomal diseases;
inborn errors of bile acid metabolism; analysis and
physiology of soy isoflavones; cholesterol supplementation
and synthesis rates in infants; regulation of plasma
cholesterol levels by cholesterol absorption, synthesis, and
LDL-receptors; intranasal vitamin B12 dosing
interval; rectal bleeding in infants; borderline pancreatic
function assessment in cystic fibrosis; role of magnesium in
pathogenesis of childhood cholestatic liver disease;
reduced bone mass in nonambulatory children and adults; intravenous
methylprednisolone versus oral prednisolone in treatment of acute
rejection in liver transplant patients; effect of fat ingestion
on serum apolipoprotein A-IV levels; pharmacokinetics of the supplement,
secoisolariciresinol diglycoside.
General Pediatrics: Melatonin metabolism studies
looking at shift work and effects on blood pressure in type
1 diabetes; suckling and PTHrP secretion and renal
activity; bone mass tracking studies; bone density and
forearm fractures in injured children.
Hematology: Sickle cell disease, including
biotinylated erythrocyte studies and causes for
thrombophilia.
Hepatology: Response of hepatitis C virus to pegylated interferon
and ribavirin in hemophilic patients with/without coinfection with HIV.
Human Genetics: Phenotype and genetics of Gaucher's
disease; enzyme therapy for Gaucher's disease;
antiresorptive therapy for osteopenia in Gaucher's disease; bone densitometry
in subjects with neurofibromatosis.
Infectious Disease: Indinavir/ritonavir therapy in HIV-affected
subjects; efavirenz/nelfinavir pharmacokinetic study; pharmacokinetic
interactions between HIV protease inhibitors and calcium
channel blockers.
Neonatology: Hypothermia trial in term infants; parenteral glutamine
supplementation in low-birthweight infants.
Nephrology: Renal tubular function in Bartter syndrome;
immunosuppressive therapy after renal transplant in children; treatment
of childhood nephrotic syndrome; urea kinetic modeling in hemodialysis
patients; vascular abnormalities in children and adolescents with
chronic renal disease; normalization of hematocrit in patients with
chronic renal disease.
Psychiatry: Clomipramine treatment trials in
depression and obsessive-compulsive disorder; fibromyalgia genetic
studies.
Psychology: Behavioral nutrition studies involving
weight gain in cystic fibrosis, feeding preterm infants, increasing
dietary calcium in juvenile rheumatoid arthritis, and young children
with chronic illness and their families; neuropsychological functioning
in adolescents with spina bifida; Children's Health and Natural Growth
Evaluation Study; depression and nutrition in pediatric sickle cell
disease.
Pulmonary Medicine: Aerosolized tobramycin in young
children with cystic fibrosis; dose cohort studies in cystic
fibrosis subjects; effect of obstructive sleep apnea on cardiac
function and structure in children.
Rheumatology: Calcium supplementation for bone
mineralization in juvenile rheumatoid arthritis; genetic juvenile rheumatoid
arthritis studies.
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General Clinical Research Center
NB20
9500 Euclid Avenue
Cleveland, OH 44195
Grant No. M01 RR018390
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Rebecca Zuti, M.B.A., M.A.
216-444-5113; Fax: 216-444-3279
E-mail: zutib@ccf.org
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Program Director
Serpil Erzurum, M.D.
216-445-6624; Fax: 216-445-8160
E-mail: erzurus@ccf.org
Principal Investigator
Richard A. Rudick, M.D.
216-445-1915; Fax: 216-444-3279
E-mail: rudickr@ccf.org
Associate Program Director
Ernest Borden, M.D.
216-444-8183; Fax: 216-636-2498
E-mail: bordene@ccf.org
Principal Research Subject Advocate
Katrina Bramstedt, Ph.D.
216-444-0204; Fax: 216-444-9275
E-mail: bramstk@ccf.org
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Nurse Manager
Kay Stelmach, R.N., R.R.T.
216-444-3588; Fax: 216-444-3279
E-mail: stelmak@ccf.org
Informatics Manager
Robert Annechiarico
216-445-1928; Fax: 216-445-2781
E-mail: annechr@ccf.org
Biostatistician
Ralph O'Brien, Ph.D.
216-445-9451; Fax: 216-444-8023
E-mail: obrienr@ccf.org
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Special Assays, Services, or Tests
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Bronchoscopy
Cleveland Clinic Cardiovascular Coordinating Center
Clinical investigator development program
Community outreach for inclusion of women or minorities
Core laboratories: Tissue processing laboratory; flow cytometry;
imaging and histology; preventive research laboratory (PRL)
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Pharmacokinetics
Professional nursing services; medical research informatics core;
biostatistics
Pulmonary physiology lab
Research program committee
Research subject advocate program staffed by bioethicist
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Cardiovascular Disease
Gastrointestinal Surgery
Hematology/Oncology
Neurology
Pulmonary Medicine:
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General Clinical Research Center
Ohio State University
10 West Rhodes Hall
450 West 10th Avenue
Columbus, OH 43210-1228
Grant No. M01 RR00034
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
David K. Phillips, M.G.S.
614-293-4406; Fax: 614-293-6140
E-mail: phillips-7@medctr.osu.edu
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Program Director
William B. Malarkey, M.D.
614-293-8775; Fax: 614-293-6140
E-mail: malarkey-1@medctr.osu.edu
Principal Investigator
Alfred P. Sanfilippo, M.D., Ph.D.
614-292-1200; Fax: 614-292-1544
E-mail: sanfilippo.5@osu.edu
Associate Program Director
Kwame Osei, M.D.
614-292-5201; Fax: 614-292-1550
E-mail: osei-1@medctr.osu.edu
Associate Program Director
Philip T. Diaz, M.D.
614-293-4925; Fax: 614-293-4799
E-mail: diaz.3@osu.edu
Research Subject Advocate
Carson R. Reider, Ph.D.
614-293-9274; Fax: 614-293-6140
E-mail: reider-1@medctr.osu.edu
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Director of Nursing
Jackie Buck, Ph.D., R.N.
614-293-8749; Fax: 614-293-3796
E-mail: buck-1@medctr.osu.edu
Core Laboratory Manager
Susan E. Moseley
614-293-4675; Fax: 614-293-6140
E-mail: moseley-1@medctr.osu.edu
Bionutrition Research Manager
Diane Habash, Ph.D., R.D., L.D.
614-293-6689; Fax: 614-293-3796
E-mail: habash-1@medctr.osu.edu
Biostatistician
Haikady N. Nagaraja, Ph.D.
614-293-4647; Fax: 614-293-3796
E-mail: hnn@osustat.ohio-state.edu
Informatics Manager
Robert Rice Jr., Ph.D.
614-293-8514; Fax: 614-293-3796
E-mail: rice.1@osu.edu
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Special Assays, Services, or Tests
Bionutrition and human performance laboratories: Basal or resting
metabolic rate and substrate oxidation; metabolic kitchen services
for feeding trials; feeding trial software (ProNutra); nutrient
analysis software (Nutrition Data Systems for Research [NDS-R]
and ESHA’s Food Processor); food frequency questionnaires and
analysis; body composition analysis with bioimpedance analysis
or anthropometrics and DEXA for research fee; nutrition assessment,
education, and counseling; max and sub-max exercise testing and
physical activity assessment measurements and counseling; assistance
with methods, protocol design, grant and paper development.
Core laboratory: RIA, enzyme immunoassay (EIA), chemiluminescence,
HPLC with electrochemical detection, molecular PCR with AlphaImager2000;
assay determinations include: C-peptide, IGF-I, DHEA sulfate,
glucose, glucagon, insulin, sex-hormone binding, growth hormone,
plasma and salivary cortisol, prolactin, ACTH, plasma catecholamines,
homocysteine, calcitonin, gastrin, gastrin-releasing peptide,
neurotensin, pancreastatin, pancreatic polypeptide, serotonin,
substance P, vasoactive intestinal polypeptide
Informatics: Teleform data capture via scanning or faxing, research data
mart, multicenter trial data management, computer lab
Nursing services: Suction blister application for wound
healing studies, chemotherapy administration, pharmacokinetic
sampling, cardiac monitoring, hepatic glucose output studies,
protocol-specific flowsheet design and development
Behavioral Psychology: Smoking cessation.
Diabetes: Glucose regulation and insulin action;
prevention trials of type 2 diabetes in African Americans;
endocrine and metabolic responses after pancreatic
transplant.
Exercise Physiology: Effect of exercise on glucose
metabolism in type 2 diabetics; effect of exercise on
reproductive hormones; effects of programs to change physical
activity in various populations.
Health Psychology: Effect of stress on fatty-acid and homocysteine
metabolism; effect of stress on immune, endocrine, and cardiovascular
function in different populations of stressed individuals; stress and
long-term survival in breast cancer patients; relaxation and
wound healing studies.
Hematology and Oncology: Phase I and II clinical
trials.
Infectious Diseases: AIDS Clinical Trials Group.
Nephrology: African Americans Study of Kidney
Disease (AASK); progression of renal disease; factors in
the progression of autosomal dominant polycystic kidney
disease.
Neurology: Multiple sclerosis; Parkinson's disease.
Neuromuscular Diseases: Duchenne muscular dystrophy;
amyotrophic lateral sclerosis; gene therapy; limb girdle
muscular dystrophy (LGMD).
Nutrition: Metabolic studies; soy and/or lycopene studies;
gestational and type 2 diabetes studies.
Psychiatry: Drug effects in autism.
Pulmonary Medicine: Emphysma lung reduction study;
HIV-induced emphysema, mechanisms of lung injury.
Women's Health: Risks and benefits of a number of
treatments that may improve the health of postmenopausal
women.
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