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General Clinical Research Center
Oregon Health & Science University
3181 Southwest Sam Jackson Park Road
Mail Code: CR107
Portland, OR 97201-3098
URL:
http://gcrc.ohsu.edu/
Grant No. M01 RR00334
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Beverly De Lanoy
503-494-0921; Fax: 503-494-6649
E-mail:
delanoyb@ohsu.edu
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Program Director
Eric Orwoll, M.D.
503-494-0225; Fax: 503-494-4816
E-mail:
orwoll@ohsu.edu
Principal Investigator
Daniel Dorsa, Ph.D.
503-494-1085; Fax: 503-494-1099
E-mail:
dorsad@ohsu.edu
Associate Program Director
Mary H. Samuels, M.D.
503-494-5242; Fax: 503-494-0165
E-mail:
samuelsm@ohsu.edu
Associate Program Director
Susan Hayflick, M.D.
503-494-6866; Fax: 503-494-4411
E-mail:
hayflick@ohsu.edu
Research Subject Advocate
Kathryn Schuff, M.D.
503-494-1685; Fax: 503-494-0165
E-mail:
schuffk@ohsu.edu
Nurse Manager
Susan Downs, R.N.
503-494-6227; Fax: 503-494-0165
E-mail:
downss@ohsu.edu
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Bionutrition Manager
Martha McMurry, M.S., R.D., L.D.
503-494-6232; Fax: 503-494-0165
E-mail:
mcmurrym@ohsu.edu
Body Energy and Composition Core Director
Jonathan Purnell, M.D.
503-494-1056; Fax: 503-494-0165
E-mail:
purnellj@ohsu.edu
Biostatistician
Dawn Peters, Ph.D.
503-494-8528; Fax: 503-494-0165
E-mail:
petersd@ohsu.edu
Biostatistician
Nichole Carlson, Ph.D.
503-494-2285; Fax: 503-494-4981
E-mail:
carlsoni@ohsu.edu
Informatics Manager
Robert Schuff, M.S.
503-494-5654; Fax: 503-494-0165
E-mail:
schuffr@ohsu.edu
Core Laboratory Manager
Clive Woffendin, Ph.D.
503-494-7148; Fax: 503-494-0165
E-mail:
woffendi@ohsu.edu
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Special Assays, Services, or Tests
Chemiluminescence assays: Cortisol, growth hormone,
thyroid-stimulating hormone
HPLC: Diltiazem, homocysteine
Radioimmunoassays: ACTH; aldosterone–plasma, urine; alkaline
phosphatase (bone-specific); cortisol–plasma, urine; cotinine;
C-peptide–plasma, urine; estradiol-17; estrone; folate;
follicle-stimulating hormone; glucagon; growth hormone;
insulin; luteinizing hormone; melatonin–plasma, saliva;
osteocalcin; parathyroid hormone (intact); plasma renin
activity; progesterone; prolactin; sex-hormone-binding
globulin; sulfatoxymelatonin; testosterone (total, free,
and dihydro); free thyroxine (free T4); vitamin B12
Special Resources,
Instruments, or Services
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Chemiluminometer
CO2 analyzer
Gamma counter
HPLC with electrochemical fluorescence and UV detection
Microcentrifuge
Organ chambers
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Plethysmograph
Polygraph
Scintillation counter
Sleep study facilities
Treadmill with metabolic cart
Ultracentrifuge
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Cardiovascular Diseases: Pathophysiology of
vasospastic disease; therapy of peripheral vascular
disease; prevention of sudden cardiac death in heart
failure; screening for familial dilated cardiomyopathy.
Endocrinology: Diabetes Prevention Trial, type 1
diabetes; evaluation of patients with Cushing's disease or
pseudo-Cushing's disease; effects of glucocorticoids on TSH
secretion; cortisol production rates in chronic illness,
infertility, and short stature; effects of estrogens and
androgens on bone metabolism; therapy of adrenal
insufficiency.
Gastroenterology: Treatment of intravenous
immunoglobulin-associated hepatitis C infection with
interferon alpha 2b and other agents;
ursodeoxycholate-methotrexate for treatment of primary
cirrhosis; kinetics of altered lipid metabolism in patients
with end-stage liver disease; turnover of glucose protein
and urea in the perioperative liver transplant patient.
Metabolism: Hyperlipidemia; cholesterol metabolism;
omega-3 fatty acids; alpha-beta-lipoproteinemia; dietary
influences on blood lipids and lipoproteins; therapy of
hyperlipidemia; lipid response to dietary fat in black
women and white women; lipid modulation of erythrocyte
membranes in sickle cell anemia; effects of lipids on
retinitis pigmentosa; metabolic and genetic studies in
Smith-Lemli-Opitz syndrome.
Neurology: Dopamine sensitivity in Parkinson's
disease; role of sex hormones in cognition; attention and
executive function on motor freezing in Parkinson's
disease; use of deep brain stimulation in Parkinson's
disease; functional studies in healthy aging subjects.
Oncology: Genetic studies of prostate and head and
neck cancer; phase I studies of high-dose vitamin D
therapy.
Pediatrics: Genetic and immune correlates of autism;
molecular and metabolic abnormalities in Smith-Lemli-Opitz
and other genetic diseases.
Psychiatry: Melatonin and depression; circadian
rhythms and melatonin secretion; relationship of work-shift
schedule to circadian desynchrony; phase-shifting
properties of intravenous melatonin; melatonin-induced
prophylactic sleep as a countermeasure for sleep
deprivation; hyperkinesia in neuroleptic-naive
schizophrenics.
Rheumatology: Hormone abnormalities in fibromyalgia.
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