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General Clinical Research Center
Children's Hospital of Philadelphia
34th and Civic Center Blvd.
CHOP North
3535 Market St., Suite 1032
Philadelphia, PA 19104-4399
URL: http://stokes.chop.edu
Grant No. M01 RR00240
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Veronica Mazzaccaro, M.B.A.
215-590-2215; Fax: 267-426-5430
E-mail:
mazzaccaro@email.chop.edu
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Program Director
Carole Marcus, M.B.B.Ch.
215-590-3749; Fax: 215-590-3500
E-mail:
marcus@email.chop.edu
Principal Investigator
Steven Altschuler, M.D.
215-590-2766; Fax: 215-590-3050
E-mail:
altschuler@email.chop.edu
Associate Program Director
Peter Adamson, M.D.
215-590-5448
E-mail:
adamsonp@mail.med.upenn.edu
Associate Program Director
Lorraine Katz, M.D.
215-590-3618
E-mail:
katz@email.chop.edu
Research Subject Advocate
Seth Schulman, M.D.
215-590-5448
E-mail:
schulman@email.chop.edu
Inpatient Nurse Coordinator
Michelle Bergman, R.N.
215-590-1399; Fax: 215-590-5143
E-mail:
Bergman@email.chop.edu
Outpatient Nurse Coordinator
Denise DePaul, R.N.
215-590-3110; Fax: 215-590-2063
E-mail:
DePaul@email.chop.edu
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Scatterbed Nurse Coordinator
Sharon Zirin, R.N.
215-590-1652; Fax: 215-590-3051
E-mail:
zirin@email.chop.edu
Core Laboratory Director
Charles Stanley, M.D.
215-590-3421; Fax: 215-590-3053
E-mail:
stanleyc@email.chop.edu
Associate Core Laboratory Director
Babette Zemel, Ph.D.
215-590-1669; Fax: 215-662-3606
E-mail:
zemel@email.chop.edu
Bionutrition Manager
Debra Cahn, R.D.
215-590-1650; Fax: 215-590-3797
E-mail:
Cahn@email.chop.edu
Biostatistician
Avital Cnaan, Ph.D.
215-590-3236; Fax: 215-590-4487
E-mail:
Cnaan@email.chop.edu
Informatics Manager
Emma Escobar, M.B.A.
215-590-3538; Fax: 215-590-4487
E-mail:
escobar@email.chop.edu
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Special Assays, Services, or Tests
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Beta-hydroxybutyrate/acetoacetate
Carnitine and carnitine esters–serum, urine
Cell bank for genetic defects in fatty acid oxidation and
hyperinsulinism
DNA isolation/extraction
Free fatty acid
Lactate/pyruvate
Myoinositol
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Nutrition services: Computerized nutrient analysis of
dietary intake records; anthropometric evaluation;
educational material for special diets; nutrient
composition of food using selected references; body
composition assessment
PCR, gel extraction
Radioimmunoassays
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Adolescent Medicine: Adolescent trial network for HIV/AIDS
intervention.
Allergy and Immunology: DiGeorge syndrome; immunogenetics;
altered airway smooth muscle function in asthma.
Cardiology: Neurologic dysfunction after repair of heart defects;
genetic etiology of left-sided cardiac defects; heart rate variability
following palliative cardiac surgery.
Endocrinology: Genetics and immunology of diabetes;
congenital hyperinsulinism; hypoglycemia; disorders of fasting
homeostasis, including glycogen storage diseases and defects in
fatty acid oxidation; growth hormone deficiency.
Gastroenterology and Nutrition: Growth, body composition,
and energy expenditures in cystic fibrosis; sickle cell disease;
Alagille syndrome; Crohn's disease; nephrotic syndrome.
Genetics: Alagille syndrome; velocardiofacial syndrome;
spina bifida; mucopolysaccharidosis.
Hematology: Hemophilia B gene therapy; treatment of sickle cell
disease; treatment of lead poisoning.
Infectious Diseases: Treatment of HIV infection in infants
and children; HIV vaccines; prevention of perinatal transmission of HIV.
Neonatology: Inhaled nitric oxide; cerebral oxygenation;
pulmonary hypertension; newborn nutrition; electrogastrography;
extracorporeal membrane oxygenation; sepsis.
Neurology: Effects of ketogenic diet on seizures, growth,
nutritional status, electroencephalology; Fabry disease;
Williams syndrome.
Oncology: Chemotherapy trials; genetics of neuroblastoma;
epipodophyllotoxin effects.
Pulmonology: Cystic fibrosis; MRI imaging of upper airway in
children with obstructive sleep apnea syndrome; respiratory
plethysmography; phenylbutyrate/genistein duotherapy in deltaF508 heterozygotes.
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Neonatal/Perinatal Satellite Program
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Grant No. M01 RR00084
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For information
about this GCRC satellite and how to access its resources, please
contact:
Scatterbed Nurse Coordinator
Kathy Mooney, R.N., B.S.N., M.S.N.
215-662-3253
E-mail:
kathymooney@yahoo.com
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Program Director
Roberta Ballard, M.D.
215-590-1653; Fax: 215-590-6367
E-mail:
ballard@email.chop.edu
Associate Program Director
George Macones, M.D.
215-662-2982
E-mail:
gmacones@obgyn.upenn.edu
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Research Subject Advocate
Seth Schulman, M.D.
215-590-3344
E-mail:
schulman@email.chop.edu
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Scatterbed nursing services are provided to approved protocols in the
nurseries at the Hospital of the University of Pennsylvania
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Chronic lung disease
Bronchopulmonary dysplasia
Neonatal antiviral immunity
Granulocyte colony-stimulating factor treatment in
very-low-birthweight preterm infants born to mothers with preeclampsia
Prevention of perinatal transmission of HIV
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General Clinical Research Center
Children's Hospital of Pittsburgh
3705 Fifth Avenue at DeSoto Street
Pittsburgh, PA 15213
URL: www.chp.edu
Grant No. M01 RR00084
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Diane E. Cline
412-692-5573; Fax: 412-692-6783
E-mail:
diane.cline@chp.edu
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Program Director
Silva A. Arslanian, M.D.
412-692-6565; Fax: 412-692-6783
E-mail:
silva.arslanian@chp.edu
Principal Investigator
David H. Perlmutter, M.D.
412-692-8071; Fax: 412-692-5946
E-mail:
david.perlmutter@chp.edu
Associate Program Director
Patrick M. Kochanek, M.D.
412-383-1901; Fax: 412-692-6783
E-mail:
kochanekpm@ccm.upmc.edu
Associate Program Director
P. David Adelson, M.D.
412-692-6347; Fax: 412-692-6783
E-mail:
david.adelson@chp.edu
Research Subject Advocate
Michael D. Green, M.D., M.P.H.
412-692-6111; Fax 412-692-6783
E-mail:
Michael.Green@chp.edu
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Research Subject Advocate
David Shackelford, B.S.N.
412-692-8289; Fax 412-692-6783
E-mail:
David.Shackelford@chp.edu
Nurse Manager
Janet Bell, R.N.
412-692-6327; Fax: 412-692-6783
E-mail:
Janet.bell@chp.edu
Biostatistician
Janine Janosky, Ph.D.
412-383-2359; Fax: 412-383-2388
E-mail:
jej@pitt.edu
Informatics Core Manager
Susan Laird, B.S.
412-383-2377; Fax: 412-383-2361
E-mail: sbl@pitt.edu
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Allergy and Immunology: Asthma; exercise-induced bronchial
hyperresponsiveness; combined immunodeficiency disease; immune
mechanisms in middle ear disease; respiratory syncytial virus
infections; inflammatory mediators in allergic disease of childhood;
immunologic basis for biochemical and cellular immune factors.
Child Development: Otitis media, hearing disorders,
balance disorders and development.
Emergency Medicine: Biomechanical and biological
approaches in femur fractures in children.
Endocrinology: Growth and its disorders: hormone secretions
and action; diabetes mellitus: etiology and pathogenesis, hypoglycemia
and counter-regulation, and cognitive function complications;
adrenal disorders and sexual differentiation: molecular diagnosis
and biochemical profiling; reproductive health program for teen
girls with diabetes; psychosocial factors in adolescents with
insulin-dependent diabetes mellitus.
Gastroenterology: Gastroesophageal reflux; infantile
esophagitis; chronic constipation; bone mineral density
with inflammatory bowel disease.
Genetics: Congenital adrenal hyperplasia; childhood
depression; otitis media; oral facial cleft disorders;
enzyme therapy for Gaucher's disease.
Hematology and Oncology: Neutropenia; osteosarcoma;
acute lymphoblastic leukemia; refractory solid tumors;
embryonal intracranial CNS tumor; intracranial malignant gliomas;
neoplastic meningitis; brainstem gliomas.
Infectious Disease: Streptococcal infections in
schoolchildren, outcome and prognosis.
Metabolism: In vivo insulin action and secretion
using clamp experiments; substrate turnover using stable
isotopes; energy metabolic study using indirect calorimetry;
organ and tissue mass changes with weight loss; evaluation
of bone mineral density and total body calcium in adolescents;
aerobic training on fat metabolism in obese women.
Neurology and Neurosurgery: Hypothermia in treatment of
severe head injury; adenosine in development of cerebrovascular
failure following severe head injury; speech development after brain
injury; biochemical markers in pediatric brain injury;
Pediatric Brain Tumor Consortium studies.
Nutrition: Racial differences in risk for obesity;
type 2 diabetes mellitus; treatment of severe pediatric obesity.
Pharmacology: Pharmacokinetics of anticancer
therapy; pharmacokinetics in transplant patients.
Psychiatry: Genetic factors of childhood-onset
depression; neurobiology of feeding behavior in bulimia and
anorexia nervosa; sleep/arousal/affect regulation in adolescence.
Pulmonary Diseases: Quality of life assessment in
cystic fibrosis patients; Therapeutic Development Network
for Cystic Fibrosis.
Transplantation: Infectious complications and
follow-up of liver transplantation; post-transplant
lymphoproliferative disorders.
Urology: Clinical, biochemical, and genetic
characterization of individuals with vesicoureteral reflux.
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General Clinical Research Center
Milton S. Hershey Medical Center, Room H4503
Mail Code H147
500 University Drive
P.O. Box 850
Hershey, PA 17033
Grant No. M01 RR10733
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Rebecca Jenkins, M.T., M.P.A.
717-531-5619; Fax: 717-531-3836
E-mail:
rjenkins@psu.edu
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Program Director
Lawrence I. Sinoway, M.D.
717-531-6853; Fax: 717-531-3836
E-mail:
lsinoway@psu.edu
Principal Investigator
Darrell G. Kirch, M.D.
717-531-8323; Fax: 717-531-5351
Associate Program Director
Diane Thiboutot, M.D.
717-531-8307; Fax: 717-531-3836
E-mail:
dthiboutot@psu.edu
Associate Program Director
Urs Leuenberger, M.D.
717-531-6853; Fax: 717-531-3836
E-mail:
uleuenberger@psu.edu
Research Subject Advocate
Thomas Lloyd, Ph.D.
717-531-6258; Fax: 717-531-3922
E-mail:
tal3@psu.edu
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Nurse Manager
Shirlynn Mottilla, R.N.
717-531-7032; Fax: 717-531-3836
E-mail:
smottilla@psu.edu
Core Laboratory Director— Microdialysis
Laurence M. Demers, Ph.D.
717-531-5051; Fax: 717-531-3836
E-mail:
ldemers@psu.edu
Core Laboratory Director—Immunomodulation
Andrea Mastro, Ph.D.
814-863-0152; Fax: 814-865-7024
E-mail: a36@psu.edu
Biostatistician
David Mauger, Ph.D.
717-531-7178; Fax: 717-531-5779
E-mail:
dmauger@psu.edu
Computer Systems Manager
John Mattey
717-531-7178; Fax: 717-531-5779
E-mail:
jfm21@psu.edu
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Special Assays, Services, or Tests
Cytokine analyses
DEXA
EKG
Glucose analyzer
Insulin (double antibody)
Lactate analyzer
Metabolic cart
Microdialysis procedure and analysis
Cardiovascular Metabolic Responses: Cardiovascular physiology
and metabolic responses to congestive heart failure; pathophysiology of
heart failure and the metabolic and neural control of sympathetic
responses; normal physiology of the sympathetic nervous system;
metabolic adaptations of the system to congestive heart failure
and bedrest; impact of sex steroids on cardiovascular metabolic
responses.
Diabetes and Metabolism: Mechanisms of human insulin resistance in
non-insulin-dependent diabetes mellitus and polycystic
ovary syndrome; pathogenesis and treatment of diabetic
retinopathy; posture and gait studies in the neuropathic
diabetic elderly.
Dermatology: Determination of mechanisms that regulate
sebum production in order to identify target sites for alternative
treatments for acne.
Microdialysis: Measurement and quantification of
compounds in interstitial space. The method, based on the
principle of diffusion through a semipermeable membrane,
allows investigation of discrete local tissue function
directly at the cellular level. The microdialysis technique
is well suited for research involving metabolism, endocrinology,
toxicology, pharmacology, drug delivery, and neurotransmission.
Pulmonary Medicine: Sleep apnea; allergies; respiratory
distress syndrome.
Sleep-Related Metabolic Responses: Sympathetic nervous system
function and cardiac metabolic responses to obstructive sleep apnea;
mechanisms of disorders of nocturnal respiration associated with the
metabolic alkalosis of congestive heart failure; metabolic effects
of exercise on sleep in insomniacs and the effects of benzodiazepines
on the sympathetic nervous system and hypothalamic-pituitary-adrenal
function in sleep disorders.
Women's Health: Bone acquisition and density with calcium
supplementation in teenage girls; relationship of bone density in
mothers and teenage daughters; relationships of dietary caffeine,
calcium intake, and bone density of postmenopausal women and infertility.
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General Clinical Research Center Satellite
Elmore Wing Noll Physiological Research Center
119 Noll Laboratory
University Park, PA 16802
Grant No. M01 RR10732
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For information
about this satellite and how to access its resources, please
contact:
Administrative Manager
Rebecca Jenkins, M.T., M.P.A.
717-531-5619; Fax: 717-531-3836
E-mail:
rjenkins@psu.edu
Assistant Administrative Manager
Sue Eberly
814-865-4302; Fax: 814-865-0351
E-mail:
sxe1@psu.edu
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Program Director
Lawrence I. Sinoway, M.D.
717-531-6853; Fax: 717-531-3836
E-mail:
lsinoway@psu.edu
Associate Program Director
Jan Ulbrecht, M.D.
814-865-9961; Fax: 814-865-0351
E-mail: jsu1@psu.edu
Research Subject Advocate
Robert B. Mooney, M.D.
814-865-7787; Fax: 814-865-0351
E-mail: rbm11@psu.edu
Nurse Coordinator
Nancy Lambert, R.N.
814-865-5811; Fax: 814-865-0351
E-mail: nyl1@psu.edu
Core Laboratory Director—Microdialysis
Laurence M. Demers, Ph.D.
717-531-5051; Fax: 717-531-3836
E-mail:
ldemers@psu.edu
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Core Laboratory Director—Immunomodulation
Andrea Mastro, Ph.D.
814-863-0152; Fax: 814-865-7024
E-mail: a36@psu.edu
Nutrition Research Manager
Denise Taylor, M.S., R.D.
814-865-0367; Fax: 814-865-0351
E-mail: ds122@psu.edu
Biostatistician
Mosuk Chow, Ph.D.
814-863-8128
E-mail: mxc18@psu.edu
Computer Systems Manager
Donald Fink
814-863-0757; Fax: 814-865-4602
E-mail: drf@psu.edu
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Special Services, Tests, and Equipment
Cytokine analyses
DEXA
EKG
Insulin (double antibody)
Lactate analyzer
Metabolic cart
Microdialysis procedure and analysis
Stress tests
Adaptation to Physiological and Environmental
Stresses: Human adaptation to different physiological
and environmental stresses; dietary supplementation;
application of information in chronic inflammatory diseases
as well as age-related declines in immune functions.
Environmental Physiology: Acute and chronic
mechanisms of adaptation to heat, cold, and altitude; specifically,
work has involved a systematic investigation
of the effects of age, fitness, and gender on human
thermoregulation and physiological effector responses to
heat stress. Of primary interest is sweating and skin blood
flow effector responses and their basic control mechanism,
control of vascular fluid volume and hydration, and
acclimation-related interactions.
Immunomodulation Core Lab: This laboratory, located at
the University Park facility, has the capability of assaying
blood and other specimens. ELISAs are used to measure IL-B,
IL-6, and tumor necrosis factor in biological fluids. The
staff of the core laboratories provide training in a wide
variety of laboratory methods to students, fellows, and
faculty.
Nutrition: Controlled feeding, nutrition counseling,
and computerized diet record analyses. Study areas include
the impact of nutrition on diabetes mellitus, obesity,
anorexia, cancer, and the cardiovascular system; psychological
and physiological controls of food intake and selection in
normal weight and obese humans across the life span; nutritional
strategies for weight management; food preference in children
and regulation of food intake in children.
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General Clinical Research Center
University of Pennsylvania Health Systems
160 Dulles Building
3400 Spruce Street
Philadelphia, PA 19104-4283
Grant No. M01 RR00040
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Linda C. McCrae
215-662-2641; Fax: 215-662-2643
E-mail:
mccrae@spirit.gcrc.upenn.edu
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Program Director
Garret A. FitzGerald, M.D.
215-898-1185; Fax: 215-573-9135
E-mail:
garret@spirit.gcrc.upenn.edu
Principal Investigator
Arthur Rubenstein, M.D.
215-898-6796; Fax: 215-573-2030
E-mail:
ahrdean@mail.med.upenn.edu
Associate Program Director
Daniel J. Rader, M.D.
215-898-4011; Fax: 215-573-8606
E-mail:
rader@mail.med.upenn.edu
Associate Program Director
Raymond Townsend, M.D.
215-662-2638; Fax: 215-349-5703
E-mail:
townsend@mail.med.upenn.edu
Associate Program Director
Karen Teff, Ph.D.
215-898-5592; Fax: 215-662-2643
E-mail:
kteff@pobox.upenn.edu
Research Subject Advocate
Stanton Segal, M.D.
215-615-3702; Fax: 215-662-2643
E-mail:
stanton@spirit.gcrc.upenn.edu
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Associate Research Subject Advocate
Mary Ellen Geda, M.S.N., R.N.
215-615-3703; Fax: 215-662-2643
E-mail:
mary@spirit.gcrc.upenn.edu
Nurse Manager
Ava Lorraine Norfleet, M.S., B.S.N., R.N.
215-662-2644; Fax: 215-349-5823
E-mail:
lorraine@spirit.gcrc.upenn.edu
Core Laboratory Director
Shiv C. Kapoor, Ph.D.
215-662-3928; Fax: 215-662-2643
E-mail:
mailto:shiv@spirit.gcrc.upenn.edu
Nutrition Research Manager
Lisa Basel-Brown, M.S., R.D.
215-662-7824; Fax: 215-662-2643
E-mail:
lisa@spirit.gcrc.upenn.edu
Biostatistician
Andrew Cucchiara, Ph.D.
215-662-6512; Fax: 215-662-6513
E-mail:
andy@spirit.gcrc.upenn.edu
Core Systems Manager
Steve Vitale
215-615-1951; Fax: 215-662-2643
E-mail:
steve@spirit.gcrc.upenn.edu
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Special Assays, Services, or Tests
ELISA: IgG–plasma, urine, microalbumin
HPLC: Adenosine, epinephrine–plasma, norepinephrine–plasma
Molecular biology assays: Western blot and dot blot
identification of Borrelia burgdorferi (Lyme
disease); polymerase chain reaction (PCR) detection of
B. burgdorferi DNA sequence–whole blood, urine,
cerebrospinal fluid, synovial fluid
Other assays: Erythrocyte protoporphyrin; delta-aminolevulinic
acid; calcium–plasma, urine (fluorometric titration); platelet
aggregation; rapid platelet function assay; GPIIb/IIIa
receptor binding
Radioenzymatic assays: Total plasma catecholamines
Radioimmunoassays–Plasma: Adrenocorticotropic hormone,
aldosterone, angiotensin II, arginine vasopressin, atrial
natriuretic peptide, digoxin, endothelin, insulin,
luteinizing hormone (hLH B subunit), parathyroid hormone,
platelet angiotensin II receptors, prostaglandin E2,
6-keto-prostaglandin F1 alpha, prorenin, renin
activity, thromboxane, transferrin.
Renal clearance studies: Inulin–plasma, urine, IgG–plasma,
urine, PAH–plasma, urine, creatinine–plasma, urine
Urine: Microalbumin, prostaglandin E2,
prostaglandin F2, 6-keto-prostaglandin
F1 alpha, thromboxane, transferrin
AIDS: AIDS Clinical Trials Group studies: DNA
plasmid vaccine in asymptomatic HIV-infected patients;
pharmacokinetics of antituberculosis agents in HIV-infected
patients; virologic responses to new nucleoside regimens;
interleukin-2 in HIV.
Cardiovascular Diseases: Improving clinical
prognostic ability in heart failure; alcohol-induced
oxidant injury; oxidative stress in cardiovascular disease;
antioxidant response to vitamin E administration; effects
of fish oils, olive oil on blood cholesterol;
cyclo-oxygenates and the cardiovascular system.
Dermatology: Recombinant human interleukin-12 in
cutaneous T cell lymphoma; photopheresis with liquid
8-methoxsalen in systematic sclerosis; DNA vaccine for
cutaneous T cell lymphoma.
Hypertension: Renin, sodium intake, and insulin
sensitivity; study of pathogenesis of hypertension and role
of electrolytes in mediating increase in blood pressure.
Obesity: Diabetes and nutrition: Role of the autonomic
nervous system in the regulation of glucose homeostasis; metabolic
consequences of islet cell transplantation; menstrual cycle effects
on insulin sensitivity; effect of nutritional supplements on weight
loss and insulin sensitivity; effect of fructose on circadian
leptin and ghrelin secretion and food intake; effect of acronutrient
restriction on weight loss; interactions between diabetes and
cardiovascular disease.
Oncology: Infusional C-MYB antisense oligodeoxy-
nucleotide in chronic myelocytic leukemia; human stem cell factor
and GCSF in autologous stem cell transplantation in relapsed non-Hodgkin’s
lymphoma; pharmacologic studies for treatment of relapsed gastric
carcinoma and pancreatic carcinoma; trial of hSVTK gene therapy for
CNS tumors; gene therapy of malignant mesothelioma.
Pharmacogenetics: DNA banking; gene/environment
interactions in determining interindividual differences in
drug response.
Psychiatry: Psychoneuroendocrine evaluation of
hormonal regulation in affective illnesses; cerebral
metabolic function in normal subjects; schizophrenia and
affective disorder studies using positron emission
tomography; chronobiology and sleep studies in affective
disorders; role of estrogen in treatment of depression.
Sleep Studies: Homeostatic and circadian regulation
in sleep deprivation; sleep disorders in the elderly;
insomnia in nondepressed elderly; rapid-eye-movement (REM)
sleep dysfunction in post-traumatic stress disorder;
pathogenesis of obstructive sleep apnea; upper airway
imaging during respiration; effect of nocturnal sleep and
acute sleep loss on cytokine and endocrine function.
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General Clinical Research Center
Montefiore University Hospital, 8 North
200 Lothrop Street
Pittsburgh, PA 15213-2582
Grant No. M01 RR00056
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Rosemary J. Sabol, M.B.A.
412-648-6694; Fax: 412-648-6697
E-mail:
sabolrj@upmc.edu
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Program Director
Robert A. Branch, M.D.
412-648-2380; Fax: 412-648-1837
E-mail:
branch@msx.dept-med.pitt.edu
Principal Investigator
Arthur Levine, M.D.
412-648-8977; Fax: 412-648-1236
E-mail:
alevine@hs.pitt.edu
Associate Program Director
Daniel Buysse, M.D.
412-624-2246; Fax: 412-624-2841
E-mail:
buyssedj@upmc.edu
Associate Program Director
James M. Roberts, M.D.
412-641-1426; Fax: 412-641-1503
E-mail:
rsijmr@mwri.magee.edu
Associate Program Director
Susan Greenspan, M.D.
412-692-2220; Fax: 412-692-2477
E-mail:
greenspans@msx.dept-med.pitt.edu
Clinical Director
Jill Huwe, R.N., B.S.N.
412-648-6529; Fax: 412-648-6697
E-mail:
huwejm@upmc.edu
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Nutrition Research Manager
Judith Arch, R.D., C.D.E.
412-648-6528; Fax: 412-648-6697
E-mail:
archjc@msx.upmc.edu
Biostatisticial Core Director
Susan Sereika, Ph.D.
412-624-0799; Fax: 412-624-1201
E-mail:
ssereikat@pitt.edu
Informatics Core Director
Alfred Cecchetti, M.S.
412-383-8998; Fax: 412-648-1837
E-mail:
cecchettiaa@msx.dept-med.pitt.edu
Positron Emissions Tomography Radiochemistry Laboratory
Director
Chester Mathis, Ph.D.
412-647-0734; Fax: 412-647-0700
E-mail:
mathis@peti.upmc.edu
Pharmacogenetics Core Laboratory Director
Marjorie Romkes, Ph.D.
412-383-8885; Fax: 412-648-7107
E-mail:
romkes@msx.dept-med.pitt.edu
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The parent GCRC, located at Montefiore University Hospital at
the University of Pittsburgh, supports 113 active approved
protocols serving 244 investigators, with 15 inpatient beds,
5 outpatient beds, a treatment room, 2 examination rooms,
2 environmentally controlled rooms, 2 indirect blood draw port
rooms, an on-site laboratory for sample processing, 2 infection
control rooms, inpatient and outpatient lounge areas with TV, VCR,
and other diversionary supplies, and a metabolic kitchen on site
with a dining area for inpatients and outpatients; a conference
room with an interactive white board, projector, and computer for
use by investigators and coordinators; a DEXA scanner, exercise
room, and administrative support and fiscal advice to investigators
related to grant budgets and ancillary costs.
Special Assays, Services, or Tests
Human gene therapy applications laboratory: A specialized support facility
for the production of gene therapy vectors provides instruction and
assistance in preparing cell banks, production of vectors, handling
of human target cells and guidance in the appropriate testing to be
performed on materials to be used in gene therapy clinical trials.
This is a single-purpose, multiple-user facility with space to collect
and culture human cells; produce gene carriers and transfer to human
cells; harvest and prepare genetically corrected cells for transplantation,
and store “clean” vectors and cells
Pharmacogenetics core laboratory (PCL) serves both the
University of Pittsburgh and the national GCRC network
as a sophisticated centralized, efficient, low-cost resource
for providing pharmacogenomic technology and expertise on drug
metabolism to clinical researchers investigating the implications
of interindividual variation in expression of drug-metabolizing
enzymes, and as a state-of-the-art facility and technical support resource
for application of a panel of genotyping, mRNA expression, and
sequencing endpoint measurements and for development and validation
of novel endpoints
Positron emissions tomography radiochemistry laboratory (PETRCL)
provides increased availability of synthesized PET imaging agents,
expanding the number of PET radiopharmaceuticals by synthesis of PET
radiopharmaceuticals used in human clinical research imaging studies
at other PET centers throughout the world
Clinical Pharmacology: Mechanisms of regulation of
interindividual drug-metabolizing enzymes and their contribution
to disease pathogenesis; the role of individual drug-metabolizing
enzymes in carcinogenesis; the effect of disease states on drug
disposition.
Endocrinology: Regulation of glucose uptake and metabolism
in muscle; modulation of insulin action; exercise and diet
modification of obesity, fertility, and infertility; hormonal
regulation of risk factors for atherosclerosis; hormonal status
and development of osteoporosis.
Exercise Physiology: Examining the effects of programs on insulin
sensitivity exercise.
Gene Transfer: Gene therapy for cerebrosidase gene
replacement of Gaucher’s disease and IL-4 and IL-12 gene
modification of the immune response in oncology with the
human gene therapy applications laboratory.
Infectious Disease: Treatment of hemophilia and HIV patients.
Oncology and Chemotherapy: Application of pharmacokinetic
and pharmacodynamic modeling of phase I and phase II drug trials;
novel approaches in chemoprevention; integration of preclinical
models to early drug development; application of biologic
response modifiers.
Rheumatology: Hormonal and environmental factors
related to systemic lupus erythematosus; cardiovascular
risk factors in rheumatoid arthritis.
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General Clinical Research Center Satellite
Magee-Women's Hospital, Room 4327
300 Halket Street
Pittsburgh, PA 15213
Grant No. M01 RR00056
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For information
about this satellite and how to access its resources, please
contact:
Administrative and Nurse Manager
Patricia Barcic, B.S.N.
412-641-5349; Fax: 412-641-6113
E-mail:
pbarcic@mail.magee.edu
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Associate Program Director
James M. Roberts, M.D.
412-641-5349; Fax: 412-641-5290
E-mail:
rsijmr@mwri.magee.edu
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Biostatistician
Marijane Krohn, Ph.D.
412-641-6416; Fax: 412-641-1133
E-mail:
mak11+@pitt.edu
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The Magee-Womens Hospital Satellite Clinical Research Center (MWH-SCRC),
a satellite of the University of Pittsburgh’s General Clinical
Research Center, is an outpatient and scatterbed facility for
clinical research studies. Investigators have access to the main
physical unit, which consists of exam rooms, interview rooms,
inpatient rooms for extended outpatient visits, a laboratory,
as well as three ancillary sites within the hospital that permit
interviews and examinations for research purposes only. Equipment,
such as ultrasound and colposcopy machines, nursing staff, and a
laboratory technician as well as the additional services provided
by the parent GCRC are also available to investigators.
A nucleus of clinical investigators with expertise in obstetrics,
gynecology and women’s reproductive health access the MWH-SCRC
and serve as consultants and reviewers.
Women’s health issues throughout the life cycle: cancer screening,
gynecological cancer, infertility, contraception, menopause,
preterm labor, preeclampsia, and sexually transmitted diseases.
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General Clinical Research Center Satellite
Clinical Neuroscience Research Center
Western Psychiatric Institute and Clinic
3811 O'Hara Street
Pittsburgh, PA 15213
Grant No. M01 RR00056
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For information
about this satellite and how to access its resources, please
contact:
Administrative Manager
Dawn G. Stocker, M.B.A.
412-246-5294; Fax: 412-624-2841
E-mail:
stockerdg@upmc.edu
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Associate Program Director
Daniel J. Buysse, M.D.
412-624-2246; Fax: 412-624-2841
E-mail:
buyssedj@upmc.edu
Research Subject Advocate
Jane Alexander, B.S.Ed., C.C.R.C.
412-648-6534; Fax: 412-648-6697
E-mail:
alexanderje@upmc.edu
Nurse Manager
Lisa A. Oross, R.N., B.S.N.
412-624-2187; Fax: 412-624-2841
E-mail:
orossla@upmc.edu
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Sleep and Circadian Rhythms Core Laboratory Director
Daniel J. Buysse, M.D.
412-624-2246; Fax: 412-624-2841
E-mail:
buyssedj@upmc.edu
Biostatistician
Susan Sereika, Ph.D.
412-624-0799; Fax: 412-624-1202
E-mail:
ssereika+@pitt.edu
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The Clinical Neuroscience Research Center (CNRC) supports
inpatient bed days throughout Western Psychiatric Institute
and Clinic (WPIC) for research patients with severe mental
disorders, thus permitting them to be cared for in an environment
that is both physically safe and appropriately staffed to meet
their needs. Designated space includes five bedrooms, a nursing
station, treatment room, equipment control room, patient lounge,
and two time isolation units. Each patient room is equipped for
electrophysiological monitoring, circadian measurements, and
mood and performance testing. Two bedrooms have ports for
intravenous administration of medications and blood sampling.
Portable polysomnographic equipment is available when data need
to be collected outside the CNRC unit. The CNRC staff are trained
to administer psychiatric assessments, insert and maintain IVs,
perform timed blood draws, and coordinate drug administration
Sleep and Circadian Rhythms Core Laboratory provides technical,
scientific, and statistical support for GCRC studies that measure
and analyze human sleep, circadian rhythms, and sleep disorders,
studies conducted in labs at the University of Pittsburgh or in
subjects' homes. This lab provides and refines methods to assess
all aspects of sleep and wakefulness in humans, including circadian
underpinnings, to develop novel techniques for data analysis, to
expand the scope and range of sleep and circadian rhythm studies,
and to provide a core set of resources for training young investigators
in the techniques of human sleep and circadian research
The Clinical Neuroscience Research Center (CNRC) supports
Aging: Improvement of the lives, health, and well-being of
elderly people through behavioral interventions designed to
enhance their sleep.
Dementia: Pharmacotherapy for agitation of dementia.
Depression: Neurobiology of treatment for geriatric depression;
sleep-guided PET studies of depression; acute pharmacotherapy of
unipolar psychotic depression.
Insomnia: Treatment response, identifying and treating
insomnia in the primary care setting; paroxetine as a treatment.
Nicotine Studies Human 31P, 1H, MRSI, and
MRI brain studies.
Schizophrenia: Neurobiology and psychosis.
Sleep: As a mediator of the stress-health relationship;
as related to schizophrenia; effect of phase shifts; functional
outcomes of continuous positive airway pressure compared to
obstructive sleep apnea; effects of aging on sleep from a functional
neuroanatomic perspective.
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