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General Clinical Research Center, Room 329
University of Tennessee
951 Court Avenue
Memphis, TN 38163
Grant No. M01 RR00211
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Patricia Hopkins, M.Ed.
901-448-5193; Fax: 901-448-7041
E-mail:
phopkins@utmem.edu
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Program Director
Bruce S. Alpert, M.D.
901-572-3380; Fax: 901-572-5107
E-mail:
bsalpert@utmem.edu
Principal Investigator
Henry G. Herrod, M.D.
901-448-5529; Fax: 901-448-7683
E-mail:
hherrod@utmem.edu
Associate Program Director
Samuel Dagogo-Jack, M.D.
901-448-5801; Fax: 901-448-5332
E-mail:
sdogogojack@utmem.edu
Assistant Program Director
Robert J. Wyatt, M.D.
901-572-5366; Fax: 901-572-5036
E-mail:
rwyatt@utmem.edu
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Research Subject Advocate
Sidney R. Ornduff, Ph.D.
901-448-5289; Fax: 901-448-7608
E-mail:
sornduff@utmem.edu
Nurse Manager
Moana Mosby, R.N.
901-448-8003; Fax: 901-448-7608
E-mail:
mmosby@utmem.edu
Biostatistician
Grant W. Somes, Ph.D.
901-448-5903; Fax: 901-448-7041
E-mail:
gsomes@utmem.edu
Computer Systems Manager
Gang Liu
901-448-6857; Fax: 901-448-7608
E-mail:
gliu@utmem.edu
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Aging: Dynamics of health, aging and body
composition (Health ABC); gene polymorphisms and prevention of
disability.
Bone: Effects of sodium on bone metabolism; magnesium
supplementation to prevent bone loss.
Cardiovascular Diseases: Hemodynamics of cardiovascular
reactivity in black and white youths; cardiac cachexia: pathogenesis
and management; assessment of androgenic hormones in patients with
coronary heart disease: relationship to insulin resistance, truncal
obesity, and hyperlipidemia.
Diabetes: Epidemiology of diabetes intervention and
complications; diabetes prevention trial for type 2 diabetes;
diabetes prevention trial for type 1 diabetes; monocyte secretory
phenotype in diabetes mellitus; human islet transplantation to
treat insulin-dependent diabetes mellitus; action for health in
diabetes (LOOK AHEAD).
Infectious Diseases: African American response to therapy for
hepatitis C; human experimental challenge with enterotoxigenic
Escherichia coli (ETEC); pathogenesis of respiratory syncytial
virus infection: interactions of immunogenetics, viral load,
and disease severity.
Nephrology: Familial IgA nephropathy: genetic and metabolic studies.
Obstetrics and Gynecology: Effect of rosiglitazone
on spontaneous and clomiphene-citrate-induced ovulation in
polycystic ovarian syndrome; prospective, randomized,
double-blind, multicenter study to compare the safety and
efficacy of immune globulin intravenous (human) 5% with
placebo in the treatment of recurrent spontaneous abortion.
Pulmonary Diseases: Prospective, double-blind,
randomized clinical trial on the effect of low-dose
hydrocortisone infusion in patients with severe sepsis.
Rheumatology: Multicenter phase II/III trial of type II collagen
in rheumatoid arthritis patients off nonsteroidal anti-inflammatory
drugs (NSAIDs); treatment of patients with SSC with
lower doses of bovine CI.
Smoking Cessation: SUCCESS–Sibutraine use in cigarette cessation:
effects on smoking study.
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General Clinical Research Center
AA-3208 Medical Center North
Vanderbilt University School of Medicine
Nashville, TN 37232-2195
URL:
www.mc.vanderbilt.edu/gcrc/
Grant No. M01 RR00095
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Lynda Lane, M.S., R.N.
615-322-2390; Fax: 615-343-2979
E-mail:
lynda.lane@vanderbilt.edu
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Program Director
David Robertson, M.D.
615-343-6499; Fax: 615-343-8649
E-mail: david.robertson@vanderbilt.edu
Principal Investigator
Jeffery R. Balser, M.D., Ph.D.
615-936-3030; Fax: 615-936-2980
E-mail:
jeff.balser@vanderbilt.edu
Associate Program Director
Stephen N. Davis, M.D.
615-936-1649; Fax: 615-936-1667
E-mail:
stephen.davis@vanderbilt.edu
Associate Program Director
Kathryn Edwards, M.D.
615-322-2250; Fax: 615-322-3098
E-mail:
kathy.edwards@vanderbilt.edu
Research Safety Advocate
Harvey Murff, M.D.
615-327-4751; Fax: 615-327-5381
E-mail: harvey.murff@vanderbilt.edu
Nurse Manager
Christa Hedstrom, M.S.N., Ed.D.
615-322-2312; Fax: 615-343-2979
E-mail: christa.hedstrom@vanderbilt.edu
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Core Laboratory Director
Thomas L. Davis, M.D.
615-936-0060; Fax: 615-936-1229
E-mail: thomas.l.davis@vanderbilt.edu
Metabolic Core Director
Kong Chen, Ph.D.
615-343-4192; Fax: 615-343-6229
E-mail:
kong.chen@vanderbilt.edu
Bionutrition Director
Maciej Buchowski, Ph.D.
615-343-4192; Fax: 615-343-6229
E-mail: maciej.buchowski@vanderbilt.edu
Nutrition Research Manager
Mary Sundell, R.D.
615-322-2430; Fax: 615-343-2979
E-mail: mary.b.sundell@vanderbilt.edu
Biostatistician
Daniel Byrne, M.S.
615-322-4228; Fax: 615-322-1754
E-mail:
daniel.byrne@vanderbilt.edu
Information Systems Manager
Paul A. Harrris, Ph.D.
615-322-6292; Fax: 615-343-2979
E-mail:
paul.harris@vanderbilt.edu
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Special Resources, Instruments, or Services
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Bicycle ergometer
BodPod body composition measurement system
Computer software for nutrient analysis of food records and
planning metabolic diets
Computers and software for bedside acquisition and analysis
of physiological signals
Continuous blood pressure monitors
Continuous Holter monitoring
Digital electroencephalography
DNA extraction and genotyping
EKG telemetry
Exercise treadmill
fMRI
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Forearm perfusion equipment
Mass spectrometry support
Meharry Genetics Initiative
Metabolic carts
Metabolic chamber
Metabolic kitchen, nutrition services; bomb calorimetry
Microneurography
Neurophysiological testing facilities
Tilt testing
Video recording equipment
Web-based volunteer database
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Anesthesiology: Pain pathophysiology
Cardiology: Ventricular arrhythmias, pediatric and
adult; atrial fibrillation; clinical trials of
antiarrhythmic drugs; elucidation of the etiology of
variant angina.
Cardiovascular Control: Autonomic dysfunction; etiology of
orthostatic intolerance; ethnicity and vascular reactivity;
dopamine-beta-hydroxylase function; cardiovascular effects of
cocaine; baroreflex control of heart rate; cardiovascular
reactivity and diet in African Americans; autonomic neurophysiology
in microgravity; cardiovascular effects of norepinephrine
transporter blockade; substance P and syncope; role of salt
and water in cardiovascular regulation.
Clinical Pharmacology: Mast cell activation; treatment
of hypertension; ethnic and genetic aspects of drug metabolism;
diagnosis and treatment of carcinoid syndrome; effects of drugs
on balance in the elderly; treatment of pheochromocytoma;
hexobarbitol and liver cirrhosis; epinephrine and cardiac
repolarization; effects of alcohol, age, and gender; nitric
oxide synthesis and enalapril; dietary sodium, the gastrointestinal
tract, and drug metabolism; ethnicity and immunosuppression;
race and angiotensin-converting enzyme activity; genetic
determinants of drug responsiveness; pharmacogenomics.
Diabetes: Epidemiology of diabetes intervention;
counterregulatory response to hypoglycemia; insulin therapy
and metabolic efficiency in insulin-dependent diabetes
mellitus; Irbesartan in diabetic subjects.
Endocrinology: Mediators of carcinoid syndrome;
endocrine function of neoplastic and hyperplastic cells;
Prader-Willi syndrome; Cushing's disease.
Hypertension: Angiotensin II modulation in essential
hypertension; bradykinin-2 receptor expression; epoxygenase
gene therapy and prostate cancer; Cox-2 inhibition and renal function.
Infectious Diseases: Smallpox vaccine; AIDS vaccine; influenza
vaccine trials; pediatric vaccines; drug therapy of AIDS; treatment
of congenital cytomegalovirus infection; treatment of cryptococcal
meningitis in patients with AIDS; cat scratch diseases.
Metabolism: Interaction of insulin, glucose, and
amino acids in muscle metabolism; hypertaurinemia with
muscle weakness; hepatic glucose metabolism; chronic
fatigue syndrome; muscle oxygenation in exercise.
Nephrology: Kidney disease and hypertension in
African Americans; malnutrition and dialysis; renovascular hypertension.
Neurology: Treatment of parkinsonism; drugs and metabolites
in plasma and cerebrospinal fluid; multiple system atrophy;
epilepsy; sleep research; multiple sclerosis.
Oncology: Metabolism of etoposide; pharmacogenetic
aspects of cyclophosphamide metabolism; diagnosis and
treatment of carcinoid disease; chemotherapy regimens in
neoplastic disease; drug treatment of pheochromocytoma;
small-cell lymphoma; lung cancer.
Pediatric Oncology: Progressive cancer; pediatric
cancer; refractory leukemia; topotecan and cisplatin in
solid tumors, brain tumors.
Pediatrics: Hyaline membrane disease; herpes simplex in
neonates; syncytial viruses; energy metabolism and sickle cell
disease; autism.
Psychiatry: Sleep deprivation and treatment of
depression; schizophrenia; Sertraline and sleep
deprivation; attention deficit-hyperactivity disorder and
aggression; alprazolam and panic attacks; alcohol brain
damage imaging; thiamine utilization; pathophysiology of depression.
Pulmonary Physiology: Primary pulmonary
hypertension; aspirin-induced asthma; mycobacteria in
cystic fibrosis; pulmonary fibrosis.
Rheumatology: Drug treatment of rheumatoid
arthritis; metabolic pathways in connective tissue
diseases; lupus erythematosus.
Surgery: Nutrient metabolism in sickle cell disease;
hyperacute lung rejection.
Women's Health: Hormone response in women; vaccines
in HIV-positive pregnant women; hormone replacement,
cardiac repolarization, and heart rate variability in
postmenopausal women.
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