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General Clinical Research Center
Texas Children's Hospital
Mail Station I-3420
6621 Fannin Street
Houston, TX 77030
URL: www.bcm.tmc.edu/pedi/gcrc
Grant No. M01 RR00188
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Donna Campbell
832-826-1079; Fax: 832-825-1061
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Program Director
Dennis M. Bier, M.D.
713-798-7022; Fax: 713-798-7046
E-mail:
dbier@bcm.tmc.edu
Principal Investigator
Ralph D. Feigin, M.D.
713-798-4433; Fax: 713-798-8811
E-mail:
rfeigin@bcm.tmc.edu
Associate Program Director
William C. Heird, M.D.
713-798-7177; Fax: 713-770-7187
E-mail:
wheird@bcm.tmc.edu
Associate Program Director
Mark W. Kline, M.D.
832-824-1083; Fax: 832-825-1281
E-mail:
mkline@bcm.tmc.edu
Research Subject Advocate
Susan Blaney, M.D.
832-822-4586; Fax: 832-825-4299
E-mail:
sblaney@bcm.tmc.edu
Nurse Manager, Pediatric Unit
Ellen Pace, B.S.N., R.N.
832-824-1355; Fax: 832-825-1393
E-mail:
eapace@texaschildrenshospital.org
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Core Laboratory Director
Adrian Gee, Ph.D.
832-824-4214; Fax: 832-825-4668
E-mail:
agee@bcm.tmc.edu
Nutritionist
Janice Stuff, Ph.D., R.D.
713-798-7066; Fax: 713-798-7098
E-mail:
jstuff@bcm.tmc.edu
Nutritionist
Ann McMeans, M.S., R.D.
832-824-2584; Fax: 832-824-1393
E-mail:
amcmeans@bcm.tmc.edu
Biostatistician
Claudia Kozinetz, Ph.D., M.P.H.
832-824-3730; Fax: 832-825-3697
E-mail:
kozinetz@bcm.tmc.edu
Biostatistician
E. O'Brian Smith, Ph.D.
713-798-7058; Fax: 713-798-7046
E-mail:
esmith@bcm.tmc.edu
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Special Assays, Services, or Tests
Metabolic balances
Neurodevelopmental assessments
Special Resources, Instruments, or Services
Dual-energy X-ray absorptiometry
GC/IR/MS
GC/MS
Gene vector core laboratory
Indirect calorimetry (hood and room)
Instruments and skills for evaluation of health care
outcomes and health services delivery
Total-body electrical conductivity analyzer
Whole-body 40K counter
Allergy and Immunology: AIDS Clinical Trials Group:
vertical transmission of AIDS; heart and lung
complications; audiologic function; oral manifestations;
severe combined immunodeficiency disorders; asthma.
Critical Care: Long-term outcomes of pediatric
intensive care unit (PICU) patients; work of breathing and
mechanically ventilated patients: gastric intramucosal pH
and predictor of cardiac output in children on mechanical
ventilation; protein intake and nitrogen balance in PICU
patients on total parenteral nutrition.
Endocrinology: Metabolic role of hormones in
pubertal growth; effects of hormones on calcium metabolism;
studies in clinical disorders of hypopituitarism, Turner's
syndrome, diabetes mellitus.
Gene Therapy: Hepatic gene transplantation; gene
therapy for pediatric AIDS; urea cycle disorders gene
therapy; thymidine kinase gene therapy in children with
brain tumors.
Genetic Diseases: Urea cycle disorders; contiguous
gene deletion syndromes (Smith-Magenis, Prader-Willi,
DiGeorge, Angelmann, Potocki-Shaffer, and Williams syndromes,
and Fabry disease).
Infectious Diseases: Maternal-infant cytomegalovirus;
Norwalk virus vaccine.
Neonatal Nutrition: Gluconeogenesis in
very-low-birthweight infants; Ca and P metabolism and
skeletal mineralization; early feeding strategies and
development in low-birthweight infants; sulfur amino acid
metabolism in low-birthweight infants; quality of energy
intake in low-birthweight infants; essential fatty acid
metabolism in very-low-birthweight and term infants.
Neurology: Hereditary ataxias; Rett syndrome.
Oncology: Pharmacokinetics of chemotherapy in CNS
tumors.
Surgery: Islet cell transplantation.
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General Clinical Research Center
Memorial Hermann Hospital
Robertson Pavilion, Room 658
6411 Fannin Street
Houston, TX 77030
URL: http://oac.hsc.uth.tmc.edu/uth_orgs/crc/
Grant No. M01 RR02558
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Joy C. Lilljedahl, M.B.A.
713-704-4269; Fax: 713-704-6417
E-mail:
joy.c.lilljedahl@uth.tmc.edu
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Program Director
Pablo Okhuysen, M.D.
713-500-6765; Fax: 713-500-5495
E-mail:
pablo.c.okhuysen@uth.tmc.edu
Principal Investigator
L. Maximilian Buja, M.D.
713-500-5012; Fax: 713-500-0602
E-mail:
L.Maximilian.Buja@uth.tmc.edu
Associate Program Director
W. Keith Hoots, M.D.
713-500-8362; Fax: 713-500-8364
E-mail:
Keith.Hoots@uth.tmc.edu
Associate Program Director
Dianna Milewicz, M.D., Ph.D.
713-500-6725; Fax: 713-500-6556
E-mail:
Dianna.M.Milewicz@uth.tmc.edu
Research Subject Advocate
Eugene Boisaubin, M.D.
713-500-6633; Fax: 713-704-6417
E-mail:
Eugene.Boisaubin@uth.tmc.edu
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Genetics Core Lab Director
Dianna Milewicz, M.D., Ph.D.
713-500-6725; Fax: 713-500-6556
E-mail:
Dianna.M.Milewicz@uth.tmc.edu
Nurse Manager
Madelene J. Ottosen, R.N., M.S.N.
713-704-4147; Fax: 713-500-6417
E-mail:
Madelene.J.Ottosen@uth.tmc.edu
Nutrition Research Manager
Christine Camarillo, R.D.
713-704-5807; Fax: 713-704-6417
E-mail:
Christine_Camarillo@mhhs.org
Biostatistician
Chul Ahn, Ph.D.
713-500-6701; Fax: 713-704-6417
E-mail:
Chul.W.Ahn@uth.tmc.edu
Computer Systems Manager
Charles E. Forbes Jr., B.A.
713-704-4195; Fax: 713-704-6417
E-mail:
Charles.E.Forbes@uth.tmc.edu
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Center Resources
Genetics core laboratory supports genomics-based clinical
research by providing high-throughput DNA genotyping and
sequencing; uses advanced equipment such as ABI sequencers
and Pyrosequencer
Informatics core: Full-time manager assists with database
design and management and software applications
Research dietician provides nutrition services, including
design and preparation of specialized diets
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Allergy and Immunology: Influence of social environmental factors
in stress response, asthma, and immune response to early HIV infection.
Dentistry: Studies on oligodontia and craniofacial abnormalities.
Endocrinology: Effects of supplemental T3 and T4 on fatigue
symptoms; interferon alpha and type 1 diabetes; obesity in
Hispanic children.
Gastroenterology: Impact on race and ethnicity in
inflammatory bowel disease.
Genetic Diseases: Genetic basis of aortic aneurysms and
intracranial aneurysms; fibrillin-1 mutations; case studies of
families with bleeding disorders and diabetes insipidus.
Hematology: Studies on hemophilia and other bleeding disorders.
Hypertension: Bypass angioplasty revascularization investigation
in type 2 diabetes (BARI 2D); genetic basis of hypertension.
Infectious Diseases: Adult AIDS clinical trials of anti-retrovirals
and immunomodulators; infectivity of Cryptosporidium parvum;
post-infectious irritable bowel syndrome; vaccine studies for
enteric infections.
Neurology: Biogenic amine metabolism in inherited CNS
disorders; multiple sclerosis therapy trials; alpha interferon in
Alzheimer’s disease; genetics of muscular dystrophy; Parkinson’s disease.
Oncology: Trials in ovarian cancer, Ewing sarcoma, and other
cancers; hyperthermia with chemotherapy for treatment of malignant
carcinoma; studies for pain control methods.
Psychiatry and Behavioral Sciences: Studies in substance
dependence and human aggressive behavior; interactions of L-dopa
and psychomotor stimulants; serotonin physiology and
cocaine dependence.
Public Health: Prevention of alcohol-exposed
pregnancies; prenatal smoking cessation.
Pulmonary Disorders and Critical Care Medicine: Studies of
orthostatic intolerance in astronauts; teamwork and error in neonatal
ICU; clinical trials in chronic obstructive pulmonary disease.
Rheumatology: Studies of systemic lupus erythematosus and
systemic sclerosis; clinical trials in ankylosing spondylitis and
scleroderma; study of osteoarthritis of the knee; genetics of
rheumatologic diseases; infectious bases of autoimmune disease.
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General Clinical Research Center
Department of Medicine/GCRC
Mail Stop 7891
7703 Floyd Curl Drive
San Antonio, TX 78284-7877
Grant No. M01 RR01346
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Susan Stappenbeck, M.Ed., M.P.H.
210-567-4629; Fax: 210-567-4651
E-mail:
stappenbeck@uthscsa.edu
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Program Director
Michael Lichtenstein, M.D., M.Sc.
210-567-4632; Fax: 210-567-4651
E-mail:
lichtenstei@uthscsa.edu
Principal Investigator
Gregory Mundy, M.D.
210-567-0907; Fax: 210-614-0797
E-mail:
mundy@uthscsa.edu
Associate Program Director
Robin Brey, M.D.
210-567-4615; Fax: 210-567-1877
E-mail:
brey@uthscsa.edu
Associate Program Director
Agustin Escalante, M.D.
210-567-4658; Fax: 210-567-6853
E-mail:
escalante@uthscsa.edu
Research Subject Advocate
Ricardo A. Martinez, Ph.D., R.N.
210-567-4636
E-mail:
martinezra0@uthscsa.edu
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Imaging Core Director
Peter Fox, M.D.
210-567-8150; Fax: 210-567-8152
E-mail:
fox@uthscsa.edu
Bioinformatics and Biostatistics Core Director
Brad Pollock, Ph.D.
210-562-1132; Fax: 210-616-5852
E-mail:
mundy@uthscsa.edu
Nurse Manager
Sharyn Pryor, R.N., M.S.N.
210-617-5300 x4757; Fax: 210-567-0957
E-mail:
pryor@uthscsa.edu
Nutritionist
Celia Darland, R.D., C.D.E.
210-617-5300 x 4755; Fax: 210-567-4651
E-mail:
darland@uthscsa.edu
Computer Systems Manager
Karen Schulz, M.S.
210-567-4632; Fax: 210-567-4651
E-mail:
schulz@uthscsa.edu
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Cardiology: Prevention and treatment of acute and chronic
heart disease.
Clinical Lab: Use of herbal and other alternative medications.
Diabetes: Pathophysiology and treatment of type 2 diabetes;
genetics of diabetes in Mexican Americans; insulin resistance and
precursors of diabetes; macrovascular effects of diabetes.
Endocrinology: Genetic and illness-related bone density studies.
Epidemiology: Longitudinal studies of diabetes,
aging, atherosclerosis, osteoporosis.
Gynecology:Genetic causes and treatment options for women with
polycystic ovary syndrome.
Hematology: Course and management of multiple
myeloma.
Infectious Disease: Treatment and outcomes of HIV-related and
non-HIV-related tuberculosis.
Nephrology: Family studies of diabetic nephropathy.
Neurology: Neuromuscular disorder and brain tumor
research.
Nursing: Nurse-guided exercise regimens for minority females.
Oncology: Phase I studies of anti-cancer drugs.
Pediatrics: Understanding and treatment of
genetically caused syndromes.
Pharmacology: Interactions and toleration of new and
tested pharmaceuticals.
Physical Therapy/Rehabilitation: Rehabilitation, outcomes, and/or
use of prosthetics for persons following stroke, limb loss, etc.
Psychiatry Adolescent, adult disorders and treatments; effect of
psychiatric illnesses on physical health.
Pulmonary Disease: Course and management of pulmonary diseases.
Rheumatology and Immunology: Rheumatoid arthritis,
effects of rheumatic inflammation on cardiovascular
diseases.
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General Clinical Research Center
John Sealy Hospital
5th Floor, A and B Units
301 University Boulevard
Galveston, TX 77555-0264
URL:
www.utmb.edu/gcrc
Grant No. M01 RR00073
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Lori A. Wiseman, B.S.
409-772-1953; Fax: 409-772-8097
E-mail:
lwiseman@utmb.edu
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Program Director
Don W. Powell, M.D.
409-772-9544; Fax: 409-772-8097
E-mail:
dpowell@utmb.edu
Principal Investigator
Stanley M. Lemon, M.D.
409-772-4793; Fax: 409-772-2684
E-mail:
smlemon@utmb.edu
Associate Program Director
Karl E. Anderson, M.D.
409-772-4661; Fax: 409-772-6287
E-mail:
kanderso@utmb.edu
Assistant Program Director
Arny A. Ferrando, Ph.D.
409-770-6612; Fax: 409-770-6825
E-mail:
aferrand@utmb.edu
Research Subject Advocate
Michele A. Carter, Ph.D.
409-772-1208; Fax: 409-772-8097
E-mail:
mcarter@utmb.edu
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Nurse Manager
Holly Paskell, R.N., B.S.N., C.C.R.C.
409-772-9542; Fax: 409-772-8097
E-mail:
hlpaskel@utmb.edu
Nutrition Research Manager
Ann Livengood, M.S., R.D., L.D.
409-772-1773; Fax: 409-772-8097
E-mail:
jaliveng@utmb.edu
Biostatistician
James J. Grady, Dr.P.H.
409-772-5276; Fax: 409-772-9127
E-mail:
jgrady@utmb.edu
Computer Systems Manager
Regina K. Minton, B.S.
409-772-6728; Fax: 409-772-8097
E-mail:
rkminton@utmb.edu
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Special Resources, Instruments, or Services
Metabolic control unit
Radiation biophysics laboratory for body composition
Sleep study facility
Volunteer database
Cancer: Genetic susceptibility to environmental carcinogens;
hyperthermia for treatment of advanced cancer.
Cardiopulmonary Disorders: Hypertension; diabetes and cardiovascular
disorders; dilated cardiomyopathy and growth hormone; obstructive
sleep apnea; warfarin metabolism.
Endocrinology: Insulin resistance, obesity, and diabetes
mellitus; growth hormone, androgens, and muscle function in
elderly; bone density and hormonal contraception; endocrine
complications of closed head injury; endocrine effects of soy diets.
Gastroenterology: Hepatitis C; hepatic steatosis; gastrointestinal
myoelectric activity and motility; virtual colonoscopy.
Genetics and Rare Diseases: Human porphyrias; angioneurotic
edema; genetic polymorphisms and drug metabolism.
Geriatrics: Androgen deficiency in elderly men;
exercise, nutrition, and muscle function in the elderly.
Infectious Diseases: Virologic and immunologic progression
in HIV infection; therapies for HIV infection; aging and
neuroimmune modulation of viral resistance; genetic and viral
influences on otitis media in children; hepatitis C; emerging
infectious diseases.
Metabolism: Protein, fat, and carbohydrate metabolism;
metabolic effects of burns and stress; effects of nutrition,
exercise, and aging on muscle; insulin resistance; bed rest
and microgravity; response to bolus intravenous infusions.
Neurology: Hyperglycemia in ischemic stroke; sleep disorders
after stroke.
Nutrition: Soy diets, the endocrine system, and breast cancer;
differential metabolism of dietary fatty acids.
Space Medicine: Effects of bed rest and microgravity on bone,
muscle, and drug metabolism.
Women's Health: Bone density and hormonal contraception;
assessment of uterine contractility and cervical ripening to
predict delivery; ovarian steroids; diet and risk for breast
cancer; effectiveness of pap smear follow-up.
Wound Healing: Metabolic stress and treatment of burned
children; childhood psychosocial development, rehabilitation,
and sleep abnormalities after burns.
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Center for Mineral Metabolism and Clinical Research
5323 Harry Hines Boulevard
Dallas, TX 75235-8891
URL:
http://gcrc.swmed.edu
Grant No. M01 RR00633
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Carol E. Parcel, R.N.
214-590-7783; Fax: 214-590-4091
E-mail:
carol.parcel@utsouthwestern.edu
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Program Director
Khashayar Sakhaee, M.D.
214-590-7783; Fax: 214-590-4091
E-mail:
khashayar.sakhaee@utsouthwestern.edu
Principal Investigator
Robert J. Alpern, M.D.
214-648-2509; Fax: 214-648-8955
E-mail:
robert.alpern@utsouthwestern.edu
Associate Program Director
Abhimanyu Garg, M.D.
214-648-2895; Fax: 214-648-4837
E-mail:
abhimanyu.garg@utsouthwestern.edu
Assistant Program Director
Dana Hardin, M.D.
214-648-3501; Fax: 214-648-9772
E-mail:
dana.hardin@utsouthwestern.edu
Research Subject Advocate
William Chappell Jr., Ph.D.
214-648-9547; Fax: 214-648-2664
E-mail:
william.chappell@utsouthwestern.edu
Nurse Manager–Inpatients
Marsha Roberts, R.N.
214-590-7781; Fax: 214-590-4276
E-mail:
marsha.roberts@utsouthwestern.edu
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Nurse Manager–Outpatients
Sharon Haynes, R.N.
214-648-2178; Fax: 214-648-2664
E-mail:
sharon.haynes@utsouthwestern.edu
Core Laboratory Director
Joseph E. Zerwekh, Ph.D.
214-648-3872; Fax: 214-648-2526
E-mail:
joseph.zerwekh@utsouthwestern.edu
Core Laboratory Manager
Alan Stewart
214-590-7785; Fax: 214-590-4091
E-mail:
alan.stewart@utsouthwestern.edu
Nutrition Research Manager
Linda J. Brinkley, R.D.
214-590-6701; Fax: 214-590-4091
E-mail:
linda.brinkley@utsouthwestern.edu
Biostatistician
Beverley Adams Huet, M.S.
214-648-2788; Fax: 214-648-2664
E-mail:
beverley.huet@utsouthwestern.edu
Computer Systems Manager
John Poindexter, B.S.
214-648-6857; Fax: 214-648-9603
E-mail:
john.poindexter@utsouthwestern.edu
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Special Assays, Services, or Tests
Blood glucose profile
Bone histomorphometry
Bone resorption and formation markers
Free 1,25(OH)2D by centrifugal ultrafiltration dialysis
HgbA1c
Intestinal Ca absorption determination by stable Ca
isotopes
Lipoprotein turnover studies
1,25(OH)2D; 24,25(OH)2D; 25(OH)D
Prostaglandins by mass spectrometry
PTH, bone-specific alkaline phosphatase
Urinary microalbumin
Urinary N-telopeptide, deoxypyridinoline
Special Resources, Instruments, or Services
Dual-energy X-ray absorptiometry
Glucose clamp techniques
Metabolic monitor for measurement of resting energy expenditure
Ultrasound bone measurements
Allergy/Immunology: Effect of 5-lipoxygenase
inhibitor on nasal polyposis.
Cardiopulmonary Medicine: Physiologic adaptation to altitude;
obesity-related hypertension in blacks.
Endocrinology: Diabetes mellitus; Diabetes Control and
Complications Trial; family screening for type 1
diabetes with intervention.
Epidemiology: Random population sampling for prevention of
atherosclerotic heart disease; exercise and leukemia
survivors.
Genetics: Genetic elucidation of various disorders
(absorptive hypercalciuria, cystinuria, gouty diathesis,
lipodystrophy).
Hepatology: Treatment of primary biliary cirrhosis;
human T cell response to hepatitis C; hepatitis C antiviral
long-term treatment to prevent cirrhosis (HALT-C) trial.
Infectious Disease: Immune reconstitution in HIV-infected
patients on highly active antiretroviral treatment
HAART); Francisella tularensis infection in humans.
Lipoprotein Metabolism: Lipoprotein disorders; metabolic
and genetic abnormalities in lipodystrophy; dietary and hormonal
influences on lipoprotein metabolism; racial differences in
high-density lipoprotein; lipodystrophy associated with HIV;
metabolic and genetic determinants of insulin resistance.
Mineral Metabolism: Osteoporosis; nephrolithiasis; parathyroid
pathophysiology; disorders of vitamin D metabolism; effect of long-term
simulated microgravity (bed rest) on bone; effect of long-term alkali
treatment on skeletal bone turnover; pathophysiologic and genetic
studies in mineral metabolism disorders; alkali effect on
bone turnover.
Obstetrics and Gynecology: Penicillin G in pregnancy.
Oncology: Ovarian cancer screening in high-risk women;
genetics of nonpolyposis colorectal cancer with endometrial cancers.
Pediatrics: Gluconeogenesis and lipogenesis in cystic fibrosis;
metabolic effects of protease inhibitors in HIV-infected children.
Psychiatry: Hypothalamic-pituitary-adrenal responsiveness
in alcohol dependence; neuroendocrine stress during cocaine
withdrawal; treatment of schizophrenia; magnetic seizure therapy
for major depression.
Radiology: Analysis of hepatic carbohydrate metabolism
using NMR; assessment of bone quality using ultrasound;
evaluation of myocardial lipids using MRS.
Surgery: Coronary heart disease risk factors after
surgical intervention for morbid obesity.
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