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General Clinical Research Center
Fletcher Allen Health Care Center
Baird 7, MCHV Campus
Burlington, VT 05401
Grant No. M01 RR00109
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Laurie S. Lester, Ph.D.
802-847-3733; Fax: 802-847-1190
E-mail:
laurie.lester@uvm.edu
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Program Director
Richard A. Galbraith, M.D., Ph.D.
802-847-2777; Fax: 802-847-5562
E-mail:
richard.galbraith@uvm.edu
Principal Investigator
John Evans, Ph.D.
802-656-8099; Fax: 802-656-4618
E-mail:
John.evans@uvm.edu
Associate Program Director
Philip A. Ades, M.D.
802-656-4514; Fax: 802-847-5371
E-mail:
philip.ades@uvm.edu
Associate Program Director
Naomi K. Fukagawa, M.D., Ph.D.
802-656-4403; Fax: 802-847-5371
E-mail:
naomi.fukagawa@uvm.edu
Research Subject Advocate
Ira Bernstein, M.D.
802-847-0433; Fax: 802-847-4306
E-mail:
ira.bernstein@uvm.edu
Biochemistry Core Laboratory Manager
Susan S. Lang, B.S.
802-847-5334; Fax: 802-847-5371
E-mail:
susan.lang@uvm.edu
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Mass Spectrometry Core Laboratory Director
Dwight E. Matthews, Ph.D.
802-656-8114; Fax: 802-847-5371
E-mail:
dwight.matthews@uvm.edu
Physiology Core Laboratory Coordinator
Catherine M. Gurgol, M.S.
802-847-4738; Fax: 802-847-5371
E-mail:
catherine.gurgol@vtmednet.org
Nurse Manager
Sandra A. True, R.N., B.S.
802-847-5098; Fax: 802-847-5371
E-mail:
sandra.true@vtmednet.org
Bionutrition Research Manager
Susan E. Ridzon, M.S., R.D.
802-847-4730; Fax: 802-847-5371
E-mail:
susan.ridzon@vtmednet.org
Biostatistician
Janice Bunn, Ph.D.
802-656-8193; Fax: 802-656-0632
E-mail:
janice.bunn@uvm.edu
Informatics Core Manager
Diantha B. Howard, M.S.
802-847-5033; Fax: 802-847-5371
E-mail:
diantha.howard@uvm.edu
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Special Assays, Services, or Tests
D2O (deuterium) dilution technique for
estimating total body water and body composition
Doubly labeled water
Immunoassays: C-peptide, cortisol, glucagon, insulin,
prolactin, GH, cotinine, nicotine, leptin
Isolation of peripheral blood mononuclear cells
Mass spectrometry assays including stable isotopomer
analysis of CO2, body water, amino acids,
sugars, and fatty acids
Online analyses of whole blood glucose, lactate, plasma
CO2
Special Resources, Instruments, or Services
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Bicycle ergometers
Bioelectrical impedance analyzers for estimating body
composition in children and adults
Continuous blood pressure monitoring
Dual-energy X-ray absorption machine for pediatric and
adult bone density and body composition analyses
EKG for monitoring subjects at rest and during exercise
Exercise treadmills
Food intake analysis system
Fuel cell O2 analyzers
GC/MS, IR/MS, LC/MS
Hand-warming devices for arterialization of venous blood
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HPLC
Human physiology lab, exercise testing, body
composition analysis
Indirect calorimetry facilities
Infrared CO2 analyzers
Insulin clamp expertise
Nutritional intervention, monitoring, and education
Pediatric total-body electrical conductivity analyzer for
measurement of infant body composition
Pneumotachygraphs
SensorMedics Deltatracs
Tissots
Underwater weighing facility with helium analyzer for lung
volumes
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Cardiac Disease: Cardiac function in heart failure;
cardiac rehabilitation.
Clinical Pharmacology: Phase I and II drug trials.
Gastroenterology: Regional enteritis; immune studies
of chronic active hepatitis; effect of diet on colonic
mucosa.
Gynecology: Estrogen metabolism in postmenopausal
women; prostaglandin synthetase inhibitors; modulating role
of body composition on reproductive hormones; effect of
estrogen on cardiac function.
Metabolism: Obesity; hypoglycemia; diabetes
mellitus; exercise; genetic studies in multiple endocrine
neoplasia; catecholamine metabolism; regulation of energy
expenditure; ketoacid effects on amino acid metabolism in
insulin-dependent diabetes mellitus; protein
metabolism-regulation of protein synthesis and degradation
by hormones and substrates; interactions between diabetes
and thromboses.
Neurology: Therapeutic intervention in idiopathic
chronic polyneuropathy; DNA damage in muscular dystrophy,
polymyositis, amyotrophic lateral sclerosis, Alzheimer's
and Parkinson's diseases.
Nutrition: Pathophysiology of weight gain; obesity;
diet-induced thermogenesis; dietary fiber; nutrition
support; effect of dietary fiber on estrogen metabolism;
effects of vitamin K1 in women of childbearing
age; low-calorie versus low-fat diets; effects of
tryptophan depletion on behavior.
Oncology: Clinical trials of chemotherapeutic agents
and immunotherapy; intraperitoneal IL-2 and
lymphokine-activated killer cells in recurrent ovarian
carcinoma; lymphatic scintigraphy.
Pediatrics: Hormonal mechanisms of pubertal growth;
relation of age-related decline in growth hormone to muscle
loss and fat accumulation; treatment of obesity with growth
hormone; testing for prediabetes.
Psychiatry: Bulimia and anorexia nervosa: treatment
comparison; stimulant and alcohol interactions;
mecamylamine model of dementia; effect of nicotine
administration on cognitive functions in Alzheimer's
disease; genetic basis of aggression in children; substance
abuse; drug discrimination.
Surgery: Subcutaneous heparin versus oral warfarin
in patients undergoing unilateral elective knee or hip
replacement surgery.
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