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General Clinical Research Center
University Hospital Health Systems
University of Virginia School of Medicine
Box 800787
Charlottesville, VA 22908
URL:
http://gcrc.med.virginia.edu
Grant No. M01 RR00847
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Pamela Sprouse
434-924-2073; Fax: 434-924-9960
E-mail:
pfs2h@virginia.edu
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Program Director
Eugene Barrett, M.D., Ph.D.
434-924-2685; Fax: 434-924-9960
E-mail:
ejb8x@virginia.edu
Principal Investigator
Arthur Garson Jr., M.D.
434-924-5118; Fax: 434-982-0874
E-mail:
atg2n@virginia.edu
Associate Program Director
William S. Evans, M.D.
434-924-5629; Fax: 434-924-0252
E-mail:
wse2p@virginia.edu
Associate Program Director
Craig L. Slingluff, M.D.
434-924-1730; Fax: 434-243-6844
E-mail:
cls8h@virginia.edu
Associate Program Director
Mary Lee Vance, M.D.
434-924-2284; Fax: 434-982-3213
E-mail:
mlv@virginia.edu
Research Subject Advocate
Walter S. Davis, M.D.
434-924-5974; Fax: 434-982-3971
E-mail:
ws3e@virginia.edu
Research Subject Advocate
Karen Parks, R.N., C.C.R.C.
434-982-4311; Fax: 434-243-5999
E-mail:
knp@virginia.edu
Nurse Manager
Sandra Ware-Jackson, R.N.
434-924-9872; Fax: 434-243-5723
E-mail:
msj@virginia.edu
Nutrition Research Manager
Viola Holmes, M.S., R.D.
434-924-5012; Fax: 434-243-5723
E-mail:
vjf7j@virginia.edu
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Core Assay Lab Manager
Pattie H. Hellmann, B.S.
434-924-9695; Fax: 434-924-9960
E-mail:
phh5j@virginia.edu
Biostatistician
Robert D. Abbott, Ph.D.
434-924-1687; Fax: 434-924-8437
E-mail:
rda3e@virginia.edu
Computer Systems Manager
Martin Phillips, M.S.
434-982-1085; Fax: 434-924-9960
E-mail: mtp0f@virginia.edu
Biomathematical Modeler
Michael L. Johnson, Ph.D.
434-924-8607; Fax: 434-982-3878
E-mail:
mlj8e@virginia.edu
Exercise Physiology Laboratory Director
Arthur L. Weltman, Ph.D.
434-924-6191; Fax: 434-924-1389
E-mail:
alw2v@virginia.edu
Exercise Physiology Laboratory Manager
Judy Y. Weltman, M.S.
434-982-3565; Fax: 434-924-9960
E-mail:
jdy8p@virginia.edu
Sleep Laboratory Director
Paul M. Suratt, M.D.
434-924-2228; Fax: 434-924-9682
E-mail:
ps4p@virginia.edu
Strength Laboratory Director
Christopher D. Ingersoll, Ph.D.
434-924-6187 Fax: 434-924-1389
E-mail:
cdi9u@virginia.edu
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Special Assays, Services, or Tests
Pituitary and steroidal hormone assays
Ultrasensitive chemiluminescent assays for GH, LH, FSH,
cortisol, TSH Special Resources, Instruments, or
Services
Computerized protocol application program and
center data management program
Computerized sleep and wake analysis: 24-hour remote blood
sampling capability, video monitoring
Custom-designed neuroendocrine pulsatility analytical software
Exercise physiology laboratory including treadmill, bicycle
ergometer, echocardiograph and exercise Doppler, metabolic
measures, biochemistry measures, body composition assessment,
regional distribution of body fat
Aging: Physical training and sex steroid replacement
in older persons; physiologic basis of decline in
reproductive and growth hormone axes with aging.
Cancer: Immunotherapy of malignant melanoma; chemoradiation
in non-small-cell lung cancer.
Cardiovascular Diseases: Hypertension.
Diabetes: Risks and preventions; meal frequency and
metabolic control in non-insulin-dependent diabetes
mellitus; placental GH and development of retinopathy or
nephropathy during pregnancy in women with type 1 diabetes;
effects of hypoglycemia on retinal function and cognition.
Endocrinology: Puberty, reproduction, and growth;
regulation of skeletal muscle protein turnover; estrogen
negative feedback in postpartum lactational amenorrhea;
feedback actions of cortisol on ACTH release; feedback actions
of testosterone on LH release; GH administration and gonadal
function; somatostatin infusion and GH release; spontaneous
and stimulated GH secretion and body composition measurements;
GH response to varying doses of GH-releasing hormone; effect
of GH-releasing peptides and analogues on GH secretion;
GH and LH secretion as influenced by ethnicity.
Exercise and Physiology: Effects of diet and 24-hour
GH release and GH response to acute exercise; effects of age,
gender, and exercise intensity on GH release and substrate
utilization; regulation of skeletal muscle protein; time course
of adaptations to exercise training; effects of arginine
and GH-releasing hormone-II infusion on GH release;
GH and physical training in older persons; feedback
mechanisms subserving exercise-induced GH release;
core temperature and GH release during exercise; exercise
responses in lean and obese adults; continuous versus
intermittent exercise on GH and metabolic responses.
Growth and Development: Alterations in body
composition and growth at puberty; effects of pubertal
timing; transient alterations in growth, body composition,
and regional body fat distribution during initiation of
hormonal therapies in children; impact of dietary
interventions in puberty.
Immunology and Allergy: Environmental factors and
colonizing yeast or fungi; effects of exposure to house
dust mite antigen on the skin of patients with topical
dermatitis, and on asthmatic reactivity.
Immunology and Allergy: Environmental factors and
colonizing yeast or fungi; effects of exposure to house dust
mite antigen on the skin of patients with topical dermatitis,
and on asthmatic reactivity.
Metabolism: Hormonal regulation of skeletal muscle
metabolism; effect of testosterone, GH, IGF-I, arginine,
adenosine on muscle protein metabolism; effects of
hyperinsulinemia on protein phosphorylation and amino acid
infusion.
Neurology: Impact of osmolality on cognition
in Alzheimer’s disease.
Nutrition: Micronutrient deficiencies as potential markers
of insulin resistance and type 2 diabetes in obese adolescents.
Sleep Studies: Mechanisms of upper airway obstruction in
children with obstructive sleep apnea; treatment of sleep apnea
by removal of lateral pharyngeal fat pad; sleep abnormalities
in acromegaly.
Women's Health: IGF-I feedback in aging women; role of
estradiol in maintaining follicular phase GnRH frequency and
the regulation of luteal GnRH frequency; polycystic ovary
disease; hypothalamic amenorrhea; insulin secretion in the
immediate postpartum period; regulation of GH throughout the
menstrual cycle and in postmenopausal women with and without
estrogen replacement; the menopausal reproductive axis.
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General Clinical Research Center
Virginia Commonwealth University
Box 980155
Richmond, VA 23298
URL:
www.vcuhealth.org/crc
Grant No. M01 RR00065
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Director
Karen J. Newman, M.S.
804-828-9230; Fax: 804-828-5002
E-mail:
kjnewman@vcu.edu
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Program Director
John N. Clore, M.D.
804-828-9228; Fax: 804-828-5002
E-mail:
jnclore@vcu.edu
Principal Investigator
Sheldon M. Retchin, M.D., M.S.P.H.
804-828-0939; Fax: 804-828-5002
E-mail:
hakontos@vcu.edu
Associate Program Director
James Arrowood, M.D.
804-828-9989; Fax: 804-828-5002
E-mail:
jarrowoo@vcu.edu
Research Subject Advocate
Leo J. Dunn, M.D., M.P.H.A.
804-828-1804; Fax: 804-828-5002
E-mail:
ljdunn@hsc.vcu.edu
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Nurse Manager
Mary E. Usry, R.N.
804-828-9229; Fax: 804-828-5002
E-mail: musry@hsc.vcu.edu
Bionutritionist
Karen Fauber, R.D., M.A.
804-828-9226; Fax: 804-828-5002
E-mail:
kfauber@vcu.edu
Biostatistician
Chris Gennings, Ph.D.
804-828-9824; Fax: 804-828-8900
E-mail:
cgenning@vcu.edu
Computer Systems Manager
Tim Aro, B.S.
804-828-4448; Fax: 804-828-5002
E-mail: timaro@vcu.edu
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Special Assays, Services, or Tests
Indirect calorimetry
Intermediary metabolite measurements of metabolic and
nutritional status
Plasma catecholamine assays, serum metabolites, bone markers
Radioimmunoassays and ELISA assays of peptide and steroid
hormones and of peptides as markers of physiologic
processes Special Resources, Instruments, or
Services
Cardiac ultrasound
Case exercise testing system
EEG for sleep monitoring
GC mass spectrometer
HPLC
Metabolic cart
Osmometer, fluorometers, beta and gamma counters
Tilt table
Treadmill
Bone Disorders: Vitamin D metabolism after gastric bypass
surgery; steroids and osteoblast function; steroid-induced
osteoporosis.
Cardiology: Endothelial function and aging; oxygen uptake
in heart failure; aortic wave velocity and cardiovascular disease;
exercise and endothelial function.
Endocrinology: Polycystic ovary syndrome; insulin and
steroidogenesis; glucocorticoids and osteocalcin; androgenic
hyperplasia in acromegaly; adrenomedullary secretion;
steroids and hypertension; aging and hypogonadism.
Gastroenterology: Hepatitis C; alcoholic hepatitis;
nonalcoholic steatohepatitis; chronic active hepatitis;
adenomatous polyps and dietary intervention; primary biliary
cirrhosis; transjugular intrahepatic portosystemic shunts;
liver transplantation; dietary replacement in pancreatitis.
Genetic Diseases: Hereditary deafness; genetics of depression;
genetics of alcoholism.
Hematology and Oncology: Modulation of protein kinase C in
combination chemotherapy; apoptotic agents in malignancies;
antisickling agents; breast cancer; microcirculation and pain
in sickle cell disease.
Immunology: Immunotherapy in recurrent abortions;
immune response and AIDS; psychoneuroimmunology in AIDS.
Infectious Diseases: Fungal meningitis; treatment of systemic
fungal infections; AIDS treatment; HIV infection and adrenal function.
Metabolism: Insulin resistance; cholesterol metabolism;
plasma lipoproteins and liver; free fatty acids in diabetes;
protein kinetics and aging; control of hepatic glucose output;
vascular permeability and insulin; muscle fiber composition
and phospholipids and insulin resistance; weight loss
and substrate metabolism; exercise training and
postprandial lipemia; resistance training and
insulin resistance; peroxisome proliferator activated
receptor alpha.
Nephrology: Prehypertension in African Americans;
dietary potassium and hypertension; pharmacokinetics in
chronic renal disease; pancreaticorenal transplantation.
Neurology: Ornithine transcarbamoylase deficiency in
migraines; new diagnostic methods in epilepsy.
Obesity: Portal vein studies; leptin pulsatility;
ghrelin and gastric bypass surgery; genetics of obesity.
Obstetrics and Gynecology: Luteal phase defects and
infertility; hormonal response to intravenously and
intramuscularly administered Pergonal; gonadotropins
in menopause; preeclampsia; gestational diabetes mellitus.
Pediatrics: Obesity and African American children;
hypophosphatemic rickets; HIV chronic renal failure; growth
failure; hypoparathyroidism; pseudohypoparathyroidism;
relationship between dietary intake and response to growth
hormone.
Pharmacology: Methadone kinetics; nicotine kinetics;
HIV/opiate interactions; aging and acetylcholine kinetics.
Psychiatry: Endocrine function in depression;
schizophrenic disorders; aggression and central serotonergic
function; cocaine withdrawal and fetal stress; nicotine
discrimination; readiness training in substance abuse; pet
therapy; stress and forgiveness in marriage.
Pulmonary/Critical Care Medicine: Sedatin withdrawal; insulin treatment.
Surgery: Living-donor liver transplantation;
hepatocellular liver transplantation; gastrointestinal
hormones after gastric bypass; total parenteral nutrition
and cell cycle kinetics in cancer; exercise therapy in
cardiac transplantation; chronic wound healing.
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