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General Clinical Research Center
University of Washington
Box 356178
Seattle, WA 98195-6178
Grant No. M01 RR00037
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Petra Erwin
206-598-4701; Fax: 206-598-2890
E-mail:
petra@u.washington.edu
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Program Director
Mary L. "Nora" Disis, M.D.
206-598-4702; Fax: 206-598-2890
E-mail:
ndisis@u.washington.edu
Principal Investigator
Paul G. Ramsey, M.D.
206-543-1515; Fax: 206-543-3639
E-mail:
bmahoney@u.washington.edu
Associate Program Director – Adult Center
D. Scott Weigle, M.D.
206-341-4621; Fax: 206-598-2890
E-mail:
weigle@u.washington.edu
Associate Program Director – Pediatric Center
Bonnie W. Ramsey, M.D.
206-987-3897; Fax: 206-987-5160
E-mail:
bonnie.ramsey@seattlechildrens.org
Associate Program Director – Pediatric Center
Sandra Watkins, M.D.
206-987-3897; Fax: 206-987-5160
E-mail:
sandra.watkins@seattlechildrens.org
Associate Program Director for Gene and Cell Therapy
Pamela S. Becker, M.D., Ph.D.
206-616-1589; Fax: 206-543-3560
E-mail:
pbecker@u.washington.edu
Research Subject Advocate
Ann Melvin, M.D.
206-987-2535; Fax: 206-987-2890
E-mail:
ann.melvin@seattlechildrens.org
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Research Subject Advocate
Thomas H. Gallagher, M.D.
206-598-6848
E-mail:
thomasg@u.washington.edu
Nurse Manager
Patricia Farrell, R.N., M.P.H., M.S.
206-598-4734; Fax: 206-598-5460
E-mail:
pfarrell@u.washington.edu
Nutrition Research Manager
Colleen Matthys, R.D.
206-598-4529; Fax: 206-548-2890
E-mail:
matthys@u.washington.edu
Core Laboratory Manager
Catherine Lindgren
206-598-7038; Fax: 206-598-2890
E-mail:
lindgren@u.washington.edu
Biostatistician
Charles Spiekerman
206-616-4363; Fax: 206-685-4258
E-mail:
cspieker@u.washington.edu
Informatics
Christoper DeVoney
206-598-6816; Fax: 206-598-2890
E-mail:
cdevoney@u.washington.edu
Research Education and Compliance Manager
Wendy Brown, R.N.
206-598-1913; Fax: 206-598-2890
E-mail:
wbrown3@u.washington.edu
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The gene and cell therapy core laboratory consists of four
critical environmental procedure rooms for the purification,
expansion, or genetic modification of patient tissues for
clinical transplantation. Resources include cell culture,
cell banking, and clinical-grade high-speed cell sorting.
Endocrinology and Metabolism: Pathophysiology of type 1 and type 2
diabetes; mechanism of insulin secretion and role of other
gastrointestinal peptides; complications of diabetes; mechanism
of body weight regulation; pathophysiology of genetic and
acquired hyperlipidemias; infertility in males.
Gene and Cell Therapy: Adoptive immunotherapy for
HIV and metastatic melanoma using genetically modified
T cells; depletion of lymphoma and T cells from
hematopoietic stem grafts using high-speed cell sorting.
Hematology: Effect of recombinant colony-stimulating
factors in cyclic and chronic neutropenia and in normal
neutrophil kinetics; progenitor cell mobilization in sickle
cell anemia.
Immunology: Acquired and genetic syndromes of
diminished resistance to infection.
Infectious Diseases: Multidrug therapy for HIV
infection; multidrug and biological response modifier
therapy for hepatitis B and C.
Obstetrics and Gynecology: Role of central obesity
in postmenopausal women and in placenta previa.
Psychiatry: Hormonal control of sleep in old age.
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General Clinical Research Center Satellite
Children's Hospital Medical Center
4800 Sand Point Way NE
Box 359300 (71-1)
Seattle, WA 98105-9300
Grant No. M01 RR00037
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For information
about this satellite and how to access its resources, please
contact:
Acting Administrative Manager
Kelli Trosvig
206-598-4701 or 206-527-3897; Fax: 206-598-2890
E-mail:
kelli@u.washington.edu
Administrative Assistant
Daniel Channing
206-987-1818; Fax: 206-987-5160
E-mail:
channing.daniel@seattlechildrens.org |
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Program Codirector
Bonnie Ramsey, M.D.
206-987-5725; Fax: 206-987-5767
E-mail:
bonnie.ramsey@seattlechildrens.org
Program Codirector (TDN)
Richard Kronmal, Ph.D.
206-685-7123
E-mail:
kronmal@biostat.washington.edu
Associate Program Director
Sandra Watkins, M.D.
206-987-3897; Fax: 206-987-5160
E-mail:
sandra.watkins@seattlechildrens.org
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Research Suject Advocate
Ann Melvin, M.D.
206-987-2535 Fax: 206-987-5160
E-mail:
ann.melvin@seattlechildrens.org
Nurse Manager
Pam Joy, R.N., M.N., P.N.P.
206-527-3897; Fax: 206-528-5160
E-mail:
pam.joy@seattlechildrens.org
Biostatistician
Kristy Seidel, Ph.D.
206-987-3968BR>
E-mail:
kristy.seidel@seattlechildrens.org
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Cystic Fibrosis Coordinating Center Therapeutics Development Network (TDN):
The General Clinical Research Center Program provides support for
the data management and study analysis components of the
Cystic Fibrosis Therapeutics Development Network, which
was established in 1998 by the Cystic Fibrosis Foundation.
The TDN provides an infrastructure to support the development
and conduct of network trials. Currently the network consists
of eight member centers that are closely affiliated with their
respective institutional GCRC programs. The TDN, which currently
supports only CF studies, serves as a model for other rare
genetic and orphan diseases requiring conduct of specialized
trials, and provides consultation to other genetic researchers.
Emergency Medicine: Assessment of sedation in
laceration repair.
Endocrinology: Prevention of insulin-dependent
diabetes mellitus and non-insulin-dependent diabetes
mellitus.
Hematology and Oncology: Measurement of
arginine-stimulated growth hormone levels with
administration of chemotherapy in children diagnosed with
osteosarcoma.
Infectious Diseases: Evaluation of dynamics of HIV-1
replication and clearance in HIV-infected children
following highly active antiretroviral therapy (HAART);
AIDS Clinical Trials Group: multidrug therapy in stable
HIV-infected children with antiretroviral experiences.
Nephrology: Graft function in children undergoing
OKT3 induction versus no induction post-transplant;
determination of the recommended dialysis for children.
Pulmonary Medicine: Use of aerosolized tobramycin in
young children with cystic fibrosis; impact of augmented
usual care, coordinated care, and coordinated care plus
environmental interventions on inner-city children with
asthma.
Rehabilitation Medicine: Botulinum-A toxin muscle
injection in children with spastic diplegic cerebral palsy.
Rheumatology: Treatment study with tumor necrosis
factor receptor: Fc in juvenile rheumatoid arthritis
patients who have failed or are intolerant of conventional
second-line drug therapy.
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