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General Clinical Research Center
Froedtert Memorial Hospital
9200 West Wisconsin Avenue
Milwaukee, WI 52336
URL:
www.mcw.edu/gcrc/
Grant No. M01 RR00058
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Sue Lorenz
414-805-7318; Fax: 414-805-7330
E-mail:
slorenz@mcw.edu
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Program Director
Gabriele E. Sonnenberg, M.D.
414-805-7325; Fax: 414-805-7330
E-mail:
gsonnen@mcw.edu
Principal Investigator
Michael J. Dunn, M.D.
414-456-8213; Fax: 414-456-6560
Associate Program Director
D. Gail McCarver, M.D.
414-456-4322; Fax: 414-456-6651
E-mail:
gmccarve@mail.mcw.edu
Assistant Program Director
Stephen Rao, Ph.D.
414-456-4665; Fax: 414-456-6562
E-mail: srao@mcw.edu
Research Subject Advocate
Theodore Kotchen, M.D.
414-805-8696; Fax: 414-805-8691
E-mail:
tkotchen@mcw.edu
Nurse Manager
Melissa Paulson-Conger, R.N., B.S.N.
414-805-7323; Fax: 414-805-7320
E-mail:
mpaulson@fmlh.edu
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Nutrition Research Manager
Joan Pleuss, R.D., C.D.E.
414-257-7306; Fax: 414-805-7330
E-mail:
jpleuss@mcw.edu
Biostatistician
Raymond Hoffmann, Ph.D.
414-805-7327; Fax: 414-805-7330
E-mail:
hoffmann@mcw.edu
Core Laboratory Director
Glenn Krakower, Ph.D.
414-805-3802; Fax: 414-259-0429
E-mail:
gkrakow@mcw.edu
Bioinformatics and Informatics Core Director
Peter Tonellato, Ph.D.
414-456-8570; Fax: 414-456-6546
E-mail: tone@mcw.edu
Imaging Core Director
Thomas Prieto, Ph.D.
414-456-8570; Fax: 414-456-6546
E-mail: tprieto@mcw.edu
Informatics Core Systems Manager
Robert Thielke, Ph.D.
414-805-7322; Fax: 414-805-7330
E-mail:
rthielke@mcw.edu
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Special Assays, Services, or Tests
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Cholecystokinin
Cholesterol, HDL cholesterol
DHEAS (all RIA)
DNA preparation
Estradiol
Estrone
Free fatty acids
Glucose
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IGF-1
Insulin and C-peptide (RIA)
LDL direct
Leptin (RIA)
Proinsulin (RIA)
Testosterone (free, total)
Triglycerides |
Cardiovascular Diseases: Hypertension in African Americans;
blood pressure monitoring in essential hypertension and coarctation
of the aorta; Pediatric Cardiac Registry; reconstructive surgery for
congenital heart disease; myocardial preconditioning prior to
coronary angioplasty; echocardiography of right ventricular
function in cystic fibrosis; effects of weight training on
vascular reactivity; MRI assessment of coronary plaque
volume in atherosclerosis.
Endocrinology and Metabolism: Prevention of diabetes
mellitus; genetics of type 1 diabetes; autoimmune mechanisms
in diabetes; insulin sensitivity in coronary artery disease;
genetics and pathophysiology of obesity and its health
complications; genetics of gallstone disease; treatment
of gout.
Gastroenterology: Esophageal motility; reflux
esophagitis and nasopharyngeal physiology/pathology;
airway protective mechanisms in health and alcoholism;
esophageal sphincter function in gastroesophageal reflux
disease; transnasal upper GI endoscopy; epidemiology,
immunology, and genetics of inflammatory bowel disease.
Gerontology: fMRI and apo E genotyping in aging and
preclinical Alzheimer’s disease; adrenal and gonadal hormones
in aging; swallowing disorders in the elderly.
Hematology: Molecular biology, genetics, and immunology
of von Willebrand’s disease and hemophilia; hepatitis factors
and HIV in hemophilia; pathology and treatment of sickle cell
disease; myoadenylate deaminase deficiency disease; pathogenesis
of neonatal alloimmune thrombocytopenia.
Nephrology: Therapy of nephrotic syndrome and autoimmune
nephritis; serum permeability factor in nephrosis; genetics
of end-stage renal disease and of childhood focal glomerulosclerosis;
renal transplantation: complications and postsurgical
treatment; human prostate tissue repository.
Neurology: fMRI brain imaging in abuse of marijuana,
cocaine, and nicotine; neuroanatomy of cognition, vision,
and language systems; neuroimaging of fear conditioning;
imaging to predict outcomes of Parkinson’s disease surgery;
imaging and memory encoding; treatment of schizophrenia and
polyneuropathy; fMRI alterations during cerebral vasospasm.
Oncology: Photodynamic therapy for brain tumors;
nutritional factors and long-term hormonal replacement
therapy on breast cancer; Wilm’s tumor 1 in leukemia;
radiosensitization and chemotherapy in treatment of
advanced squamous cell carcinoma; chemotherapy and
radiotherapy of rectal cancer; therapy after autologous
transplant for lymphoma and advanced breast cancer;
epidemiology and diet on cervical cancer risk; prostatic
cancer prevention modalities; minimally invasive surgical
therapies for prostate cancer and small breast cancers;
fMRI imaging to assess tumor angiogenesis.
Pediatrics: Therapeutic electrical stimulation in
treatment of juvenile rheumatoid arthritis; nitric oxide in
treatment of acute chest syndrome in sickle cell disease
and in evaluation of acute asthma exacerbation; basis of
fetal alcohol syndrome; early atherogenesis in adolescent
type 2 diabetes and obesity; reversibility of early atherogenesis
in hypercholesterolemic children; genetics of pediatric-onset
systemic lupus erythematosus; serum markers to identify brain
injury in young children with nonaccidental head trauma;
treatment of attention-deficit/hyperactivity disorder;
esophageal motility and airway protection in infants.
Pulmonary Diseases: Role of respiratory pathogens,
imaging of chronic lung disease, determinants of early pancreatic
injury, and genetics of cystic fibrosis; fMRI imaging of pulmonary
aspiration; effects of cigarette smoking on airway function;
clotting mechanisms in deep venous thrombosis; treatment of
end-stage lung disease; genetics of acute mountain sickness.
Women's Health: Effects of long-term hormonal replacement
therapy on cardiovascular disease; mechanisms of gestational
diabetes; repository for normal and ovarian, cervical, and uterine
tumor tissues; amenorrhea, eating disorders, and osteoporosis in
athletes; pharmacogenomics of chemical exposure during pregnancy.
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General Clinical Research Center
University of Wisconsin School of Medicine
600 Highland Avenue
Madison, WI 53792-6724
Grant No. M01 RR03186
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For information
about this GCRC and how to access its resources, please
contact:
Administrative Manager
Paulette A. Sacksteder
608-263-3271; Fax: 608-265-9225
E-mail:
pasacksteder@wisc.edu
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Program Director
William W. Busse, M.D.
608-263-6183; Fax: 608-263-3104
E-mail:
wwb@medicine.wisc.edu
Principal Investigator
Philip M. Farrell, M.D., Ph.D.
608-263-4910; Fax: 608-265-9225
E-mail:
pmfarrel@facstaff.wisc.edu
Associate Program Director
Howard Bailey, M.D.
608-263-8624; Fax: 608-265-9225
E-mail:
hhbailey@facstaff.wisc.edu
Assistant Program Director
Frank M. Graziano, M.D., Ph.D.
608-263-6186; Fax: 608-265-9225
E-mail:
fmg@medicine.wisc.edu
Assistant Program Director
Nizar N. Jarjour, M.D.
608-263-3035; Fax: 608-265-9225
E-mail:
nnj@medicine.wisc.edu
Assistant Program Director
James E. Gern, M.D.
608-263-6201; Fax: 608-265-9225
E-mail:
gern@medicine.wisc.edu
Research Subject Advocate
Yoram Shenker, M.D.
608-280-7056; Fax: 608-265-9225
E-mail:
yshenker@facstaff.wisc.edu
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Assistant Director for Education
Lori Bakken, Ph.D.
608-262-4238; Fax: 608-265-9225
E-mail:
lbakken@facstaff.wisc.edu
Clinical Research Nurse Manager
Mary Jane Williams, R.N., B.S.N., M.P.H.
608-263-0201; Fax: 608-265-9225
E-mail:
mj.williams@hosp.wisc.edu
Research Bionutritionist
Lisa Davis, R.D., M.S.
608-263-8244; Fax: 608-265-9225
E-mail:
ldavis@biostat.wisc.edu
Biostatistics/Informatics Core Director
Jason Fine, Ph.D.
608-263-8244; Fax: 608-265-9225
E-mail:
fine@biostat.wisc.edu
Informatics Core Manager – Biostatistics
Abhik Bhattacharya, M.Stat.
608-263-8495; Fax: 608-265-9225
E-mail:
abhik@biostat.wisc.edu
Informatics Core Manager – Computing
William Annis
608-263-8625; Fax: 608-265-9225
E-mail:
annis@biostat.wisc.edu
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Special Resources, Instruments, or Services
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Bioimpedance measurement
Biological safety hood
Cardiac telemetry
Exhaled breath condensate
Glucose and L-lactate analyzer (YSI)
Histology preparation services
Human calorimeter system for noninvasive measurements of
metabolic activity, assessment of the metabolic rates of
smokers, and studies of obesity and weight regulation
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Polysomnography
Pulse oximeter
Refrigerated centrifuge
Sleep research laboratory
Spirometer, Koko Jaeger with ISO
Stationary exercise cycles
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Asthma/Allergy/Immunology: Asthma in adults and children; chronic
obstructive pulmonary disease (COPD); allergic disorders, rhinovirus,
allergen immunotherapy, asthma prevention in children.
Cancer/Oncology: Studies in monoclonal antibodies,
interleukin-2, melanoma, gene therapy; new chemotherapeutic
agents; gynecological cancer treatment; lymphoma; ovarian
and breast cancers; glioma studies; lung cancer; phase I, II,
and III studies of anticancer agents; cancer pain management;
urologic cancer.
Drug Metabolism: Influenza vaccine response; immune response
to hepatitis A and B vaccines.
Neurology: Studies in epilepsy, stroke; postherpetic
neuralgia and other chronic pain disorders; carotid
artery occlusion.
Nutrition: Exercise intensity and utilization of
dietary fat.
Pediatrics: Pulmonary benefits of cystic fibrosis
screening; studies in childhood cancers, including phase I
and II oncology studies; immune function, metabolism, and energy
expenditure in premature infants; childhood asthma; obesity;
Prader-Willi syndrome.
Psychology and Psychiatry: Influence of the mind and
body on later-life resilience; psychological well-being in
chronic disease; immunological correlates of psychological
conflict; stress, emotion, and healing; central and
peripheral biology of resistance.
Pulmonary Medicine: Airway inflammation and remodeling
in asthma; functional activity of airway eosinophils in allergic
disease; beta adrenergic response by genotype.
Sleep Disorders: Epidemiology and prevalence of
sleep-disordered breathing; effect on daytime blood
pressure; determinants of upper airway obstruction;
nocturnal hypoxemia.
Surgery: Digital splenorenal shunt versus
transjugular intrahepatic portal-systemic shunt; islet transplantation
in type 1 diabetes; surgical pain management.
Women's Health: Women's Health Initiative and
ancillary studies.
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