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Environmental Health
Perspectives
Toxicogenomics
Section
Children's
Health Section
Environmental
Medicine Section
New technologies offer promise for improved health but can also add new complexities to the process of sorting through, validating, and accepting new science as a basis for decision making. The Focus (p. A678) examines how two federal agencies, the EPA and the FDA, are navigating the winding road toward regulatory acceptance of toxicogenomics data as a tool to improve public health.
image credit: Design Pics /Alamy
Environmental Health Perspectives Toxicogenomics August 2004
 Cover Highlights
  • Toxicogenomics Data:
    The Regulatory Road Ahead
    A 678
  • Applying Support Vector Machines to Predict Hepatotoxicity
    A 686 & 1236
  • Linking Gene Networks: Proof of Concept
    A 687 & 1217

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Table of Contents

Perspectives

Editorial
p. A 662-A 664
  • Toxicogenomics in Risk Assessment: Communicating the Challenges
    Syril D. Pettit
    [HTML] [ Download PDF]
  • Regulatory Acceptance of Toxicogenomics Data
    Felix W. Frueh, Shiew-Mei Huang, and Lawrence J. Lesko
    [HTML] [ Download PDF]
  • Note from the Editor: Addressing Applications of Genomics Data
    Thomas J. Goehl
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Correspondence
p. A 666

Environews

Forum
p. A 670
  • Encyclopedia of DNA
  • BAC to the Future
  • The Path to Species Comparison
  • Activating Cancer Drug Discovery
  • TXGnet: National Center for Biotechnology Information
    [HTML] [ Download PDF]
NCT Update
p. A 676 Focus
p. A 678 Science Selections
p. A 686

Toxicogenomics

Articles

Gene Interaction Network Suggests Dioxin Induces a Significant Linkage between Aryl Hydrocarbon Receptor and Retinoic Acid Receptor Beta
Hiroyoshi Toyoshiba, Takeharu Yamanaka, Hideko Sone, Frederick M. Parham, Nigel J. Walker, Jeanelle Martinez, and Christopher J. Portier
p. 1217
[HTML] [ Download PDF]

Valproic Acid Teratogenicity: A Toxicogenomics Approach
Kim Kultima, Anna-Maja Nyström, Birger Scholz, Anne-Lee Gustafson, Lennart Dencker, and Michael Stigson
p. 1225
[HTML][ Download PDF]
[ Supplemental Data PDF]

Discriminating Different Classes of Toxicants by Transcript Profiling
Guido Steiner, Laura Suter, Franziska Boess, Rodolfo Gasser, Maria Cristina de Vera, Silvio Albertini, and Stefan Ruepp
p. 1236
[HTML] [ Download PDF]
[ Supplemental PDF]

Assessment of Prediction Confidence and Domain Extrapolation of Two Structure–Activity Relationship Models for Predicting Estrogen Receptor Binding Activity
Weida Tong, Qian Xie, Huixiao Hong, Leming Shi, Hong Fang, and Roger Perkins
p. 1249
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Biokinetics and Subchronic Toxic Effects of Oral Arsenite, Arsenate, Monomethylarsonic Acid, and Dimethylarsinic Acid in v-Ha-ras Transgenic (Tg.AC) Mice
Yaxiong Xie, Kevin J. Trouba, Jie Liu, Michael P. Waalkes, and Dori R. Germolec
p. 1255
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