Protocol Number: 76-DK-0081

Title:

Studies with 1,25-Dihydroxycholecalciferol

Number:

76-DK-0081

Summary:

Vitamin D in the diet undergoes changes in the liver and kidneys to several forms. Patients suffering from disorders with Vitamin D resistance are unable to absorb calcium from food. Patients diagnosed with these disorders will be evaluated and treated with high doses of another form of Vitamin D (1,25-dihydroxyvitamin D3). Patients will be monitored and observed throughout the study to avoid experiencing side effects from the medication.

Sponsoring Institute:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Patient resistant to a fixed extremely high dose of calcitriol for at least two months at that dose level.

Malabsorption of calcitriol has been excluded.

Non-compliance very unlikely.

Special Instructions: Currently Not Provided

Keywords:

Calciferol

Hypocalcemia

Rickets

Recruitment Keywords:

None

Conditions:

Hypocalcemia

Rickets

Investigational Drug(s):

1,25-Dihydroxycholecalciferol

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Regulation of vitamin D metabolism and function

Pathogenesis of hereditary vitamin-D-dependent rickets An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1 alpha,25-dihydroxyvitamin D

1,25-dihydroxychoecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/27/2004