NIH Clinical Research Studies

Protocol Number: 76-N-0021

Active Accrual, Protocols Recruiting New Patients

Title:
Combined Clinical, Immunological and Virological Assessment of Patients with Multiple Sclerosis (MS)
Number:
76-N-0021
Summary:
Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is unknown, but it is believed to be an autoimmune condition. Autoimmune conditions are diseases that cause the body's immune system and natural defenses to attack healthy cells. In the case of MS, the immune system begins attacking myelin, the cells that make up the sheath covering nerves. Without myelin, nerves are unable to transmit signals effectively and symptoms occur.

This study is directed toward a better understanding of the cause of Multiple Sclerosis (MS). Researchers will evaluate patients with a tentative diagnosis of MS or other neurological diseases possibly caused by a immunological reaction. Patients will undergo a series of three MRIs, taken once a month for three months and submit blood samples for immunological studies.

Sponsoring Institute:
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria:
INCLUSION CRITERIA:

Diagnosis of possible MS.

Age between 18 and 65.

EXCLUSION CRITERIA:

Clinically significant medical condition other than MS that could cause neurological dysfunction.

Currently enrolled in an experimental study.

Medical contraindication for MRI.

Psychological contraindications for MRI.

Unable to provide informed consent.

Special Instructions: Currently Not Provided
Keywords:
Immunogenetics
Tropical Spastic Paraplegia
Twins
Epstein-Barr Virus
HTLV-I
Vasculitis
Cerebrospinal Fluid
Immunity to Viruses
Multiple Sclerosis
Magnetic Resonance Imaging
Recruitment Keywords:
None
Conditions:
Herpesviridae Infection
HTLV-I Infection
Multiple Sclerosis
Tropical Spastic Paraparesis
Vasculitis
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Immunological aspects of demyelinating diseases

Brain magnetic imaging in primary Sjogren's syndrome central nervous system disease

The germline repertoire of T cell receptor beta-chain genes in patients with chronic progressive multiple sclerosis

Active Accrual, Protocols Recruiting New Patients

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