NIH Clinical Research Studies

Protocol Number: 81-N-0010

Active Accrual, Protocols Recruiting New Patients

Title:
Regional Cerebral Utilization of Glucose in Patients with a Diagnosis of Frontal Lobe Dementia, Atypical Parkinsonian Disorder, and Other Basal Ganglia Disorders
Number:
81-N-0010
Summary:
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these important and possibly related brain disorders.
Sponsoring Institute:
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria:
INCLUSION CRITERIA:

Patients with frontotemporal dementia and atypical basal ganglia disorders will be recruited from neurological and psychiatric clinics, from self or family referral in response to advertisements or from private physicians.

Only patients without evidence or history of significant chronic disease who meet standard clinical criteria for the diagnosis of dementia of the Frontotemporal disease type (possible or probable) or atypical basal ganglia disease (e.g., CBD) will be accepted into this protocol.

Normal volunteers will be recruited through the NIH normal volunteer office and will undergo the same screening process as the patient group.

All subjects need to be off all medications, except for thyroid replacement, for the two weeks prior to the PET scan, and off psychotropic medication for one month.

EXCLUSION CRITERIA:

No subject will be accepted for study if he or she shows undue anxiety or appears unmanageable.

Subjects will be cautioned not to consume alcohol, marijuana, or psychotropic drugs while on the study, nor to smoke for at least 24 hours prior to the PET scan.

Urine pregnancy tests will be conducted prior to PET and MRI scans in women of childbearing age.

Special Instructions: Currently Not Provided
Keywords:
Alzheimer's Disease
Cerebral Metabolism
Cerebrospinal Fluid
Dementia of the Alzheimer Type
18-F-Fluoro-2-Deoxy-D-Glucose (FDG)
Magnetic Resonance Imaging
Positron Emission Tomography
X-Ray Computed Tomography (CT)
Senile Dementia
Recruitment Keywords:
Down Syndrome
Trisomy 21
Conditions:
Alzheimer's Disease
Dementia
Down's Syndrome
Investigational Drug(s):
18 FDG
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Computed tomographic analysis of barin morphometrics in 30 healthy men, aged 21 to 81 years

Relation of maesured brain glucose utilization and cerebral atrophy in man

Human brain glucose utilization and cognitive function in relation to age

Active Accrual, Protocols Recruiting New Patients

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