INCLUSION CRITERIA:
Patients with frontotemporal dementia and atypical basal ganglia disorders will be recruited from neurological and psychiatric clinics, from self or family referral in response to advertisements or from private physicians.
Only patients without evidence or history of significant chronic disease who meet standard clinical criteria for the diagnosis of dementia of the Frontotemporal disease type (possible or probable) or atypical basal ganglia disease (e.g., CBD) will be accepted into this protocol.
Normal volunteers will be recruited through the NIH normal volunteer office and will undergo the same screening process as the patient group.
All subjects need to be off all medications, except for thyroid replacement, for the two weeks prior to the PET scan, and off psychotropic medication for one month.
EXCLUSION CRITERIA:
No subject will be accepted for study if he or she shows undue anxiety or appears unmanageable.
Subjects will be cautioned not to consume alcohol, marijuana, or psychotropic drugs while on the study, nor to smoke for at least 24 hours prior to the PET scan.
Urine pregnancy tests will be conducted prior to PET and MRI scans in women of childbearing age.