Protocol Number: 84-M-0050

Title:

Biochemical, Physiological, and Psychological Measures in Normal Controls and Relatives of Psychiatric Patients

Number:

84-M-0050

Summary:

The purpose of this study is to understand the role of genetics in the development of childhood-onset schizophrenia (COS).

Early studies of COS have concentrated on the relationship between COS and adult-onset schizophrenia (AOS). Recent COS studies, however, focus more on inherited risk factors. Evidence suggests that some individuals with COS have genetic abnormalities. This study will evaluate individuals with COS and AOS along with their first-degree relatives to determine whether risk factors for developing COS are genetic and whether genetic risk factors are more prevalent in individuals with COS than in those with AOS. Control groups of healthy volunteers for COS and AOS participants will also be evaluated. Study assessments will include psychiatric, neuropsychological, and genetic tests.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Inclusion criteria for healthy controls will continue to be:

Ages 6-70.

Evidence of normal developmental history and normal functioning.

Inclusion criteria for relatives of probands will continue to be:

Ages 6-65.

Evidence of blood relationship to proband with a disorder under study, with usual selection of first-degree relatives.

EXCLUSION CRITERIA:

Exclusion criteria for community controls are:

Evidence of medical or neurological disease.

Diagnosis of schizophrenia or schizoaffective disorder in subject or in his/her first degree relatives by history, clinical interview, or by structured, diagnostic psychiatric interview.

Exclusion criteria for relatives of probands:

Absence of consent on the part of the proband or parent(s) of proband to contact relatives.

Absence of signed consent or assent by relative(s) to participate.

Special Instructions:

This is not a treatment protocol.

Keywords:

Normal Controls

Psychophysiological

Neuropsychological

Biochemical

Psychological Measures

Immunological

Physiology

Eye Movements

Family Studies

Schizophrenia

Recruitment Keywords:

None

Conditions:

Healthy

Schizophrenia

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Maureen Tobin
National Institutes of Health
Building 10
Room 4C110
10 Center Drive
Bethesda, Maryland 20892
Phone: (301) 435-4518
Fax: (301) 480-8898

Electronic Address: adair@box-a.nih.gov

Citations:

Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder

Pubertal development and onset of psychosis in childhood onset schizophrenia

Autonomic nervous system markers of psychopathology in childhood-onset schizophrenia

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/20/2004