NIH Clinical Research Studies

Protocol Number: 89-I-0174

Active Accrual, Protocols Recruiting New Patients

Title:
Study of Patients with Known or Suspected Infection with Strongyloides Stercoralis
Number:
89-I-0174
Summary:
This study will explore faster and easier ways to detect infection with the intestinal parasite Strongyloides stercoralis and learn more about the conditions under which it causes serious disease. Ordinarily, the Strongyloides helminth (type of intestinal worm) causes only few, if any, symptoms, but in people with weakened immunity it may be very serious, and even deadly.

People between 5 and 80 years of age with known or suspected S. stercoralis infection, or infection with another helminth, such as filariasis, that might cause a cross-reaction with S. stercoralis may be eligible for this study.

Participants found to be infected with S. stercoralis will be treated with ivermectin, thiabendazole, or albendazole. In addition, they will undergo the following tests and procedures:

- Blood tests and stool samples: Samples will be collected before and after treatment to check general health status and immune function, and to look for parasites in stool. Up to 50 milliliters (10 teaspoons) of blood will be drawn in adults and up to 25 ml (5 teaspoons) in children.

- Skin tests: A test similar to those used for tuberculosis and allergies will be conducted to determine if there is sensitization to products of the parasite. Such a test might be used as a rapid method to diagnose the infection. About three drops of several different antigens (proteins) are injected into the skin of the arm. After 15 to 20 minutes, the area is checked to see if a red spot has formed and, if so, the spot is measured.

Sponsoring Institute:
National Institute of Allergy and Infectious Diseases (NIAID)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

Age of 5 to 80 years and of either sex.

Parents or guardian for children under 18 years must be able to understand and sign informed consent.

Presence of known or suspected infection with Stronglyloides stercoralis, such as significant peripheral blood eosinophilia (greater than 1000 eosinophils/mm(3)) for which no other cause is apparent.

EXCLUSION CRITERIA:

None, other than those conditions which fail to meet the inclusion criteria listed above.

Pregnancy is not a criteria for exclusion.

Special Instructions: Currently Not Provided
Keywords:
Strongyloidiasis
Immediate Hypersensitivity Skin Test
IgE
Nematode
Immunosuppression
Recruitment Keywords:
None
Conditions:
HIV Infection
Nematode Infection
Strongyloidiasis
Investigational Drug(s):
Strongyloides Skin Test Antigen
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Biology and immunology of human strongyloidiasis

Strongyloides stercoralis hyperinfection in a carrier of HTLV-1 virus with evidence of selective immunosuppression

Intradermal reactions in strongyloidiasis

Active Accrual, Protocols Recruiting New Patients

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