NIH Clinical Research Studies

Protocol Number: 89-M-0006

Active Accrual, Protocols Recruiting New Patients

Title:
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Controls
Number:
89-M-0006
Summary:
Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. MRI use as the name implies, magnetism to create pictures with excellent anatomical resolution. Functional MRIs are diagnostic tests that allow doctors to not only view anatomy, but physiology and function. It is for these reasons that MRIs are excellent methods for studying the brain.

In this study, researchers will use MRIs to assess brain anatomy and function in normal volunteers and patients with a variety of childhood onset psychiatric disorders. The disorders include attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, multidimensional impairment syndrome, obsessive compulsive disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS), stuttering, Sydenham's chorea, and Tourette's syndrome.

Results of the MRIs showing the anatomy of the brain and brain function will be compared across age, sex (gender), and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations.

Sponsoring Institute:
National Institute of Mental Health (NIMH)
Recruitment Detail
Type: Active Accrual Of New Subjects
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

Normal controls will be recruited from the community.

Clinical subjects to be scanned will have met screening and diagnositc criteria set forth by protocols pertaining to specific diagnosis.

Any patient with cognitive impairment over the age of 18 will require a durable-power-of-attorney.

Competent patients who turn 18 should sign the consent themselves.

Special Instructions:
This is not a treatment protocol.
Keywords:
Autism
Dyslexia
Magnetic Resonance Imaging
Attention Deficit Hyperactivity Disorder
Twin
Childhood Onset Schizophrenia
Obsessive Compulsive Disorder
Sydenham's Chorea
Tourette's Disorder
Klinefelter's Syndrome
Recruitment Keywords:
Congenital Adrenal Hyperplasia
Twin
Conditions:
Autoimmune Disease
Congenital Adrenal Hyperplasia
Healthy
Mental Disorder Diagnosed in Childhood
Neurologic Manifestations
Investigational Drug(s):
None
Investigational Device(s):
None

Contacts:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:
Quantitative magnetic resonance imaging of human brain development: ages 4-18

Sexual dimorphism of the developing human brain

Quantitative magnetic resonance imaging of the corpus callosum in children and adolescents

Active Accrual, Protocols Recruiting New Patients

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