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Protocol Number:
89-M-0006
- Title:
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Controls
- Number:
89-M-0006
- Summary:
Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. MRI use as the name implies, magnetism to create pictures with excellent anatomical resolution. Functional MRIs are diagnostic tests that allow doctors to not only view anatomy, but physiology and function. It is for these reasons that MRIs are excellent methods for studying the brain.
In this study, researchers will use MRIs to assess brain anatomy and function in normal volunteers and patients with a variety of childhood onset psychiatric disorders. The disorders include attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, multidimensional impairment syndrome, obsessive compulsive disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS), stuttering, Sydenham's chorea, and Tourette's syndrome.
Results of the MRIs showing the anatomy of the brain and brain function will be compared across age, sex (gender), and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations.
- Sponsoring Institute:
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National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
Active Accrual Of New Subjects
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
Normal controls will be recruited from the community.
Clinical subjects to be scanned will have met screening and diagnositc criteria set forth by protocols pertaining to specific diagnosis.
Any patient with cognitive impairment over the age of 18 will require a durable-power-of-attorney.
Competent patients who turn 18 should sign the consent themselves.
- Special Instructions:
This is not a treatment protocol.
- Keywords:
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Autism
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Dyslexia
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Magnetic Resonance Imaging
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Attention Deficit Hyperactivity Disorder
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Twin
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Childhood Onset Schizophrenia
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Obsessive Compulsive Disorder
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Sydenham's Chorea
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Tourette's Disorder
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Klinefelter's Syndrome
- Recruitment Keywords:
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Congenital Adrenal Hyperplasia
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Twin
- Conditions:
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Autoimmune Disease
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Congenital Adrenal Hyperplasia
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Healthy
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Mental Disorder Diagnosed in Childhood
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Neurologic Manifestations
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Contacts:
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citations:
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Quantitative magnetic resonance imaging of human brain development: ages 4-18
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Sexual dimorphism of the developing human brain
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Quantitative magnetic resonance imaging of the corpus callosum in children and adolescents
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Warren Grant Magnuson Clinical Center (CC) National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/23/2004
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