INCLUSION CRITERIA:
Control subjects with history of psychiatric or neurologic disorders or medical illness or surgeries that might have relevance to the investigation of brain physiology will be excluded.
Normal subjects taking medications with relevance to cerebral blood flow and metabolism will be excluded from study.
Patients with schizophrenia will be recruited from the inpatient population of the NIMH at NIH.
Patients with history of neurological illness other than those of interest to the study, or other medical illness or surgery that might have impact on the study of brain physiology, will be excluded.
Additional neuropsychiatric patients (those with affective disorder, Tourette's Syndrome, Huntington's Disease, Parkinson's Disease, Alzheimer's Disease, special genetic disorders (e.g. William's Syndrome), and other neuropsychiatric patients) will be recruited from the medical community, from NIH inpatient and outpatient services, and through the National Alliance for the Mentally Ill (NAMI).
All subjects will be asked to refrain from nicotine and caffeine for four hours prior to the PET scan.
In the case of female subjects of childbearing age and potential, a urine pregnancy test will be obtained within 24 hours prior to the PET scan.
Subjects will be queried for history of metal objects in the head or neck and for other contraindications as listed in the consent form and will only be studied if such history is negative.
To acclimate subjects to the testing procedure and to ensure comprehension and ability to cooperate with the study, subjects will practice all tasks, except those to which they must be naive, with equipment similar to that used during the PET scan. In particular, psychotic patients or those for whom cooperation is otherwise difficult will be further screened and acclimated with a "dry run" in the PET scanner. Subjects who are unable to cooperate will be excluded from the study.
Warren Grant Magnuson Clinical Center (CC)