Protocol Number: 90-M-0142

Title:

Brain Procurement for the Neuropathology Section, CBDB

Number:

90-M-0142

Summary:

The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders.

This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Individuals suffering from a variety of neuropsychiatric disorders, especially schizophrenia, but also Huntington's chorea, suicide, manic-depressive illness, depression, Tourette's Syndrome, drug addictions (PCP, cocaine, alcohol, heroin or the like) and any form of dementia.

Brain tissue from afflicted individuals is needed for the study.

Brains (fresh or preserved tissue) from normal individuals without a history of neuropsychiatric disease.

Special Instructions: Currently Not Provided

Keywords:

Schizophrenia

Neuropathology

Neurochemistry

Substance Abuse

Bipolar Illness

Aging

Normal Development

Alcoholism

Recruitment Keywords:

Dementia

Depression

Drug Addiction

Huntington's Chorea

Manic Depressive Illness

Neuropsychiatric Disorders

Suicide

Tourette's Syndrome

Normal Controls

Conditions:

Bipolar Disorder

Huntington Disease

Schizophrenia

Tourette Syndrome

Dementia

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Joel E. Kleinman, M.D.
National Institutes of Health
Building 10
Room 4S237A
10 Center Drive
Bethesda, Maryland 20892
Phone: (301) 402-7909
Fax: (301) 480-7795

Electronic Address: kleinmaj@intra.nimh.nih.gov

Citations:

The subnuclear distribution of 5-HT3 receptors in the human nucleus of the solitary tract and other structures of the caudal medulla

Fewer dopamine transporter receptors in the prefrontal cortex of cocaine users

Autoradiographic characterization of (125)I-neurotensin binding sites in human entorhinal cortex

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/16/2004