Protocol Number: 92-EI-0113

Title:

Immunopathology of Ocular Diseases in Humans

Number:

92-EI-0113

Summary:

The purpose of this study is to better understand the processes involved in the development of various eye conditions, such as uveitis, disorders of the conjunctiva, cornea, vitreous and retina, metabolic or genetic eye diseases or eye tumors, in order to develop better methods of diagnosis and treatment.

Patients who require eye surgery to treat an eye disease or other disease in which the eye is involved may participate in this study. Samples of eye tissue and fluid that are normally removed and discarded during eye surgery will instead be given to researchers for study. The tissues will be examined under microscope and studied using sophisticated chemical and biological tests. Immune cells from blood samples may also be examined. These studies will help better understand and diagnose the various eye diseases and to develop more attractive therapies.

Sponsoring Institute:

National Eye Institute (NEI)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

All specimens either male or female of any age with ocular disease that are collected at the NEI or its collaborating institutes, will be included in the study.

These would include but would not be limited to cases involving uveal, conjunctival, corneal, vitreo-retinal, orbital disorders, tumor, and metabolic abnormalities.

Special Instructions: Currently Not Provided

Keywords:

Ocular Pathology

Ocular Immunology

Clinicopathological Correlation

Immunohistochemical Methods

In Situ Hybridization

Polymerase Chain Reaction

Microdissection

Recruitment Keywords:

Ocular Disease

Conditions:

Conjunctival Disease

Corneal Disease

Eye Disease

Uveitis

Vitreoretinopathy, Proliferative

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Association of interleukin-10 in the vitreous and cerebral spinal fluid and primary central nervous system lymphoma

Apoptosis in posterior uveitis

The immunopathology of uveitis

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/23/2004