Protocol Number: 92-H-0189

Title:

Evaluation of Patients with Known or Suspected Heart Disease (Screening Protocol)

Number:

92-H-0189

Summary:

In this study researchers will admit and evaluate patients with known or suspected heart disease referred to the Cardiology Branch of the National Heart, Lung, and Blood Institute (NHLBI).

Patients participating in this study will undergo a general medical evaluation, including blood tests, urine, examination, chest x-ray and electrocardiogram (EKG). In addition, patients may be asked to have an echocardiogram (ultrasound scan of the heart) and to perform an exercise stress test.

These tests are designed to assess the types and causes of patient's heart diseases and to determine if they can participate in other, specific research studies.

Sponsoring Institute:

National Heart, Lung and Blood Institute (NHLBI)

Recruitment Detail

Type: Active Accrual Of New Subjects

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

The following is a representative list of the types of patient presentations and potential diagnoses eligible for this protocol:

1. Coronary artery disease with effort or rest angina or inducible myocardial ischemia as determined by noninvasive testing.

2. Cardiomyopathies, including restrictive, congestive, and hypertrophic phenotypes.

3. Peripheral artery disease with intermittent claudication or limb-threatening ischemia.

4. Renovascular disease with uncontrolled hypertension, intermittent pulmonary edema, or evidence of ischemic nephropathy.

5. Upper extremity peripheral artery disease.

6. Symptomatic supraventricular and ventricular arrhythmias.

EXCLUSION CRITERIA:

Pregnancy, for those patients who require catheterization-based diagnostics.

Inability to provide informed consent.

Special Instructions: Currently Not Provided

Keywords:

Cardiac Diagnosis

Chest Pain

Hypertrophic Cardiomyopathy

Coronary Artery Disease

Microvascular Angina

Cardiac Investigation

Follow-up

Recruitment Keywords:

Heart Disease

Chest Pain

Coronary Artery Disease

Conditions:

Chest Pain

Coronary Disease

Heart Disease

Hypertrophic Cardiomyopathy

Syndrome X

Investigational Drug(s):

None

Investigational Device(s):

None

Contacts:

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citations:

Prognostic applications of exercise testing

Exercise-induced ischemia in mildly symptomatic patients with coronary artery disease and preserved left ventricular function: indentifcation of subgroups at risk of death during medical therapy

Electrophysiologic abnormalities in patients with hypertrophic cardiomyopathy: a consecutive analysis in 155 patients

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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Warren Grant Magnuson Clinical Center (CC)
National Institutes of Health (NIH)
Bethesda, Maryland 20892. Last update: 10/16/2004